LIVIVO - Search results -

Search results

Result 1 - 9 of total 9

Search options

Article ; Online: Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues.

Kucukdumlu, Asligul / Tuncbilek, Meral / Guven, Ebru Bilget / Atalay, Rengul Cetin

2021 Volume 67, Issue 1, Page(s) 70–82

Abstract: A series of new 6,9-disubstituted purine analogs with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds (7-26) were screened initially for their in vitro anticancer ... ...

Abstract	A series of new 6,9-disubstituted purine analogs with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds (7-26) were screened initially for their in vitro anticancer activity on Huh7 liver, HCT116 colon and MCF7 breast carcinoma cell lines. Cytotoxic bioactivity studies revealed that all compounds screened, with compound 19 being the exception, were found to have promising cytotoxic activities at IC50 range of 0.05-21.8 ∆M against cancer cells Huh7, HCT116 and MCF7. Among the prepared purine analogs, two of them (12 and 22) exhibited excellent cytotoxic activities, with IC50 0.08-0.13 ∆M, on Huh7 cells comparable to camptothecin (CPT) and better than cladribine, fludarabine and 5-FU. Afterwards, the evaluation of cytotoxicity of the most potent purine analogs was screened against further hepatocellular cancer (HCC) cell lines. The 6-(4-(4-trifluoromethylphenyl)piperazine (12) and 6-(4-(3,4-dichlorophenyl)piperazine analogs (25) displayed a significant IC50 values (IC50 < 0.1-0.13 ∆M) comparable to CPT and better cytotoxic bioactivity when compared with 5-FU, cladribine and fludarabine on HCC cells (Huh7 and HepG2).
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cladribine/pharmacology ; Drug Design ; Drug Screening Assays, Antitumor ; Fluorouracil/pharmacology ; Humans ; Molecular Structure ; Purines/chemical synthesis ; Purines/pharmacology ; Vidarabine/analogs & derivatives ; Vidarabine/pharmacology
Chemical Substances	Antineoplastic Agents ; Purines ; Cladribine (47M74X9YT5) ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2021-02-08
Publishing country	Slovenia
Document type	Journal Article
ZDB-ID	2029709-9
ISSN	1580-3155 ; 1318-0207
ISSN (online)	1580-3155
ISSN	1318-0207
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Design, Synthesis and Biological Evaluation of Novel Triazolothiadiazoles Derived from NSAIDs as Anticancer Agents.

Aytaç, Peri / Sahin, Irem Durmaz / Atalay, Rengül Çetin / Tozkoparan, Birsen

Anti-cancer agents in medicinal chemistry

2021 Volume 22, Issue 7, Page(s) 1340–1347

Abstract: Background: Although transplantation, surgical resection, and tumor ablation are treatment options available following early diagnosis of HCC, poor prognosis and high recurrence rates restrict the efficacy of these approaches. Hence, small molecules ... ...

Abstract	Background: Although transplantation, surgical resection, and tumor ablation are treatment options available following early diagnosis of HCC, poor prognosis and high recurrence rates restrict the efficacy of these approaches. Hence, small molecules with high selectivity and bioactivity are urgently required. Objective: This study presents the synthesis of a series of new triazolothiadiazole derivatives (1a-3j) with NSAID moieties and their cytotoxic bioactivities. Methods: The new synthetic derivatives (1-3; 1a-3j) and NSAIDs ibuprofen, naproxen, and flurbiprofen that commonly used in clinics were screened against human liver (Huh7), breast (MCF7), and colon (HCT116) carcinoma cell lines under in vitro conditions via NCI-sulforhodamine B assay. Results: The 4-methoxyphenyl substituted condensed derivatives 1h, 2h, and 3h were the most active compounds. Based on its high potency, compound 3h was selected for the further biological evaluation of hepatocellular carcinoma cell lines, and the mechanisms underlying cell death induced by 3h were determined. The results revealed that compound 3h induced apoptosis and cell cycle arrest in the sub G1 phase in human liver cancer cells. Conclusion: These new small molecules may be used for the development of new lead compounds.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antineoplastic Agents ; Carcinoma, Hepatocellular/drug therapy ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Humans ; Liver Neoplasms/drug therapy ; Molecular Structure ; Structure-Activity Relationship
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Antineoplastic Agents
Language	English
Publishing date	2021-06-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520621666210623093550
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5583: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells.

Narci, Kubra / Kahraman, Deniz Cansen / Koyas, Altay / Ersahin, Tulin / Tuncbag, Nurcan / Atalay, Rengul Cetin

BMC cancer

2022 Volume 22, Issue 1, Page(s) 320

Abstract: Background: Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chronic liver ... ...

Abstract	Background: Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chronic liver disease stages and cirrhosis. Although combinatorial therapy can increase the efficiency of targeted therapies through synergistic activities, isoform specific effects of the inhibitors are usually ignored. This study concentrated on PI3K/Akt/mTOR pathway and the differential combinatory bioactivities of isoform specific PI3K-α inhibitor (PIK-75) or PI3K-β inhibitor (TGX-221) with Sorafenib dependent on PTEN context. Methods: The bioactivities of inhibitors on PTEN adequate Huh7 and deficient Mahlavu cells were investigated with real time cell growth, cell cycle and cell migration assays. Differentially expressed genes from RNA-Seq were identified by edgeR tool. Systems level network analysis of treatment specific pathways were performed with Prize Collecting Steiner Tree (PCST) on human interactome and enriched networks were visualized with Cytoscape platform. Results: Our data from combinatory treatment of Sorafenib and PIK-75 and TGX-221 showed opposite effects; while PIK-75 displays synergistic effects on Huh7 cells leading to apoptotic cell death, Sorafenib with TGX-221 display antagonistic effects and significantly promotes cell growth in PTEN deficient Mahlavu cells. Signaling pathways were reconstructed and analyzed in-depth from RNA-Seq data to understand mechanism of differential synergistic or antagonistic effects of PI3K-α (PIK-75) and PI3K-β (TGX-221) inhibitors with Sorafenib. PCST allowed as to identify AOX1 and AGER as targets in PI3K/Akt/mTOR pathway for this combinatory effect. The siRNA knockdown of AOX1 and AGER significantly reduced cell proliferation in HCC cells. Conclusions: Simultaneously constructed and analyzed differentially expressed cellular networks presented in this study, revealed distinct consequences of isoform specific PI3K inhibition in PTEN adequate and deficient liver cancer cells. We demonstrated the importance of context dependent and isoform specific PI3K/Akt/mTOR signaling inhibition in drug resistance during combination therapies. ( https://github.com/cansyl/Isoform-spesific-PI3K-inhibitor-analysis ).
MeSH term(s)	Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Drug Resistance ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Niacinamide/therapeutic use ; Phenylurea Compounds/therapeutic use ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Isoforms/genetics ; Proto-Oncogene Proteins c-akt/metabolism
Chemical Substances	Phenylurea Compounds ; Protein Isoforms ; Niacinamide (25X51I8RD4) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-09357-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transfer learning for drug-target interaction prediction.

Dalkıran, Alperen / Atakan, Ahmet / Rifaioğlu, Ahmet S / Martin, Maria J / Atalay, Rengül Çetin / Acar, Aybar C / Doğan, Tunca / Atalay, Volkan

Bioinformatics (Oxford, England)

2023 Volume 39, Issue 39 Suppl 1, Page(s) i103–i110

Abstract: Motivation: Utilizing AI-driven approaches for drug-target interaction (DTI) prediction require large volumes of training data which are not available for the majority of target proteins. In this study, we investigate the use of deep transfer learning ... ...

Abstract	Motivation: Utilizing AI-driven approaches for drug-target interaction (DTI) prediction require large volumes of training data which are not available for the majority of target proteins. In this study, we investigate the use of deep transfer learning for the prediction of interactions between drug candidate compounds and understudied target proteins with scarce training data. The idea here is to first train a deep neural network classifier with a generalized source training dataset of large size and then to reuse this pre-trained neural network as an initial configuration for re-training/fine-tuning purposes with a small-sized specialized target training dataset. To explore this idea, we selected six protein families that have critical importance in biomedicine: kinases, G-protein-coupled receptors (GPCRs), ion channels, nuclear receptors, proteases, and transporters. In two independent experiments, the protein families of transporters and nuclear receptors were individually set as the target datasets, while the remaining five families were used as the source datasets. Several size-based target family training datasets were formed in a controlled manner to assess the benefit provided by the transfer learning approach. Results: Here, we present a systematic evaluation of our approach by pre-training a feed-forward neural network with source training datasets and applying different modes of transfer learning from the pre-trained source network to a target dataset. The performance of deep transfer learning is evaluated and compared with that of training the same deep neural network from scratch. We found that when the training dataset contains fewer than 100 compounds, transfer learning outperforms the conventional strategy of training the system from scratch, suggesting that transfer learning is advantageous for predicting binders to under-studied targets. Availability and implementation: The source code and datasets are available at https://github.com/cansyl/TransferLearning4DTI. Our web-based service containing the ready-to-use pre-trained models is accessible at https://tl4dti.kansil.org.
MeSH term(s)	Neural Networks, Computer ; Peptide Hydrolases ; Software ; Machine Learning
Chemical Substances	Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btad234
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2374: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines.

Avci, M Ender / Keskus, Ayse Gokce / Targen, Seniye / Isilak, M Efe / Ozturk, Mehmet / Atalay, Rengul Cetin / Adams, Michelle M / Konu, Ozlen

Scientific reports

2018 Volume 8, Issue 1, Page(s) 1570

Abstract: Acetylcholinesterase (AChE), an enzyme responsible for degradation of acetylcholine, has been identified as a prognostic marker in liver cancer. Although in vivo Ache tumorigenicity assays in mouse are present, no established liver cancer xenograft model ...

Abstract	Acetylcholinesterase (AChE), an enzyme responsible for degradation of acetylcholine, has been identified as a prognostic marker in liver cancer. Although in vivo Ache tumorigenicity assays in mouse are present, no established liver cancer xenograft model in zebrafish using an ache mutant background exists. Herein, we developed an embryonic zebrafish xenograft model using epithelial (Hep3B) and mesenchymal (SKHep1) liver cancer cell lines in wild-type and ache
MeSH term(s)	Acetylcholinesterase/deficiency ; Animals ; Cell Line, Tumor ; Disease Models, Animal ; Heterografts ; Liver Neoplasms/pathology ; Neoplasm Transplantation ; Zebrafish
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2018-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-19817-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.

Demir, Zeynep / Guven, Ebru Bilget / Ozbey, Suheyla / Kazak, Canan / Atalay, Rengul Cetin / Tuncbilek, Meral

European journal of medicinal chemistry

2015 Volume 89, Page(s) 701–720

Abstract: Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purines (15-27), 9-(p-toluenesulfonyl/cyclopentyl/ethoxycarbonylmethyl)-6-(substituted amino/piperazino)purines (28-34, 36, 37, 38-41) were synthesized and ... ...

Abstract	Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purines (15-27), 9-(p-toluenesulfonyl/cyclopentyl/ethoxycarbonylmethyl)-6-(substituted amino/piperazino)purines (28-34, 36, 37, 38-41) were synthesized and evaluated initially for their cytotoxic activities on liver Huh7, breast T47D and colon HCT116 carcinoma cells. N(6)-(4-Trifluoromethylphenyl)piperazine derivative (17) and its 9-(p-toluene-sulfonyl)/9-cyclopentyl analogues (28, 36) had promising cytotoxic activities. Compounds 17, 28 and 36 were further analysed for their cytotoxicity in a panel of a liver cancer cell lines. The compound 36 had better cytotoxic activities (IC50 ≤ 1 μM) than the nucleobase 5-FU and nucleosides fludarabine, cladribine, and pentostatine on Huh7 cells. Cytotoxicity induced by 36 was later identified as senescence associated cell death by SA-β-Gal assay.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HCT116 Cells ; Hep G2 Cells ; Humans ; Models, Molecular ; Molecular Structure ; Purines/chemistry ; Purines/pharmacology ; Structure-Activity Relationship ; Tumor Cells, Cultured
Chemical Substances	Antineoplastic Agents ; Purines ; purine (W60KTZ3IZY)
Language	English
Publishing date	2015-01-07
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2014.10.080
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 784: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Bi-k-bi clustering: mining large scale gene expression data using two-level biclustering.

Carkacioğlu, Levent / Atalay, Rengül Cetin / Konu, Ozlen / Atalay, Volkan / Can, Tolga

International journal of data mining and bioinformatics

2011 Volume 4, Issue 6, Page(s) 701–721

Abstract: Due to the increase in gene expression data sets in recent years, various data mining techniques have been proposed for mining gene expression profiles. However, most of these methods target single gene expression data sets and cannot handle all the ... ...

Abstract	Due to the increase in gene expression data sets in recent years, various data mining techniques have been proposed for mining gene expression profiles. However, most of these methods target single gene expression data sets and cannot handle all the available gene expression data in public databases in reasonable amount of time and space. In this paper, we propose a novel framework, bi-k-bi clustering, for finding association rules of gene pairs that can easily operate on large scale and multiple heterogeneous data sets. We applied our proposed framework on the available NCBI GEO Homo sapiens data sets. Our results show consistency and relatedness with the available literature and also provides novel associations.
MeSH term(s)	Cluster Analysis ; Data Mining/methods ; Databases, Genetic ; Gene Expression ; Gene Expression Profiling ; Humans ; Oligonucleotide Array Sequence Analysis
Language	English
Publishing date	2011-02-24
Publishing country	Switzerland
Document type	Journal Article
ISSN	1748-5673
ISSN	1748-5673
DOI	10.1504/ijdmb.2010.037548
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents.

Gurdal, Enise Ece / Turgutalp, Bengisu / Gulcan, Hayrettin Ozan / Ercetin, Tugba / Sahin, Mustafa Fethi / Durmaz, Irem / Atalay, Rengul Cetin / Nguyen, Quoc Dat / Sippl, Wolfgang / Yarim, Mine

Anti-cancer agents in medicinal chemistry

2017 Volume 17, Issue 13, Page(s) 1837–1845

Abstract: Objective and method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast ( ... ...

Abstract	Objective and method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay. Result and discussion: All compounds showed cytotoxic activity against hepatocellular (Huh7) and breast (MCF-7) cancer cell lines. Dihalo substituted benzylpiperazine derivatives (2a, 2e) had the highest cytotoxic activities in all the tested cell lines. In addition, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities of synthesized compounds were investigated by in vitro Ellman's method. Compound 2j led to moderate and selective inhibition against AChE. Docking study was utilized to understand the binding mode of compound 2j in comparision with donepezil on AChE. The other tested compounds showed weak or no inhibition against AChE as promising anticancer agents.
MeSH term(s)	Acetylcholinesterase/drug effects ; Benzothiazoles/chemistry ; Cell Line, Tumor ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Donepezil/pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Piperazine/chemistry ; Spectrum Analysis/methods ; Structure-Activity Relationship
Chemical Substances	Benzothiazoles ; Cholinesterase Inhibitors ; Piperazine (1RTM4PAL0V) ; Donepezil (8SSC91326P) ; Acetylcholinesterase (EC 3.1.1.7) ; benzothiazole (G5BW2593EP)
Language	English
Publishing date	2017-02-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520617666170412153604
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5583: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A novel form of recessive limb girdle muscular dystrophy with mental retardation and abnormal expression of alpha-dystroglycan.

Dinçer, Pervin / Balci, Burcu / Yuva, Yeliz / Talim, Beril / Brockington, Martin / Dinçel, Deniz / Torelli, Silvia / Brown, Sue / Kale, Gülsev / Haliloglu, Göknur / Gerçeker, Filiz Ozbas / Atalay, Rengül Cetin / Yakicier, Cengiz / Longman, Cheryl / Muntoni, Francesco / Topaloglu, Haluk

Neuromuscular disorders : NMD

2004 Volume 13, Issue 10, Page(s) 771–778

Abstract: The limb girdle muscular dystrophies are a heterogeneous group of conditions characterized by proximal muscle weakness and disease onset ranging from infancy to adulthood. We report here eight patients from seven unrelated families affected by a novel ... ...

Abstract	The limb girdle muscular dystrophies are a heterogeneous group of conditions characterized by proximal muscle weakness and disease onset ranging from infancy to adulthood. We report here eight patients from seven unrelated families affected by a novel and relatively mild form of autosomal recessive limb girdle muscular dystrophy (LGMD2) with onset in the first decade of life and characterized by severe mental retardation but normal brain imaging. Immunocytochemical studies revealed a significant selective reduction of alpha-dystroglycan expression in the muscle biopsies. Linkage analysis excluded known loci for both limb girdle muscular dystrophy and congenital muscular dystrophies in the consanguineous families. We consider that this represents a novel form of muscular dystrophy with associated brain involvement. The biochemical studies suggest that it may belong to the growing number of muscular dystrophies with abnormal expression of alpha-dystroglycan.
MeSH term(s)	Adolescent ; Adult ; Age of Onset ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Child ; Chromosome Mapping ; Cytoskeletal Proteins/biosynthesis ; Cytoskeletal Proteins/deficiency ; Cytoskeletal Proteins/genetics ; DNA Mutational Analysis ; Dystroglycans ; Female ; Genes, Recessive/genetics ; Genetic Testing ; Humans ; Immunohistochemistry ; Intellectual Disability/complications ; Intellectual Disability/genetics ; Intellectual Disability/metabolism ; Male ; Membrane Glycoproteins/biosynthesis ; Membrane Glycoproteins/deficiency ; Membrane Glycoproteins/genetics ; Microcephaly/genetics ; Microcephaly/pathology ; Muscle Proteins/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiopathology ; Muscular Dystrophies/complications ; Muscular Dystrophies/genetics ; Muscular Dystrophies/metabolism ; Turkey
Chemical Substances	Cytoskeletal Proteins ; DAG1 protein, human ; Membrane Glycoproteins ; Muscle Proteins ; Dystroglycans (146888-27-9)
Language	English
Publishing date	2004-03-01
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077681-3
ISSN	1873-2364 ; 0960-8966
ISSN (online)	1873-2364
ISSN	0960-8966
DOI	10.1016/s0960-8966(03)00161-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3258: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito