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  1. AU="Attila Frigy"
  2. AU="Solyst, W"
  3. AU="Mitchell, Colleen C"
  4. AU="Kurbatov, Ilya Y"
  5. AU="Guevara-Álvarez, A"
  6. AU="Barker, Darren"
  7. AU="Muschaweckh, Andreas"
  8. AU="Saibi, Lotfi"
  9. AU=Wagener Jeffrey S AU=Wagener Jeffrey S
  10. AU="Christian Tschuschke"
  11. AU="Gong, Hexiang"
  12. AU="Ziembiec, Nancy A"
  13. AU="Hameed, Safraj Shahul"
  14. AU="Elliott, Alison M"
  15. AU="Nakeshbandi, Mohamed"
  16. AU=Sonthalia Nikhil AU=Sonthalia Nikhil
  17. AU="Kohanbash, Gary" AU="Kohanbash, Gary"
  18. AU=Nawrocki Mariusz J.
  19. AU="Jayme Borensztajn"
  20. AU=Schaerf Raymond H M
  21. AU="Chachar, Aijaz Zeeshan Khan"
  22. AU=Forster H V
  23. AU=Yang G-F
  24. AU="Kaplan, Robert C"
  25. AU="Rood, Julian I."
  26. AU="Manhes, Caroline"
  27. AU="Jacobsen, Cristiane Cavalcanti"
  28. AU="Anja Kukic"
  29. AU="Zhang, N"
  30. AU="Cunningham, Thomas J"
  31. AU="Wu, Y P"
  32. AU="Sumbul, Sabiha"
  33. AU="Razolli, Daniela S"
  34. AU="Asif, Mohsin"
  35. AU="Choudhary, Diksha"
  36. AU="Liu, Yongmei"
  37. AU=Goldshaid Liat
  38. AU="Sandeep Dhayade"
  39. AU="Ashkin, David"
  40. AU="Yukioka, Hideo"
  41. AU="Giles, M"
  42. AU="Keshavarzian, Tina"
  43. AU="Richard Holtmeier"
  44. AU=Sanborn Keri B
  45. AU=Crestani Larissa AU=Crestani Larissa
  46. AU=Nassiri Amir Ahmad
  47. AU="Keiser, Olivia"
  48. AU="Scholz, Martin"
  49. AU="Vassilis Pigadas" AU="Vassilis Pigadas"
  50. AU="Schlievert, Patrick M"
  51. AU=Egan Katie G
  52. AU="Benzadón, Mariano"
  53. AU="Truong, Thérèse"
  54. AU="de Oliveira, Aline Lima"
  55. AU="Lehto, Sonya G"
  56. AU="Simi Jacob"
  57. AU="Shipman, Michael"
  58. AU=Pons Linda
  59. AU="Notoya, A"
  60. AU="Williams, Olajide A"
  61. AU=Errington Jeff
  62. AU="Tortolani, Christina C"
  63. AU="Patel, Jenil R"
  64. AU="Aires, Rafaela"
  65. AU="Habibelahi, Abbas"
  66. AU="Temes, Javier"
  67. AU="Miwa, Toru"
  68. AU="Jaller, Elvira"
  69. AU="Manso Sanchez, L M"

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  1. Artikel ; Online: Giant left atrium causing severe dysphagia

    Attila Frigy

    The Pan African Medical Journal, Vol 29, Iss

    2018  Band 52

    Abstract: A 65 years old men with mechanical mitral prosthesis (implanted for rheumatic valve disease) was referred to our clinic with signs of advanced heart failure and associated severe dysphagia. This symptom started a couple of years before and became ... ...

    Abstract A 65 years old men with mechanical mitral prosthesis (implanted for rheumatic valve disease) was referred to our clinic with signs of advanced heart failure and associated severe dysphagia. This symptom started a couple of years before and became worsened in the last months causing severe difficulties in alimentation, both for solid and liquid foods. Echocardiography revealed a normofunctional mitral prosthesis, a dilated left ventricle with severe systolic dysfunction (EF 15%) and a giant left atrium (A-parasternal long axis view, left atrial postero-anterior diameter = 80mm, B-apical four chamber view, left atrial longitudinal diameter = 105mm). The X-ray examination with barium of the upper gastrointestinal tract demonstrated significant lumen reduction in the middle and lower part of the esophagus (C), corresponding to the external compression caused by the huge left atrium. The explanations for the severely enlarged left atrium would be the late valvular intervention (also suggested by the dilated and dysfunctional left ventricle) and the progression of left atrial remodeling due to chronic inflammation. The patient was referred to esophageal balloon dilation and stent implantation.
    Schlagwörter left atrium ; esophageal stenosis ; mitral prosthesis ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag The Pan African Medical Journal
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Bayés’ Syndrome—A Comprehensive Short Review

    Emma Murariu / Attila Frigy

    Medicina, Vol 56, Iss 410, p

    2020  Band 410

    Abstract: Prediction and early detection of atrial fibrillation (AF) remain a permanent challenge in everyday practice. Timely identification of an increased risk for AF episodes (which are frequently asymptomatic) is essential in the primary and secondary ... ...

    Abstract Prediction and early detection of atrial fibrillation (AF) remain a permanent challenge in everyday practice. Timely identification of an increased risk for AF episodes (which are frequently asymptomatic) is essential in the primary and secondary prevention of cardioembolic events. One of the noninvasive modalities of AF prediction is represented by the electrocardiographic P-wave analysis. This includes the study and diagnosis of interatrial conduction block (Bachmann’s bundle block). Bayés’ Syndrome (named after its first descriptor) denotes the association between interatrial conduction defect and supraventricular arrhythmias (mainly AF) predisposing to cardioembolic events. Our short review presents an update of the most important data concerning this syndrome: brief history, main ECG features, pathophysiological background and clinical implications.
    Schlagwörter electrocardiography ; P-wave ; interatrial conduction block ; atrial fibrillation ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Targeting Mediators of Inflammation in Heart Failure

    Timea Magdolna Szabo / Attila Frigy / Előd Ernő Nagy

    International Journal of Molecular Sciences, Vol 22, Iss 13053, p

    A Short Synthesis of Experimental and Clinical Results

    2021  Band 13053

    Abstract: Inflammation has emerged as an important contributor to heart failure (HF) development and progression. Current research data highlight the diversity of immune cells, proteins, and signaling pathways involved in the pathogenesis and perpetuation of heart ...

    Abstract Inflammation has emerged as an important contributor to heart failure (HF) development and progression. Current research data highlight the diversity of immune cells, proteins, and signaling pathways involved in the pathogenesis and perpetuation of heart failure. Chronic inflammation is a major cardiovascular risk factor. Proinflammatory signaling molecules in HF initiate vicious cycles altering mitochondrial function and perturbing calcium homeostasis, therefore affecting myocardial contractility. Specific anti-inflammatory treatment represents a novel approach to prevent and slow HF progression. This review provides an update on the putative roles of inflammatory mediators involved in heart failure (tumor necrosis factor-alpha; interleukin 1, 6, 17, 18, 33) and currently available biological and non-biological therapy options targeting the aforementioned mediators and signaling pathways. We also highlight new treatment approaches based on the latest clinical and experimental research.
    Schlagwörter inflammation ; heart failure ; pro-inflammatory cytokines ; mitochondria ; interleukins ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Extensive Left Ventricular Thrombosis with Concomitant Pulmonary Embolism

    Annamária Magdás / Cristian Podoleanu / Attila Frigy

    Clinics and Practice, Vol 11, Iss 43, Pp 303-

    2021  Band 308

    Abstract: A 57-year-old non-obese female patient with a history of heavy smoking, chronic obstructive pulmonary disease and hypertension was admitted to the hospital as an emergency for acute hemoptysis and signs of congestive heart failure. To assess the source ... ...

    Abstract A 57-year-old non-obese female patient with a history of heavy smoking, chronic obstructive pulmonary disease and hypertension was admitted to the hospital as an emergency for acute hemoptysis and signs of congestive heart failure. To assess the source of hemoptysis, computed tomography (CT) pulmonary angiography was performed, which confirmed a bilateral pulmonary embolism of the apical branches. The routinely performed transthoracic echocardiography (TTE) revealed an enlarged left ventricle with severely reduced ejection fraction (EF = 25%) due to global hypokinesia and multiple, mobile, echogenic masses. To increase the diagnostic accuracy, real-time three-dimensional (Live 3D) imaging of the masses was added which described multiple left ventricular (LV) thrombi. Successful resolution of intraventricular thrombi was noticed after treatment with oral anticoagulant therapy (acenocumarol), despite the lack of regular INR control.
    Schlagwörter ventricle ; thrombi ; pulmonary embolism ; 3D echocardiography ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Cor Triatriatum Sinister Presenting as Cardioembolic Stroke in a Young Woman

    Timea Magdolna Szabo / Erhard Heidenhoffer / Ádám Kirchmaier / Benedek Pelok / Attila Frigy

    Diagnostics, Vol 13, Iss 1, p

    2022  Band 97

    Abstract: Cor triatriatum sinister is a rare congenital heart disease characterized by an additional fibromuscular membrane in the left atrium. Cardioembolic stroke is a rare complication of cor triatriatum sinister, especially among women. We hereby describe the ... ...

    Abstract Cor triatriatum sinister is a rare congenital heart disease characterized by an additional fibromuscular membrane in the left atrium. Cardioembolic stroke is a rare complication of cor triatriatum sinister, especially among women. We hereby describe the case of an 18-year-old female patient, without a past medical history, presenting with cardioembolic stroke in the territory of the right posterior cerebral artery. During extensive diagnostic work-up, nonrestrictive cor triatriatum sinister and patent foramen ovale were diagnosed using transthoracic and transesophageal echocardiography. In clinical practice, it is important to identify congenital cardiac defects as potential substrates for cardioembolism in young patients. In our case, cor triatriatum sinister presenting as ischemic stroke was diagnosed, which is an uncommon finding, especially in young females. Determining the optimal management strategy for patients with cor triatriatum sinister complicated by cardioembolic stroke requires a multidisciplinary approach.
    Schlagwörter cor triatriatum sinister ; cardioembolic stroke ; congenital heart disease ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Elevated Serum Cystatin C and Decreased Cathepsin S/Cystatin C Ratio Are Associated with Severe Peripheral Arterial Disease and Polyvascular Involvement

    Előd Ernő Nagy / Attila Puskás / Piroska Kelemen / Katalin Makó / Zoltán Brassai / Jolán Hársfalvi / Attila Frigy

    Diagnostics, Vol 12, Iss 833, p

    2022  Band 833

    Abstract: Peripheral arterial disease (PAD) is frequently associated with atherosclerotic manifestations of the carotids and coronaries. Polyvascular involvement and low ankle–brachial index predict major cardiovascular events and high mortality. Cathepsin S (Cat ... ...

    Abstract Peripheral arterial disease (PAD) is frequently associated with atherosclerotic manifestations of the carotids and coronaries. Polyvascular involvement and low ankle–brachial index predict major cardiovascular events and high mortality. Cathepsin S (Cat S) promotes the inflammatory pathways of the arterial wall, while Cystatin C (Cys C) functions as its inhibitor; therefore, Cys C was proposed to be a biomarker of progression in PAD. In a single-center observational study, we investigated the correlations of serum Cys C and Cat S/Cys C ratio in a group of 90 PAD patients, predominantly with polyvascular involvement. Cys C and Cat S/Cys C were associated with ankle–brachial index (ABI) scores <0.4 in univariate and multiple regression models. Furthermore, both markers correlated positively with the plasma Von Willebrand Factor Antigen (VWF: Ag) and Von Willebrand Factor collagen-binding activity (VWF: CB). In addition, Cat S/Cys C was significantly decreased, whereas Cys C increased in subjects with three-bed atherosclerotic involvement. According to our results, high serum Cys C and low Cat S/Cys C ratios may indicate severe peripheral arterial disease and polyvascular atherosclerotic involvement.
    Schlagwörter cystatin C ; cathepsin S ; atherosclerosis ; peripheral arterial disease ; ankle–brachial index ; polyvascular disease ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction

    Lajos Fehérvári / Attila Frigy / Lóránd Kocsis / István Adorján Szabó / Timea Magdolna Szabo / Melinda Urkon / Zita Jakó / Előd Ernő Nagy

    Diagnostics, Vol 11, Iss 764, p

    2021  Band 764

    Abstract: Arterial stiffness (AS) is a complex vascular phenomenon with consequences for central hemodynamics and left-ventricular performance. Circulating biomarkers have been associated with AS; however, their value in heart failure is poorly characterized. Our ... ...

    Abstract Arterial stiffness (AS) is a complex vascular phenomenon with consequences for central hemodynamics and left-ventricular performance. Circulating biomarkers have been associated with AS; however, their value in heart failure is poorly characterized. Our aim was to evaluate the clinical and biomarker correlates of AS in the setting of heart failure with reduced ejection fraction (HFrEF). In 78 hospitalized, hemodynamically stable patients (20 women, 58 men, mean age 65.8 ± 1.41 years) with HFrEF, AS was measured using aortic pulse wave velocity (PWV). Serum OPG, RANKL, sclerostin, and DKK-1 were determined, and the relationships between the clinical variables, vascular-calcification-related biomarkers, and PWV were evaluated by correlation analysis and linear and logistic regression models. OPG and the OPG/RANKL ratio were significantly higher in the group of patients ( n = 37, 47.4%) with increased PWV (>10 m/s). PWV was positively correlated with age, left-ventricular ejection fraction, and carotid intima-media thickness (cIMT), and negatively correlated with the glomerular filtration rate. OPG and cIMT were significantly associated with PWV in the logistic regression models when adjusted for hypertension, EF, and the presence of atherosclerotic manifestations. Elevated serum OPG, together with cIMT, were significantly related to increased AS in the setting of HFrEF.
    Schlagwörter osteoprotegerin ; calcification biomarkers ; arterial stiffness ; pulse wave velocity ; heart failure ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: The prevalence and clinical significance of anemia in patients hospitalized with acute heart failure [version 2; referees

    Attila Frigy / Zoltán Fogarasi / Ildikó Kocsis / Lehel Máthé / Előd Nagy

    F1000Research, Vol

    2 approved, 1 not approved]

    2017  Band 5

    Abstract: Abstract: In a cohort of patients hospitalized with acute heart failure (AHF) the prevalence of anemia and the existence of a correlation between anemia and the severity of the clinical picture were assessed. Methods: 50 consecutive patients (34 men, 16 ... ...

    Abstract Abstract: In a cohort of patients hospitalized with acute heart failure (AHF) the prevalence of anemia and the existence of a correlation between anemia and the severity of the clinical picture were assessed. Methods: 50 consecutive patients (34 men, 16 women, mean age 67.5 years) hospitalized with AHF were enrolled. Statistical analysis was performed for studying correlations between anemia and the presence/levels of diverse parameters (clinical, laboratory, echocardiographic, treatment related) reflecting the severity and prognosis of AHF (α=0.05). Results: 21 patients (14 men, 7 women, mean age 69.6 years), representing 42%, had anemia at admission. Comparing patients with and without anemia there were no significant differences regarding age, gender, presence of atrial fibrillation (p=0.75), diabetes (p=1), ischemic heart disease (p=0.9), left ventricular ejection fraction (EF) (p=1), hypotension (p=0.34) and tachycardia>100 b/min at admission (p=0.75), level of eGFR (p=0.72), and need of high dose (>80 mg/day) loop diuretic (p=0.23). However, EF showed a significant positive correlation with eGFR only in AHF patients with anemia (r=0,65, p=0.001). In a multiple regression model, EF had a significant effect on the eGFR quartiles (p=0,004). Conclusions: Anemia is a frequent finding in patients hospitalized with AHF. The presence of anemia was not correlated with other factors related to AHF severity and prognosis. However, a low EF associated with low eGFR was characteristic for patients with anemia, suggesting that the decrease of renal perfusion by low cardiac output further aggravates anemia on the background of chronic kidney disease.
    Schlagwörter Anemias & Hypocellular Marrow Disorders ; Heart Failure ; Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2017-08-01T00:00:00Z
    Verlag F1000 Research Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: The Value of a Simplified Lung Ultrasound Protocol in the Pre-Discharge Evaluation of Patients Hospitalized with Acute Heart Failure

    Attila Frigy / Ildikó Kocsis / Lajos Fehérvári / Adorján Szabó István

    Acta Medica Marisiensis, Vol 62, Iss 3, Pp 318-

    2016  Band 320

    Abstract: Optimal timing of hospital discharge in patient with acute heart failure (AHF) is an important factor of preventing rehospitalizations. ...

    Abstract Optimal timing of hospital discharge in patient with acute heart failure (AHF) is an important factor of preventing rehospitalizations.
    Schlagwörter acute heart failure ; biomarkers ; lung ultrasound ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2016-09-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Increase of Short-Term Heart Rate Variability Induced by Blood Pressure Measurements during Ambulatory Blood Pressure Monitoring

    Attila Frigy / Annamária Magdás / Victor-Dan Moga / Ioana Georgiana Coteț / Miklós Kozlovszky / László Szilágyi

    Computational and Mathematical Methods in Medicine, Vol

    2017  Band 2017

    Abstract: Objective. The possible effect of blood pressure measurements per se on heart rate variability (HRV) was studied in the setting of concomitant ambulatory blood pressure monitoring (ABPM) and Holter ECG monitoring (HM). Methods. In 25 hypertensive ... ...

    Abstract Objective. The possible effect of blood pressure measurements per se on heart rate variability (HRV) was studied in the setting of concomitant ambulatory blood pressure monitoring (ABPM) and Holter ECG monitoring (HM). Methods. In 25 hypertensive patients (14 women and 11 men, mean age: 58.1 years), 24-hour combined ABPM and HM were performed. For every blood pressure measurement, 2-minute ECG segments (before, during, and after measurement) were analyzed to obtain time domain parameters of HRV: SDNN and rMSSD. Mean of normal RR intervals (MNN), SDNN/MNN, and rMSSD/MNN were calculated, too. Parameter variations related to blood pressure measurements were analyzed using one-way ANOVA with multiple comparisons. Results. 2281 measurements (1518 during the day and 763 during the night) were included in the analysis. Both SDNN and SDNN/MNN had a constant (the same for 24-hour, daytime, and nighttime values) and significant change related to blood pressure measurements: an increase during measurements and a decrease after them (p<0.01 for any variation). Conclusion. In the setting of combined ABPM and HM, the blood pressure measurement itself produces an increase in short-term heart rate variability. Clarifying the physiological basis and the possible clinical value of this phenomenon needs further studies.
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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