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Article ; Online: Low self-esteem is related to depression and anxiety during recovery from an ectopic pregnancy.

Hasani, Sonia / Aung, Eindra / Mirghafourvand, Mojgan

2021 Volume 21, Issue 1, Page(s) 326

Abstract: Background: Considering the increasing incidence of ectopic pregnancy and the negative effects of pregnancy loss on mental health, this study aimed to determine the status of mental health in women with ectopic pregnancy and examine its relationship ... ...

Abstract	Background: Considering the increasing incidence of ectopic pregnancy and the negative effects of pregnancy loss on mental health, this study aimed to determine the status of mental health in women with ectopic pregnancy and examine its relationship with their self-esteem. Methods: This was a cross-sectional study on 150 women (with a 100% response rate) hospitalized for ectopic pregnancy et al.-Zahra hospital in Tabriz, Iran, during 2018-2019, and recruited via convenience sampling. Data were collected using the General Health Questionnaire-28, which has four subscales (overall score range: 0 to 84; subscale score range: 0 to 21 with a lower score indicating a better mental state), and Rosenberg Self-Esteem Scale (score range: - 10 to + 10 with a higher score indicating higher self-esteem). To determine the association between self-esteem and mental health, independent t-tests, and multivariable logistic regression were used. Results: The response rate was 100%. The mean score (SD) of participants' mental health was 31.4 (8.5), and that of self-esteem was 4.5 (3.80). The percentage of participants who were considered as having mental distress (i.e., overall GHQ-28 score ≥ 24) was 76%. Among the subscales of mental health, social dysfunction was the most prevalent (observed in 100% of the participants), followed by somatic symptoms (79.3%). Lower self-esteem was significantly associated with overall mental distress (odds ratio (OR): 0.74; 95% confidence interval (95% CI): 0.64-0.87; P < 0.001), depression (OR: 0.70; 95% CI: 0.60-0.80; P < 0.001) and anxiety/insomnia (OR: 0.76; 95% CI: 0.66-0.87; P < 0.001). Discussion: Mental distress was common among women with ectopic pregnancy. This study is the first to examine the relationship between self-esteem and mental health among women with ectopic pregnancy and highlights the important role of self-esteem in mental wellbeing among those women.
MeSH term(s)	Anxiety/epidemiology ; Anxiety Disorders ; Cross-Sectional Studies ; Depression/epidemiology ; Female ; Humans ; Pregnancy ; Pregnancy, Ectopic/epidemiology ; Self Concept
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050444-5
ISSN	1472-6874 ; 1472-6874
ISSN (online)	1472-6874
ISSN	1472-6874
DOI	10.1186/s12905-021-01467-2
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Article ; Online: Estimation of adherence to urate-lowering therapy in people living with gout using Australia's Pharmaceutical Benefits Scheme and patient-reported dosing.

Schulz, Marcel / Coleshill, Matthew J / Day, Richard O / Wright, Daniel F B / Brett, Jonathan / Briggs, Nancy E / Aung, Eindra

British journal of clinical pharmacology

2024 Volume 90, Issue 5, Page(s) 1322–1332

Abstract: Aims: The aim of this study was to estimate adherence to urate-lowering therapy (ULT), predominately allopurinol, from Australia's Pharmaceutical Benefits Scheme (PBS) claims database in association with (1) patient-reported doses and (2) World Health ... ...

Abstract	Aims: The aim of this study was to estimate adherence to urate-lowering therapy (ULT), predominately allopurinol, from Australia's Pharmaceutical Benefits Scheme (PBS) claims database in association with (1) patient-reported doses and (2) World Health Organization's (WHO) defined daily doses (DDD), namely, allopurinol (400 mg/day) or febuxostat (80 mg/day). Methods: Proportion of days covered (PDC) was calculated in 108 Gout App (Gout APP) trial participants with at least two recorded ULT dispensings in an approximately 12-month period before provision of intervention or control apps. Adherence was defined as PDC ≥80%. We measured the correlation between the two methods of calculating PDC using a Wilcoxon signed rank test. Agreement between ULT-taking status (self-reports) and ULT-dispensed status (PBS records) was tested with Cohen's kappa (κ), and positive and negative percent agreement. Results: Allopurinol was prescribed in 93.5% of participants taking ULT. Their self-reported mean daily dose (SD) was 291 (167) mg/day. Mean PDC (SD) for allopurinol was 83% (21%) calculated using self-reported dose, and 63% (24%) using WHO's DDD. Sixty-three percent of allopurinol users were identified as adherent (PDC ≥80%) using self-reported dose. There was good agreement between self-reported ULT use and PBS dispensing claims (κ = 0.708, P < .001; positive percent agreement = 90%, negative percent agreement = 82%). Conclusions: Participant-reported allopurinol daily doses, in addition to PBS dispensing claims, may enhance confidence in estimating PDC and adherence compared to using DDD. This approach improves adherence estimations from pharmaceutical claims datasets for medications where daily doses vary between individuals or where there is a wide therapeutic dose range.
MeSH term(s)	Humans ; Gout/drug therapy ; Gout/blood ; Allopurinol/administration & dosage ; Allopurinol/therapeutic use ; Gout Suppressants/administration & dosage ; Gout Suppressants/therapeutic use ; Medication Adherence/statistics & numerical data ; Australia ; Male ; Female ; Middle Aged ; Febuxostat/administration & dosage ; Febuxostat/therapeutic use ; Self Report/statistics & numerical data ; Uric Acid/blood ; Aged ; Adult ; Databases, Factual
Chemical Substances	Allopurinol (63CZ7GJN5I) ; Gout Suppressants ; Febuxostat (101V0R1N2E) ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.16016
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Zs.A 1118: Show issues

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Article ; Online: Patient factors and health outcomes associated with illness perceptions in people with gout.

Selvadurai, Daniel / Coleshill, Matthew J / Day, Richard O / Briggs, Nancy E / Schulz, Marcel / Reath, Jennifer / Aung, Eindra

Rheumatology (Oxford, England)

2023

Abstract: Objective: Illness perceptions are views and beliefs formed in response to a health threat which may influence self-management behaviours and chronic disease outcomes. Despite effective medication, sub-optimal outcomes in gout are common. This study ... ...

Abstract	Objective: Illness perceptions are views and beliefs formed in response to a health threat which may influence self-management behaviours and chronic disease outcomes. Despite effective medication, sub-optimal outcomes in gout are common. This study aimed to quantitatively investigate illness perceptions in gout to examine how illness perceptions relate to health outcomes. Methods: Data were obtained from a randomised-controlled trial where people with gout (n = 493) completed surveys measuring illness perceptions (Brief Illness Perception Questionnaire (B-IPQ)), gout flares, medication adherence, health-related quality of life, healthcare utilisation and productivity, alongside serum urate blood tests at baseline, 6- and 12-month follow-ups. Multivariable linear regression identified patient factors independently associated with each B-IPQ item score. Logistic and linear regression, adjusted for age and sex, determined whether baseline B-IPQ items could predict current and future health outcomes. Results: Younger individuals and those with severe gout were more likely to experience pessimistic illness perceptions at baseline. Optimistic illness perceptions were associated with lower odds of having at least one flare in the preceding 6 months. Every 1-point increase in B-IPQ treatment control, indicating the optimistic view that gout is treatable, decreased the odds of a recent flare prior to baseline by 33% (OR : 0.67; 95%CI : 0.53,0.85; p< 0.001) and prior to 12-month follow-up by 15% (OR : 0.85; 95%CI : 0.76,0.96; p= 0.01). Pessimistic illness perceptions also predicted poorer medication adherence, health-related quality of life and productivity but not serum urate levels. Conclusion: Modifying pessimistic illness perceptions, including, but not limited to, patient education, may promote prudent self-management behaviours and better outcomes in gout. Trial registration: Australian New Zealand Clinical Trials Registry; https://www.anzctr.org.au/; ACTRN12616000455460.
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead501
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: Rebranding Gout: Could a Name Change for Gout Improve Adherence to Urate-Lowering Therapy?

Coleshill, Matthew J / Aung, Eindra / Carland, Jane E / Faasse, Kate / Stocker, Sophie / Day, Richard O

Therapeutic innovation & regulatory science

2020 Volume 55, Issue 1, Page(s) 138–141

Abstract: Gout is the most common form of inflammatory arthritis in men, yet both patients and the public often do not recognise gout as a form of arthritis. Instead, due to historical misconceptions, gout is typically seen as a lifestyle disease caused by poor ... ...

Abstract	Gout is the most common form of inflammatory arthritis in men, yet both patients and the public often do not recognise gout as a form of arthritis. Instead, due to historical misconceptions, gout is typically seen as a lifestyle disease caused by poor diet. In reality, there are a number of risk factors that contribute to gout, including genetic factors. Views of gout as precipitated by lifestyle alone can lead to stigma, and maladaptive beliefs that it should be treated primarily through dietary changes. This is thought to contribute to poor uptake of, and adherence to, effective pharmaceutical treatments. Gout has some of the poorest medication adherence rates of any chronic disease, contributing to suboptimal health outcomes for patients. Recent research suggests that when gout is referred to as 'urate crystal arthritis' (a rarely used name for gout), the perception of the disease by members of the public was more accurate. It was viewed as being less under personal control (i.e. less appropriately managed by behaviours such as dietary intake), and more appropriately managed by long-term medical treatment. This finding raises the possibility that patients themselves might also benefit from gout being explicitly labelled as arthritis. Indeed, parallels can be drawn between this case and other diseases that have recently had their names changed to improve outcomes, namely primary biliary cirrhosis and schizophrenia. A movement away from the term gout may benefit those living with the disease by changing illness perceptions and increasing uptake of, and adherence to, guideline-recommended treatment(s).
MeSH term(s)	Chronic Disease ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Humans ; Male ; Medication Adherence ; Uric Acid/therapeutic use
Chemical Substances	Gout Suppressants ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2020-07-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708397-4
ISSN	2168-4804 ; 2168-4790
ISSN (online)	2168-4804
ISSN	2168-4790
DOI	10.1007/s43441-020-00198-0
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Article: Predictors of Success in Gout Treatment.

Day, Richard Osborne / Coleshill, Mathew James / Stocker, Sophie Lena / Nguyen, Amy Danh / Robinson, Philip / Aung, Eindra

The Journal of rheumatology

2020 Volume 47, Issue 3, Page(s) 313–315

MeSH term(s)	Allopurinol ; Gout ; Gout Suppressants ; Humans ; Uric Acid ; Veterans
Chemical Substances	Gout Suppressants ; Uric Acid (268B43MJ25) ; Allopurinol (63CZ7GJN5I)
Language	English
Publishing date	2020-01-09
Publishing country	Canada
Document type	Editorial ; Comment
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.191150
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article ; Online: Better outcomes for patients with gout.

Day, Richard / Nguyen, Amy / Graham, Garry / Aung, Eindra / Coleshill, Mathew / Stocker, Sophie

Inflammopharmacology

2020 Volume 28, Issue 5, Page(s) 1395–1400

Abstract: Gout is increasing in prevalence despite effective pharmacotherapies. Barriers to effective management are largely educational deficiencies. Sufferers, usually men, need to understand more about gout, especially that maintaining serum urate below 0.36 ... ...

Abstract	Gout is increasing in prevalence despite effective pharmacotherapies. Barriers to effective management are largely educational deficiencies. Sufferers, usually men, need to understand more about gout, especially that maintaining serum urate below 0.36 mmol/L will eliminate recurrent attacks. Also, of great importance is appreciating that sub-optimal adherence to urate-lowering therapy (ULT) will result in a return of attacks. Prescribers also need to understand that acute attacks are likely to occur in the first few months of urate-lowering therapy (ULT), but these can be mitigated by commencing with a dose of ULT reflective of renal function and escalating the dose slowly, every 2-5 weeks until target serum urate is achieved. Prophylaxis against acute attacks over the initial 6 months period of ULT can be enhanced further with concomitant colchicine or nonsteroidal anti-inflammatory drugs (NSAIDs).Gout is largely managed in primary care. Rates of adherence to ULT are 50% or less, worse than most other chronic illnesses. Efforts at educating primary care physicians to, firstly, manage gout effectively and, secondly, to educate their gout patients sufficiently have not been successful. Allied health practitioners, such as nurses, working with prescribers in primary care settings and given the mandate to educate and manage patients with gout, have been spectacularly effective. However, this approach is resource intensive. 'Personalised' eHealth interventions show promise as an alternative strategy, notably in improving adherence to ULT.Numerous applications for smart phones (apps) are now available to assist people with chronic health conditions. Their design needs to accommodate the barriers and enablers perceived by patients to maintaining adherence to prescribed therapies. Personalised feedback of serum urate may represent an important enabler of adherence to ULT in the case of gout.Harnessing mobile apps to support patients managing their chronic illnesses represents an important opportunity to enhance health outcomes. Rigorous, patient-centred and driven development is critical. These tools also require careful evaluation for effectiveness.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Colchicine/administration & dosage ; Colchicine/pharmacology ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Gout/drug therapy ; Gout/physiopathology ; Gout Suppressants/administration & dosage ; Gout Suppressants/pharmacology ; Humans ; Medication Adherence ; Mobile Applications ; Uric Acid/blood
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Gout Suppressants ; Uric Acid (268B43MJ25) ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2020-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-020-00694-7
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Zs.A 3274: Show issues

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Article: Building health systems capacity: an introductory training course on health information systems.

Aung, Eindra / Whittaker, Maxine

Pacific health dialog

2012 Volume 18, Issue 1, Page(s) 91–102

Abstract: The inadequate capacity of health information systems (HIS) in developing countries of Asia and the Pacific has been an ongoing issue. Training of data producers and data users in generating, analysing and using data has been identified as a key option ... ...

Abstract	The inadequate capacity of health information systems (HIS) in developing countries of Asia and the Pacific has been an ongoing issue. Training of data producers and data users in generating, analysing and using data has been identified as a key option in strengthening HIS in the region and consequently building health system capacity. Accordingly, the HIS Knowledge Hub at the School of Population Health, the University of Queensland, has developed HIS curriculum, piloted and evaluated the course. Experiences in the development and design of the curriculum, and delivery and evaluation of the course, are presented in this article. The participants evaluated that the course met their expectations in usefulness to their roles, demonstrated adequate HIS knowledge and skills in their group presentations at the end of the course, and applied what they learnt from the course in their workplace.
MeSH term(s)	Capacity Building/methods ; Curriculum ; Data Collection ; Delivery of Health Care/organization & administration ; Humans ; Inservice Training/organization & administration ; Medical Informatics/education ; Queensland
Language	English
Publishing date	2012-04
Publishing country	New Zealand
Document type	Evaluation Studies ; Journal Article
ZDB-ID	2582245-7
ISSN	1015-7867
ISSN	1015-7867
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Article ; Online: Preparing routine health information systems for immediate health responses to disasters.

Aung, Eindra / Whittaker, Maxine

Health policy and planning

2012 Volume 28, Issue 5, Page(s) 495–507

Abstract: During disaster times, we need specific information to rapidly plan a disaster response, especially in sudden-onset disasters. Due to the inadequate capacity of Routine Health Information Systems (RHIS), many developing countries face a lack of quality ... ...

Abstract	During disaster times, we need specific information to rapidly plan a disaster response, especially in sudden-onset disasters. Due to the inadequate capacity of Routine Health Information Systems (RHIS), many developing countries face a lack of quality pre-disaster health-related data and efficient post-disaster data processes in the immediate aftermath of a disaster. Considering the significance of local capacity during the early stages of disaster response, RHIS at local, provincial/state and national levels need to be strengthened so that they provide relief personnel up-to-date information to plan, organize and monitor immediate relief activities. RHIS professionals should be aware of specific information needs in disaster response (according to the Sphere Project's Humanitarian Minimum Standards) and requirements in data processes to fulfil those information needs. Preparing RHIS for disasters can be guided by key RHIS-strengthening frameworks; and disaster preparedness must be incorporated into countries' RHIS. Mechanisms must be established in non-disaster times and maintained between RHIS and information systems of non-health sectors for exchanging disaster-related information and sharing technologies and cost.
MeSH term(s)	Delivery of Health Care ; Disaster Planning/organization & administration ; Health Information Management ; Health Information Systems/organization & administration
Language	English
Publishing date	2012-09-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632896-9
ISSN	1460-2237 ; 0268-1080
ISSN (online)	1460-2237
ISSN	0268-1080
DOI	10.1093/heapol/czs081
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Zs.B 2946: Show issues

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Article ; Online: Persistence with urate-lowering therapy in Australia: A longitudinal analysis of allopurinol prescriptions.

Coleshill, Matthew J / Day, Richard O / Tam, Karson / Kouhkamari, Mahsa / Caillet, Vincent / Aung, Eindra / Kannangara, Diluk R W / Cronin, Peter / Rodgers, Anthony / Stocker, Sophie L

British journal of clinical pharmacology

2022 Volume 88, Issue 11, Page(s) 4894–4901

Abstract: Aim: Gout is the most common form of inflammatory arthritis in men. Despite the availability of effective urate-lowering therapies (ULT), the management of gout is suboptimal due to poor persistence with ULT. This study examined national prescribing ... ...

Abstract	Aim: Gout is the most common form of inflammatory arthritis in men. Despite the availability of effective urate-lowering therapies (ULT), the management of gout is suboptimal due to poor persistence with ULT. This study examined national prescribing patterns of ULT to determine persistence with allopurinol in Australia. Methods: A 10% sample of the Australian Pharmaceutical Benefits Scheme dispensing claims database was used to identify individuals initiated on allopurinol between April 2014 and December 2019. The number of allopurinol scripts dispensed was used to estimate persistence with allopurinol. Persistence was defined as the number of months from initiation until discontinuation (last prescription with no further scripts acquired for a period thereafter). Kaplan-Meier curves were used to examine persistence, while Cox regression analysis was used to examine the influence of gender, concomitant colchicine and age. Results: The largest drop in persistence occurred immediately after initiation, with 34% of patients discontinuing allopurinol 300-mg therapy in the first month. Median persistence with allopurinol 300 mg was 5 months (95% confidence interval 4.76-5.24), with around 63% of individuals not persisting with this therapy for more than 12 months. Concomitant prescription of colchicine on the day of allopurinol initiation only occurred in 7% of allopurinol initiations. No increase in persistence was observed for those co-prescribed colchicine. Conclusion: Persistence with allopurinol was poor. More effective methods targeting prescribers, patients and systems are required to promote persistence with allopurinol. Improving persistence to allopurinol is an important public health goal given the proven potential of this medication to eliminate gout.
MeSH term(s)	Allopurinol/therapeutic use ; Australia/epidemiology ; Colchicine/therapeutic use ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Humans ; Male ; Medication Adherence ; Pharmaceutical Preparations ; Prescriptions ; Uric Acid
Chemical Substances	Gout Suppressants ; Pharmaceutical Preparations ; Uric Acid (268B43MJ25) ; Allopurinol (63CZ7GJN5I) ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2022-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15435
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Zs.A 1118: Show issues

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Article ; Online: Association between patient activation and patient-assessed quality of care in type 2 diabetes: results of a longitudinal study.

Aung, Eindra / Donald, Maria / Coll, Joseph R / Williams, Gail M / Doi, Suhail A R

Health expectations : an international journal of public participation in health care and health policy

2016 Volume 19, Issue 2, Page(s) 356–366

Abstract: Background: Previous research using cross-sectional data has shown a positive relationship between patient activation and quality of care. The quantitative relationships in the same patients over time, however, remain undefined.: Objective: To ... ...

Abstract	Background: Previous research using cross-sectional data has shown a positive relationship between patient activation and quality of care. The quantitative relationships in the same patients over time, however, remain undefined. Objective: To examine the relationship between changes in activation over time and patient-assessed quality of chronic illness care. Design: Prospective cohort study. Participants: The study used data reported annually from 2008 (N = 3761) to 2010 (N = 3040), using self-report survey questionnaires, completed by patients with type 2 diabetes in a population-based cohort in Queensland, Australia. Main measures: Principal measures were the 13-item Patient Activation Measure (PAM), and the 20-item Patient Assessment of Chronic Illness Care (PACIC) instrument. Methods: Nonparametric anova was used to determine the association between patient activation and patient-assessed quality of care in low and high patient activation groups at baseline (2008), and in 2009 and 2010, when patients had changed group membership. The Wilcoxon signed ranks test was used to compare the PACIC scores between baseline and each follow-up survey for the same patient activation level. Results: Patient activation was positively associated with the median PACIC score within each survey year and within each of the groups defined at baseline (high- and low-activation groups; P < 0.001). Conclusions: Patient activation and the PACIC change in the same direction and should be considered together in the interpretation of patient care assessment. This can be carried out by interpreting PACIC scores within strata of PAM.
MeSH term(s)	Aged ; Chronic Disease ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/therapy ; Female ; Humans ; Long-Term Care ; Longitudinal Studies ; Male ; Middle Aged ; Patient Participation ; Patient Satisfaction ; Quality of Health Care/standards ; Queensland ; Self Care/standards ; Surveys and Questionnaires
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2119434-8
ISSN	1369-7625 ; 1369-6513
ISSN (online)	1369-7625
ISSN	1369-6513
DOI	10.1111/hex.12359
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