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Article ; Online: Natural disaster stress during pregnancy is linked to reprogramming of the placenta transcriptome in relation to anxiety and stress hormones in young offspring.

Nomura, Yoko / Rompala, Gregory / Pritchett, Lexi / Aushev, Vasily / Chen, Jia / Hurd, Yasmin L

2021 Volume 26, Issue 11, Page(s) 6520–6530

Abstract: Prenatal stress can lead to long-term adverse effects that increase the risk of anxiety and other emotional disorders in offspring. The in utero underpinnings contributing to such phenotypes remain unknown. We profiled the transcriptome of placental ... ...

Abstract	Prenatal stress can lead to long-term adverse effects that increase the risk of anxiety and other emotional disorders in offspring. The in utero underpinnings contributing to such phenotypes remain unknown. We profiled the transcriptome of placental specimens from women who lived through Hurricane Sandy during pregnancy compared to those pregnant during non-Sandy conditions. Following birth, longitudinal assessments were conducted in their offspring during childhood (~3-4 years old) to measure steroid hormones (in hair) and behavioral and emotional problems. This revealed a significant link between prenatal Sandy stress (PNSS) and child HPA dysfunction, evident by altered cortisol, dehydroepiandrosterone (DHEA), and cortisol:DHEA levels. In addition, PNSS was associated with significantly increased anxiety and aggression. These findings coincided with significant reorganization of the placental transcriptome via vascular, immune, and endocrine gene pathways. Interestingly, many of the most prominently altered genes were known to be uniquely expressed in syncytiotrophoblast (STB)-subtype of placental cells and harbored glucocorticoid response elements in promoter regions. Finally, several vascular development- and immune-related placental gene sets were found to mediate the relationship between PNSS and childhood phenotypes. Overall, these findings suggest that natural disaster-related stress during pregnancy reprograms the placental molecular signature, potentially driving long-lasting changes in stress regulation and emotional health. Further examination of placental mechanisms may elucidate the environment's contribution to subsequent risk for anxiety disorders later in life.
MeSH term(s)	Anxiety/genetics ; Anxiety/metabolism ; Anxiety Disorders/genetics ; Anxiety Disorders/metabolism ; Female ; Humans ; Hydrocortisone/metabolism ; Natural Disasters ; Placenta/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects/metabolism ; Stress, Psychological/metabolism ; Transcriptome/genetics
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2021-05-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-021-01123-z
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Zs.A 4812: Show issues

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Article: High expression of shMDG1 gene is associated with low metastatic potential of tumor cells.

Isachenko, N / Dyakova, N / Aushev, V / Chepurnych, T / Gurova, K / Tatosyan, A

Oncogene

2006 Volume 25, Issue 2, Page(s) 317–322

Abstract: Metastasis is the primary cause of mortality associated with cancer. Molecular mechanisms leading to metastatic spread are poorly studied. To get a better understanding of this process, we compared the gene expression pattern of two isogenic cell lines, ... ...

Abstract	Metastasis is the primary cause of mortality associated with cancer. Molecular mechanisms leading to metastatic spread are poorly studied. To get a better understanding of this process, we compared the gene expression pattern of two isogenic cell lines, HET-SR and HET-SR1 (Rous Sarcoma Virus-transformed embryo hamster fibroblasts) with different metastatic activity using the differential display technique. A novel cDNA of hamster gene shMDG1 (Syrian hamster homologue of microvascular differentiation gene 1), which had 94% homology with rat MDG1 gene, was identified. Expression of shMDG1 was increased in low metastatic HET-SR cell line in comparison to high metastatic HET-SR1. Sequence analysis of the ORF of shMDG1 gene showed that it belongs to the DnaJ/heat-shock proteins of 40 kDa (HSP40) chaperones family, considered to function as a cochaperone of HSP70 family. In order to confirm involvement of shMDG1 in metastasis, we injected parental and shMDG1 overexpressed cells into animals. We showed that overexpression of the shMDG1 gene significantly diminished the metastatic activity of both HET-SR and HET-SR1 cells. The shMDG1-induced repression of metastasis was not connected with alterations in cell proliferation and motility in vitro, but correlated well with a decrease in content of the Asn-linked beta1-6 branched oligosaccharides on cell surface.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Cricetinae ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Embryo, Mammalian/pathology ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gene Expression Profiling ; HSP40 Heat-Shock Proteins/genetics ; HSP40 Heat-Shock Proteins/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/prevention & control ; Lung Neoplasms/secondary ; Mesocricetus ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Molecular Sequence Data ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/prevention & control ; Oligosaccharides, Branched-Chain/metabolism ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Survival Rate
Chemical Substances	HSP40 Heat-Shock Proteins ; Molecular Chaperones ; Oligosaccharides, Branched-Chain
Language	English
Publishing date	2006-01-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/sj.onc.1209022
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Book ; Online: Climatology of planetary wave type oscillations with periods of 2–20 days derived from O2 atmospheric and OH(6-2) airglow observations at mid-latitude with SATI

López-González, M. J. / Rodríguez, E. / García-Comas, M. / Costa, V. / Shepherd, M. G. / Shepherd, G. G. / Aushev, V. M. / Sargoytchev, S.

eISSN: 1432-0576

2018

Abstract: The presence of planetary wave type oscillations at mid-latitudes in the mesosphere/lower thermosphere region has been investigated using airglow observations. The observations were taken with a Spectral Airglow Temperature Imager (SATI) installed at ... ...

Abstract	The presence of planetary wave type oscillations at mid-latitudes in the mesosphere/lower thermosphere region has been investigated using airglow observations. The observations were taken with a Spectral Airglow Temperature Imager (SATI) installed at Sierra Nevada Observatory (37.06° N, 3.38° W) at 2900 m height. Airglow data of the column emission rate of the O 2 Atmospheric (0-1) band and of the OH Meinel (6-2) band and deduced rotational temperatures from 1998 to 2007 have been used in this study. From these observations a climatology of planetary wave type oscillations at this location is inferred. It has been found that the planetary wave type oscillations of 5-day period is predominant in our data throughout the year, with activity greater than 50% during March/April and October/November months. The planetary wave type oscillations of 2-day period is predominant during both solstices, being predominant during winter solstice in O 2 while a 10-day oscillation appears throughout the year with activity around 20% and with maximum activity during spring and autumn equinoxes. The 16-day oscillation has maximum occurrence during autumn-winter while its activity is almost disappeared during spring-summer. No clear seasonal dependence of the amplitude of the planetary wave type oscillations was observed in the cases considered in this study. The waves simultaneously detected in the rotational temperatures deduced from both OH and O 2 emissions usually show an upward energy propagation and are affected by dissipation processes.
Subject code	551
Language	English
Publishing date	2018-09-27
Publishing country	de
Document type	Book ; Online
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Article: Cytostatic activity of peptide extracts of medicinal plants on transformed A549, H1299, and HeLa Cells.

Tepkeeva, I I / Aushev, V N / Zborovskaya, I B / Demushkin, V P

Bulletin of experimental biology and medicine

2009 Volume 147, Issue 1, Page(s) 48–51

Abstract: Biological activity of peptide extracts of medicinal plants was studied on transformed non-small-cell lung carcinoma A549 cells, lung cancer H1299 cells, and cervical cancer HeLa cells at various cell densities. Cell survival and proliferation were ... ...

Abstract	Biological activity of peptide extracts of medicinal plants was studied on transformed non-small-cell lung carcinoma A549 cells, lung cancer H1299 cells, and cervical cancer HeLa cells at various cell densities. Cell survival and proliferation were evaluated 72 h after treatment with extracts in concentrations of 0.05, 0.25, and 0.5 microg/microl. The cytostatic effect was produced by peptide extracts of Camelia sinesis Kuntze, Inonotus obliquus, and a mixture Inula helenium L., Chelidonium majus L., Equisetum arvense L., and Inonotus obliquus. Peptide extracts of Hypericum perforatum L. and Laurus nobilis L. in the same concentrations had no effects on proliferative activity and growth of tumor cells.
MeSH term(s)	Cell Line, Transformed ; Humans ; Peptides/pharmacology ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry ; Species Specificity
Chemical Substances	Peptides ; Plant Extracts
Language	English
Publishing date	2009-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390407-6
ISSN	1573-8221 ; 0007-4888 ; 0365-9615
ISSN (online)	1573-8221
ISSN	0007-4888 ; 0365-9615
DOI	10.1007/s10517-009-0452-z
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Book ; Online: Angular analysis of $B^+ \to \rho^+\rho^0$ decays reconstructed in 2019, 2020, and 2021 Belle II data

Belle II Collaboration / Abudinén, F. / Adachi, I. / Adamczyk, K. / Aggarwal, L. / Ahlburg, P. / Ahmed, H. / Ahn, J. K. / Aihara, H. / Akopov, N. / Aloisio, A. / Ameli, F. / Andricek, L. / Ky, N. Anh / Asner, D. M. / Atmacan, H. / Aulchenko, V. / Aushev, T. / Aushev, V. /

Aziz, T. / Babu, V. / Bacher, S. / Bae, H. / Baehr, S. / Bahinipati, S. / Bakich, A. M. / Bambade, P. / Banerjee, Sw. / Bansal, S. / Barrett, M. / Batignani, G. / Baudot, J. / Bauer, M. / Baur, A. / Beaubien, A. / Beaulieu, A. / Becker, J. / Behera, P. K. / Bennett, J. V. / Bernieri, E. / Bernlochner, F. U. / Bertacchi, V. / Bertemes, M. / Bertholet, E. / Bessner, M. / Bettarini, S. / Bhardwaj, V. / Bhuyan, B. / Bianchi, F. / Bilka, T.

2022

Abstract: We report on a Belle II measurement of the branching fraction ($\mathcal{B}$), longitudinal polarization fraction ($f_L$), and CP asymmetry ($\mathcal{A}_{CP}$) of $B^+\to \rho^+\rho^0$ decays. We reconstruct $B^+\to \rho^+(\to \pi^+\pi^0(\to \gamma\ ... ...

Abstract	We report on a Belle II measurement of the branching fraction ($\mathcal{B}$), longitudinal polarization fraction ($f_L$), and CP asymmetry ($\mathcal{A}_{CP}$) of $B^+\to \rho^+\rho^0$ decays. We reconstruct $B^+\to \rho^+(\to \pi^+\pi^0(\to \gamma\gamma))\rho^0(\to \pi^+\pi^-)$ decays in a sample of SuperKEKB electron-positron collisions collected by the Belle II experiment in 2019, 2020, and 2021 at the $\Upsilon$(4S) resonance and corresponding to 190 fb$^{-1}$ of integrated luminosity. We fit the distributions of the difference between expected and observed $B$ candidate energy, continuum-suppression discriminant, dipion masses, and decay angles of the selected samples, to determine a signal yield of $345 \pm 31$ events. The signal yields are corrected for efficiencies determined from simulation and control data samples to obtain $\mathcal{B}(B^+ \to \rho^+\rho^0) = [23.2^{+\ 2.2}_{-\ 2.1} (\rm stat) \pm 2.7 (\rm syst)]\times 10^{-6}$, $f_L = 0.943 ^{+\ 0.035}_{-\ 0.033} (\rm stat)\pm 0.027(\rm syst)$, and $\mathcal{A}_{CP}=-0.069 \pm 0.068(\rm stat) \pm 0.060 (\rm syst)$. The results agree with previous measurements. This is the first measurement of $\mathcal{A}_{CP}$ in $B^+\to \rho^+\rho^0$ decays reported by Belle II.
Keywords	High Energy Physics - Experiment ; High Energy Physics - Phenomenology
Subject code	571
Publishing date	2022-06-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Measurements of the branching fraction, isospin asymmetry, and lepton-universality ratio in $B \to J/\psi K$ decays at Belle II

Belle II Collaboration / Abudinén, F. / Adachi, I. / Adak, R. / Adamczyk, K. / Aggarwal, L. / Ahlburg, P. / Ahmed, H. / Ahn, J. K. / Aihara, H. / Akopov, N. / Aloisio, A. / Ameli, F. / Andricek, L. / Ky, N. Anh / Asner, D. M. / Atmacan, H. / Aulchenko, V. / Aushev, T. /

Aushev, V. / Aziz, T. / Babu, V. / Bacher, S. / Bae, H. / Baehr, S. / Bahinipati, S. / Bakich, A. M. / Bambade, P. / Banerjee, Sw. / Bansal, S. / Barrett, M. / Batignani, G. / Baudot, J. / Bauer, M. / Baur, A. / Beaubien, A. / Beaulieu, A. / Becker, J. / Behera, P. K. / Bennett, J. V. / Bernieri, E. / Bernlochner, F. U. / Bertemes, M. / Bertholet, E. / Bessner, M. / Bettarini, S. / Bhardwaj, V. / Bhuyan, B. / Bianchi, F. / Bilka, T.

2022

Abstract: We report a study of $B \to J/\psi(\ell^{+}\ell^{-})K$ decays, where $\ell$ represents an electron or a muon, using $e^{+}e^{-}$ collisions at the $\Upsilon(4S)$ resonance. The data were collected by the Belle II experiment at the SuperKEKB asymmetric- ... ...

Abstract	We report a study of $B \to J/\psi(\ell^{+}\ell^{-})K$ decays, where $\ell$ represents an electron or a muon, using $e^{+}e^{-}$ collisions at the $\Upsilon(4S)$ resonance. The data were collected by the Belle II experiment at the SuperKEKB asymmetric-energy collider during 2019-2021, corresponding to an integrated luminosity of $189$ fb$^{-1}$. The measured quantities are the branching fractions (${\mathcal B}$) of the decay channels $B^{+} \to J/\psi(e^{+}e^{-})K^{+}$, $B^{+} \to J/\psi(\mu^{+}\mu^{-}) K^{+}$, $B^{0} \to J/\psi(e^{+}e^{-}) K^{0}_{S}$, and $B^{0} \to J/\psi(\mu^{+}\mu^{-})K^{0}_{S}$; the lepton-flavor-dependent isospin asymmetries for the electron [$A_{I}\left(B \to J/\psi(e^{+}e^{-}) K\right)$] and muon [$A_{I}\left(B \to J/\psi(\mu^{+} \mu^{-}) K\right)$] channels; and the ratios of branching fractions between the muon and electron channels for the charged [$R_{K^{+}}\left(J/\psi\right)$] and neutral kaon [$R_{K^{0}}\left(J/\psi\right)$] case. The measurements are consistent with the world-average values.
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2022-07-22
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cytostatic Activity of Peptide Extracts of Medicinal Plants on Transformed A549, H1299, and HeLa Cells

Tepkeeva, I. I / Aushev, V. N / Zborovskaya, I. B / Demushkin, V. P

Bulletin of experimental biology and medicine. 2009 Jan., v. 147, no. 1

2009

Abstract	Biological activity of peptide extracts of medicinal plants was studied on transformed non-small-cell lung carcinoma A549 cells, lung cancer H1299 cells, and cervical cancer HeLa cells at various cell densities. Cell survival and proliferation were evaluated 72 h after treatment with extracts in concentrations of 0.05, 0.25, and 0.5 μg/μl. The cytostatic effect was produced by peptide extracts of Camelia sinesis Kuntze, Inonotus obliquus, and a mixture Inula helenium L., Chelidonium majus L., Equisetum arvense L., and Inonotus obliquus. Peptide extracts of Hypericum perforatum L. and Laurus nobilis L. in the same concentrations had no effects on proliferative activity and growth of tumor cells.
Language	English
Dates of publication	2009-01
Size	p. 48-51.
Publisher	Springer US
Publishing place	Boston
Document type	Article
ZDB-ID	390407-6
ISSN	1573-8221 ; 0007-4888 ; 0365-9615
ISSN (online)	1573-8221
ISSN	0007-4888 ; 0365-9615
DOI	10.1007/s10517-009-0452-z
Database	NAL-Catalogue (AGRICOLA)

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Z 83/703: Show issues

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Book ; Online: Tidal variations of O2 Atmospheric and OH(6-2) airglow and temperature at mid-latitudes from SATI observations

López-González, M. J. / Rodríguez, E. / Shepherd, G. G. / Sargoytchev, S. / Shepherd, M. G. / Aushev, V. M. / Brown, S. / García-Comas, M. / Wiens, R. H.

eISSN: 1432-0576

2018

Abstract: Airglow observations with a Spectral Airglow Temperature Imager (SATI), installed at the Sierra Nevada Observatory (37.06° N, 3.38° W) at 2900-m height, have been used to investigate the presence of tidal variations at mid-latitudes in the mesosphere/ ... ...

Abstract	Airglow observations with a Spectral Airglow Temperature Imager (SATI), installed at the Sierra Nevada Observatory (37.06° N, 3.38° W) at 2900-m height, have been used to investigate the presence of tidal variations at mid-latitudes in the mesosphere/lower thermosphere region. Diurnal variations of the column emission rate and vertically averaged temperature of the O 2 Atmospheric (0-1) band and of the OH Meinel (6-2) band from 5 years (1998-2003) of observations have been analysed. From these observations a clear tidal variation of both emission rates and rotational temperatures is inferred. It is found that the amplitude of the daily variation for both emission rates and temperatures is greater from late autumn to spring than during summer. The amplitude decreases by more than a factor of two during summer and early autumn with respect to the amplitude in the winter-spring months. Although the tidal modulations are preferentially semidiurnal in both rotational temperatures and emission rates during the whole year, during early spring the tidal modulations seem to be more consistent with a diurnal modulation in both rotational temperatures and emission rates. Moreover, the OH emission rate from late autumn to early winter has a pattern suggesting both diurnal and semidiurnal tidal modulations.
Subject code	520 ; 551
Language	English
Publishing date	2018-09-27
Publishing country	de
Document type	Book ; Online
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Article: UK-Russia Researcher Links Workshop: extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 March 2015.

Kapustin, Alexander N / Kalinina, Natalia / Lopatina, Tatiana / Davidson, Sean M / Iraci, Nunzio / Tamkovich, Svetlana / Smyth, Lesley / Ter-Ovanesyan, Dmitry / Evtushenko, Evgeniy G / Savelieva, Olga / Bertazzo, Sergio / Aushev, Vassiliy / Dragovic, Rebecca / Gracia, Tannia / Heck, Margarete / Parfyonova, Yelena V / Shanahan, Catherine M / Tkachuk, Vsevolod

Journal of extracellular vesicles

2015 Volume 4, Page(s) 28094

Language	English
Publishing date	2015-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2683797-3
ISSN	2001-3078
ISSN	2001-3078
DOI	10.3402/jev.v4.28094
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume IV

Abi, B. / Acciarri, R. / Acero, Mario A. / Adamov, G. / Adams, D. / Adinolfi, M. / Ahmad, Z. / Ahmed, J. / Alion, T. / Monsalve, S. Alonso / Alt, C. / Anderson, J. / Andreopoulos, C. / Andrews, M. P. / Andrianala, F. / Andringa, S. / Ankowski, A. / Anthony, J. / Antonova, M. /

Antusch, S. / Fernandez, A. Aranda / Ariga, A. / Arnold, L. O. / Arroyave, M. A. / Asaadi, J. / Aurisano, A. / Aushev, V. / Autiero, D. / Azfar, F. / Back, H. / Back, J. J. / Backhouse, C. / Baesso, P. / Bagby, L. / Bajou, R. / Balasubramanian, S. / Baldi, P. / Bambah, B. / Barao, F. / Barenboim, G. / Barker, G. J. / Barkhouse, W. / Barnes, C. / Barr, G. / Monarca, J. Barranco / Barros, N. / Barrow, J. L. / Bashyal, A. / Basque, V. / Bay, F.

Far Detector Single-phase Technology

2020

Abstract: The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and ... ...

Abstract	The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. Central to achieving DUNE's physics program is a far detector that combines the many tens-of-kiloton fiducial mass necessary for rare event searches with sub-centimeter spatial resolution in its ability to image those events, allowing identification of the physics signatures among the numerous backgrounds. In the single-phase liquid argon time-projection chamber (LArTPC) technology, ionization charges drift horizontally in the liquid argon under the influence of an electric field towards a vertical anode, where they are read out with fine granularity. A photon detection system supplements the TPC, directly enhancing physics capabilities for all three DUNE physics drivers and opening up prospects for further physics explorations. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume IV presents an overview of the basic operating principles of a single-phase LArTPC, followed by a description of the DUNE implementation. Each of the subsystems is described in detail, connecting the high-level design requirements and decisions to the overriding physics goals of DUNE. Comment: Minor corrections made for JINST submission, 673 pages, 312 figures (corrected errors in author list)
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	910
Publishing date	2020-02-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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