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Article ; Online: Efficacy and safety of balloon dilation of eustachian tube in children: Systematic review and meta-analysis.

Aboueisha, Mohamed A / Attia, Abdallah S / McCoul, Edward D / Carter, John

International journal of pediatric otorhinolaryngology

2022 Volume 154, Page(s) 111048

Abstract: Objectives: Eustachian tube dysfunction is a common condition that may lead to otitis media with effusion, hearing loss and developmental delays in children. We sought to determine the efficacy and safety of balloon dilation of the eustachian tube (BDET) ...

Abstract	Objectives: Eustachian tube dysfunction is a common condition that may lead to otitis media with effusion, hearing loss and developmental delays in children. We sought to determine the efficacy and safety of balloon dilation of the eustachian tube (BDET) in the pediatric population. Data sources: Original studies of BDET in a pediatric population were identified in PubMed, Embase, Web of Science, Cochrane, Clinicaltrials.gov and CINAHL. Methods: Outcomes of efficacy included audiometric findings and adverse events were summarized for each study. Results: Seven articles were included involving 408 children with a mean age of 9.9 years old (95%CI 8.8, 11.1) and a mean follow up of 19.2 months (95%CI 15, 23). Type B tympanograms decreased after BDET from 64.2% (95%CI 53.3, 73.8) to 16.1% (95%CI 8.5, 28.4). Air-bone gap (ABG) decreased after BDET from a mean of 25.3 dB (95%CI 18.9, 31.6) to 10.2 dB (95%CI 8.9, 11.5). The pooled estimate of adverse events after BDET was 5.1% (95%CI 3.2, 8.1), the majority being self-limited epistaxis with no major adverse events reported. Three studies compared BDET to ventilation tube insertion; analysis of post-operative ABG showed a greater decrease in the BDET group (mean difference -6.4 dB; 95%CI -9.8, -3.1; p = 0.002). Conclusion: Although there are no prospective randomized control trials, BDET ± tympanostomy tube placement may produce outcomes that are comparable to tympanostomy tube placement in the treatment of otitis media with effusion in the pediatric population. Most children undergoing the procedure are those with recalcitrant disease. The procedure is safe with the most common complication being epistaxis.
MeSH term(s)	Catheterization ; Child ; Dilatation ; Ear Diseases/surgery ; Eustachian Tube/surgery ; Humans ; Middle Ear Ventilation ; Otitis Media with Effusion/surgery
Language	English
Publishing date	2022-01-21
Publishing country	Ireland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2022.111048
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Article ; Online: Hyperthyroidism as an Underlying Cause of Premature Ejaculation.

Tannenbaum, Jacob / Youssef, Mohanad / Attia, Abdallah S / Hsieh, Tung-Chin / Raheem, Omer

Sexual medicine reviews

2021 Volume 10, Issue 1, Page(s) 108–112

Abstract: Introduction: Hormonal imbalances have been associated with various sexual dysfunction disorders. In particular, the connection of hyperthyroidism has been discovered to correlate to premature ejaculation (PE) but has yet to been thoroughly elucidated. ... ...

Abstract	Introduction: Hormonal imbalances have been associated with various sexual dysfunction disorders. In particular, the connection of hyperthyroidism has been discovered to correlate to premature ejaculation (PE) but has yet to been thoroughly elucidated. As one of the most frequently self-reported sexual dysfunctions, it is imperative for health care professionals to evaluate possible underlying conditions in regard to treatment options for individuals with PE. Objectives: To review the literature regarding hyperthyroidism effects on sexual dysfunction, with a focus on hyperthyroidism and PE. Methods: A literature review of articles and clinical studies was performed to define the classification, pathophysiology, diagnostic considerations, and management of hyperthyroidism on PE. Search terms included "hyperthyroidism" and/or "premature ejaculation," "treatment of premature ejaculation," "defining premature ejaculation," and "management of premature ejaculation." Results: To improve the accuracy of diagnosing PE, there needs to be a set definition amongst the different guidelines, as using these guidelines can help determine possible underlying etiologies of PE. The correlation of hyperthyroidism and PE has been described in a limited number of studies. It has been reported that individuals with hyperthyroidism are much more likely to have PE than individuals with euthryoidism. Management of hyperthyroidism has been shown to alleviate the symptoms of PE. Conclusion: Further understanding of hyperthyroidism as an underlying cause of PE could lead to increased efficacy of treatment and management of PE. Tannenbaum J, Youssef M, Attia AS, et al. Hyperthyroidism as an Underlying Cause of Premature Ejaculation. Sex Med Rev 2022;10:108-112.
MeSH term(s)	Ejaculation/physiology ; Humans ; Hyperthyroidism/complications ; Male ; Premature Ejaculation/etiology
Language	English
Publishing date	2021-07-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2722257-3
ISSN	2050-0521 ; 2050-0513
ISSN (online)	2050-0521
ISSN	2050-0513
DOI	10.1016/j.sxmr.2021.03.005
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Article: Radiofrequency ablation as a novel modality in the USA for treating toxic thyroid nodules: case series and literature review.

Kandil, Emad / Omar, Mahmoud / Attia, Abdallah S / Shihabi, Areej / Shaear, Mohammad / Metz, Tyler / Issa, Peter P / Russell, Jonathon O / Tufano, Ralph P

Gland surgery

2022 Volume 11, Issue 9, Page(s) 1574–1583

Abstract: Background: Radiofrequency ablation (RFA) is widely accepted as a treatment for non-functioning benign thyroid nodules, mainly to reduce compressive symptoms. In addition to potential compressive symptoms, autonomously functioning thyroid nodules (AFTNs) ...

Abstract	Background: Radiofrequency ablation (RFA) is widely accepted as a treatment for non-functioning benign thyroid nodules, mainly to reduce compressive symptoms. In addition to potential compressive symptoms, autonomously functioning thyroid nodules (AFTNs) can cause palpitations, weight loss, diarrhea, increased appetite, flushing, irritability, tiredness, poor sleep, and long-term cardiovascular and musculoskeletal consequences. Currently, there are no United States based RFA practice guidelines for the treatment of AFTNs. However, several reports from Asia and Europe have described the resolution of hyperthyroidism secondary to AFTNs with RFA. Case description: Three patients with toxic thyroid nodules presented with symptomatic hyperthyroidism, suppressed thyroid-stimulating hormone (TSH), and increased uptake on nuclear medicine thyroid scan. These patients were treated with RFA. At 3 months following ablation, TSH normalized to 2.09, 1.91, and 1.34 mIU/mL respectively. However, temporary hypothyroidism was encountered at 1 month following ablation. All patients discontinued their antithyroid medications following ablation. Nodules exhibited significant volume reductions of 38%, 32%, and 54% from the baseline at 1-month follow-up. Conclusions: RFA potentiates as a safe and effective treatment of toxic thyroid nodules. Though it carries a risk of temporary hypothyroidism following ablation, long-term consequences appear to be minimal. Future study with larger sample size and longer follow-up are encouraged to identify factors predicting response.
Language	English
Publishing date	2022-09-21
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.21037/gs-22-35
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Article: Nuclear Localization of BRAF

Zerfaoui, Mourad / Toraih, Eman / Ruiz, Emmanuelle / Errami, Youssef / Attia, Abdallah S / Krzysztof, Moroz / Abd Elmageed, Zakaria Y / Kandil, Emad

Cancers

2022 Volume 14, Issue 2

Abstract: Background: Previously, we have demonstrated that nuclear BRAF: Methods: Proteomics analysis was performed to identify the interacting partner(s) of nuclear BRAF: Results: Proteomics results showed that HMOX-1 protein expression was 10-fold higher ...

Abstract	Background: Previously, we have demonstrated that nuclear BRAF Methods: Proteomics analysis was performed to identify the interacting partner(s) of nuclear BRAF Results: Proteomics results showed that HMOX-1 protein expression was 10-fold higher in resistant A375R cells compared to parental counterpart cells. In vitro and in vivo results illustrate that nuclear BRAF Conclusions: Our results highlight a previously unknown mechanism in which the nuclear BRAF
Language	English
Publishing date	2022-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14020311
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Article ; Online: Robotic Thyroidectomy: Past, Future, and Current Perspectives.

Kandil, Emad / Attia, Abdallah S / Hadedeya, Deena / Shihabi, Areej / Elnahla, Ahmad

Otolaryngologic clinics of North America

2020 Volume 53, Issue 6, Page(s) 1031–1039

Abstract: Through the past decades, there was a tremendous revolution in the surgical approaches for thyroidectomy. Remote access approaches (RAA) use the axillary approach, the axillary-bilateral breast approach, the bilateral axilla-breast approach, the ... ...

Abstract	Through the past decades, there was a tremendous revolution in the surgical approaches for thyroidectomy. Remote access approaches (RAA) use the axillary approach, the axillary-bilateral breast approach, the bilateral axilla-breast approach, the retroauricular approach, and the transoral approach. The installation of the robotic system in surgery overcomes many limitations of the RAA. Although there are various types of robotic thyroidectomy by far, transaxillary is the commonly used approach. Moreover, the transoral approach is the most novel approach. In this article, the authors demonstrate the benefits and the constraints of each method and future directions of robotic thyroidectomy.
MeSH term(s)	Humans ; Natural Orifice Endoscopic Surgery/methods ; Otolaryngology/trends ; Outcome Assessment, Health Care ; Robotic Surgical Procedures/methods ; Thyroidectomy/methods
Language	English
Publishing date	2020-10-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417489-6
ISSN	1557-8259 ; 0030-6665
ISSN (online)	1557-8259
ISSN	0030-6665
DOI	10.1016/j.otc.2020.09.001
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Article: Diagnostic Performance of Afirma and Interpace Diagnostics Genetic Testing in Indeterminate Thyroid Nodules: A Single Center Study.

Kandil, Emad / Metz, Tyler A / Issa, Peter P / Aboueisha, Mohamed / Omar, Mahmoud / Attia, Abdallah S / Chabot, Bert / Hussein, Mohammad / Moroz, Krzysztof / Shama, Mohamed / Toraih, Eman

Cancers

2023 Volume 15, Issue 7

Abstract: Indeterminate thyroid nodules (ITN) represent 20-30% of biopsied nodules, with a 10-60% risk of malignancy. Molecular testing can stratify the risk of malignancy among ITNs, and subsequently reduce the need for unnecessary diagnostic surgery. We aimed to ...

Abstract	Indeterminate thyroid nodules (ITN) represent 20-30% of biopsied nodules, with a 10-60% risk of malignancy. Molecular testing can stratify the risk of malignancy among ITNs, and subsequently reduce the need for unnecessary diagnostic surgery. We aimed to assess the performance of these molecular tests at a single institution. Patients with Bethesda III, IV, and V nodules with Afirma and Interpace Diagnostics genetic testing data from November 2013 to November 2021 were included. Three cohorts were formed, including GSC + XA, ThyGeNEXT + ThyraMIR, and GSC + GEC. Statistical analysis determined the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), diagnostic odds ratio (DOR), and accuracy of each type of testing. The PPV of nodules undergoing genetic testing by ThyGeNEXT + ThyraMIR (45.00%, 95%CI: 28.28-62.93%,
Language	English
Publishing date	2023-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15072098
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Article ; Online: From ablation to operation: Unraveling the surgical outcomes and complications of thyroidectomy after radiofrequency ablation.

Hussein, Mohammad / Toraih, Eman / Issa, Peter P / Omar, Mahmoud / Aboueisha, Mohamed / Buti, Yusef / Issa, Chad P / Albuck, Aaron L / Cironi, Katherine / Attia, Abdallah S / LaForteza, Alexandra C / Shama, Mohamed / Kandil, Emad

Surgery

2023 Volume 175, Issue 1, Page(s) 146–152

Abstract: Background: Radiofrequency ablation is a minimally invasive treatment for thyroid nodules; however, concerns exist regarding its impact on subsequent thyroid surgery. We compared surgical outcomes and complications between patients undergoing ... ...

Abstract	Background: Radiofrequency ablation is a minimally invasive treatment for thyroid nodules; however, concerns exist regarding its impact on subsequent thyroid surgery. We compared surgical outcomes and complications between patients undergoing thyroidectomy after radiofrequency ablation (post-radiofrequency ablation thyroidectomy group) and those without prior radiofrequency ablation (non-radiofrequency ablation thyroidectomy group). Methods: We retrospectively analyzed thyroidectomy patients, comparing post-radiofrequency ablation thyroidectomy and non-radiofrequency ablation thyroidectomy groups, examining demographics, nodule characteristics, surgical techniques, and complications. Results: The study included 96 patients (73 in the non-radiofrequency ablation thyroidectomy group and 23 in the post-radiofrequency ablation thyroidectomy group). The mean age was 53.3 ± 14.4 years, with 78.1% female patients and 36.5% African American patients. Median operative time was similar between the post-radiofrequency ablation thyroidectomy (110 minutes) and the non-radiofrequency ablation thyroidectomy (92 minutes) cohorts (P = .40). Complications were reported in 13 patients, without significant differences between groups (P = .54). No permanent complications, including nerve injury or hypoparathyroidism, were reported in either cohort. Prior radiofrequency ablation treatment did not increase the risk of complications (odds ratio = 3.48, 95% confidence interval = 0.70-17.43, P = .16). Conclusion: Our work found no differences in outcomes or safety in patients undergoing thyroidectomy with or without previous radiofrequency ablation treatment, potentiating the post-radiofrequency ablation thyroidectomy group as a safe management option. Accordingly, this may reassure both clinicians and patients of the safety of radiofrequency ablation in treating patients with thyroid nodules.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Male ; Thyroidectomy/adverse effects ; Thyroidectomy/methods ; Thyroid Nodule/surgery ; Retrospective Studies ; Radiofrequency Ablation/adverse effects ; Treatment Outcome ; Catheter Ablation/adverse effects ; Catheter Ablation/methods
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2023.09.025
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Article ; Online: A combination of computed tomography scan and ultrasound provides optimal detection of cervical lymph node metastasis in papillary thyroid carcinomas: A systematic review and meta-analysis.

Albuck, Aaron L / Issa, Peter P / Hussein, Mohammad / Aboueisha, Mohamed / Attia, Abdallah S / Omar, Mahmoud / Munshi, Ruhul / Shama, Mohamed / Toraih, Eman / Randolph, Gregory W / Kandil, Emad

Head & neck

2023 Volume 45, Issue 9, Page(s) 2173–2184

Abstract: Background: Lymph node metastasis (LNM) in patients with papillary thyroid carcinoma (PTC) is common. This meta-analysis assesses the diagnostic accuracy of computed tomography (CT), ultrasound (US), and CT + US in detecting central and lateral LNM.: ... ...

Abstract	Background: Lymph node metastasis (LNM) in patients with papillary thyroid carcinoma (PTC) is common. This meta-analysis assesses the diagnostic accuracy of computed tomography (CT), ultrasound (US), and CT + US in detecting central and lateral LNM. Methods: A systematic review and meta-analysis was performed by searching PubMed, Embase, and Cochrane for studies published up to April 2022. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated. The area under the curve (AUC) for summary receiver operating curves (sROC) were compared. Results: The study population included 7902 patients with a total of 15 014 lymph nodes. Twenty-four studies analyzed the sensitivity of the overall neck region in which dual CT + US imaging (55.9%) had greater sensitivities (p < 0.001) than either US (48.4%) or CT (50.4%) alone. The specificity of US alone (89.0%) was greater (p < 0.001) than CT alone (88.5%) or dual imaging (86.8%). The DOR for dual CT + US imaging was greatest (p < 0.001) at 11.134, while the AUCs of the three imaging modalities were similar (p > 0.05). Twenty-one studies analyzed the sensitivity of the central neck region in which both CT (45.8%) and CT + US imaging (43.4%) had greater sensitivities (p < 0.001) than US alone (35.3%). The specificity of all three modalities was higher than 85%. The DOR for CT (7.985) was greater than US alone (4.723, p < 0.001) or dual CT + US imaging (4.907, p = 0.015). The AUC of both CT + US (0.785) and CT alone (0.785) were significantly greater (p < 0.001) than US alone (0.685). Of the 19 studies that reported lateral LNM, CT + US imaging sensitivity (84.5%) was higher than CT alone (69.2%, p < 0.001) and US alone (79.7%, p = 0.038). The specificity of all imaging techniques was all greater than 80.0%. CT + US imaging DOR (35.573) was greater than CT (20.959, p = 0.024) and US (15.181, p < 0.001) individually. The AUC of independent imaging was high (CT: 0.863, US: 0.858) and improved significantly when combined (CT + US: 0.919, p = 0.024 and p < 0.001, respectively). Conclusions: We report an up-to-date analysis elucidating the diagnostic accuracy of LNM detection by either CT, US, or in combination. Our work suggests dual CT + US to be the best for overall detection of LNM and CT to be preferable in detecting central LNM. The use of either CT or US alone may detect lateral LNM with acceptable accuracy, yet dual imaging (CT + US) significantly improved detection rates.
MeSH term(s)	Humans ; Thyroid Cancer, Papillary/diagnostic imaging ; Lymphatic Metastasis/diagnostic imaging ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27451
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Article ; Online: Thyroid lobectomy as a cost-effective approach in low-risk papillary thyroid cancer versus active surveillance.

Youssef, Mohanad R / Attia, Abdallah S / Omar, Mahmoud / Aboueisha, Mohamed / Freeman, Meredith N / Shama, Mohamed / Kandil, Emad

Surgery

2021 Volume 171, Issue 1, Page(s) 190–196

Abstract: Background: An ongoing debate exists over the optimal management of low-risk papillary thyroid cancer. The American Thyroid Association supports the concept of active surveillance to manage low-risk papillary thyroid cancer; however, the cost- ... ...

Abstract	Background: An ongoing debate exists over the optimal management of low-risk papillary thyroid cancer. The American Thyroid Association supports the concept of active surveillance to manage low-risk papillary thyroid cancer; however, the cost-effectiveness of active surveillance has not yet been established. We sought to perform a cost-effectiveness analysis comparing active surveillance versus surgical intervention for patients in the United States. Methods: A Markov decision tree model was developed to compare active surveillance and thyroid lobectomy. Our reference case is a 40-year-old female who was diagnosed with unifocal (<15 mm), low-risk papillary thyroid cancer. Probabilistic outcomes, costs, and health utilities were determined using an extensive literature review. The willingness-to-pay threshold was set at $50,000/quality-adjusted life year gained. Sensitivity analyses were performed to account for uncertainty in the model's variables. Results: Lobectomy provided a final effectiveness of 21.7/quality-adjusted life years, compared with 17.3/quality-adjusted life years for active surveillance. Furthermore, incremental cost effectiveness ratio for lobectomy versus active surveillance was $19,560/quality-adjusted life year (<willing-to-pay threshold of $50,000/quality-adjusted life year), and thus surgical intervention proved to be cost-effective in patients between 40 and 69 years old. Further analysis revealed that, at the age of 69 years, active surveillance is more cost-effective than lobectomy, with a final effectiveness of 17.3/quality-adjusted life years. Compared to active surveillance, the incremental cost effectiveness ratio for lobectomy at the age of 69 was $27,235/quality-adjusted life year, which decreases quality-adjusted life years by 1.5.<br />Conclusion: Lobectomy is a cost-effective strategy in middle-aged patients with low-risk papillary thyroid cancer. In contrast, active surveillance is cost-effective beginning at the age of 69. Identification of such nuances can help physicians and patients determine the best, most individualized long-term management strategy for low-risk papillary thyroid cancer.
MeSH term(s)	Adult ; Aged ; Computer Simulation ; Cost-Benefit Analysis ; Female ; Humans ; Male ; Markov Chains ; Middle Aged ; Models, Economic ; Quality-Adjusted Life Years ; Thyroid Cancer, Papillary/economics ; Thyroid Cancer, Papillary/mortality ; Thyroid Cancer, Papillary/therapy ; Thyroid Gland/pathology ; Thyroid Gland/surgery ; Thyroid Neoplasms/economics ; Thyroid Neoplasms/mortality ; Thyroid Neoplasms/therapy ; Thyroidectomy/economics ; Thyroidectomy/methods ; Thyroidectomy/statistics & numerical data ; United States/epidemiology ; Watchful Waiting/economics ; Watchful Waiting/statistics & numerical data
Language	English
Publishing date	2021-08-10
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2021.05.057
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Article ; Online: Chemoembolization Versus Radioembolization for Neuroendocrine Liver Metastases: A Meta-analysis Comparing Clinical Outcomes.

Ngo, Lisa / Elnahla, Ahmed / Attia, Abdallah S / Hussein, Mohamed / Toraih, Eman A / Kandil, Emad / Killackey, Mary

Annals of surgical oncology

2021 Volume 28, Issue 4, Page(s) 1950–1958

Abstract: Background: Studies have shown intra-arterial therapies to be effective in controlling neuroendocrine liver metastases (NELMs), but the evidence supporting the selection of specific methods is limited. This meta-analysis is the first to compare survival ...

Abstract	Background: Studies have shown intra-arterial therapies to be effective in controlling neuroendocrine liver metastases (NELMs), but the evidence supporting the selection of specific methods is limited. This meta-analysis is the first to compare survival outcomes between transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) in the treatment of NELM. Methods: A systematic search according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in PubMed and Embase databases was conducted in February 2020 for published studies comparing survival outcomes between TACE and TARE in the treatment of NELM. Results: Six eligible cohort studies with a total of 643 patients were identified. The TACE and TARE groups were similar in terms of age, sex, hepatic tumor burden, tumor grade, and Eastern Cooperative Oncology Group (ECOG) score. The patients treated with TACE had significantly better overall survival (odds ratio [OR], 1.92; 95% confidence interval [CI] 1.14-3.22, p = 0.014) than those treated with TARE. Overall survival ranged from 16.8 to 81.9 months with TACE and from 14.5 to 66.8 months with TARE. No significant differences in hepatic progression-free survival (OR, 1.01; 95% CI 0.75-1.35; p = 0.96) or tumor response were observed within the first 3 months (OR, 2.87; 95% CI 0.81-10.21; p = 0.10) or thereafter (OR, 0.98; 95% CI 0.12-7.86; p = 0.99). The complication rates were similar between the two groups, with 6.9% of the TACE patients versus 8.5% of TARE patients reporting major complications (OR, 1.16; 95% CI 0.54-2.48; p = 0.71) and respectively 44.6% and 58.8% of the TACE and TARE patients reporting minor adverse events (OR, 1.08; 95% CI 0.39-2.99; p = 0.88). Conclusions: Despite similar tumor responses, an overall survival benefit was associated with TACE treatment of NELM compared with TARE treatment. Randomized controlled trials are warranted to confirm this finding and clarify whether certain subpopulations benefit from different transarterial methods.
MeSH term(s)	Brachytherapy ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic ; Humans ; Liver Neoplasms/therapy ; Treatment Outcome
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-020-09469-4
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