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  1. Article: Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population.

    Neelam, Kumari / Aung, Khin Chaw Yu / Ang, Keven / Tavintharan, Subramaniam / Sum, Chee Fang / Lim, Su Chi

    Clinical ophthalmology (Auckland, N.Z.)

    2023  Volume 17, Page(s) 445–454

    Abstract: Objective: To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes.: Methods: 1339 patients from an ongoing Singapore ... ...

    Abstract Objective: To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes.
    Methods: 1339 patients from an ongoing Singapore Study of Macro-angiopathy and Micro-Vascular Reactivity in Type 2 Diabetes (SMART2D) were included in this study. Fasting triglyceride and glucose levels were quantified and color fundus photographs were assessed for DR presence and severity. Logistic regression models were used to evaluate associations of TyG index with DR prevalence and incidence (median follow-up period = 3.2 years).
    Results: Mean TyG index was higher in patients with DR than no DR (9.24±0.7 versus 9.04± 0.6, p<0.001). TyG index was significantly associated with DR prevalence (OR=1.4, CI 1.1-1.7, p=0.002) and incidence (OR=1.8, CI 1.04-2.9, p=0.03), after adjusting for confounders. In a stratified analysis, the association between TyG index and DR prevalence reached significance only in the subgroup with HbA1c levels < 7.0% (OR=2, CI 1.1-3.8, p=0.03). TyG index significantly predicted DR prevalence and incidence with area under receiver operating curve as 0.77 (CI 0.74-0.80, p <0.001) and 0.66 (CI 0.57-0.76, p value <0.01), respectively.
    Conclusion: TyG index is a good predictor for DR prevalence and incidence. It can also be a secondary treatment target for patients with optimally controlled levels of HbA1c.
    Language English
    Publishing date 2023-02-02
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S382336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Factors influencing quality of life of Asian breast cancer patients and their caregivers at diagnosis: perceived medical and psychosocial needs.

    Chow, Wai Leng / Tan, Su-Ming / Aung, Khin Chaw Yu / Chua, Sophia Yen Nee / Sim, Hong Chui

    Singapore medical journal

    2019  Volume 61, Issue 10, Page(s) 532–539

    Abstract: Introduction: We aimed to examine the relative importance of medical and psychosocial needs of Asian breast cancer patients and their caregivers, and to identify the determinants of quality of life (QoL) at the time of diagnosis.: Methods: This is a ... ...

    Abstract Introduction: We aimed to examine the relative importance of medical and psychosocial needs of Asian breast cancer patients and their caregivers, and to identify the determinants of quality of life (QoL) at the time of diagnosis.
    Methods: This is a prospective observational study of the perceived needs and QoL of 99 dyads of breast cancer patients and their caregivers at diagnosis. A self-administered questionnaire was used to measure the perceived importance of medical and psychosocial support needs. Short Form-36 health survey (SF-36) version 2 was used to measure QoL. We also collected patient and caregiver demographic profiles and disease-specific information. Descriptive analysis of perceived needs was performed. SF-36 scores for eight domains and composite scores were calculated. Bivariate analysis and linear regression were performed to identify significant independent predictors of QoL of patients and caregivers.
    Results: The mean ages of the patients and caregivers were 56.5 years and 51.7 years, respectively. To have family around (73%), prompt information about treatment and treatment options, including side effects (71%), and prompt treatment for side effects (71%) were the top three needs among patients and their caregivers. Supportive nurses and prompt treatment for side effects positively improved patients' social functioning and bodily pain scores. Stage of disease, age, education and ethnicity also influenced QoL. Only the presence of chronic disease influenced caregivers' physical functioning and role-physical scores.
    Conclusion: Patients and caregivers have similar perceptions of needs at diagnosis. A supportive healthcare team can positively influence patients' QoL, highlighting the importance of tailoring support according to needs.
    MeSH term(s) Adult ; Aged ; Asian Continental Ancestry Group/psychology ; Breast Neoplasms/psychology ; Caregivers/psychology ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality of Life/psychology ; Singapore/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2019-08-16
    Publishing country Singapore
    Document type Journal Article ; Observational Study
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2019099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study.

    Ng, Tze-Pin / Aung, Khin Chaw Yu / Feng, Lei / Scherer, Samuel C / Yap, Keng Bee

    The American journal of clinical nutrition

    2012  Volume 96, Issue 6, Page(s) 1362–1368

    Abstract: Background: There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.: Objective: We investigated the independent associations ... ...

    Abstract Background: There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.
    Objective: We investigated the independent associations of homocysteine, folate, and vitamin B-12 with gait and balance performance and Instrumental Activities of Daily Living (IADL) in community-living older persons.
    Design: We performed cross-sectional analyses on baseline data of 796 respondents in the Singapore Longitudinal Ageing Study who had laboratory measurements of fasting homocysteine folate and vitamin B-12 and completed Performance Oriented Mobility Assessment (POMA) of gait and balance and self-reports of IADLs.
    Results: In multivariate analyses in which sex, age, education, housing type, comorbidities, hospitalization, depression and global cognitive scores, BMI, creatinine, arthritis and hip fracture, serum albumin and hemoglobin, and physical activities were controlled for, we showed that homocysteine, independently of folate and vitamin B-12, showed significant negative associations with POMA balance (P = 0.02), POMA gait scores (P < 0.01), and IADL (P < 0.01). Serum folate showed a significant positive association only with POMA balance scores (P < 0.045). No significant independent associations for vitamin B-12 were observed.
    Conclusions: The independent association of elevated homocysteine and low folate, but not vitamin B-12, on physical and functional decline was supported in this study. Interventional studies of the physical functional effects of folate and vitamin B-12 status in different populations are needed.
    MeSH term(s) Activities of Daily Living ; Aged ; Aged, 80 and over ; Aging ; Cross-Sectional Studies ; Female ; Folic Acid/blood ; Folic Acid Deficiency/blood ; Folic Acid Deficiency/epidemiology ; Folic Acid Deficiency/physiopathology ; Gait ; Geriatric Assessment ; Homocysteine/blood ; Humans ; Hyperhomocysteinemia/blood ; Hyperhomocysteinemia/epidemiology ; Hyperhomocysteinemia/physiopathology ; Longitudinal Studies ; Male ; Middle Aged ; Mobility Limitation ; Postural Balance ; Prospective Studies ; Singapore/epidemiology ; Vitamin B 12/blood ; Vitamin B 12 Deficiency/blood ; Vitamin B 12 Deficiency/epidemiology ; Vitamin B 12 Deficiency/physiopathology
    Chemical Substances Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2012-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.3945/ajcn.112.035741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.208: Show issues Location:
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  4. Article: Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study

    Ng, Tze-Pin / Aung, Khin Chaw Yu / Feng, Lei / Scherer, Samuel C / Yap, Keng Bee

    American journal of clinical nutrition. 2012 Dec., v. 96, no. 6

    2012  

    Abstract: Background: There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.Objective: We investigated the independent associations of ... ...

    Abstract Background: There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.Objective: We investigated the independent associations of homocysteine, folate, and vitamin B-12 with gait and balance performance and Instrumental Activities of Daily Living (IADL) in community-living older persons.Design: We performed cross-sectional analyses on baseline data of 796 respondents in the Singapore Longitudinal Ageing Study who had laboratory measurements of fasting homocysteine folate and vitamin B-12 and completed Performance Oriented Mobility Assessment (POMA) of gait and balance and self-reports of IADLs.Results: In multivariate analyses in which sex, age, education, housing type, comorbidities, hospitalization, depression and global cognitive scores, BMI, creatinine, arthritis and hip fracture, serum albumin and hemoglobin, and physical activities were controlled for, we showed that homocysteine, independently of folate and vitamin B-12, showed significant negative associations with POMA balance (P = 0.02), POMA gait scores (P < 0.01), and IADL (P < 0.01). Serum folate showed a significant positive association only with POMA balance scores (P < 0.045). No significant independent associations for vitamin B-12 were observed.Conclusions: The independent association of elevated homocysteine and low folate, but not vitamin B-12, on physical and functional decline was supported in this study. Interventional studies of the physical functional effects of folate and vitamin B-12 status in different populations are needed.
    Keywords arthritis ; blood serum ; body mass index ; clinical nutrition ; cognition ; comorbidity ; creatinine ; education ; elderly ; fasting ; folic acid ; gait ; hemoglobin ; hip fractures ; homocysteine ; multivariate analysis ; serum albumin ; vitamin B12 ; Singapore
    Language English
    Dates of publication 2012-12
    Size p. 1362-1368.
    Publishing place American Society for Clinical Nutrition
    Document type Article
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.3945/ajcn.112.035741
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 72/516: Show issues

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  5. Article ; Online: Risk Stratification Model for 30-Day Heart Failure Readmission in a Multiethnic South East Asian Community.

    Leong, Kui Toh Gerard / Wong, Lai Yin / Aung, Khin Chaw Yu / Macdonald, Michael / Cao, Yan / Lee, Sheldon / Chow, Wai Leng / Doddamani, Sanjay / Richards, Arthur Mark

    The American journal of cardiology

    2017  Volume 119, Issue 9, Page(s) 1428–1432

    Abstract: There are limited accurate 30-day heart failure (HF) readmission risk scores using readily available clinical patient information on a well-defined HF cohort. We analyzed 1,475 admissions discharged from our hospital with a primary diagnosis of HF ... ...

    Abstract There are limited accurate 30-day heart failure (HF) readmission risk scores using readily available clinical patient information on a well-defined HF cohort. We analyzed 1,475 admissions discharged from our hospital with a primary diagnosis of HF between 2010 and 2012. HF diagnostic criteria included satisfying clinical Framingham criteria, elevated serum N-terminal pro-natriuretic peptide, and evidence of cardiac dysfunction on transthoracic echocardiography. The patients were randomly divided into 2 groups; 60% were used as the derivation cohort and 40% as the validation cohort. Bivariate analysis and logistic regression were used to develop the model. Weighted risk scores were derived from the odds ratio of the logistic regression model. Total risk scores were computed by simple summation for each patient. The 7 significant independent predictors of 30-day HF readmission used to derive the risk scoring tool were the number of previous HF-related admission in the preceding 1 year, index admission length of stay, serum creatinine level, electrocardiograph QRS duration, serum N-terminal pro-natriuretic peptide level, number of Medical Social Service needs, and β blocker prescription on discharge. The area under the curve was 0.76. Sensitivity and specificity were 78.3% and 60.7%, respectively. The positive predictive value and negative predictive value were 18.9% and 96%, respectively. The actual observed and predicted 30-day heart failure readmission rates matched. In conclusion, we have developed the first 30-day HF readmission risk score, with good discriminatory ability, for an urban multiethnic Asian heart failure cohort with stringent diagnostic criteria. It consists of 7 easily obtained variables.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Aged ; Aged, 80 and over ; Area Under Curve ; Asian Continental Ancestry Group ; Cohort Studies ; Creatinine/blood ; Echocardiography ; Electrocardiography ; Female ; Heart Failure/blood ; Heart Failure/diagnostic imaging ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Hospitalization/statistics & numerical data ; Humans ; Length of Stay ; Logistic Models ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Needs Assessment ; Odds Ratio ; Patient Readmission/statistics & numerical data ; Peptide Fragments/blood ; Random Allocation ; Reproducibility of Results ; Risk Assessment ; Singapore
    Chemical Substances Adrenergic beta-Antagonists ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2017-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2017.01.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.73: Show issues Location:
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  6. Article ; Online: Over-expression of adenine nucleotide translocase 1 (ANT1) induces apoptosis and tumor regression in vivo.

    Jang, Ji-Young / Choi, Yun / Jeon, Yoon-Kyung / Aung, Khin Chaw Yu / Kim, Chul-Woo

    BMC cancer

    2008  Volume 8, Page(s) 160

    Abstract: Background: Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP. ANT has been known to be a major component of the permeability transition pore complex of ... ...

    Abstract Background: Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP. ANT has been known to be a major component of the permeability transition pore complex of mitochondria and contributes to mitochondria-mediated apoptosis. Human ANT has four isoforms (ANT1, ANT2, ANT3, and ANT4), and the expression of the ANT isoforms is variable depending on the tissue and cell type, developmental stage, and proliferation status. Among the isoforms, ANT1 is highly expressed in terminally-differentiated tissues, but expressed in low levels in proliferating cells, such as cancer cells. In particular, over-expression of ANT1 induces apoptosis in cultured tumor cells.
    Methods: We applied an ANT1 gene transfer approach to induce apoptosis and to evaluate the anti-tumor effect of ANT1 in a nude mouse model.
    Results: We demonstrated that ANT1 transfection induced apoptosis of MDA-MB-231 cells, inactivated NF-kappaB activity, and increased Bax expression. ANT1-inducing apoptosis was accompanied by the disruption of mitochondrial membrane potential, cytochrome c release and the activation of caspases-9 and -3. Moreover, ANT1 transfection significantly suppressed tumor growth in vivo.
    Conclusion: Our results suggest that ANT1 transfection may be a useful therapeutic modality for the treatment of cancer.
    MeSH term(s) Adenine Nucleotide Translocator 1/biosynthesis ; Adenine Nucleotide Translocator 1/genetics ; Animals ; Apoptosis/physiology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cell Growth Processes/physiology ; Cell Line, Tumor ; Genetic Therapy/methods ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; NF-kappa B/metabolism ; Signal Transduction ; Transfection ; Xenograft Model Antitumor Assays
    Chemical Substances Adenine Nucleotide Translocator 1 ; NF-kappa B
    Language English
    Publishing date 2008-06-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/1471-2407-8-160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study

    Ng, Tze-Pin / Aung, Khin Chaw Yu / Feng, Lei / Scherer, Samuel C / Yap, Keng Bee

    American journal of clinical nutrition

    Volume v. 96,, Issue no. 6

    Abstract: Background: There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.Objective: We investigated the independent associations of ... ...

    Abstract Background: There is a paucity of studies, as well as inconsistent findings, on the associations of homocysteine, folate, and vitamin B-12 with physical function and decline in older persons.Objective: We investigated the independent associations of homocysteine, folate, and vitamin B-12 with gait and balance performance and Instrumental Activities of Daily Living (IADL) in community-living older persons.Design: We performed cross-sectional analyses on baseline data of 796 respondents in the Singapore Longitudinal Ageing Study who had laboratory measurements of fasting homocysteine folate and vitamin B-12 and completed Performance Oriented Mobility Assessment (POMA) of gait and balance and self-reports of IADLs.Results: In multivariate analyses in which sex, age, education, housing type, comorbidities, hospitalization, depression and global cognitive scores, BMI, creatinine, arthritis and hip fracture, serum albumin and hemoglobin, and physical activities were controlled for, we showed that homocysteine, independently of folate and vitamin B-12, showed significant negative associations with POMA balance (P = 0.02), POMA gait scores (P < 0.01), and IADL (P < 0.01). Serum folate showed a significant positive association only with POMA balance scores (P < 0.045). No significant independent associations for vitamin B-12 were observed.Conclusions: The independent association of elevated homocysteine and low folate, but not vitamin B-12, on physical and functional decline was supported in this study. Interventional studies of the physical functional effects of folate and vitamin B-12 status in different populations are needed.
    Keywords blood serum ; comorbidity ; clinical nutrition ; arthritis ; creatinine ; body mass index ; fasting ; education ; hip fractures ; folic acid ; multivariate analysis ; serum albumin ; vitamin B12 ; hemoglobin ; gait ; cognition ; elderly ; homocysteine
    Language English
    Document type Article
    ISSN 0002-9165
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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