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  1. Article ; Online: Nanodrug delivery systems for metabolic chronic liver diseases: advances and perspectives.

    Athanasopoulou, Foteini / Manolakakis, Michail / Vernia, Santiago / Kamaly, Nazila

    Nanomedicine (London, England)

    2023  Volume 18, Issue 1, Page(s) 67–84

    Abstract: Nanomedicines are revolutionizing healthcare as recently demonstrated by the Pfizer/BioNTech and Moderna COVID-2019 vaccines, with billions of doses administered worldwide in a safe manner. Nonalcoholic fatty liver disease is the most common ... ...

    Abstract Nanomedicines are revolutionizing healthcare as recently demonstrated by the Pfizer/BioNTech and Moderna COVID-2019 vaccines, with billions of doses administered worldwide in a safe manner. Nonalcoholic fatty liver disease is the most common noncommunicable chronic liver disease, posing a major growing challenge to global public health. However, due to unmet diagnostic and therapeutic needs, there is great interest in the development of novel translational approaches. Nanoparticle-based approaches offer novel opportunities for efficient and specific drug delivery to liver cells, as a step toward precision medicines. In this review, the authors highlight recent advances in nanomedicines for the generation of novel diagnostic and therapeutic tools for nonalcoholic fatty liver disease and related liver diseases.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/diagnosis ; COVID-19 ; Nanomedicine ; Drug Delivery Systems ; Nanoparticles/therapeutic use
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2022-0261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
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  2. Article: Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm.

    Morgulchik, Nelli / Athanasopoulou, Foteini / Chu, Edmund / Lam, Yoriko / Kamaly, Nazila

    Interface focus

    2021  Volume 12, Issue 1, Page(s) 20210006

    Abstract: Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome coronavirus 2, which has caused a global pandemic since early 2020 and severely threatened people's livelihoods and health. Patients with pre- ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome coronavirus 2, which has caused a global pandemic since early 2020 and severely threatened people's livelihoods and health. Patients with pre-diagnosed conditions admitted to hospital often develop complications leading to mortality due to acute respiratory distress syndrome (ARDS) and associated multiorgan failure and blood clots. ARDS is associated with a cytokine storm. Cytokine storms arise due to elevated levels of circulating cytokines and are associated with infections. Targeting various pro-inflammatory cytokines in a specific manner can result in a potent therapeutic approach with minimal host collateral damage. Immunoregulatory therapies are now of interest in order to regulate the cytokine storm, and this review will summarize and discuss advances in targeted therapies against cytokine storms induced by COVID-19.
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2021.0006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genomic-transcriptomic evolution in lung cancer and metastasis.

    Martínez-Ruiz, Carlos / Black, James R M / Puttick, Clare / Hill, Mark S / Demeulemeester, Jonas / Larose Cadieux, Elizabeth / Thol, Kerstin / Jones, Thomas P / Veeriah, Selvaraju / Naceur-Lombardelli, Cristina / Toncheva, Antonia / Prymas, Paulina / Rowan, Andrew / Ward, Sophia / Cubitt, Laura / Athanasopoulou, Foteini / Pich, Oriol / Karasaki, Takahiro / Moore, David A /
    Salgado, Roberto / Colliver, Emma / Castignani, Carla / Dietzen, Michelle / Huebner, Ariana / Al Bakir, Maise / Tanić, Miljana / Watkins, Thomas B K / Lim, Emilia L / Al-Rashed, Ali M / Lang, Danny / Clements, James / Cook, Daniel E / Rosenthal, Rachel / Wilson, Gareth A / Frankell, Alexander M / de Carné Trécesson, Sophie / East, Philip / Kanu, Nnennaya / Litchfield, Kevin / Birkbak, Nicolai J / Hackshaw, Allan / Beck, Stephan / Van Loo, Peter / Jamal-Hanjani, Mariam / Swanton, Charles / McGranahan, Nicholas

    Nature

    2023  Volume 616, Issue 7957, Page(s) 543–552

    Abstract: Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to ... ...

    Abstract Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Genomics ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mutation ; Neoplasm Metastasis/genetics ; Transcriptome/genetics ; Evolution, Molecular ; Alleles ; Machine Learning ; Genome, Human/genetics
    Chemical Substances APOBEC3A protein, human (EC 3.5.4.5) ; ADAR protein, human (EC 3.5.4.37)
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05706-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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