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Article ; Online: AA-type amyloidosis associated with lymphoma: a study of 19 cases including 5 new French cases and a systematic literature review.

Collet, Aurore / Attias, Philippe / Lacou, Mathieu / Fieschi, Claire / Moktefi, Anissa / Sannier, Aurélie / Grateau, Gilles / Buob, David / Georgin-Lavialle, Sophie

Leukemia & lymphoma

2023 Volume 64, Issue 11, Page(s) 1857–1863

MeSH term(s)	Humans ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Lymphoma/complications ; Lymphoma/diagnosis ; Serum Amyloid A Protein
Chemical Substances	Serum Amyloid A Protein
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2023.2239971
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Zs.A 2997: Show issues

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Article ; Online: Vaccination anti-COVID-19 chez les patients dialysés et transplantés rénaux.

Sakhi, Hamza / Chavarot, Nathalie / Attias, Philippe / El Karoui, Khalil / Anglicheau, Dany

Nephrologie & therapeutique

2021 Volume 17, Issue 4, Page(s) 208–213

Abstract: Patients with end stage renal disease, including dialysis and kidney transplantation, have a high risk of severe COVID-19. In these populations, post-COVID-19 humoral response is prolonged until 6 months post-infection. However, post-vaccination humoral ... ...

Title translation	COVID-19 vaccination in dialysis and kidney transplant patients.
Abstract	Patients with end stage renal disease, including dialysis and kidney transplantation, have a high risk of severe COVID-19. In these populations, post-COVID-19 humoral response is prolonged until 6 months post-infection. However, post-vaccination humoral responses are frequently weak even when positive, notably in kidney transplant patients treated with belatacept. Actually, after 2 injectionos of mRNA vaccines, humoral response rates are 80-95% in dialysis patients, 30-50% in transplant patients, and about 5% in transplant patients treated with belatacept. These results have led to propose a 3rd injection of mRNA vaccine in dialysis and transplant patients in France. Numerous questions, regarding cellular responses, durability of response and clinical efficacy of vaccines remain in these high risk populations.
MeSH term(s)	COVID-19 Vaccines ; Humans ; Kidney Transplantation ; Renal Dialysis ; Transplant Recipients
Chemical Substances	COVID-19 Vaccines
Language	French
Publishing date	2021-07-01
Publishing country	France
Document type	Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2021.06.005
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Zs.A 6298: Show issues

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Article ; Online: Kinetics of Anti-SARS-CoV-2 IgG Antibodies in Hemodialysis Patients Six Months after Infection.

Sakhi, Hamza / Dahmane, Djamal / Attias, Philippe / Kofman, Thomas / Bouvier, Magali / Lapidus, Nathanael / Fourati, Slim / El Karoui, Khalil

Journal of the American Society of Nephrology : JASN

2021 Volume 32, Issue 5, Page(s) 1033–1036

Abstract: Background: The humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the hemodialysis population, including its dynamics over time, remains poorly understood.: Methods: To analyze initial and long-term humoral ... ...

Abstract	Background: The humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the hemodialysis population, including its dynamics over time, remains poorly understood. Methods: To analyze initial and long-term humoral responses against SARS-CoV-2 in a hemodialysis population, we retrospectively evaluated findings from SARS-CoV-2 IgG serologic assays targeting the nucleocapsid antigen or spike antigen up to 6 months of follow-up in patients on hemodialysis in the Paris, France, region who had recovered from coronavirus disease 2019 (COVID-19). Results: Our analysis included 83 patients (median age 65 years); 59 (71%) were male and 28 (34%) had presented with severe COVID-19. We observed positive initial SARS-CoV-2 IgG antinucleocapsid serology in 74 patients (89%) at a median of 67 days postdiagnosis. By multivariable analysis, immunocompromised status was the only factor significantly associated with lack of an IgG antinucleocapsid antibody response. Follow-up data were available at 6 months postdiagnosis for 60 of 74 patients (81%) with positive initial antinucleocapsid serology, and 15 (25%) of them had negative antinucleocapsid serology at month 6. In total, 14 of 15 sera were tested for antispike antibodies, 3 of 14 (21%) of which were also negative. Overall, 97% of antinucleocapsid-antibody-positive specimens were also antispike-antibody positive. Female sex, age >70 years, and nonsevere clinical presentation were independently associated with faster IgG antinucleocapsid titer decay in multivariable analysis. After adjustment for sex and age >70 years, nonsevere clinical presentation was the only factor associated with faster decay of IgG antispike antibodies. Conclusions: This study characterizes evolution of the SARS-CoV-2 antibody response in patients on hemodialysis and identifies factors that are associated with lack of seroconversion and with IgG titer decay.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/immunology ; Coronavirus Nucleocapsid Proteins/immunology ; Female ; Humans ; Immunocompromised Host ; Immunoglobulin G/blood ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/immunology ; Kinetics ; Male ; Middle Aged ; Pandemics ; Paris/epidemiology ; Phosphoproteins/immunology ; Renal Dialysis/adverse effects ; Retrospective Studies ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Transplant Recipients ; Transplantation Immunology
Chemical Substances	Antibodies, Viral ; Coronavirus Nucleocapsid Proteins ; Immunoglobulin G ; Phosphoproteins ; Spike Glycoprotein, Coronavirus ; nucleocapsid phosphoprotein, SARS-CoV-2 ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2020111618
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Zs.A 3344: Show issues

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Article ; Online: Antibody response to the BNT162b2 vaccine in maintenance hemodialysis patients.

Attias, Philippe / Sakhi, Hamza / Rieu, Philippe / Soorkia, Arvish / Assayag, David / Bouhroum, Sabrina / Nizard, Patrice / El Karoui, Khalil

Kidney international

2021 Volume 99, Issue 6, Page(s) 1490–1492

MeSH term(s)	Antibody Formation ; BNT162 Vaccine ; COVID-19 ; COVID-19 Vaccines ; Humans ; Renal Dialysis/adverse effects ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Letter
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2021.04.009
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Zs.A 797: Show issues

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Article ; Online: Three-Year Outcomes in Kidney Transplant Recipients Switched From Calcineurin Inhibitor-Based Regimens to Belatacept as a Rescue Therapy.

Morel, Antoine / Hoisnard, Léa / Dudreuilh, Caroline / Moktefi, Anissa / Kheav, David / Pimentel, Ana / Sakhi, Hamza / Mokrani, David / Attias, Philippe / El Sakhawi, Karim / Champy, Cécile Maud / Remy, Philippe / Sbidian, Emilie / Grimbert, Philippe / Matignon, Marie

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10228

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Abatacept/therapeutic use ; Calcineurin Inhibitors/therapeutic use ; Graft vs Host Disease ; Humans ; Kidney Transplantation ; Retrospective Studies ; Thrombotic Microangiopathies ; Transplant Recipients
Chemical Substances	Calcineurin Inhibitors ; Abatacept (7D0YB67S97)
Language	English
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10228
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Zs.A 2358: Show issues

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Article ; Online: Immune Responses after a Third Dose of mRNA Vaccine Differ in Virus-Naive versus SARS-CoV-2- Recovered Dialysis Patients.

Attias, Philippe / Azzaoui, Imane / El Karoui, Khalil / de La Selle, Andréa / Sokal, Aurélien / Chappert, Pascal / Grimbert, Philippe / Fernandez, Ignacio / Bouvier, Magali / Samson, Chloé / Dahmane, Djamal / Rieu, Philippe / Nizard, Patrice / Fourati, Slim / Sakhi, Hamza / Mahévas, Matthieu

Clinical journal of the American Society of Nephrology : CJASN

2022 Volume 17, Issue 7, Page(s) 1008–1016

Abstract: Background and objectives: After two doses of mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), patients on dialysis show a defective humoral response, but a third dose could increase anti-SARS-CoV-2 spike IgG titers. ... ...

Abstract	Background and objectives: After two doses of mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), patients on dialysis show a defective humoral response, but a third dose could increase anti-SARS-CoV-2 spike IgG titers. Responses could be different in virus-naive and SARS-CoV-2-recovered patients on dialysis. However, characterization of memory B cell response after three doses is lacking. Design, setting, participants, & measurements: We evaluated the dynamics of antireceptor binding domain IgG titers and antireceptor binding domain memory B cells until 6 months after two and three doses (administered within 6 months after the second dose) of mRNA vaccine in SARS-CoV-2-recovered and virus-naive dialysis populations. Results were analyzed by ordinary one-way ANOVA, the Kruskal-Wallis test, or the Wilcoxon matched-pairs test as appropriate. Results: In total, 108 individuals (59 patients on dialysis and 49 controls) were included. In virus-naive patients on dialysis, antireceptor binding domain IgG response was quantitatively lower after two doses compared with healthy controls, but IgG titers increased by three-fold after three doses ( Conclusions: The third dose of mRNA vaccine given within 6 months after the second dose boosts serologic and memory response in virus-naive patients but not in SARS-CoV-2-recovered patients on dialysis. Clinical trial registry name and registration number: COVID-19: SARS-CoV-2 Specific Memory B and T-CD4+ Cells (MEMO-COV2), NCT04402892.
MeSH term(s)	Antibodies, Viral ; COVID-19/prevention & control ; Humans ; Immunity ; Immunoglobulin G ; Renal Dialysis ; SARS-CoV-2 ; Vaccination ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Vaccines, Synthetic ; mRNA Vaccines
Language	English
Publishing date	2022-06-28
Publishing country	United States
Document type	Clinical Study ; Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.00830122
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Zs.A 6584: Show issues

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Article ; Online: Arteriovenous fistulas thrombosis in hemodialysis patients with COVID-19.

Desbuissons, Geoffroy / Michon, Arthur / Attias, Philippe / Burbach, Maren / Diaconita, Mirela / Karie-Guiges, Svetlana / Novelli, Luigi / Abou Rjeili, Marawa / Awad, Sameh / Besse, Francis / Viglietti, Denis / Beaudreuil, Severine / Zaidan, Mohamad / Lefèvre, Edouard / Hebibi, Hadia

The journal of vascular access

2021 Volume 23, Issue 3, Page(s) 412–415

Abstract: Background: The current Coronavirus disease 2019 (COVID-19) outbreak is associated with significant mortality, especially in patients suffering from end stage renal disease (ESRD) and hemodialysis patients. Several previous studies reported an over-risk ...

Abstract	Background: The current Coronavirus disease 2019 (COVID-19) outbreak is associated with significant mortality, especially in patients suffering from end stage renal disease (ESRD) and hemodialysis patients. Several previous studies reported an over-risk of arterial and venous thrombosis, in particular pulmonary embolism and venous thrombosis of catheter in COVID19 patients in intensive care unit. However, arteriovenous fistula (AVF) thrombosis has rarely been reported yet in these patients. AVF thrombosis is a serious complication that impacts significantly patients outcome. Here, we aim to describe characteristics and prognosis of a cohort of COVID-19 hemodialysis (HD) patients presenting with AVF thrombosis. Methods: In the Ile de France region (Paris area) during the March 11th-April 30th 2020 period, fistula thrombosis cases were collected among COVID-19 hemodialysis patients in seven dialysis units and in interventional vascular departments. These patients' characteristics were analyzed through a review of the patient's medical records. Results: Seventeen patients were included in our study (median age 69 years). Ten patients (59%) were men. Ten patients (59%) were diabetic and 88% had a high blood pressure. The mortality rate in these patients was 47%. All thrombosis treated with a declotting procedures (64%) were successfully cleared, but with early relapse in 36%. Conclusion: Our study highlights AVF thrombosis as a severe complication in COVID-19 hemodialysis patients that contributed to the severity and accelerated death.
MeSH term(s)	Aged ; Arteriovenous Fistula/etiology ; Arteriovenous Shunt, Surgical/adverse effects ; COVID-19/complications ; COVID-19/therapy ; Female ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Male ; Renal Dialysis/adverse effects ; Retrospective Studies ; Thrombosis/etiology
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.1177/1129729821996091
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Zs.A 6414: Show issues

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Article: Epidemiology, Risk Factors, and Outcomes of Opportunistic Infections after Kidney Allograft Transplantation in the Era of Modern Immunosuppression: A Monocentric Cohort Study.

Attias, Philippe / Melica, Giovanna / Boutboul, David / De Castro, Nathalie / Audard, Vincent / Stehlé, Thomas / Gaube, Géraldine / Fourati, Slim / Botterel, Françoise / Fihman, Vincent / Audureau, Etienne / Grimbert, Philippe / Matignon, Marie

Journal of clinical medicine

2019 Volume 8, Issue 5

Abstract: Epidemiology of opportunistic infections (OI) after kidney allograft transplantation in the modern era of immunosuppression and the use of OI prevention strategies are poorly described. We retrospectively analyzed a single-center cohort on kidney ... ...

Abstract	Epidemiology of opportunistic infections (OI) after kidney allograft transplantation in the modern era of immunosuppression and the use of OI prevention strategies are poorly described. We retrospectively analyzed a single-center cohort on kidney allograft adult recipients transplanted between January 2008 and December 2013. The control group included all kidney recipients transplanted in the same period, but with no OI. We analyzed 538 kidney transplantations (538 patients). The proportion of OI was 15% (80 and 72 patients). OI occurred 12.8 (6.0-31.2) months after transplantation. Viruses were the leading cause (
Language	English
Publishing date	2019-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8050594
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Article: Bedside prediction of intradialytic hemodynamic instability in critically ill patients: the SOCRATE study.

Bigé, Naïke / Lavillegrand, Jean-Rémi / Dang, Julien / Attias, Philippe / Deryckere, Stéphanie / Joffre, Jérémie / Dubée, Vincent / Preda, Gabriel / Dumas, Guillaume / Hariri, Geoffroy / Pichereau, Claire / Baudel, Jean-Luc / Guidet, Bertrand / Maury, Eric / Boelle, Pierre-Yves / Ait-Oufella, Hafid

Annals of intensive care

2020 Volume 10, Issue 1, Page(s) 47

Abstract: Background: Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain ...

Abstract	Background: Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the relationship between baseline macrohemodynamic, tissue hypoperfusion parameters and IHI occurrence. Methods: Prospective observational study conducted in a 18-bed medical ICU of a tertiary teaching hospital. Cardiovascular SOFA score, index capillary refill time (CRT) and lactate level were measured just before (T0) consecutive intermittent hemodialysis sessions performed for AKI. The occurrence of IHI requiring a therapeutic intervention was recorded. Results: Two hundred eleven sessions, corresponding to 72 (34%) first sessions and 139 (66%) later sessions, were included. As IHI mostly occurred during first sessions (43% vs 12%, P < 0.0001), following analyses were performed on the 72 first sessions. At T0, cardiovascular SOFA score ≥1 (87% vs 51%, P = 0.0021) was more frequent before IHI sessions, as well as index CRT ≥ 3 s (55% vs 15%, P = 0.0004), and hyperlactatemia > 2 mmol/L (68% vs 29%, P = 0.0018). Moreover, the occurrence of IHI increased with the number of macrohemodynamic and tissue perfusion impaired parameters, named SOCRATE score (cardiovascular SOFA, index CRT and lactATE): 10% (95% CI [3%, 30%]), 33% (95% CI [15%, 58%]), 55% (95% CI [35%, 73%]) and 80% (95% CI [55%, 93%]) for 0, 1, 2 and 3 parameters, respectively (AUC = 0.79 [0.69-0.89], P < 0.0001). These results were confirmed by analyzing the 139 later sessions included in the study. Conclusions: The SOCRATE score based on 3 easy-to-use bedside parameters correlates with the risk of IHI. By improving risk stratification of IHI, this score could help clinicians to manage intermittent hemodialysis initiation in critically ill AKI patients.
Language	English
Publishing date	2020-04-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-020-00663-x
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Article: Belatacept-based immunosuppressive regimen in HIV-positive kidney transplant recipients.

El Sakhawi, Karim / Melica, Giovanna / Scemla, Anne / Bertrand, Dominique / Garrouste, Cyril / Malvezzi, Paolo / Rémy, Philippe / Moktefi, Anissa / Ingels, Alexandre / Champy, Cécile / Lelièvre, Jean-Daniel / Kheav, David / Morel, Antoine / Mokrani, David / Attias, Philippe / Grimbert, Philippe / Matignon, Marie

Clinical kidney journal

2020 Volume 14, Issue 8, Page(s) 1908–1914

Abstract: Background: Kidney allograft survival in human immunodeficiency virus (HIV)-positive patients is lower than that in the general population. Belatacept increases long-term patient and allograft survival rates when compared with calcineurin inhibitors ( ... ...

Abstract	Background: Kidney allograft survival in human immunodeficiency virus (HIV)-positive patients is lower than that in the general population. Belatacept increases long-term patient and allograft survival rates when compared with calcineurin inhibitors (CNIs). Its use in HIV-positive recipients remains poorly documented. Methods: We retrospectively report a French cohort of HIV-positive kidney allograft recipients who were switched from CNI to belatacept, between June 2012 and December 2018. Patient and allograft survival rates, HIV immunovirological and clinical outcomes, acute rejection, opportunistic infections (OIs) and HLA donor-specific antibodies (DSAs) were analysed at 3 and 12 months, and at the end of follow-up (last clinical visit attended after transplantation). Results were compared with HIV-positive recipients group treated with CNI. Results: Twelve patients were switched to belatacept 10 (2-25) months after transplantation. One year after belatacept therapy, patient and allograft survival rates scored 92% for both, two (17%) HIV virological rebounds occurred due to antiretroviral therapy non-compliance, and CD4 Conclusions: Switch from CNI to belatacept can be considered safe and may increase long-term kidney allograft survival in HIV-positive kidney allograft recipients. These results need to be confirmed in a larger cohort.
Language	English
Publishing date	2020-12-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfaa231
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