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  1. Article ; Online: A Tight Squeeze: Focal Tamponade and Obstructive Shock From Esophageal Stenting.

    Atri, Deepak / Shappell, Claire / Dieffenbach, Paul B / Sun, Yee-Ping

    JACC. Case reports

    2019  Volume 1, Issue 1, Page(s) 70–72

    Abstract: Cardiac tamponade is a rare cause of shock in the medical intensive care unit. This paper describes the case of a focal cardiac tamponade caused by compression of the left atrium due to an esophageal stent. Echocardiography yielded a diagnosis when other ...

    Abstract Cardiac tamponade is a rare cause of shock in the medical intensive care unit. This paper describes the case of a focal cardiac tamponade caused by compression of the left atrium due to an esophageal stent. Echocardiography yielded a diagnosis when other diagnostic methods did not. (
    Language English
    Publishing date 2019-06-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2019.05.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ST-Segment Elevation Myocardial Infarction Due to Right Coronary Artery Compression by Cardiac Synovial Sarcoma.

    Atri, Deepak S / Tsao, Allison L / Yu, Paul B / Berry, Natalia C

    JACC. Cardiovascular interventions

    2019  Volume 12, Issue 17, Page(s) e145–e147

    MeSH term(s) Angioplasty, Balloon, Coronary/instrumentation ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/etiology ; Coronary Stenosis/therapy ; Drug-Eluting Stents ; Heart Neoplasms/complications ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Humans ; Male ; Middle Aged ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/etiology ; ST Elevation Myocardial Infarction/therapy ; Sarcoma, Synovial/complications ; Sarcoma, Synovial/diagnostic imaging ; Sarcoma, Synovial/pathology ; Treatment Outcome
    Language English
    Publishing date 2019-08-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2019.05.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies.

    Atri, Deepak / Siddiqi, Hasan K / Lang, Joshua P / Nauffal, Victor / Morrow, David A / Bohula, Erin A

    JACC. Basic to translational science

    2020  Volume 5, Issue 5, Page(s) 518–536

    Abstract: Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global ... ...

    Abstract Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global economy, and led to a devastating loss of life. Widespread efforts from regulators, clinicians, and scientists are driving a rapid expansion of knowledge of the SARS-CoV-2 virus and COVID-19. The authors review the most current data, with a focus on the basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. The authors discuss the basic virology, epidemiology, clinical manifestation, multiorgan consequences, and outcomes. With a focus on cardiovascular complications, they propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2020.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CRISPR-Cas9 Genome Editing of Primary Human Vascular Cells In Vitro.

    Atri, Deepak S / Lee-Kim, Vivian S / Vellarikkal, Shamsudheen K / Sias-Garcia, Oscar / Yanamandala, Mounica / Schniztler, Gavin R / Gupta, Rajat M

    Current protocols

    2021  Volume 1, Issue 11, Page(s) e291

    Abstract: Genome editing of primary human cells with CRISPR-Cas9 is a powerful tool to study gene function. For many cell types, there are efficient protocols for editing with optimized plasmids for Cas9 and sgRNA expression. Vascular cells, however, remain ... ...

    Abstract Genome editing of primary human cells with CRISPR-Cas9 is a powerful tool to study gene function. For many cell types, there are efficient protocols for editing with optimized plasmids for Cas9 and sgRNA expression. Vascular cells, however, remain refractory to plasmid-based delivery of CRISPR machinery for in vitro genome editing due to low transfection efficiency, poor expression of the Cas9 machinery, and toxic effects of the selection antibiotics. Here, we describe a method for high-efficiency editing of primary human vascular cells in vitro using nucleofection for direct delivery of sgRNA:Cas9-NLS ribonucleoprotein complexes. This method is more rapid and its high editing efficiency eliminates the need for additional selection steps. The edited cells can be employed in diverse applications, such as gene expression measurement or functional assays to assess various genetic perturbation effects in vitro. This method proves effective in vascular cells that are refractory to standard genome manipulation techniques using viral plasmid delivery. We anticipate that this technique will be applied to other non-vascular cell types that face similar barriers to efficient genome editing. © 2021 Wiley Periodicals LLC. Basic Protocol: CRISPR-Cas9 genome editing of primary human vascular cells in vitro.
    MeSH term(s) CRISPR-Cas Systems/genetics ; Gene Editing ; Gene Expression ; Humans ; Plasmids ; Transfection
    Language English
    Publishing date 2021-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Going from A to Z.

    Atri, Deepak / Furfaro, David / Dhaliwal, Gurpreet / Feingold, Kenneth R / Manesh, Reza

    The New England journal of medicine

    2018  Volume 378, Issue 1, Page(s) 73–79

    MeSH term(s) Abdomen/diagnostic imaging ; Abdominal Pain/etiology ; Aged ; Blood Chemical Analysis ; Chronic Disease ; Diagnosis, Differential ; Diarrhea/etiology ; Gastrinoma/complications ; Gastrinoma/diagnosis ; Gastrinoma/diagnostic imaging ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Magnetic Resonance Imaging ; Male ; Neoplasms, Unknown Primary/complications ; Neoplasms, Unknown Primary/diagnosis ; Polycythemia/complications ; Positron Emission Tomography Computed Tomography ; Zollinger-Ellison Syndrome/complications ; Zollinger-Ellison Syndrome/diagnosis
    Language English
    Publishing date 2018-01-03
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/nejmcps1701264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies

    Atri, Deepak / Siddiqi, Hasan K / Lang, Joshua / Nauffal, Victor / Morrow, David A / Bohula, Erin A

    Abstract: The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global ... ...

    Abstract The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #306628
    Database COVID19

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  7. Article ; Online: COVID-19 for the Cardiologist

    Atri, Deepak / Siddiqi, Hasan K. / Lang, Joshua / Nauffal, Victor / Morrow, David A. / Bohula, Erin A.

    JACC Basic to translational science, In Press

    A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies

    2020  

    Abstract: The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global ... ...

    Abstract The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
    Keywords COVID-19 ; Virology ; Treatments ; Cardiovascular ; SARS-CoV-2 ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: COVID-19 for the Cardiologist

    Atri, Deepak / Siddiqi, Hasan K. / Lang, Joshua P. / Nauffal, Victor / Morrow, David A. / Bohula, Erin A.

    JACC: Basic to Translational Science

    2020  Volume 5, Issue 5, Page(s) 518–536

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2452-302X
    DOI 10.1016/j.jacbts.2020.04.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Endothelial ERK signaling controls lymphatic fate specification.

    Deng, Yong / Atri, Deepak / Eichmann, Anne / Simons, Michael

    The Journal of clinical investigation

    2013  Volume 123, Issue 3, Page(s) 1202–1215

    Abstract: Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We ... ...

    Abstract Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducible expression of an RAF1 gene with a gain-of-function mutation (RAF1(S259A)) that is associated with Noonan syndrome. Expression of mutant RAF1(S259A) in ECs activated ERK and induced SOX18 and PROX1 expression, leading to increased commitment of venous ECs to the lymphatic fate. Excessive production of lymphatic ECs resulted in lymphangiectasia that was highly reminiscent of abnormal lymphatics seen in Noonan syndrome and similar "RASopathies." Inhibition of ERK signaling during development abrogated the lymphatic differentiation program and rescued the lymphatic phenotypes induced by expression of RAF1(S259A). These data suggest that ERK activation plays a key role in lymphatic EC fate specification and that excessive ERK activation is the basis of lymphatic abnormalities seen in Noonan syndrome and related diseases.
    MeSH term(s) Animals ; Aorta/pathology ; Body Patterning ; Butadienes/pharmacology ; Cells, Cultured ; Endothelium, Lymphatic/embryology ; Endothelium, Lymphatic/pathology ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Gene Expression ; Gene Expression Regulation, Developmental ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/physiology ; Humans ; Lymphangiectasis/genetics ; Lymphangiectasis/metabolism ; Lymphangiectasis/pathology ; Lymphangiogenesis ; MAP Kinase Signaling System ; Male ; Mice ; Mice, Transgenic ; Mutation, Missense ; Nitriles/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-raf/genetics ; Proto-Oncogene Proteins c-raf/metabolism ; SOXF Transcription Factors/genetics ; SOXF Transcription Factors/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Up-Regulation ; Vascular Endothelial Growth Factor Receptor-3/metabolism
    Chemical Substances Butadienes ; Homeodomain Proteins ; Nitriles ; SOXF Transcription Factors ; Sox18 protein, mouse ; Tumor Suppressor Proteins ; U 0126 ; prospero-related homeobox 1 protein ; Vascular Endothelial Growth Factor Receptor-3 (EC 2.7.10.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2013-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI63034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Chronic Thromboembolic Pulmonary Hypertension: the Bench.

    Alba, George A / Atri, Deepak / Darbha, Sriranjani / Singh, Inderjit / Tapson, Victor F / Lewis, Michael I / Chun, Hyung J / Yu, Yen-Rei / Maron, Bradley A / Rajagopal, Sudarshan

    Current cardiology reports

    2021  Volume 23, Issue 10, Page(s) 141

    Abstract: Purpose of review: Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon complication of acute pulmonary embolism (PE), in which the red, platelet-rich thrombus does not resolve but forms into an organized yellow, fibrotic scar-like ... ...

    Abstract Purpose of review: Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon complication of acute pulmonary embolism (PE), in which the red, platelet-rich thrombus does not resolve but forms into an organized yellow, fibrotic scar-like obstruction in the pulmonary vasculature. Here we review the pathobiology of CTEPH.
    Recent findings: Our current knowledge has predominantly been informed by studies of human samples and animal models that are inherently limited in their ability to recapitulate all aspects of the disease. These studies have identified alterations in platelet biology and inflammation in the formation of a scar-like thrombus that comprised endothelial cells, myofibroblasts, and immune cells, along with a small vessel pulmonary arterial hypertension-like vasculopathy. The development of CTEPH-specific therapies is currently hindered by a limited knowledge of its pathobiology. The development of new CTEPH medical therapies will require new insights into its pathobiology that bridge the gap from bench to bedside.
    MeSH term(s) Animals ; Chronic Disease ; Endothelial Cells ; Humans ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Pulmonary Embolism/complications ; Pulmonary Embolism/therapy ; Thromboembolism/etiology
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-021-01572-6
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