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Article ; Online: Registered Nurses' Experiences of Medication Errors-An Original Research Protocol: Methodology, Methods, and Ethics.

Athanasakis, Efstratios

The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres

2020 Volume 53, Issue 2, Page(s) 171–183

Abstract: Background: The investigation of medication errors in nursing includes both methodological and ethical considerations because it is a sensitive field of research.: Purpose: To present an original research protocol for the investigation of nurses' ... ...

Abstract	Background: The investigation of medication errors in nursing includes both methodological and ethical considerations because it is a sensitive field of research. Purpose: To present an original research protocol for the investigation of nurses' experiences of medication errors with interpretative phenomenological analysis and the relevant methodological and ethical considerations. Methods: A discursive paper which presents an original research protocol about nurses' experiences of medication errors with interpretative phenomenological analysis followed by a literature review and personal reflections about the relevant methodological and ethical considerations. The review included papers published in English from 1990 to February 2019 on PubMed, BNI (British Nursing Index), CINAHL (Cumulative Index to Allied Health Literature), ScienceDirect, and Wiley Online Library. Results: The following methodological considerations were identified: recruitment of participants, data collection, and data analysis, and the ethical considerations included researcher's morality, ethics committees, sensitivity, phrasing of sentences and words, recruitment of participants, location of interviews, type of interviews, emotionality management, medication error incidents' management, researcher, or nurse? Conclusion: By facing as many as possible methodological and ethical considerations and establishing solutions for them, the study's validity, reliability, and rigor are enhanced, and the study is ethically robust. Finally, their understanding enables researchers to uncover nurses' experiences and interpret the meanings they generate in depth.
MeSH term(s)	Humans ; Medication Errors/prevention & control ; Nurses ; Qualitative Research ; Reproducibility of Results
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1036826-7
ISSN	1705-7051 ; 0844-5621
ISSN (online)	1705-7051
ISSN	0844-5621
DOI	10.1177/0844562120902668
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Article ; Online: A meta-synthesis of how registered nurses make sense of their lived experiences of medication errors.

Athanasakis, Efstratios

Journal of clinical nursing

2019 Volume 28, Issue 17-18, Page(s) 3077–3095

Abstract: Background: Medication errors are a frequent phenomenon in nursing, as the nurses are primarily responsible for preparation and administration of medications to patients. Little is known about how nurses make sense of their experiences of medication ... ...

Abstract	Background: Medication errors are a frequent phenomenon in nursing, as the nurses are primarily responsible for preparation and administration of medications to patients. Little is known about how nurses make sense of their experiences of medication errors as a lived phenomenon. Objective: To aggregate, synthesise and interpret the qualitative evidence of studies which explored nurses' lived experiences of medication errors. Method: A meta-synthesis is presented with thematic analysis by Thomas & Harden (BMC Medical Research Methodology, 8, 2008, 45). Qualitative studies (January 1980-June 2018) retrieved from PubMed, BNI, CINAHL, EMBASE, AMED, PsycINFO, ProQuest, ScienceDirect and Wiley Online Library. The PRISMA flow chart, CASP tool and COREQ checklist are integrated in the meta-synthesis. Findings: Eight primary research studies were included with the follow themes: "moral impact," "emotional impact," "constructive learning," "impact on professional registration and employment," "nurses' coping strategies with the experience," "patient and family," "identification of contributing factors to medication errors" and "preventive measures for medication errors." Conclusion: The moral and emotional impact of medication errors to nurses was devastating for themselves. Yet, they detected strategies to cope with their error and its consequences and even more translated their experience into a constructive lesson and identified ways to prevent future errors. Relevance for clinical practice: The meta-synthesis provides a holistic perspective about how registered nurses made sense of their lived experiences of medication errors. Its findings reveal that the experience has both positive impact and negative impact to the nurses. Its findings should inform mainly the clinical nursing practice, clinical nurses, nurse educators, nurse leaders and policymakers of medication administration.
MeSH term(s)	Adaptation, Psychological ; Humans ; Medication Errors/psychology ; Nurses/psychology ; Qualitative Research
Language	English
Publishing date	2019-06-06
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	1159483-4
ISSN	1365-2702 ; 0962-1067 ; 1752-9816
ISSN (online)	1365-2702
ISSN	0962-1067 ; 1752-9816
DOI	10.1111/jocn.14917
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Zs.A 3764: Show issues

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Article ; Online: Systematic reviews.

Athanasakis, Efstratios

Nursing standard (Royal College of Nursing (Great Britain) : 1987)

2016 Volume 30, Issue 50, Page(s) 64–65

Abstract: What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article discussed the purpose of systematic reviews in nursing practice. It outlined the process of undertaking a systematic ... ...

Abstract	What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article discussed the purpose of systematic reviews in nursing practice. It outlined the process of undertaking a systematic review, and how this can benefit future research and clinical practice.
MeSH term(s)	Biomedical Research/methods ; Clinical Competence/standards ; Evidence-Based Nursing/standards ; Humans ; Research Design ; Review Literature as Topic ; United Kingdom
Language	English
Publishing date	2016-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	645016-7
ISSN	2047-9018 ; 0029-6570
ISSN (online)	2047-9018
ISSN	0029-6570
DOI	10.7748/ns.30.50.64.s45
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Zs.A 2410: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Buried Bumper Syndrome is not caused by levodopa infusion. Reply to Dr Kotzampassi's Letter to the Editor. Concerning the publication: Buried Bumper Syndrome: A common complication of levodopa intestinal infusion for Parkinson disease. By: Spanaki C, Boura I, Avgoustaki A, Orfanoudaki E, Giannopoulou IA, Giakoumakis E, Chlouverakis G, Athanasakis E, Koulentaki M. Parkinsonism Relat Disord. 2021 Apr; 85:59-62.

Spanaki, Cleanthe / Boura, Iro / Orfanoudaki, Eleni / Avgoustaki, Aikaterini / Athanasakis, Elias / Koulentaki, Mairi

Parkinsonism & related disorders

2022 Volume 102, Page(s) 121

MeSH term(s)	Enteral Nutrition ; Gastrostomy ; Humans ; Levodopa/adverse effects ; Parkinson Disease/drug therapy
Chemical Substances	Levodopa (46627O600J)
Language	English
Publishing date	2022-04-25
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2022.04.010
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Article ; Online: Systematic analysis of factors that improve homologous direct repair (HDR) efficiency in CRISPR/Cas9 technique.

Di Stazio, Mariateresa / Foschi, Nicola / Athanasakis, Emmanouil / Gasparini, Paolo / d'Adamo, Adamo Pio

PloS one

2021 Volume 16, Issue 3, Page(s) e0247603

Abstract: The CRISPR/Cas9 bacterial system has proven to be an powerful tool for genetic manipulation in several organisms, but the efficiency of sequence replacement by homologous direct repair (HDR) is substantially lower than random indel creation. Many studies ...

Abstract	The CRISPR/Cas9 bacterial system has proven to be an powerful tool for genetic manipulation in several organisms, but the efficiency of sequence replacement by homologous direct repair (HDR) is substantially lower than random indel creation. Many studies focused on improving HDR efficiency using double sgRNA, cell synchronization cycle, and the delivery of single-stranded oligo DNA nucleotides (ssODN) with a rational design. In this study, we evaluate these three methods' synergistic effects to improve HDR efficiency. For our tests, we have chosen the TNFα gene (NM_000594) for its crucial role in various biological processes and diseases. For the first time, our results showed how the use of two sgRNA with asymmetric donor design and triple transfection events dramatically increase the HDR efficiency from an undetectable HDR event to 39% of HDR efficiency and provide a new strategy to facilitate CRISPR/Cas9-mediated human genome editing. Besides, we demonstrated that the TNFα locus could be edited with CRISPR/Cas9 methodology, an opportunity to safely correct, in the future, the specific mutations of each patient.
MeSH term(s)	CRISPR-Cas Systems ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair/genetics ; DNA, Single-Stranded/genetics ; Gene Editing/methods ; Genome, Human ; HEK293 Cells ; Humans ; Mutation ; Nucleotides/genetics ; RNA, Guide, CRISPR-Cas Systems/genetics ; Recombinational DNA Repair/genetics ; Transfection ; Trinucleotide Repeats/genetics ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	DNA, Single-Stranded ; Nucleotides ; RNA, Guide, CRISPR-Cas Systems ; TNF protein, human ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0247603
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Article ; Online: MYO5B Gene Mutations: A Not Negligible Cause of Intrahepatic Cholestasis of Infancy With Normal Gamma-Glutamyl Transferase Phenotype.

Matarazzo, Lorenza / Bianco, Anna Monica / Athanasakis, Emmanouil / Serveres, Marco / Francalanci, Paola / Cenacchi, Giovanna / Maggiore, Giuseppe / D'Adamo, Adamo Pio

Journal of pediatric gastroenterology and nutrition

2022 Volume 74, Issue 5, Page(s) e115–e121

Abstract: Objectives: Progressive familial intrahepatic cholestasis is an expanding group of autosomal recessive intrahepatic cholestatic disorders. Recently, next-generation sequencing allowed identifying new genes responsible for new specific disorders. Two ... ...

Abstract	Objectives: Progressive familial intrahepatic cholestasis is an expanding group of autosomal recessive intrahepatic cholestatic disorders. Recently, next-generation sequencing allowed identifying new genes responsible for new specific disorders. Two biochemical phenotypes have been identified according to gamma-glutamyltransferase (GGT) activity. Mutations of the myosin 5B gene (MYO5B) are known to cause microvillus inclusion disease. Recently, different mutations in MYO5B gene have been reported in patients with low-GGT cholestasis. Methods: A multicenter retrospective and prospective study was conducted in 32 children with cryptogenic intrahepatic cholestasis. Clinical, biochemical, histological, and treatment data were analyzed in these patients. DNA from peripheral blood was extracted, and all patients were studied by whole exome sequencing followed by Sanger sequencing. Results: Six patients out of 32 had mutations in the MYO5B gene. Of these six patients, the median age at disease onset was 0.8 years, and the median length of follow-up was 4.2 years. The most common signs were pruritus, poor growth, hepatomegaly, jaundice, and hypocholic stools. Two patients also showed intestinal involvement. Transaminases and conjugated bilirubin were moderately increased, serum bile acids elevated, and GGT persistently normal. At anti-Myo5B immunostaining, performed in liver biopsy of two patients, coarse granules were evident within the cytoplasm of hepatocytes while bile salt export pump was normally expressed at the canalicular membrane. Six variants in homozygosity or compound heterozygosity in the MYO5B gene were identified, and three of them have never been described before. All nucleotide alterations were located on the myosin motor domain except one missense variant found in the isoleucine-glutamine calmodulin-binding motif. Conclusions: We identified causative mutations in MYO5B in 18.7% of a selected cohort of patients with intrahepatic cholestasis confirming a relevant role for the MYO5B gene in low-GGT cholestasis.
MeSH term(s)	Cholestasis/genetics ; Cholestasis, Intrahepatic/diagnosis ; Humans ; Mutation ; Myosin Heavy Chains/genetics ; Myosin Type V/genetics ; Myosins/genetics ; Phenotype ; Prospective Studies ; Retrospective Studies ; gamma-Glutamyltransferase/genetics
Chemical Substances	MYO5B protein, human ; gamma-Glutamyltransferase (EC 2.3.2.2) ; Myosin Type V (EC 3.6.1.-) ; Myosin Heavy Chains (EC 3.6.4.1) ; Myosins (EC 3.6.4.1)
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003399
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Article: Advanced Mesodermal (Müllerian) Adenosarcoma of the Ovary: Metastases to the Lungs, Mouth, and Brain.

Daskalaki, A / Xenaki, S / Athanasakis, E / Chrysos, E / Chalkiadakis, G

Case reports in surgery

2015 Volume 2015, Page(s) 403431

Abstract: Background. A malignant mixed Müllerian tumor (MMMT) is a malignant neoplasm found in the uterus, the ovaries, the fallopian tubes, and other parts of the body that contains both carcinomatous (epithelial tissue) and sarcomatous (connective tissue) ... ...

Abstract	Background. A malignant mixed Müllerian tumor (MMMT) is a malignant neoplasm found in the uterus, the ovaries, the fallopian tubes, and other parts of the body that contains both carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. Outcome of MMMTs is determined primarily by depth of invasion and stage. The metastatic background of these lesions is controversial and unknown. Case Report. A 75-year-old woman was admitted to the hospital with anorexia, weakness, and persistent coughing. The imaging exams revealed a solid, promiscuous lesion of 16 × 14 cm in dimensions located into the small pelvis, surrounding the uterus and the ovaries. The patient underwent exploratory laparotomy. The mass was removed and the histological examination of the specimen revealed an advanced mesodermal adenocarcinoma of the ovary (MMMT). Nine days after the operation the patient presented with metastatic lesions in the mouth as well as the lungs. Within a month after the discharge from the hospital metastatic lesions of the MMMT were also depicted in the CT brain scan. Conclusion. Despite the fact that sarcomas have a long-term metastatic potential, to our knowledge this is the first case of Müllerian adenosarcoma presenting with such extraperitoneal metastases.
Language	English
Publishing date	2015-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2657697-1
ISSN	2090-6919 ; 2090-6900
ISSN (online)	2090-6919
ISSN	2090-6900
DOI	10.1155/2015/403431
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Article ; Online: Copy number variation, gene expression and histological localization of human beta-defensin 2 in patients with adeno-tonsillar hypertrophy.

Celsi, Fulvio / Zupin, Luisa / Athanasakis, Emmanouil / Orzan, Eva / Grasso, Domenico Leonardo / Crovella, Sergio

Biotechnic & histochemistry : official publication of the Biological Stain Commission

2020 Volume 95, Issue 8, Page(s) 634–640

Abstract: Both bacterial infections and innate oral immunity response participate in development of adeno-tonsillar hypertrophy (ATH). ATH can lead to obstructive sleep apnea. We investigated the beta-defensin 2 (hBD-2) encoding gene, ...

Abstract	Both bacterial infections and innate oral immunity response participate in development of adeno-tonsillar hypertrophy (ATH). ATH can lead to obstructive sleep apnea. We investigated the beta-defensin 2 (hBD-2) encoding gene,
MeSH term(s)	Adenoids/pathology ; Child ; Child, Preschool ; DNA Copy Number Variations ; Female ; Gene Expression Regulation/physiology ; Genetic Predisposition to Disease ; Humans ; Hypertrophy/genetics ; Hypertrophy/pathology ; Infant ; Male ; Palatine Tonsil/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; beta-Defensins/genetics ; beta-Defensins/metabolism
Chemical Substances	DEFB4A protein, human ; RNA, Messenger ; beta-Defensins
Language	English
Publishing date	2020-06-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1069349-x
ISSN	1473-7760 ; 1052-0295
ISSN (online)	1473-7760
ISSN	1052-0295
DOI	10.1080/10520295.2020.1752936
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Article: Well-promising outcomes with vacuum-assisted closure in an infected wound following laparotomy: A case report.

Daskalaki, A / Xenaki, S / Venianaki, M / Topalidou, A / Athanasakis, E / Chrysos, E / Chalkiadakis, G

Annals of medicine and surgery (2012)

2016 Volume 10, Page(s) 73–76

Abstract: Introducation: Negative pressure wound therapy (NPWT) represents an alternative method to optimize conditions for wound healing. Delayed wound closure is a significant health problem, which is directly associated with pain and suffering from patient's ... ...

Abstract	Introducation: Negative pressure wound therapy (NPWT) represents an alternative method to optimize conditions for wound healing. Delayed wound closure is a significant health problem, which is directly associated with pain and suffering from patient's aspect, as well with social and financial burden. Presentation of case: We report a case of vacuum-assisted wound therapy with hypertonic solution distillation and continuous negative pressure application, in an infected wound after laparotomy for incisional hernia reconstruction with mesh placement. Negative pressure was initiated at the wound margins after failure of conventional treatment with great outcomes, achieving a total closure of the incision within two weeks. Discussion: Each wound has particular characteristics which must be managed. Vacuum assisted closure (VAC) with continuous negative pressure and simultaneous wound instillation and cleanse can provide optimum results, reducing the cavity volume, by newly produced granulated tissue. Conclusion: The simultaneous use of instillation and constant pressure seemed to be superior in comparison with NPWT alone. Compared to conventional methods, the use of VAC ends to better outcomes, in cases of infected wounds following laparotomy.
Language	English
Publishing date	2016-08-02
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2016.07.027
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Article: Newly recognized extratumoral features of colorectal cancer challenge the current tumor-node-metastasis staging system.

Athanasakis, Elias / Xenaki, Sofia / Venianaki, Maria / Chalkiadakis, George / Chrysos, Emmanuel

Annals of gastroenterology

2018 Volume 31, Issue 5, Page(s) 525–534

Abstract: One of the most common malignant tumors in humans, colorectal cancer has been extensively studied during the past few decades. Staging colorectal cancer allows clinicians to obtain precise prognostic information and apply specific treatment procedures. ... ...

Abstract	One of the most common malignant tumors in humans, colorectal cancer has been extensively studied during the past few decades. Staging colorectal cancer allows clinicians to obtain precise prognostic information and apply specific treatment procedures. Apart from remote metastases, the depth of tumor infiltration and lymph node involvement have traditionally been recognized as the most important factors predicting outcome. Variations in the molecular signature of colorectal cancer have also revealed differences in phenotypic aggressiveness and therapeutic response rates. This article presents a review of the extratumoral environment in colorectal surgery.
Language	English
Publishing date	2018-06-19
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2032850-3
ISSN	1108-7471
ISSN	1108-7471
DOI	10.20524/aog.2018.0284
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