Article ; Online: Vascular endothelial growth factor and pulmonary hypertension in children with beta thalassemia major.
2018 Volume 95, Issue 5, Page(s) 593–599
Abstract: Objective: The purpose of this study was to illustrate the association between vascular endothelial growth factor level and pulmonary artery hypertension in children with β-thalassemia major.: Method: This case-control study was conducted on 116 ... ...
| Abstract | Objective: The purpose of this study was to illustrate the association between vascular endothelial growth factor level and pulmonary artery hypertension in children with β-thalassemia major. Method: This case-control study was conducted on 116 children with β-thalassemia major; 58 of them had pulmonary artery hypertension. They were compared to 58 healthy children who were age and sex-matched (control group). Serum levels of vascular endothelial growth factor and echocardiographic assessment were done for all children. Results: Vascular endothelial growth factor serum level was significantly higher in children with β-thalassemia major with pulmonary artery hypertension than in those without pulmonary artery hypertension, as well as in control groups (p<0.001). Vascular endothelial growth factor serum level had a significant positive correlation with pulmonary artery pressure and serum ferritin, as well as a significant negative correlation with the duration of chelation therapy. Logistic regression analysis revealed that elevated vascular endothelial growth factor (Odd Ratio=1.5; 95% Confidence Interval, 1.137-2.065; p=0.005) was an independent risk factor of pulmonary artery hypertension in such children. Vascular endothelial growth factor serum level at a cutoff point of >169pg/mL had 93.1% sensitivity and 93.1% specificity for the presence of pulmonary artery hypertension in children with β-thalassemia major. Conclusion: Elevated vascular endothelial growth factor serum level is associated with pulmonary artery hypertension in children with β-thalassemia. |
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| MeSH term(s) | Adolescent ; Age of Onset ; Analysis of Variance ; Case-Control Studies ; Child ; Echocardiography, Doppler ; Female ; Humans ; Hypertension, Pulmonary/blood ; Hypertension, Pulmonary/physiopathology ; Male ; ROC Curve ; Reference Values ; Risk Factors ; Splenectomy ; Statistics, Nonparametric ; Time Factors ; Vascular Endothelial Growth Factor A/blood ; beta-Thalassemia/blood ; beta-Thalassemia/physiopathology |
| Chemical Substances | Vascular Endothelial Growth Factor A |
| Language | English |
| Publishing date | 2018-06-01 |
| Publishing country | Brazil |
| Document type | Journal Article |
| ZDB-ID | 731324-x |
| ISSN | 1678-4782 ; 0021-7557 |
| ISSN (online) | 1678-4782 |
| ISSN | 0021-7557 |
| DOI | 10.1016/j.jped.2018.05.003 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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