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  1. Article ; Online: International Conventions & One Health

    Atanu Basu / Harpreet Sandhu

    Indian Journal of Medical Research, Vol 153, Iss 3, Pp 253-

    2021  Volume 255

    Keywords Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Transmission electron microscopy imaging of SARS-CoV-2

    Sharda Prasad / Varsha Potdar / Sarah Cherian / Priya Abraham / Atanu Basu / ICMR-NIV NIC Team

    Indian Journal of Medical Research, Vol 151, Iss 2, Pp 241-

    2020  Volume 243

    Keywords Medicine ; R ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Perspectives for repurposing drugs for the coronavirus disease 2019

    Sarah S Cherian / Megha Agrawal / Atanu Basu / Priya Abraham / Raman R Gangakhedkar / Balram Bhargava

    Indian Journal of Medical Research, Vol 151, Iss 2, Pp 160-

    2020  Volume 171

    Abstract: The newly emerged 2019 novel coronavirus (CoV), named as severe acute respiratory syndrome CoV-2 (SARS-CoV-2), like SARS-CoV (now, SARS-CoV-1) and Middle East respiratory syndrome CoV (MERS-CoV), has been associated with high infection rates with over 36, ...

    Abstract The newly emerged 2019 novel coronavirus (CoV), named as severe acute respiratory syndrome CoV-2 (SARS-CoV-2), like SARS-CoV (now, SARS-CoV-1) and Middle East respiratory syndrome CoV (MERS-CoV), has been associated with high infection rates with over 36,405 deaths. In the absence of approved marketed drugs against coronaviruses, the treatment and management of this novel CoV disease (COVID-19) worldwide is a challenge. Drug repurposing that has emerged as an effective drug discovery approach from earlier approved drugs could reduce the time and cost compared to de novo drug discovery. Direct virus-targeted antiviral agents target specific nucleic acid or proteins of the virus while host-based antivirals target either the host innate immune responses or the cellular machineries that are crucial for viral infection. Both the approaches necessarily interfere with viral pathogenesis. Here we summarize the present status of both virus-based and host-based drug repurposing perspectives for coronaviruses in general and the SARS-CoV-2 in particular.
    Keywords coronavirus - covid-19 - drugs - host-based - repurposing - severe acute respiratory syndrome coronavirus 2 - virus-based ; Medicine ; R ; covid19
    Subject code 572
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Development of in vitro transcribed RNA as positive control for laboratory diagnosis of SARS-CoV-2 in India

    Manohar Lal Choudhary / Veena Vipat / Sheetal Jadhav / Atanu Basu / Sarah Cherian / Priya Abraham / Varsha A Potdar

    Indian Journal of Medical Research, Vol 151, Iss 2, Pp 251-

    2020  Volume 254

    Keywords Medicine ; R ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Full-genome sequences of the first two SARS-CoV-2 viruses from India

    Pragya D Yadav / Varsha A Potdar / Manohar Lal Choudhary / Dimpal A Nyayanit / Megha Agrawal / Santosh M Jadhav / Triparna D Majumdar / Anita Shete-Aich / Atanu Basu / Priya Abraham / Sarah S Cherian

    Indian Journal of Medical Research, Vol 151, Iss 2, Pp 200-

    2020  Volume 209

    Abstract: Background & objectives: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has globally affected 195 countries. In India, suspected cases were screened for SARS-CoV-2 as per the advisory of the Ministry of Health and ... ...

    Abstract Background & objectives: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has globally affected 195 countries. In India, suspected cases were screened for SARS-CoV-2 as per the advisory of the Ministry of Health and Family Welfare. The objective of this study was to characterize SARS-CoV-2 sequences from three identified positive cases as on February 29, 2020. Methods: Throat swab/nasal swab specimens for a total of 881 suspected cases were screened by E gene and confirmed by RdRp (1), RdRp (2) and N gene real-time reverse transcription-polymerase chain reactions and next-generation sequencing. Phylogenetic analysis, molecular characterization and prediction of B- and T-cell epitopes for Indian SARS-CoV-2 sequences were undertaken. Results: Three cases with a travel history from Wuhan, China, were confirmed positive for SARS-CoV-2. Almost complete (29,851 nucleotides) genomes of case 1, case 3 and a fragmented genome for case 2 were obtained. The sequences of Indian SARS-CoV-2 though not identical showed high (~99.98%) identity with Wuhan seafood market pneumonia virus (accession number: NC 045512). Phylogenetic analysis showed that the Indian sequences belonged to different clusters. Predicted linear B-cell epitopes were found to be concentrated in the S1 domain of spike protein, and a conformational epitope was identified in the receptor-binding domain. The predicted T-cell epitopes showed broad human leucocyte antigen allele coverage of A and B supertypes predominant in the Indian population. Interpretation & conclusions: The two SARS-CoV-2 sequences obtained from India represent two different introductions into the country. The genetic heterogeneity is as noted globally. The identified B- and T-cell epitopes may be considered suitable for future experiments towards the design of vaccines and diagnostics. Continuous monitoring and analysis of the sequences of new cases from India and the other affected countries would be vital to understand the genetic evolution and rates of substitution of the SARS-CoV-2.
    Keywords epitope - genomes - india - kerala - next-generation sequencing - phylogeny - real-time reverse transcription-polymerase chain reaction - severe acute respiratory syndrome coronavirus 2 ; Medicine ; R ; covid19
    Subject code 572
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Retrospective analysis of clinical information in Crimean-Congo haemorrhagic fever patients

    Devendra T Mourya / Rajlakshmi Viswanathan / Santosh Kumar Jadhav / Pragya D Yadav / Atanu Basu / Mandeep S Chadha

    Indian Journal of Medical Research, Vol 145, Iss 5, Pp 673-

    2014-2015, India

    2017  Volume 678

    Abstract: Background & objectives: Differential diagnosis of Crimean-Congo haemorrhagic fever (CCHF) from other acute febrile illnesses with haemorrhagic manifestation is challenging in India. Nosocomial infection is a significant mode of transmission due to ... ...

    Abstract Background & objectives: Differential diagnosis of Crimean-Congo haemorrhagic fever (CCHF) from other acute febrile illnesses with haemorrhagic manifestation is challenging in India. Nosocomial infection is a significant mode of transmission due to exposure of healthcare workers to blood and body fluids of infected patients. Being a risk group 4 virus, laboratory confirmation of infection is not widely available. In such a situation, early identification of potential CCHF patients would be useful in limiting the spread of the disease. The objective of this study was to retrospectively analyse clinical and laboratory findings of CCHF patients that might be useful in early detection of a CCHF case in limited resource settings. Methods: Retrospective analysis of clinical and laboratory data of patients suspected to have CCHF referred for diagnosis from Gujarat and Rajasthan States of India (2014-2015) was done. Samples were tested using CCHF-specific real time reverse transcription (RT)-PCR and IgM ELISA. Results: Among the 69 patients referred, 21 were laboratory confirmed CCHF cases of whom nine had a history of occupational exposure. No clustering of cases was noted. Platelet count cut-off for detection of positive cases by receiver operating characteristic curve was 21.5×10[9]/l with sensitivity 82.4 per cent and specificity 82.1 per cent. Melaena was a significant clinical presentation in confirmed positive CCHF patients. Interpretation & conclusions: The study findings suggest that in endemic areas thrombocytopenia and melaena may be early indicators of CCHF. Further studies are needed to confirm these findings.
    Keywords Crimean-Congo haemorrhagic fever - diagnosis - Gujarat - haemorrhage - India - melaena - platelet - suspected case ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Respiratory virus detection among the overseas returnees during the early phase of COVID-19 pandemic in India

    Varsha Potdar / Manohar L Choudhary / Sumit Bhardwaj / Rohan Ghuge / A P Sugunan / Yogesh Gurav / Pragya D Yadav / Anita Shete / Shilpa Tomar / B Anukumar / Himanshu Kaushal / Gajanan Sapkal / Atanu Basu / Sarah Cherian / Priya Abraham

    Indian Journal of Medical Research, Vol 151, Iss 5, Pp 486-

    2020  Volume 489

    Keywords Medicine ; R ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation

    Brunda Ganneru / Harsh Jogdand / Vijaya Kumar Daram / Dipankar Das / Narasimha Reddy Molugu / Sai D. Prasad / Srinivas V. Kannappa / Krishna M. Ella / Rajaram Ravikrishnan / Amit Awasthi / Jomy Jose / Panduranga Rao / Deepak Kumar / Raches Ella / Priya Abraham / Pragya D. Yadav / Gajanan N. Sapkal / Anita Shete-Aich / Gururaj Desphande /
    Sreelekshmy Mohandas / Atanu Basu / Nivedita Gupta / Krishna Mohan Vadrevu

    iScience, Vol 24, Iss 4, Pp 102298- (2021)

    2021  

    Abstract: Summary: We report the development and evaluation of safety and immunogenicity of a whole virion inactivated (WVI) SARS-CoV-2 vaccine (BBV152), adjuvanted with aluminum hydroxide gel (Algel), or TLR7/8 agonist chemisorbed Algel. We used a well- ... ...

    Abstract Summary: We report the development and evaluation of safety and immunogenicity of a whole virion inactivated (WVI) SARS-CoV-2 vaccine (BBV152), adjuvanted with aluminum hydroxide gel (Algel), or TLR7/8 agonist chemisorbed Algel. We used a well-characterized SARS-CoV-2 strain and an established Vero cell platform to produce large-scale GMP-grade highly purified inactivated antigen. Product development and manufacturing process were carried out in a BSL-3 facility. Immunogenicity and safety were determined at two antigen concentrations (3μg and 6μg), with two different adjuvants, in mice, rats, and rabbits. Our results show that BBV152 vaccine formulations generated significantly high antigen-binding and neutralizing antibody titers (NAb), at both concentrations, in all three species with excellent safety profiles. The inactivated vaccine formulation contains TLR7/8 agonist adjuvant-induced Th1-biased antibody responses with elevated IgG2a/IgG1 ratio and increased levels of SARS-CoV-2-specific IFN-γ+ CD4+ T lymphocyte response. Our results support further development for phase I/II clinical trials in humans.
    Keywords Immune Response ; Immunology ; Virology ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Acute Encephalitis with Atypical Presentation of Rubella in Family Cluster, India

    Sumit D. Bharadwaj / Rima R. Sahay / Pragya D. Yadav / Sara Dhanawade / Atanu Basu / Virendra K. Meena / Suji George / Rekha Damle / Gajanan N. Sapkal

    Emerging Infectious Diseases, Vol 24, Iss 10, Pp 1923-

    2018  Volume 1925

    Abstract: We report 3 atypical rubella cases in a family cluster in India. The index case-patient showed only mild febrile illness, whereas the other 2 patients showed acute encephalitis and died of the disease. We confirmed rubella in the index and third cases ... ...

    Abstract We report 3 atypical rubella cases in a family cluster in India. The index case-patient showed only mild febrile illness, whereas the other 2 patients showed acute encephalitis and died of the disease. We confirmed rubella in the index and third cases using next-generation sequencing and IgM.
    Keywords acute encephalitis ; atypical ; rash ; rubella ; next-generation sequencing ; viruses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: First isolation of SARS-CoV-2 from clinical samples in India

    Prasad Sarkale / Savita Patil / Pragya D Yadav / Dimpal A Nyayanit / Gajanan Sapkal / Shrikant Baradkar / Rajen Lakra / Anita Shete-Aich / Sharda Prasad / Atanu Basu / Lalit Dar / Veena Vipat / Sidhartha Giri / Varsha Potdar / Manohar Lal Choudhary / Ira Praharaj / Amita Jain / Bharati Malhotra / Pranita Gawande /
    Kaumudi Kalele / Nivedita Gupta / Sarah S Cherian / Priya Abraham

    Indian Journal of Medical Research, Vol 151, Iss 2, Pp 244-

    2020  Volume 250

    Keywords Medicine ; R ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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