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Article ; Online: Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

Heeseog Kang / Audrey Kerloc’h / Maxime Rotival / Xiaoqing Xu / Qing Zhang / Zelpha D’Souza / Michael Kim / Jodi Carlson Scholz / Jeong-Hun Ko / Prashant K. Srivastava / Jonathan R. Genzen / Weiguo Cui / Timothy J. Aitman / Laurence Game / James E. Melvin / Adedayo Hanidu / Janice Dimock / Jie Zheng / Donald Souza /
Aruna K. Behera / Gerald Nabozny / H. Terence Cook / J.H. Duncan Bassett / Graham R. Williams / Jun Li / Agnès Vignery / Enrico Petretto / Jacques Behmoaras

Cell Reports, Vol 8, Iss 4, Pp 1210-

2014  Volume 1224

Abstract: Macrophages can fuse to form osteoclasts in bone or multinucleate giant cells (MGCs) as part of the immune response. We use a systems genetics approach in rat macrophages to unravel their genetic determinants of multinucleation and investigate their role ...

Abstract Macrophages can fuse to form osteoclasts in bone or multinucleate giant cells (MGCs) as part of the immune response. We use a systems genetics approach in rat macrophages to unravel their genetic determinants of multinucleation and investigate their role in both bone homeostasis and inflammatory disease. We identify a trans-regulated gene network associated with macrophage multinucleation and Kcnn4 as being the most significantly trans-regulated gene in the network and induced at the onset of fusion. Kcnn4 is required for osteoclast and MGC formation in rodents and humans. Genetic deletion of Kcnn4 reduces macrophage multinucleation through modulation of Ca2+ signaling, increases bone mass, and improves clinical outcome in arthritis. Pharmacological blockade of Kcnn4 reduces experimental glomerulonephritis. Our data implicate Kcnn4 in macrophage multinucleation, identifying it as a potential therapeutic target for inhibition of bone resorption and chronic inflammation.
Keywords Biology (General) ; QH301-705.5
Subject code 616
Language English
Publishing date 2014-08-01T00:00:00Z
Publisher Elsevier
Document type Article ; Online
Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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