Article ; Online: Prevention of bleomycin-induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway.
Pharmacology research & perspectives
2022 Volume 10, Issue 6, Page(s) e01028
Abstract: Bleomycin-induced lung fibrosis is a debilitating disease, linked to high morbidity and mortality in chemotherapy patients. The MRTF/SRF transcription pathway has been proposed as a potential therapeutic target, as it is critical for myofibroblast ... ...
| Abstract | Bleomycin-induced lung fibrosis is a debilitating disease, linked to high morbidity and mortality in chemotherapy patients. The MRTF/SRF transcription pathway has been proposed as a potential therapeutic target, as it is critical for myofibroblast differentiation, a hallmark of fibrosis. In human lung fibroblasts, the MRTF/SRF pathway inhibitor, CCG-257081, effectively decreased mRNA levels of downstream genes: smooth muscle actin and connective tissue growth factor, with IC |
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| MeSH term(s) | Humans ; Animals ; Mice ; Bleomycin/toxicity ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/prevention & control ; Inflammation ; Fibroblasts ; Prednisolone |
| Chemical Substances | Bleomycin (11056-06-7) ; Prednisolone (9PHQ9Y1OLM) |
| Language | English |
| Publishing date | 2022-11-24 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2740389-0 |
| ISSN | 2052-1707 ; 2052-1707 |
| ISSN (online) | 2052-1707 |
| ISSN | 2052-1707 |
| DOI | 10.1002/prp2.1028 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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