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  1. Article ; Online: Toxocarosis in a patient with autism spectrum disorder presenting with severe hypereosinophilia and acute respiratory distress: a case report.

    Üblagger, Daniel / Auer, Herbert / Bezakova, Milina / Kirchlechner, Veronika

    Parasitology research

    2024  Volume 123, Issue 1, Page(s) 99

    Abstract: A boy with known autism spectrum disorder was transferred to our department due to a rapidly worsening respiratory situation. The patient's history revealed previous treatment with albendazole against a Toxocara infection 2 weeks prior in Poland. Blood ... ...

    Abstract A boy with known autism spectrum disorder was transferred to our department due to a rapidly worsening respiratory situation. The patient's history revealed previous treatment with albendazole against a Toxocara infection 2 weeks prior in Poland. Blood analysis showed such severe eosinophilia and markedly elevated levels of IgE that, initially, a hematologic malignancy was suspected. However, diagnostic workup including autoimmune diagnostic, molecular genetic testing, fluorescence in situ hybridization (FISH), bone marrow aspiration, and parasitological testing led to the diagnosis of an insufficiently treated Toxocara infection. Treatment with albendazole and prednisone (six cycles for 4 weeks each) was administered. This treatment regime led to prompt improvement of symptoms and normalization of laboratory findings.
    MeSH term(s) Male ; Animals ; Humans ; Albendazole/therapeutic use ; Autism Spectrum Disorder/complications ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/drug therapy ; In Situ Hybridization, Fluorescence ; Toxocariasis/diagnosis ; Eosinophilia/diagnosis ; Eosinophilia/drug therapy ; Respiratory Distress Syndrome
    Chemical Substances Albendazole (F4216019LN)
    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-024-08119-y
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  2. Article ; Online: Malaria in Austria : A retrospective analysis of malaria cases diagnosed at a reference center in 2010-2020.

    Horak, Paul / Auer, Herbert / Wiedermann, Ursula / Walochnik, Julia

    Wiener klinische Wochenschrift

    2023  Volume 135, Issue 21-22, Page(s) 617–624

    Abstract: Background: Although malaria is not endemic to Austria, each year infections are imported by travellers, migrants and refugees. This study aims to provide an overview of malaria cases diagnosed at an Austrian institute for tropical medicine between 2010 ...

    Abstract Background: Although malaria is not endemic to Austria, each year infections are imported by travellers, migrants and refugees. This study aims to provide an overview of malaria cases diagnosed at an Austrian institute for tropical medicine between 2010 and 2020.
    Methods: A retrospective, descriptive study was conducted based on the data of malaria cases confirmed at the Institute of Specific Prophylaxis and Tropical Medicine of the Medical University of Vienna. Laboratory diagnostics included microscopy, polymerase chain reaction (PCR) and real-time quantitative PCR.
    Results: Overall, 122 cases were identified. Annual case numbers were consistently higher from 2016 to 2020 than during the first half of the decade. Most malaria cases were diagnosed during summer and early autumn. This seasonal trend was not observed during the year 2020. With 55.1% (65/118) Plasmodium falciparum was the most common species, followed by Plasmodium vivax (19.5%, 23/118). The majority of patients were male (71.1%, 86/121) and the median age was 34.5 years (interquartile range, IQR 22.5-47.0 years). With a median age of 20.0 years (IQR 14.0-32.0 years), patients with P. vivax infections were younger than those infected with other Plasmodium species. Moreover, they were mostly male (82.6%, 19/23).
    Conclusion: From 2010 to 2020, the number of malaria cases diagnosed at the center increased. Growing international mobility and changing travel behavior could at least partly be responsible for this trend and there are indications that particularly P. vivax infections were imported by migrants and refugees.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Adolescent ; Young Adult ; Austria/epidemiology ; Antimalarials/therapeutic use ; Retrospective Studies ; Malaria/diagnosis ; Malaria/epidemiology ; Plasmodium ; Travel
    Chemical Substances Antimalarials
    Language English
    Publishing date 2023-04-17
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-023-02179-3
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  3. Article: Tropenmedizin: Parasitosen der Leber

    Auer, Herbert

    Der Allgemeinarzt

    2019  Volume 41, Issue 8, Page(s) 21

    Language German
    Document type Article
    ZDB-ID 603653-3
    ISSN 0172-7249
    Database Current Contents Medicine

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  4. Article ; Online: Medical parasitology. Editorial.

    Auer, Herbert

    Wiener medizinische Wochenschrift (1946)

    2014  Volume 164, Issue 19-20, Page(s) 381

    MeSH term(s) Austria ; Emigrants and Immigrants ; Forecasting ; Parasitic Diseases/prevention & control ; Parasitic Diseases/transmission ; Parasitology/trends ; Rare Diseases ; Research/trends ; Travel
    Language English
    Publishing date 2014-10
    Publishing country Austria
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-014-0320-y
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  5. Book: Pathophysiologie, Immunologie, Klinik und Therapie von Wurmkrankheiten

    Wiedermann, Gerhard / Auer, Herbert

    (Vademecum / Facultas)

    2006  

    Author's details Gerhard Wiedermann ; Herbert Auer
    Series title Vademecum / Facultas
    Keywords Helminthiasis ; Intestinal Diseases, Parasitic ; Wurmkrankheit
    Subject Helminthiasis ; Helminthose ; Helminthiase ; Wurmerkrankung
    Language German
    Size 268 S.
    Publisher Facultas Univ.-Verl
    Publishing place Wien
    Publishing country Austria
    Document type Book
    HBZ-ID HT014872986
    ISBN 978-3-85076-788-0 ; 3-85076-788-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 A 6862 order for loan Magazin
    2008 A 6760 order for loan Magazin

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  6. Article ; Online: Autochthonous Human Dirofilaria repens Infection in Austria.

    Geissler, Nora / Ruff, Johanna / Walochnik, Julia / Ludwig, Wilhelm / Auer, Herbert / Wiedermann, Ursula / Geissler, Werner

    Acta parasitologica

    2022  Volume 67, Issue 2, Page(s) 1039–1043

    Abstract: Purpose: This report describes a rare autochthonous case of human D. repens infection in Austria. Dirofilariosis is a mosquito-borne parasitic infection that predominantly affects dogs. Human D. repens infections have primarily been reported in ... ...

    Abstract Purpose: This report describes a rare autochthonous case of human D. repens infection in Austria. Dirofilariosis is a mosquito-borne parasitic infection that predominantly affects dogs. Human D. repens infections have primarily been reported in Mediterranean countries, but are emerging throughout Central and Northern Europe.
    Methods: The worm was removed surgically and identified using PCR and DNA sequencing. The consensus sequences were compared against reference sequences of Dirofilaria repens from GenBank.
    Results: The 56-year-old woman acquired the infection, which presented as a subcutaneous nodule, in Vienna, Austria. This is the second autochthonous case of human D. repens infection in Austria.
    Conclusion: The reasons for the emergence of D. repens and other parasitic infections in Central and Northern Europe are manifold, including climate change and globalization. This case demonstrates that with the growing number of D. repens infections, health care professionals must place further emphasis on emerging infectious diseases to ensure appropriate diagnostics and treatment in the future.
    MeSH term(s) Animals ; Austria ; Dirofilaria repens/genetics ; Dirofilariasis/diagnosis ; Dirofilariasis/parasitology ; Female ; Humans ; Middle Aged
    Language English
    Publishing date 2022-01-12
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 1132735-2
    ISSN 1896-1851 ; 0065-1478 ; 1230-2821
    ISSN (online) 1896-1851
    ISSN 0065-1478 ; 1230-2821
    DOI 10.1007/s11686-021-00506-0
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  7. Article ; Online: Diaphragmatic perforation as a result of cystic echinococcosis in an HIV-positive migrant.

    Schwarz, Caroline / Schmidbauer, Victor / Lagler, Heimo / Stremitzer, Stefan / Kaczirek, Klaus / Langenberger, Herbert / Chromy, David / Auer, Herbert / Gschwantler, Michael

    Journal of travel medicine

    2023  Volume 30, Issue 6

    MeSH term(s) Animals ; Humans ; Transients and Migrants ; Echinococcosis ; Echinococcus granulosus ; HIV Infections
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad108
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  8. Article: A new ELISA and western blot technique based on recombinant TES antigen and/or larval antigen for the detection of toxocariasis in humans

    Raulf, Marie-Kristin / Jordan, Daniela / Auer, Herbert / Warnecke, Jens M / Lepenies, Bernd / Strube, Christina

    Parasitology. 2021 Mar., v. 148, no. 3

    2021  

    Abstract: Serological antibody detection by enzyme-linked immunosorbent assay (ELISA)- and immunoblot-based methods constitutes the best indicator of human Toxocara infection. Nevertheless, the availability of serological tests, particularly western blots (WB), ... ...

    Abstract Serological antibody detection by enzyme-linked immunosorbent assay (ELISA)- and immunoblot-based methods constitutes the best indicator of human Toxocara infection. Nevertheless, the availability of serological tests, particularly western blots (WB), evaluated for sensitivity and specificity is limited. Therefore, an Anti-Toxocara-ELISA immunoglobulin g (IgG) prototype (Proto-ELISA) and an Anti-Toxocara-Westernblot (IgG) prototype (Proto-WB) were evaluated by testing 541 human sera pre-determined for Toxocara infection by an established in-house Anti-Toxocara-ELISA (IH-ELISA). To evaluate sensitivity and specificity of the newly developed ELISA and WB prototypes, results were compared to IH-ELISA and a commercial WB (Com-WB). Compared to the IH-ELISA, a sensitivity of 93.1% (229/246) and a specificity of 94.6% (279/295) of the Proto-ELISA with a Cohen's κ of 0.88 were obtained. The sensitivity of the Proto-WB was 76.7% (240/313) and specificity was 99.6% (227/228) with a Cohen's κ of 0.73 compared to those of Com-WB. A comparison to the IH-ELISA revealed 91.5% (225/246) sensitivity and 94.6% (279/295) specificity of the Proto-WB with a Cohen's κ of 0.86. Cross-reactivity was observed for some samples positive for Ascaris and Trichinella spp. in the Proto-ELISA, Proto-WB and Com-WB. Overall, the evaluated ELISA and WB prototypes showed high sensitivity and specificity, indicating high reliability of these newly developed tests.
    Keywords Ascaris ; Trichinella ; Western blotting ; antibody detection ; antigens ; cross reaction ; enzyme-linked immunosorbent assay ; humans ; immunoglobulin G ; larvae ; parasitology ; prototypes ; toxocariasis
    Language English
    Dates of publication 2021-03
    Size p. 333-340.
    Publishing place Cambridge University Press
    Document type Article
    Note NAL-light
    ZDB-ID 207627-5
    ISSN 1469-8161 ; 0031-1820
    ISSN (online) 1469-8161
    ISSN 0031-1820
    DOI 10.1017/S0031182020002085
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: A case of human Dirofilaria repens infection, causing an asymptomatic subcutaneous nodule.

    Haim, Andreas / Kitchen, Maria / Auer, Herbert / Rettenbacher, Thomas / Schmuth, Matthias

    Parasitology research

    2020  Volume 119, Issue 5, Page(s) 1703–1705

    Abstract: We present a case of subcutaneous dirofilariasis, a vector-borne zoonotic disease, in a young woman from Austria. The diagnosis was confirmed by ultrasound and histology of the excised subcutaneous nodule. The parasite species was identified as ... ...

    Abstract We present a case of subcutaneous dirofilariasis, a vector-borne zoonotic disease, in a young woman from Austria. The diagnosis was confirmed by ultrasound and histology of the excised subcutaneous nodule. The parasite species was identified as Dirofilaria repens by polymerase chain reaction. We expect to see more cases of human dirofilariasis also due to climate change and associated increase of the spectrum of suitable mosquito vectors.
    MeSH term(s) Adult ; Animals ; Austria ; Dirofilaria repens/genetics ; Dirofilaria repens/isolation & purification ; Dirofilariasis/diagnosis ; Dirofilariasis/pathology ; Female ; Humans ; Mosquito Vectors/parasitology ; Polymerase Chain Reaction ; Skin Diseases, Parasitic/diagnosis ; Skin Diseases, Parasitic/pathology
    Language English
    Publishing date 2020-03-23
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-020-06655-x
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  10. Article ; Online: Incidence of Ascaris suum-specific antibodies in Austrian patients with suspected larva migrans visceralis (VLM) syndrome.

    Schneider, Renate / Auer, Herbert

    Parasitology research

    2016  Volume 115, Issue 3, Page(s) 1213–1219

    Abstract: The pig roundworm, Ascaris suum, is commonly found in domestic pigs all over the world. The transmission to humans takes place by ingestion of infective A. suum eggs present in soil because pig manure is widely used as fertilizer. The possible role of A. ...

    Abstract The pig roundworm, Ascaris suum, is commonly found in domestic pigs all over the world. The transmission to humans takes place by ingestion of infective A. suum eggs present in soil because pig manure is widely used as fertilizer. The possible role of A. suum in the human visceral larva migrans (VLM) syndrome has been discussed controversially during past decades, even though various case reports, particularly from Japan document pulmonal, hepatic and even cerebral symptoms caused by migrating A. suum larvae after ingestion of infected row meat (liver) or contaminated vegetables. We examined 4481 sera by A. suum immunoblot (As-IB) and 5301 sera by Toxocara-ELISA from patients with symptoms associated with the VLM syndrome during three consecutive years (2012-2014). The incidence of A. suum-specific antibodies was 13.2 %, the incidence of T. canis specific antibodies 12.9 % and from a part of the As-IB positive sera (n = 417) additional Toxocara serology was performed to demonstrate the specificity of our tests. Only 56 out of the 417 (13.4 %) sera showed antibodies to both helminth species demonstrating that double infections exist. Interestingly the age distribution of the patients showed that 2.8 % of the Ascaris-positive patients were younger than 21 years, while in the Toxocara-positive group 13.4 % were <21 years. These results are in accordance with a Dutch study suspecting different ways of transmission as cause for this interesting age distribution. Due to the fact that large amounts of untreated pig manure are used as fertilizer and that the expulsion of adult A. suum worms causing intestinal ascariosis is extremely rare in Central European countries, the zoonotic potential of A. suum is considerably underestimated. We suggest that the performance of reliable immunoserological tests, in all industrialized countries where pigs are raised and their manure is used as fertilizer, could help to assess the actual potential of A. suum as causative agent of the VLM syndrome in humans.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Animals ; Antibodies, Helminth/blood ; Ascaris suum/immunology ; Austria/epidemiology ; Child ; Child, Preschool ; Female ; Humans ; Immunoglobulin G/blood ; Incidence ; Infant ; Larva/immunology ; Larva Migrans, Visceral/diagnosis ; Larva Migrans, Visceral/epidemiology ; Larva Migrans, Visceral/immunology ; Male ; Manure/parasitology ; Middle Aged ; Sensitivity and Specificity ; Sex Distribution ; Soil/parasitology ; Toxocara canis/immunology ; Toxocariasis/epidemiology ; Young Adult
    Chemical Substances Antibodies, Helminth ; Immunoglobulin G ; Manure ; Soil
    Language English
    Publishing date 2016-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-015-4857-5
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