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Article ; Online: Perceived advantages and disadvantages of substance use in a dual diagnosis population with severe mental disorders and severe substance use disorder. Considering the self-medication hypothesis.

Düring, Signe Wegmann / Austin, Stephen Fitzgerald / Mårtensson, Solvej / Johansen, Katrine Schepelern

2024 , Page(s) 1–9

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1104974-1
ISSN	1502-4725 ; 0803-9488 ; 0029-1455
ISSN (online)	1502-4725
ISSN	0803-9488 ; 0029-1455
DOI	10.1080/08039488.2024.2318649
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Article ; Online: Promoting well-being in psychosis.

Austin, Stephen Fitzgerald

Nordic journal of psychiatry

2018 Volume 72, Issue 6, Page(s) 437–441

Abstract: Background: Traditionally, treatment of psychosis has focused on the amelioration of psychopathology and return to adequate functioning: clinical recovery although there is growing recognition of the importance of subjective experiences associated with ... ...

Abstract	Background: Traditionally, treatment of psychosis has focused on the amelioration of psychopathology and return to adequate functioning: clinical recovery although there is growing recognition of the importance of subjective experiences associated with recovery: personal recovery. Positive psychiatry extends the focus of psychiatric treatment to go beyond the reduction of psychiatric symptoms and and improvement of functional disability to promote the attainment of well-being. Aim: This article examined the conceptualization of well-being from the context of treatment for psychosis, its relationship with clinical recovery and highlighted some of challenges and implications for mental health services in promoting well-being. Discussion: Recovery from psychosis is a complex and individual process, where well-being is more than just the absence of mental illness. Clinical and personal recovery processes may contribute to well-being although further longitudinal studies are required. A recent framework for understanding well-being in psychosis helps address the lack of consensus in this field. There is a considerable overlap between the indicators of well-being in this model and the CHIME framework for personal recovery. Thus, interventions targeting personal recovery processes may be a potential way to promote well-being. Current mental health services face a considerable challenge if they are to fulfill the dual role of reducing psychopathology and/or disability whilst concurrently addressing personal recovery to promote well-being. The attainment of well-being may not only be a desirable treatment goal in recovery-orientated mental health services but also a potential protective factor against serious mental illness.
MeSH term(s)	Humans ; Mental Health Recovery ; Mental Health Services ; Psychotherapy/methods ; Psychotic Disorders/psychology ; Psychotic Disorders/therapy ; Quality of Life
Language	English
Publishing date	2018-07-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1104974-1
ISSN	1502-4725 ; 0803-9488 ; 0029-1455
ISSN (online)	1502-4725
ISSN	0803-9488 ; 0029-1455
DOI	10.1080/08039488.2018.1492016
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Article ; Online: Non-prescribing of clozapine for outpatients with schizophrenia in real-world settings: The clinicians' perspectives.

Jakobsen, Michelle Iris / Austin, Stephen Fitzgerald / Storebø, Ole Jakob / Nielsen, Jimmi / Simonsen, Erik

Schizophrenia (Heidelberg, Germany)

2023 Volume 9, Issue 1, Page(s) 91

Abstract: Clozapine is the gold standard for treating treatment-resistant schizophrenia although continuously underutilized. Previous surveys of clinicians have found that some of the most frequently cited barriers to clozapine prescribing are related to the blood- ...

Abstract	Clozapine is the gold standard for treating treatment-resistant schizophrenia although continuously underutilized. Previous surveys of clinicians have found that some of the most frequently cited barriers to clozapine prescribing are related to the blood-monitoring requirements. However, these surveys tend to explore general perspectives and may not reflect the true impact of different barriers in real-world outpatient settings. This study aimed to explore this issue. First, by surveying the clinicians responsible for the treatment of 39 clozapine-eligible, yet clozapine-naive, outpatients with schizophrenia. Then, based on the survey results, explanatory interviews with the participating psychiatrists were conducted and analyzed thematically. The most frequently cited reason for non-prescribing of clozapine was the expected non-compliance with blood-monitoring requirements; however, overall stability and/or severe mental illness was chosen as the most important reason in most patient-cases. The qualitative analysis highlighted the combined impact of standard clinical practice, personal experiences, and organizational constraints on clozapine utility.
Language	English
Publishing date	2023-12-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	3133210-9
ISSN	2754-6993 ; 2754-6993
ISSN (online)	2754-6993
ISSN	2754-6993
DOI	10.1038/s41537-023-00423-3
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Article ; Online: Trauma exposure and diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) posttraumatic stress disorder among Danish adults: Implications of narrow and broad operationalizations of criterion A.

Vang, Maria Louison / Elklit, Ask / Simonsen, Sebastian / Austin, Stephen Fitzgerald / Møller, Stine Bjerrum

Psychological trauma : theory, research, practice and policy

2023

Abstract: Objective: Posttraumatic stress disorder (PTSD) has long been recognized as a debilitating psychiatric disorder. The definition of Criterion A has been a topic of controversy, and : Method: The study was based on a cross-sectional survey conducted in ...

Abstract	Objective: Posttraumatic stress disorder (PTSD) has long been recognized as a debilitating psychiatric disorder. The definition of Criterion A has been a topic of controversy, and Method: The study was based on a cross-sectional survey conducted in March 2021 among the general population of adult Danish residents in Denmark, ranging in age between 18 and 79 years ( Results: Psychologically threatening events did not lead to a statistically significant increase in probable PTSD diagnoses, but psychologically threatening events were independently related to probable PTSD risk and severity. Controlling for other potentially traumatizing events and demographic factors, psychologically threatening events were the strongest risk factor for higher symptom severity. We found probable PTSD rates higher but comparable to other Scandinavian countries such as Norway and Sweden. Conclusion: Exposure to psychologically threatening events is an important factor in explaining probable PTSD risk and severity although not independently leading to a significant increase in probable PTSD rates. Probable rates of
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001589
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Article ; Online: Psychosocial interventions promoting personal recovery in people with schizophrenia: a scoping review protocol.

Quistgaard, Maria / Myklebust, Oda Leonarda Pollestad / Aure, Thomas / Austin, Stephen Fitzgerald / Berring, Lene Lauge / Vernal, Ditte Lammers / Storebø, Ole Jakob

BMJ open

2023 Volume 13, Issue 12, Page(s) e073901

Abstract: Introduction: Personal recovery is an important aspect for many individuals diagnosed with schizophrenia, as people can live rich, fulfilling lives despite ongoing symptoms. Prior reviews have found several factors to be associated with personal ... ...

Abstract	Introduction: Personal recovery is an important aspect for many individuals diagnosed with schizophrenia, as people can live rich, fulfilling lives despite ongoing symptoms. Prior reviews have found several factors to be associated with personal recovery, but a comprehensive overview of the psychosocial interventions aimed at improving personal recovery in schizophrenia is needed. Methods and analysis: Key terms relating to personal recovery and psychosocial interventions to promote personal recovery will be searched for in the following databases: PubMed, EMBASE, PsycINFO, CINAHL, MEDLINE, Google Scholar, Web of Science Core Collection and Cochrane. Additionally, a simple search for grey literature will be conducted in The Networked Digital Library of Theses and Dissertations. Two reviewers will individually screen and extract the data, and the selection of sources will be documented in a Preferred Reporting Items for Systematic reviews and Meta-Analyses flow chart. A content analysis will be conducted on the data, and the findings will be presented in tables, and narratively synthesised. Lastly, research gaps will be identified, and recommendations for future research will be proposed. Ethics and dissemination: Ethics approval was not required for the development or publishing of this protocol. Findings will be disseminated through conferences, meeting with patient organisations and consumers, and published in a peer-reviewed scientific journal.
MeSH term(s)	Humans ; Schizophrenia/therapy ; Psychosocial Intervention ; Research Design ; Systematic Reviews as Topic
Language	English
Publishing date	2023-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-073901
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Article ; Online: Social Processes of Young Adults' Recovery and Identity Formation during Life-Disruptive Mental Distress-A Meta-Ethnography.

Storm, Ida Marie Skou / Mikkelsen, Anne Kathrine Kousgaard / Holen, Mari / Hybholt, Lisbeth / Austin, Stephen Fitzgerald / Berring, Lene Lauge

International journal of environmental research and public health

2023 Volume 20, Issue 17

Abstract: Young people's mental health recovery is well-explored in empirical research, yet there is a lack of meta-studies synthesizing the characteristics of young people's recovery. This meta-ethnography explores young adults' recovery during life-disruptive ... ...

Abstract	Young people's mental health recovery is well-explored in empirical research, yet there is a lack of meta-studies synthesizing the characteristics of young people's recovery. This meta-ethnography explores young adults' recovery during life-disruptive experiences of early psychosis or schizophrenia. Based on a systematic literature review search, 11 empirical qualitative studies were included for synthesis. Inspired by young people's prominent experience of social isolation in the included studies, we applied an interpretive lens of belonging deriving from the sociology of youth. The synthesis presents five themes: (1) expectations of progression in youth in contrast with stagnation during psychosis, (2) feeling isolated, lost and left behind, (3) young adults' recovery involves belonging with other young people, (4) forming identity positions of growth and disability during psychosis, and the summarizing line of argument, (5) navigating relational complexities in the process of recovery. While suffering from social isolation, young people's recovery is conceived as getting on with life, like any other young person involving connecting and synchronizing life rhythms with their age peers. Socializing primarily with caring adults entails being stuck in the position of a child, while connecting with young people enables the identity positions of young people. This synthesis can inspire support for young people's recovery through social inclusion in youth environments.
MeSH term(s)	Adolescent ; Child ; Humans ; Young Adult ; Anthropology, Cultural ; Dissent and Disputes ; Emotions ; Psychotic Disorders ; Qualitative Research
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20176653
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Article ; Online: Patients' and psychiatrists' perspectives on clozapine treatment-a scoping review protocol.

Jakobsen, Michelle Iris / Storebø, Ole Jakob / Austin, Stephen Fitzgerald / Nielsen, Jimmi / Simonsen, Erik

BMJ open

2021 Volume 11, Issue 10, Page(s) e054308

Abstract: Introduction: The atypical antipsychotic clozapine has shown superior efficacy compared with other antipsychotics and is the gold standard for treating otherwise treatment resistant schizophrenia. However, multiple studies have found that clozapine is ... ...

Abstract	Introduction: The atypical antipsychotic clozapine has shown superior efficacy compared with other antipsychotics and is the gold standard for treating otherwise treatment resistant schizophrenia. However, multiple studies have found that clozapine is underutilised in most parts of the world. A few reviews of literature addressing barriers to clozapine prescribing have been conducted. While there is some variation in the literature included in these reviews, a common feature of the studies included is that they primarily focus on clinical staff's attitudes and perceived barriers for prescribing. Studies of patient perspectives are only sparsely included. A preliminary literature search revealed though, that additional literature on the subject exists, including literature on patient perspectives. It is therefore difficult to conclude if the formerly synthesised literature is representative of current evidence or if the topic has been adequately investigated to inform clinical practice. A scoping review is warranted in order to map and synthesise primary literature on patients' and psychiatrists' perspectives on clozapine treatment, and to identify gaps for future research. Methods and analysis: The electronic databases Cochrane Library, CINAHL, Web of Science, Psychinfo, MEDLINE and EMBASE will be searched for relevant publications, supplied with searches of Google scholar, The Networked Digital Library of Theses and Dissertations and OpenGrey. Citation tracking of selected studies will furthermore be undertaken. Two researchers will independently screen and extract data. Data will be collated to provide a descriptive summary of the literature, along with a qualitative content analysis of key findings. Identified gaps in research will be accompanied by recommendations for future investigations. Ethics and dissemination: Findings will be disseminated through a peer-reviewed journal and conference presentations. The scoping review does not require ethics approval.
MeSH term(s)	Clozapine/therapeutic use ; Delivery of Health Care ; Humans ; Peer Review ; Psychiatry ; Research Design ; Review Literature as Topic
Chemical Substances	Clozapine (J60AR2IKIC)
Language	English
Publishing date	2021-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-054308
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Article ; Online: Patient reported outcome measures (PROMs): examination of the psychometric properties of two measures for burden of symptoms and quality of life in patients with depression or anxiety.

Bech, Per / Austin, Stephen Fitzgerald / Lau, Marianne Engelbrecht

Nordic journal of psychiatry

2018 Volume 72, Issue 4, Page(s) 251–258

Abstract: Introduction: Patient-reported outcome measures (PROMs) for anxiety and depressive disorders are an important aspect of measurement-based care.: Aim: The aim of the study was to perform a clinimetric analysis of two PROMs scales in patents with ... ...

Abstract	Introduction: Patient-reported outcome measures (PROMs) for anxiety and depressive disorders are an important aspect of measurement-based care. Aim: The aim of the study was to perform a clinimetric analysis of two PROMs scales in patents with depression and anxiety. Methods: Patients completed a 10-item version (SCL-10) of the Symptom Checklist to measure burden of symptoms and a brief 5-item version of World Health Organization Well-being scale (WHO-5) to measure quality of life. T-scores were used to standardize the SCL-10 and WHO-5 in terms of being in need of treatment. The coefficient of alpha and the coefficient of homogeneity were used to evaluate the internal consistency or scalability respectively of SCL-10 and WHO-5. Effect size statistics and Spearman correlation coefficients were used to measure the effect of gender and age, respectively. Results: A total of 801 patients were recruited from two Danish mental health centers with anxiety or depression. The standardization of the SCL-10 and WHO-5 by T-scores indicated that a T-score of 65 corresponding to being moderately in need of treatment and a T-score of 75 to be severely in need of treatment. The coefficient of alpha and the coefficient of homogeneity were both found acceptable for SCL-10 and WHO-5. No gender or age factors were found being in operation. Conclusion: The results from the current study supported the use of the SCL-10 and WHO-5 as potential PROMs to capture symptom burden and quality of life within groups of people with anxiety or depression undergoing psychotherapy treatment.
MeSH term(s)	Adult ; Anxiety Disorders/therapy ; Cost of Illness ; Depressive Disorder/therapy ; Female ; Humans ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Psychometrics/instrumentation ; Psychometrics/standards ; Quality of Life
Language	English
Publishing date	2018-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1104974-1
ISSN	1502-4725 ; 0803-9488 ; 0029-1455
ISSN (online)	1502-4725
ISSN	0803-9488 ; 0029-1455
DOI	10.1080/08039488.2018.1451918
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Article ; Online: IMPACHS: Feasibility and acceptability of an m-health solution integrated into routine clinical treatment for psychosis.

von Malachowski, Alissa / Schlier, Björn / Austin, Stephen Fitzgerald / Frost, Mads / Frøsig, Anna Julie / Heinzle, Marlene / Holzapfel, Hartwig / Lipps, Anja / Simonsen, Erik / Lincoln, Tania M

Schizophrenia research

2022 Volume 240, Page(s) 150–152

MeSH term(s)	Cognitive Behavioral Therapy ; Feasibility Studies ; Humans ; Psychotic Disorders/therapy ; Telemedicine
Language	English
Publishing date	2022-01-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2021.12.011
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Article: Validity of the BPRS, the BDI and the BAI in dual diagnosis patients.

Lykke, Jørn / Hesse, Morten / Austin, Stephen Fitzgerald / Oestrich, Irene

Addictive behaviors

2008 Volume 33, Issue 2, Page(s) 292–300

Abstract: Aim: The psychometric properties of the Brief Psychiatric Rating Scale, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory (BDI) were tested in a sample of 134 patients with a substance use disorder and a non-substance related ... ...

Abstract	Aim: The psychometric properties of the Brief Psychiatric Rating Scale, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory (BDI) were tested in a sample of 134 patients with a substance use disorder and a non-substance related psychiatric disorder in a special inpatient dual diagnosis treatment unit. Methods: Subjects were assessed at baseline. At discharge on average 6 months post-intake, 78% of patients were re-assessed using the same instruments. All instruments were tested in (1) their ability to discriminate patients with different diagnoses at baseline and follow-up using comparison of area under the curves, and (2) their temporal stability. Moderator regression was used to test whether thought disorder at baseline had any effect on the test-retest rank-order stability of other instruments. Findings: The BPRS Thought Disorder scale was able to discriminate between patients with and without schizophrenia spectrum diagnoses, and the BDI was able to discriminate between patients with and without mood disorders and schizoaffective disorders at intake to treatment, and each instrument was significantly better than the other at discriminating relevant diagnostic groups. Discriminant correlations between the BDI and the BAI were high and statistically significant. Moderator regression analyses showed no indication that any of the scales were less stable at higher levels of thought disorder. Conclusions: It is concluded that dual diagnosis patients can be reliably assessed for symptoms using the BDI and some subscales of the BPRS.
MeSH term(s)	Adult ; Aged ; Brief Psychiatric Rating Scale ; Diagnosis, Differential ; Diagnosis, Dual (Psychiatry) ; Female ; Hospitalization ; Humans ; Male ; Mental Disorders/diagnosis ; Middle Aged ; Mood Disorders/diagnosis ; Psychiatric Status Rating Scales ; Psychometrics ; Psychotic Disorders/diagnosis ; Substance-Related Disorders/diagnosis
Language	English
Publishing date	2008-02
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	197618-7
ISSN	1873-6327 ; 0306-4603
ISSN (online)	1873-6327
ISSN	0306-4603
DOI	10.1016/j.addbeh.2007.09.020
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