LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 127

Search options

  1. Article ; Online: Early childhood caries risk indicators among preschool children in rural Egypt: a case control study.

    Attia, Dina / ElKashlan, Mona K / Saleh, Susan M

    BMC oral health

    2024  Volume 24, Issue 1, Page(s) 10

    Abstract: Background: Early childhood caries (ECC) is a public health problem, especially in developing countries like Egypt which has an ECC prevalence of 74%. This research aimed to assess the risk indicators associated with ECC in a rural, socially- ... ...

    Abstract Background: Early childhood caries (ECC) is a public health problem, especially in developing countries like Egypt which has an ECC prevalence of 74%. This research aimed to assess the risk indicators associated with ECC in a rural, socially-disadvantaged population in Alexandria, Egypt.
    Methods: A case-control study was conducted in 8 nurseries of preschool children aged 3 to 5 years in rural, deprived areas in Alexandria, Egypt, from October 2019 till January 2020. Two groups, 93 with ECC and 93 without ECC. A validated questionnaire was used to collect sociodemographic data including age, sex, number of siblings, socioeconomic status, oral health practices including toothbrushing frequency, pattern of dental visits, daily frequency of sugary snacks. Also, salivary pH and buffering capacity were assessed. A trained and calibrated dentist assessed caries status clinically according to the World Health Organization (WHO) criteria using the dmft index and oral hygiene status using Silness and Loe Plaque Index. Chi-squared test, followed by multivariable logistic regression were performed to assess the relation between independent variables and ECC, P < 0.05 was considered to be statistically significant.
    Results: Bivariate analysis showed that age, mother's education, dental visits, dietary habits, Plaque index, salivary pH and buffering capacity were significantly associated with ECC. The significant risk indicators for ECC in multivariable regression were age (AOR = 4.73, 95% CI: 2.76-7.83), mother's education (illiterate vs. university educated, AOR = 28.36, 95% CI: 8.51-112.92), frequency of daily sugary snacks (twice vs. once, AOR = 2.00, 95% CI: 1.29-3.49, and three or more vs. once, AOR = 2.67, 95% CI: 1.72-3.27), night feeding (AOR = 1.89, 95% CI: 1.38-10.21), Plaque index (AOR = 21.34, 95% CI: 5.56-81.99), and salivary pH (AOR = 0.16, 95% CI: 0.05-0.58).
    Conclusion: This study suggests that sociodemographic indicators, dietary habits, plaque accumulation and salivary pH are risk indicators for ECC in the studied population.
    MeSH term(s) Humans ; Child, Preschool ; Case-Control Studies ; Dental Caries Susceptibility ; Egypt/epidemiology ; Dental Caries/epidemiology ; Dental Caries/etiology ; Oral Health ; Risk Factors ; Prevalence
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03771-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Letter to the editor: Pitfalls in the outcome differences between NAFLD and MAFLD.

    Attia, Dina / Gomaa, Ahmed / Abdel Alem, Shereen

    Hepatology (Baltimore, Md.)

    2022  Volume 76, Issue 5, Page(s) E100

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Risk Factors
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32563
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Evolving Treatment Options for Cancer-Related Venous Thromboembolism.

    Attia, Doaa / Khorana, Alok A

    JACC. CardioOncology

    2020  Volume 2, Issue 3, Page(s) 441–442

    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Editorial
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2020.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Charge Regulation of Poly(acrylic acid) in Solutions of Non-Charged Polymer and Colloids.

    Yekymov, Evgenee / Attia, David / Levi-Kalisman, Yael / Bitton, Ronit / Yerushalmi-Rozen, Rachel

    Polymers

    2023  Volume 15, Issue 5

    Abstract: Weak polyelectrolytes (WPEs) are responsive materials used as active charge regulators in a variety of applications, including controlled release and drug delivery in crowded bio-related and synthetic environments. In these environments, high ... ...

    Abstract Weak polyelectrolytes (WPEs) are responsive materials used as active charge regulators in a variety of applications, including controlled release and drug delivery in crowded bio-related and synthetic environments. In these environments, high concentrations of solvated molecules, nanostructures, and molecular assemblies are ubiquitous. Here, we investigated the effect of high concentrations of non-adsorbing, short chains of poly(vinyl alcohol), PVA, and colloids dispersed by the very same polymers on charge regulation (CR) of poly(acrylic acid), PAA. PVA does not interact with PAA (throughout the full pH range) and thus can be used to examine the role of non-specific (entropic) interactions in polymer-rich environments. Titration experiments of PAA (mainly 100 kDa in dilute solutions, no added salt) were carried out in high concentrations of PVA (13-23 kDa, 5-15 wt%) and dispersions of carbon black (CB) decorated by the same PVA (CB-PVA, 0.2-1 wt%). The calculated equilibrium constant (and pKa) was up-shifted in PVA solutions by up to ~0.9 units and down-shifted in CB-PVA dispersions by ~0.4 units. Thus, while solvated PVA chains increase the charging of the PAA chains, as compared to PAA in water, CB-PVA particles reduce PAA charging. To investigate the origins of the effect, we analyzed the mixtures using small-angle X-ray scattering (SAXS) and cryo-TEM imaging. The scattering experiments revealed re-organization of the PAA chains in the presence of the solvated PVA but not in the CB-PVA dispersions. These observations clearly indicate that the acid-base equilibrium and the degree of ionization of PAA in crowded liquid environments is affected by the concentration, size, and geometry of seemingly non-interacting additives, probably due to depletion and excluded volume interactions. Thus, entropic effects that do not depend on specific interactions should be taken into consideration when designing functional materials in complex fluid environments.
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15051121
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Enantioselective disruption of cellulose nanocrystal self-assembly into chiral nematic phases in D-alanine solutions.

    Attia, David / Mendelson, Orit / Levi-Kalisman, Yael / Bitton, Ronit / Yerushalmi-Rozen, Rachel

    Nanoscale

    2023  Volume 15, Issue 42, Page(s) 16890–16895

    Abstract: The chiral environment of enantiomerically pure D-alanine solutions is observed to disrupt and modify the entropy-driven assembly of cellulose nanocrystals (CNCs) into a chiral nematic mesophase. The effect is specific to D-alanine and cannot be ... ...

    Abstract The chiral environment of enantiomerically pure D-alanine solutions is observed to disrupt and modify the entropy-driven assembly of cellulose nanocrystals (CNCs) into a chiral nematic mesophase. The effect is specific to D-alanine and cannot be attributed to the adsorption of alanine molecules (neither D- nor L-alanine) onto the CNC particles.
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr03077f
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Unroasted Green Coffee Extract-Loaded Solid Lipid Nanoparticles for Enhancing Intestinal Permeation.

    Moussa, Yomna A / Teaima, Mahmoud H / Attia, Dalia / Elmazar, Mohey M / El-Nabarawi, Mohamed A

    ACS omega

    2023  Volume 8, Issue 23, Page(s) 20251–20261

    Abstract: Green coffee bean extract (GCBE) provides diversified health benefits. However, its reported low bioavailability impeded its utilization in various applications. In this study, GCBE-loaded solid lipid nanoparticles (SLNs) were prepared to improve the ... ...

    Abstract Green coffee bean extract (GCBE) provides diversified health benefits. However, its reported low bioavailability impeded its utilization in various applications. In this study, GCBE-loaded solid lipid nanoparticles (SLNs) were prepared to improve the bioavailability through enhanced intestinal absorption of GCBE. During the preparation of promising GCBE-loaded SLNs, the lipid concentration, surfactant concentration, and co-surfactant amount are crucial that were optimized using the Box-Behnken design, while particle size, polydispersity index (PDI), ζ-potential, entrapment efficiency, and cumulative drug release were the measured responses. GCBE-SLNs were successfully developed by a high shear homogenization technique using geleol as a solid lipid, tween 80 as a surfactant, and propylene glycol as Co-SAA. The optimized SLNs contained 5.8% geleol, 5.9% tween 80, and 80.4 mg PG resulting in a small particle size of 235.7 ± 12.5 nm, reasonably acceptable PDI of 0.417 ± 0.023, and ζ-potential of -15 ± 0.14 mV, with a high entrapment efficiency of 58.3 ± 0.85% and cumulative release of 7575 ± 0.78%. Furthermore, the performance of the optimized GCBE-SLN was evaluated using an ex vivo everted sac model where the intestinal permeation of GCBE was improved due to nanoencapsulation using SLN. Consequently, the results enlightened the auspicious potential of exploiting oral GCBE-SLNs for boosting intestinal absorption of chlorogenic acid.
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c06629
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Disheveled EGL-10 and pleckstrin domain-containing 5 rs1012068 T/G gene polymorphism among Egyptian chronic HCV-infected patients: disease progression and related complications.

    Farhan, Hanan M / Abougabal, Khadiga / Gaber, Heba F / Attia, Dina

    The Egyptian journal of immunology

    2022  Volume 29, Issue 3, Page(s) 36–43

    Abstract: Hepatitis C virus (HCV) infection related complications including fibrosis, cirrhosis and hepatocellular carcinoma (HCC) are influenced by host genetic factors. Identification of emerging host genetic variations is of promising value. Disheveled EGL-10 ... ...

    Abstract Hepatitis C virus (HCV) infection related complications including fibrosis, cirrhosis and hepatocellular carcinoma (HCC) are influenced by host genetic factors. Identification of emerging host genetic variations is of promising value. Disheveled EGL-10 and pleckstrin domain-containing 5 (DEPDC5) rs1012068 T/G gene polymorphism has been implicated in liver disease. This study aimed to assess DEPDC5 rs1012068 T/G gene polymorphism with disease progression and related complications among Egyptian patients with chronic HCV infection. Sixty chronic HCV-infected patients and 60 apparently healthy controls were recruited in this study. Patients were classified into 20 with liver fibrosis, 20 with liver cirrhosis and 20 with HCC; all recruited from Outpatients Clinic and Tropical Medicine Inpatient Department, Faculty of Medicine, Beni-Suef University Hospital. DEPDC5 rs1012068 T/G gene polymorphism was assayed by real time-polymerase chain reaction (RT-PCR) TaqMan allelic discrimination. DEPDC5 rs1012068 GG genotype and G allele variants showed statistically significant higher frequency among patients with liver fibrosis when compared to controls (OR (95% CI) 10.500 (2.086 - 52.851), P= 0.004 and 0.388 (0.155 - 0.971), P= 0.011), respectively. DEPDC5 rs1012068G allele variant showed statistically significant higher frequency among patients with liver fibrosis when compared to HCC patients (OR (95% CI) 3.316 (1.286 - 8.550), P= 0.012) and to both HCC and cirrhosis patients (OR (95% CI) 2.579 (1.187-5.645), P= 0.016). In conclusion, our results suggest that DEPDC5 rs1012068 G allele could be considered genetic risk allele for liver fibrosis and disease progression among Egyptian patients with chronic HCV infection.
    MeSH term(s) Blood Proteins ; Carcinoma, Hepatocellular/genetics ; Disease Progression ; Egypt ; GTPase-Activating Proteins/genetics ; Hepacivirus/genetics ; Hepatitis C/complications ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/genetics ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/genetics ; Liver Neoplasms/genetics ; Phosphoproteins ; Polymorphism, Single Nucleotide
    Chemical Substances Blood Proteins ; DEPDC5 protein, human ; GTPase-Activating Proteins ; Phosphoproteins ; platelet protein P47
    Language English
    Publishing date 2022-06-27
    Publishing country Egypt
    Document type Journal Article
    ISSN 1110-4902
    ISSN 1110-4902
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: The EMRG Consortium: a gate to identify the burden of metabolic (dysfunction)-associated fatty liver disease in Egypt.

    Fouad, Yasser / Gomaa, Ahmed / Attia, Dina

    Therapeutic advances in endocrinology and metabolism

    2021  Volume 12, Page(s) 20420188211054678

    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 2554822-0
    ISSN 2042-0196 ; 2042-0188
    ISSN (online) 2042-0196
    ISSN 2042-0188
    DOI 10.1177/20420188211054678
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: The change from NAFLD to MAFLD expands fatty liver information flow.

    Fouad, Yasser / Abdel Salam, Sherief / AbdAllah, Mohamed / Attia, Dina

    Hepatology research : the official journal of the Japan Society of Hepatology

    2022  Volume 52, Issue 5, Page(s) 488–489

    Language English
    Publishing date 2022-05-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1387041-5
    ISSN 1386-6346 ; 0928-4346
    ISSN 1386-6346 ; 0928-4346
    DOI 10.1111/hepr.13752
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Rosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy.

    Hashem, Mona M / Attia, Dalia / Hashem, Yomna A / Hendy, Moataz S / AbdelBasset, Safa / Adel, Farah / Salama, Maha M

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7780

    Abstract: Dandruff, a common scalp disorder characterized by flaking dead skin, is often treated with conventional topical products. However, limitations exist due to potential side effects and high costs. Therefore, searching for natural, cost-effective solutions ...

    Abstract Dandruff, a common scalp disorder characterized by flaking dead skin, is often treated with conventional topical products. However, limitations exist due to potential side effects and high costs. Therefore, searching for natural, cost-effective solutions for dandruff and hair loss is crucial. Rosemary herb and neem tree, both cultivated in Egypt, possess well-documented anti-inflammatory properties derived from their rich phenolic phytoconstituents. This study formulated a standardized combined extract of rosemary and neem (RN-E 2:1) into hair gel and leave-in tonic formats. This extract demonstrated superior efficacy against Malassezia furfur (a causative agent of dandruff) and Trichophyton rubrum (associated with scalp disorders) compared to the conventional antifungal agent, ketoconazole. The combined extract (RN-E 2:1) also exhibited potent anti-inflammatory activity. Additionally, the suppression of iNOS expression is considered concentration-dependent. Quality control verified formulation stability, and ex-vivo studies confirmed effective ingredient penetration into the epidermis, the primary site of fungal presence. Remarkably, both formulations outperformed the standard treatment, minoxidil in hair growth trials. These findings highlight the potential of natural extracts for scalp and hair health.
    MeSH term(s) Dandruff/drug therapy ; Dandruff/microbiology ; Rosmarinus ; Azadirachta ; Alopecia/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances Plant Extracts ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57838-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top