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Article ; Online: The first spectrofluorimetric protocol for sensitive quantitative analysis of bromocriptine in its pure and pharmaceutical forms: evaluation of the greenness of the method.

Abdulrazik, Shrouk G / Attia, Tamer Z / Derayea, Sayed M

RSC advances

2023 Volume 13, Issue 50, Page(s) 35733–35740

Abstract: Bromocriptine mesylate, a dopamine ... ...

Abstract	Bromocriptine mesylate, a dopamine D
Language	English
Publishing date	2023-12-08
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra06626f
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Article ; Online: Quantitative spectrofluorimetric method for determination of octreotide acetate synthetic peptide derivative in pure and its Sandostatin ampules forms.

Derayea, Sayed M / Abdulrazik, Shrouk G / Attia, Tamer Z

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 305, Page(s) 123546

Abstract: A unique spectrofluorimetric protocol has been conceived for octreotide (a synthetic peptide drug) quantitation in both its authentic form and its application to dosage form. The protocol has been established simply upon condensation of octreotide by ... ...

Abstract	A unique spectrofluorimetric protocol has been conceived for octreotide (a synthetic peptide drug) quantitation in both its authentic form and its application to dosage form. The protocol has been established simply upon condensation of octreotide by ninhydrin / phenyl acetaldehyde reagent in buffered media (pH 6.2). An intense fluorescence product has been formed and quantified at 463 nm (390 nm for excitation). After optimization for various experimental conditions, a wide linear interval (0.2-4.0 µg/ml) has been used to construct the calibration curve with a determination coefficient (r
MeSH term(s)	Octreotide ; Spectrometry, Fluorescence/methods ; Indicators and Reagents ; Ninhydrin
Chemical Substances	Octreotide (RWM8CCW8GP) ; Indicators and Reagents ; Ninhydrin (HCL6S9K23A)
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.123546
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Article ; Online: Facile spectrofluorimetric quantitation of octreotide, a synthetic peptide, in its pure form and pharmaceutical formulation; evaluation of the method's greenness.

Attia, Tamer Z / Abdulrazik, Shrouk G / Derayea, Sayed M

Luminescence : the journal of biological and chemical luminescence

2022 Volume 37, Issue 11, Page(s) 1914–1920

Abstract: A new, rapid, highly sensitive, and affordable spectrofluorimetric approach has been constructed and validated for the determination of octreotide in its authentic form and pharmaceutical dosage form. Octreotide is an important synthetic analog of the ... ...

Abstract	A new, rapid, highly sensitive, and affordable spectrofluorimetric approach has been constructed and validated for the determination of octreotide in its authentic form and pharmaceutical dosage form. Octreotide is an important synthetic analog of the naturally occurring somatostatin hormone. The developed spectrofluorimetric approach is actually dependent on the measurement of octreotide native fluorescence at emission wavelength of 342 nm after excitation at 218 nm. At optimal reaction conditions, the calibration curve has been constructed over the concentration range 200-2000 ng ml
MeSH term(s)	Drug Compounding ; Octreotide ; Spectrometry, Fluorescence ; Calibration ; Pharmaceutical Preparations
Chemical Substances	Octreotide (RWM8CCW8GP) ; Pharmaceutical Preparations
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4375
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Article ; Online: Simultaneous determination of rutin and ascorbic acid mixture in their pure forms and combined dosage form.

Attia, Tamer Z

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2016 Volume 169, Page(s) 82–86

Abstract: A simple, rapid, sensitive and selective high performance liquid chromatographic (HPLC) method with ultraviolet detection has been developed for simultaneous determination of ascorbic acid and rutin in pure forms and pharmaceutical dosage form. HPLC ... ...

Abstract	A simple, rapid, sensitive and selective high performance liquid chromatographic (HPLC) method with ultraviolet detection has been developed for simultaneous determination of ascorbic acid and rutin in pure forms and pharmaceutical dosage form. HPLC separation was performed on Phenomenex C18 analytical column with 0.1% v/v acetic acid in water and acetonitrile (75:25, v/v), as mobile phase. The separation was done at ambient temperature with flow rate of 1mL·min(-1) in isocratic mode. HPLC measurements were carried out using ultraviolet detection wavelength at 257nm. The average retention times were 2.72 and 7.00min for ascorbic acid and rutin, respectively. The calibration plots were constructed over the concentration range of 5.0-30.0 for ascorbic acid and 10.0-60.0μg·mL(-1) for rutin. The limits of detection were 1.06 and 1.89μg·mL(-1) and limits of quantification were 3.54 and 6.31μg·mL(-1) for ascorbic acid and rutin, respectively. The proposed HPLC-UV method was successfully applied for determination of ascorbic acid in its tablets and for simultaneous determination of the studied drugs in their laboratory prepared mixtures and in pharmaceutical formulation. Statistical comparisons of the results with the reference method show an excellent agreement and indicate no significant difference in respect to accuracy and precision.
Language	English
Publishing date	2016-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2016.06.030
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Article ; Online: Spectrofluorimetric Protocol for Estimation of Commonly Used Antispasmodic Drotaverine. Fluorescence Quenching Study.

Derayea, Sayed M / Mahmoud, Nihad A / Noureldeen, Deena A M / Attia, Tamer Z

Journal of fluorescence

2023

Abstract: A fast, simple, accurate, precise, and cheap fluorimetric protocol has been proposed for analysis of a phosphodiesterase-IV inhibitor, namely drotaverine hydrochloride. Fluorimetric protocol is based on estimating the decrease in the eosin Y fluorescence ...

Abstract	A fast, simple, accurate, precise, and cheap fluorimetric protocol has been proposed for analysis of a phosphodiesterase-IV inhibitor, namely drotaverine hydrochloride. Fluorimetric protocol is based on estimating the decrease in the eosin Y fluorescence intensity by quantitative addition of drotaverine at pH 3.1 (acetate buffer). An ion pair complex is formed, which leads to quenching in the fluorescence intensity of the dye without need of prior extraction at 534 nm (λ
Language	English
Publishing date	2023-11-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-023-03487-7
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Article ; Online: Green spectrofluorimetric determination of salmeterol xinafoate in its pure forms, medicinal commercial formula, and human plasma: Application for stability studies.

Omar, Mahmoud A / Nagy, Dalia M / Ahmed, Hoda S / Attia, Tamer Z

Luminescence : the journal of biological and chemical luminescence

2021 Volume 36, Issue 4, Page(s) 937–942

Abstract: A natural, accurate, extremely rapid, and precise spectrofluorometric method has been developed and validated for determination of salmeterol (SAL) xinafoate in its medicinal commercial form and spiked human plasma. The native SAL fluorescence has been ... ...

Abstract	A natural, accurate, extremely rapid, and precise spectrofluorometric method has been developed and validated for determination of salmeterol (SAL) xinafoate in its medicinal commercial form and spiked human plasma. The native SAL fluorescence has been measured at 415 nm (after 340 nm as excitation) in distilled water. Different factors affecting the native fluorescence consistency of SAL were surveyed and optimized. The suggested procedure was capable of SAL determination over concentrations ranging 200-2000 ng.mL
MeSH term(s)	Humans ; Salmeterol Xinafoate ; Spectrometry, Fluorescence
Chemical Substances	Salmeterol Xinafoate (6EW8Q962A5)
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4019
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Article ; Online: Spectrofluorimetric determination of the anti-Covid 19 agent, remdesivir, in vials and spiked human plasma.

Attia, Tamer Z / Boushra, John M / Abdel Hakiem, Ahmed F / Lashien, Adel S / Noureldeen, Deena A M

Luminescence : the journal of biological and chemical luminescence

2022 Volume 37, Issue 7, Page(s) 1192–1199

Abstract: Following the sudden widespread of the novel coronavirus (COVID-19) which first appeared in Wuhan city. Remdesivir (REM) was the first medicine licensed by the US Food and Drug Administration (FDA) for COVID-19 infected hospitalized patients. Hence, ... ...

Abstract	Following the sudden widespread of the novel coronavirus (COVID-19) which first appeared in Wuhan city. Remdesivir (REM) was the first medicine licensed by the US Food and Drug Administration (FDA) for COVID-19 infected hospitalized patients. Hence, there was an urgent demand for the optimization of efficient selective and sensitive methods to be developed for the determination of REM in pharmaceuticals as well as biological samples. A sensitive and simple green spectrofluorimetric method has been developed to determine REM in pharmaceutical formulation, in addition to, spiked human plasma. The technique involves measuring the native fluorescence of REM in distilled water at 410 nm followed by excitation at 241 nm, giving a linear relationship over the range 50.00-500.00 ng/mL, and then improving the sensitivity of REM through micellar formation using 2.00% w/v sodium dodecyl sulfate (SDS). A linear relationship has been obtained over the range 10.00-350.00 ng/mL having detection and quantitation limits of 2.34 and 7.10 ng/mL, respectively. Different analytical parameters have been carefully studied. A validation study has been conducted successfully in accordance with the FDA and the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines. The developed methods' greenness was assessed utilizing a greenness profile and analytical eco-scale standards. Both methods were discovered to be environmentally friendly and could be successfully used for the determination of the studied drugs in pharmaceutical formulation and human plasma with good accuracy and high precision. As a result, the developed spectrofluorimetric methods could be ideally suited for determination of REM in quality control and medicinal laboratories.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; COVID-19/drug therapy ; Humans ; Micelles ; Spectrometry, Fluorescence/methods
Chemical Substances	Micelles ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-05-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4274
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Article ; Online: Salvage parenteral antibiotics for multidrug-resistant (MDR) Gram-negative bacteria; a fluorescamine-based technique for ultrasensitive spectrofluorimetric measurement of Polymyxins; human plasma application.

Badr El-Din, Khalid M / Abdelmajed, Mahmoud A / Omar, Mahmoud A / Attia, Tamer Z

Luminescence : the journal of biological and chemical luminescence

2022 Volume 37, Issue 6, Page(s) 971–979

Abstract: Polymyxins (PMS), namely Colistin (CS) and polymyxin B (poly B), are antimicrobial drugs that have been recently used to treat multiresistant Gram-negative bacteria infections and their resurgence, owing to a lack of new antibiotics. A speedy, simple, ... ...

Abstract	Polymyxins (PMS), namely Colistin (CS) and polymyxin B (poly B), are antimicrobial drugs that have been recently used to treat multiresistant Gram-negative bacteria infections and their resurgence, owing to a lack of new antibiotics. A speedy, simple, and ultrasensitive spectrofluorimetric screening of PMS in pharmaceutical formulations and biological fluids was urgently required from this point forwards. A reaction between fluorescamine and the aliphatic amino moiety found in both drugs was performed in a slightly alkaline borate buffer (pH 8.5) resulted in highly fluorescent products measured at λ
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Colistin/pharmacology ; Fluorescamine ; Gram-Negative Bacteria ; Humans ; Pharmaceutical Preparations ; Polymyxins ; Spectrometry, Fluorescence/methods
Chemical Substances	Anti-Bacterial Agents ; Pharmaceutical Preparations ; Polymyxins ; Fluorescamine (38183-12-9) ; Colistin (Z67X93HJG1)
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4245
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Article ; Online: Selective Spectrofluorimetric Protocol for Determination of Commonly Used Gram-negative Bactericidal Drug in Combined Pharmaceutical Dosage Forms and Human Plasma.

Attia, Tamer Z / Abdelmajed, Mahmoud A / Omar, Mahmoud A / El-Din, Khalid M Badr

Journal of fluorescence

2022 Volume 32, Issue 2, Page(s) 603–612

Abstract: Gram-negative bacteria cause infections such as skin infection, meningitis, and pneumonia in human being. Gram-negative bacteria are highly resistant to most availaible bactericidal drugs. One of the most commonly used Gram-negative bactericidal drug is ... ...

Abstract	Gram-negative bacteria cause infections such as skin infection, meningitis, and pneumonia in human being. Gram-negative bacteria are highly resistant to most availaible bactericidal drugs. One of the most commonly used Gram-negative bactericidal drug is Polymyxin B sulfate (PMS). In addition, it is used in cases of highly resistant Gram-negative bacterial infections. The widespread of PMS necessitate the development of an exceedingly sensitive and selective fluorimetric assay for its determination in pure form, different pharmaceutical dosage forms, and human plasma. The presented method is used to determine PMS in their dosage form (vials) and combined pharmaceutical formulations (skin and eye ointments) with a high degree of accuracy and selectivity. The described procedure relies on the structure of a derivative of a high degree of fluorescence called dihydropyridine, via the condensation of the amino moiety of PMS with two equivalents of acetylacetone in the presence of formaldehyde and Teorell buffer (pH = 3). The fluorescent product was measured at 471 nm (λ
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/analysis ; Anti-Bacterial Agents/blood ; Buffers ; Dihydropyridines/chemistry ; Dosage Forms ; Fluorescent Dyes ; Humans ; Hydrogen-Ion Concentration ; Molecular Structure ; Polymyxin B/administration & dosage ; Polymyxin B/analysis ; Polymyxin B/blood ; Spectrometry, Fluorescence/methods ; Temperature
Chemical Substances	Anti-Bacterial Agents ; Buffers ; Dihydropyridines ; Dosage Forms ; Fluorescent Dyes ; 1,4-dihydropyridine (7M8K3P6I89) ; Polymyxin B (J2VZ07J96K)
Language	English
Publishing date	2022-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-021-02862-6
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Article: A highly sensitive fluorimetric protocol based on isoindole formation for determination of gabapentin

Attia, Tamer Z / Elnady, Mohamed / Derayea, Sayed M

RSC advances. 2019 Sept. 23, v. 9, no. 51

2019

Abstract: A new, simple, highly sensitive and selective spectrofluorimetric method was developed for determination of gabapentin through its derivatization with o-phthalaldehyde in the presence of 2-mercaptoethanol. The resulting product was highly fluorescent and ...

Abstract	A new, simple, highly sensitive and selective spectrofluorimetric method was developed for determination of gabapentin through its derivatization with o-phthalaldehyde in the presence of 2-mercaptoethanol. The resulting product was highly fluorescent and its emission intensity was measured at 431 nm after excitation at 335 nm. The effect of different experimental parameters on the formation and stability of the fluorescent product was carefully studied and optimized. The fluorescence–concentration plot was rectilinear over the range of 25–125 ng mL⁻¹. The lower detection and quantification limits were 3.4 mL⁻¹ and 11.2 ng mL⁻¹, respectively. The procedure was fully validated according to the guidelines of the International Conference on Harmonization. The proposed method was successfully applied for the determination of the investigated drug in its pharmaceutical capsules and the results were in agreement with those of the reported method, in terms of the accuracy and precision. The low cost of analysis and high sensitivity make the proposed method ideally suited for analysis of the investigated drug in quality control laboratories.
Keywords	beta-mercaptoethanol ; derivatization ; drugs ; emissions factor ; fluorescence ; fluorometry ; guidelines ; quality control
Language	English
Dates of publication	2019-0923
Size	p. 29942-29948.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c9ra06164a
Database	NAL-Catalogue (AGRICOLA)

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