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Book ; Online ; Conference proceedings: Silicon Valley Cybersecurity Conference

Bathen, Luis / Saldamli, Gokay / Sun, Xiaoyan / Austin, Thomas H / Nelson, Alex J

Third Conference, SVCC 2022, Virtual Event, August 17-19, 2022, Revised Selected Papers

(Communications in Computer and Information Science)

2022

Series title	Communications in Computer and Information Science
Keywords	Computer security ; Computer vision ; Artificial intelligence ; Computer networking & communications ; artificial intelligence ; blockchain ; classification ; computer crime ; computer networks ; computer security ; computer systems ; computer vision ; cryptography ; data communication systems ; data security ; distributed computer systems ; distributed ledger ; image analysis ; intrusion detection ; machine learning ; network protocols ; network security ; parallel processing systems ; query languages
Language	English
Size	1 electronic resource (137 pages)
Publisher	Springer Nature
Publishing place	Cham
Document type	Book ; Online ; Conference proceedings
Note	English
HBZ-ID	HT030375756
ISBN	9783031240492 ; 3031240499
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; Conference proceedings: Silicon Valley Cybersecurity Conference

Bathen, Luis / Saldamli, Gokay / Sun, Xiaoyan / Austin, Thomas H. / Nelson, Alex J.

Third Conference, SVCC 2022, Virtual Event, August 17–19, 2022, Revised Selected Papers

(Communications in Computer and Information Science ; 1683)

2022

Author's details	edited by Luis Bathen, Gokay Saldamli, Xiaoyan Sun, Thomas H. Austin, Alex J. Nelson
Series title	Communications in Computer and Information Science ; 1683
Keywords	Data protection ; Image processing—Digital techniques ; Computer vision ; Artificial intelligence ; Computer engineering ; Computer networks
Subject code	005.8
Language	English
Size	1 Online-Ressource (IX, 137 p. 64 illus., 53 illus. in color)
Edition	1st ed. 2022
Publisher	Springer Nature Switzerland ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; Conference proceedings
HBZ-ID	HT021711719
ISBN	978-3-031-24049-2 ; 9783031240485 ; 9783031240508 ; 3-031-24049-9 ; 3031240480 ; 3031240502
DOI	10.1007/978-3-031-24049-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Auditory robustness and resilience in the aging auditory system of the desert locust.

Austin, Thomas T / Thomas, Christian L / Warren, Ben

Neurobiology of aging

2023 Volume 133, Page(s) 39–50

Abstract: After overexposure to loud music, we experience a decrease in our ability to hear (robustness), which usually recovers (resilience). Here, we exploited the amenable auditory system of the desert locust, Schistocerca gregaria, to measure how robustness ... ...

Abstract	After overexposure to loud music, we experience a decrease in our ability to hear (robustness), which usually recovers (resilience). Here, we exploited the amenable auditory system of the desert locust, Schistocerca gregaria, to measure how robustness and resilience depend on age. We found that gene expression changes are dominated by age as opposed to noise exposure. We measured sound-evoked nerve activity for young and aged locusts directly, after 24 hours and 48 hours after noise exposure. We found that both young and aged locusts recovered their auditory nerve function over 48 hours. We also measured the sound-evoked transduction current in individual auditory neurons, and although the transduction current magnitude recovered in the young locusts after noise exposure, it failed to recover in the aged locusts. A plastic mechanism compensates for the decreased transduction current in aged locusts. We suggest key genes upregulated in young noise-exposed locusts that mediate robustness to noise exposure and find potential candidates responsible for compensatory mechanisms in the auditory neurons of aged noise-exposed locusts.
MeSH term(s)	Animals ; Grasshoppers/genetics ; Hearing ; Cochlear Nerve ; Noise ; Aging/genetics
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2023.09.009
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Sesquiterpene Induction by the Balsam Woolly Adelgid ( Adelges piceae ) in Putatively Resistant Fraser Fir ( Abies fraseri )

Austin Thomas / David C. Tilotta / John Frampton / Robert M. Jetton

Forests, Vol 13, Iss 716, p

2022 Volume 716

Abstract: Fraser fir, Abies fraseri (Pursh) Poir., is a tree endemic to the Southern Appalachians and is found only in a few isolated populations at high elevations. Fraser firs are also cultivated on a commercial scale as Christmas trees. The species is imperiled ...

Abstract	Fraser fir, Abies fraseri (Pursh) Poir., is a tree endemic to the Southern Appalachians and is found only in a few isolated populations at high elevations. Fraser firs are also cultivated on a commercial scale as Christmas trees. The species is imperiled by an introduced insect, the balsam woolly adelgid, Adelges piceae Ratzeburg (BWA). The insect severely damages Christmas tree crops and has caused substantial Fraser fir mortality in natural stands. Foliar terpenoids are one mechanism of host plant defense against invading insects and may be one focus of future Christmas tree breeding efforts. This study examines the correlation of foliar terpenoids with Fraser fir performance when infested with BWA. GC-MS and GC-FID analysis of artificially infested Fraser fir foliage reveals that increased concentrations of four terpenoid compounds are associated with BWA infestations. Foliar concentrations of two sesquiterpenes, camphene and humulene, are significantly higher in putatively resistant Fraser fir clones than in more susceptible clones after sustained adelgid feeding for a period of 20 weeks. Although it is unclear if the induction of these sesquiterpenes in the host fir is directly contributing to adelgid resistance, these compounds could serve as effective indicators while screening for BWA resistance in future Christmas tree breeding programs.
Keywords	Fraser fir ; Abies fraseri ; balsam woolly adelgid ; Adelges piceae ; terpenoids ; resistance ; Plant ecology ; QK900-989
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Post-operative steroids in patients with patients with severe cerebral palsy undergoing posterior spinal fusion.

Ruska, Tracy / Austin, Thomas M / Bruce, Robert W / Fletcher, Nicholas D

Spine deformity

2022 Volume 11, Issue 2, Page(s) 415–422

Abstract: Introduction: Posterior spinal fusion (PSF) represents a large physiologic challenge for children with neuromuscular scoliosis (NMS). Perioperative complications are numerous with many occurring in the post-operative period due to pain and relative ... ...

Abstract	Introduction: Posterior spinal fusion (PSF) represents a large physiologic challenge for children with neuromuscular scoliosis (NMS). Perioperative complications are numerous with many occurring in the post-operative period due to pain and relative immobilization. This study assessed the impact of steroids on patients undergoing PSF for NMS. Methods: A retrospective review of consecutive patients managed at a single center with PSF for NMS was reviewed. Clinical and radiographic analysis was used to evaluate baseline demographics, curve characteristics, and post-operative course. Results: Eighty-nine patients who underwent PSF for NMS were included. Fifty-seven of these patients did not receive post-operative steroids (NS) while 32 patients were treated with post-operative steroids (dexamethasone, WS) for a median of 3 doses (median 6.0 mg/dose every 8 h after surgery). The demographic variables of the cohorts were similar with no difference in curve magnitude, number of vertebrae fused, number of osteotomies, or EBL between groups. A 70% decrease in the median post-operative morphine equivalents was observed in the steroid cohort (0.50 mg/kg WS vs 1.65 mg/kg NS, p value < 0.001). There was an association between post-operative morphine equivalents and length of stay (Spearman's rho = 0.22, p value = 0.04). There was no difference in wound healing, infection, and pulmonary or gastrointestinal complications between groups. No difference was found in pain at discharge, 30-day ED returns, or 30-day OR returns between groups. Conclusions: Post-operative dexamethasone resulted in a 70% decrease in morphine equivalent use after PSF for NMS without any increase in perioperative wound infections. Level of evidence: Level 3: case-control series.
MeSH term(s)	Child ; Humans ; Cerebral Palsy/complications ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Scoliosis/complications ; Neuromuscular Diseases/complications ; Pain/etiology ; Dexamethasone/therapeutic use ; Morphine Derivatives
Chemical Substances	Dexamethasone (7S5I7G3JQL) ; Morphine Derivatives
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-022-00603-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Gastric ultrasound to assess gastric volume for 1-h NPO times.

McLaughlin, Chris / Austin, Thomas / Gilbertson, Laura / Karlik, Joelle

Paediatric anaesthesia

2022 Volume 32, Issue 5, Page(s) 685–686

MeSH term(s)	Fasting ; Humans ; Stomach/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2022-02-15
Publishing country	France
Document type	Journal Article
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.14409
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3306: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: The Incidence of Residual Neuromuscular Block in Pediatrics: A Prospective, Pragmatic, Multi-institutional Cohort Study.

Faulk, Debra J / Karlik, Joelle B / Strupp, Kim M / Tran, Stephanie M / Twite, Mark / Brull, Sorin J / Yaster, Myron / Austin, Thomas M

Cureus

2024 Volume 16, Issue 3, Page(s) e56408

Abstract: Introduction Residual neuromuscular block, defined as a quantitatively measured train-of-four ratio (TOFr) <0.9, is common postoperatively. Using a pragmatic trial design, we hypothesized that qualitative and/or clinical assessment of neuromuscular block ...

Abstract	Introduction Residual neuromuscular block, defined as a quantitatively measured train-of-four ratio (TOFr) <0.9, is common postoperatively. Using a pragmatic trial design, we hypothesized that qualitative and/or clinical assessment of neuromuscular block would inadequately detect residual block following antagonism with neostigmine or sugammadex. Method After IRB approval and written informed consent, 74 children (aged 2-17 years), undergoing elective surgery and receiving rocuronium, were prospectively enrolled in the study at Children's Hospital Colorado and Children's Healthcare of Atlanta. Routine clinical practice at both institutions consisted of clinical signs and/or qualitative assessment with peripheral nerve stimulators. Children at the Colorado hospital routinely received sugammadex antagonism; whereas children at the Atlanta hospital received neostigmine. Residual neuromuscular block was assessed postoperatively using quantitative electromyography. If TOFr was <0.9, patients received sugammadex until TOFr ≥0.9. Result Qualitative and clinical assessment failed to detect residual block in 29.7% of patients in the neostigmine reversal cohort (adjusted odds ratio (aOR) 29.8, 95% confidence interval (CI): 2.7 to 5,559.5, p-value = 0.002). No residual block was detected in the sugammadex reversal cohort. A correlation between increasing patient weight and incidence of postoperative residual block was observed in the neostigmine cohort (aOR 1.05, 95% CI: 1.02 to 1.10, p-value = 0.002). Conclusion Qualitative and/or clinical assessment of neuromuscular block inadequately detects residual block following neostigmine antagonism.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56408
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metabolic decline in an insect ear: correlative or causative for age-related auditory decline?

Austin, Thomas T / Thomas, Christian L / Lewis, Clifton / Blockley, Alix / Warren, Ben

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1138392

Abstract: One leading hypothesis for why we lose our hearing as we age is a decrease in ear metabolism. However, direct measurements of metabolism across a lifespan in any auditory system are lacking. Even if metabolism does decrease with age, a question remains: ... ...

Abstract	One leading hypothesis for why we lose our hearing as we age is a decrease in ear metabolism. However, direct measurements of metabolism across a lifespan in any auditory system are lacking. Even if metabolism does decrease with age, a question remains: is a metabolic decrease a cause of age-related auditory decline or simply correlative? We use an insect, the desert locust
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1138392
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Single-Center Retrospective Review of Patients with Suspected Malignant Hyperthermia Susceptibility.

Edwards, Chris / Dooley, Fred C / Gonzalez, Sandra / Austin, Thomas M / Gravenstein, Nikolaus

Cureus

2023 Volume 15, Issue 9, Page(s) e44661

Abstract: Purpose The diagnosis of malignant hyperthermia susceptibility (MHS) has significant implications for the perioperative period that may persist for generations. Anesthetic medication options are reduced, anesthetic workstations require preparation to ... ...

Abstract	Purpose The diagnosis of malignant hyperthermia susceptibility (MHS) has significant implications for the perioperative period that may persist for generations. Anesthetic medication options are reduced, anesthetic workstations require preparation to reduce exposure to inhaled volatile anesthetics, and patients may be excluded from surgery at ambulatory centers. In this study, we sought to better characterize the etiology of MHS diagnoses in our health system and the downstream effects of this diagnosis on anesthetic care. Methods We retrospectively reviewed the electronic medical records of 55 patients with a documented concern for MHS who received care at University of Florida (UF) Health between 2014 and 2020. We characterized the etiology of the patient's MHS diagnosis, whether this diagnosis was supported by formal genetic or muscle contracture testing, and the details of the recorded anesthetics that were delivered to these patients. Results The 55 patients with suspected MHS were evenly split between those with a family history of malignant hyperthermia (MH) (28/55) and those with a concern for MHS in their personal medical history (27/55). Of the 28 patients with a family history of MH, 16 reported that the affected family member was a first-degree relative, and two of these 16 reported that the affected family member had undergone confirmatory muscle contracture testing. Of the 27 patients with a personal history suspicious for MHS, two had undergone confirmatory genetic testing, and two patients had anesthetic records available for review where intraoperative MH was suspected and treated with dantrolene. An additional four patients were told of a concern about MHS due to another underlying diagnosis. No patients with a personal history suspicious of MHS had undergone confirmatory muscle contracture testing. These 55 patients underwent 87 anesthetics, and exclusively non-triggering anesthetic techniques were utilized in nearly all cases. In pediatric patients, some perioperative challenges were identified, related to the avoidance of mask inhalational induction. Only six of these 87 anesthetics occurred at our ambulatory surgery centers, a proportion (6.9%) lower than that of the general surgical population at UF Health (20.0%). Conclusions Among patients suspected to be MH susceptible in our health system over a six-year period, a minority (8/55) were supported by clear records of a prior MH event, confirmatory genetic or muscle contracture testing, or an underlying diagnosis closely linked to MH. The vast majority had limited documentation supporting their MH risk but continued to be treated with non-triggering anesthetics and were less likely to have surgery at an ambulatory surgery center than our overall surgical population. Among pediatric patients, some anesthetic challenges related to delivering non-triggering anesthetics were identified. Improving the documentation of index cases of MH and increasing referrals to clinical geneticists and genetic testing may be a viable route to decreasing the proportion of suspected MHS patients with a poorly characterized risk profile.
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44661
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Article: Optimizing Pediatric Mask Induction Fresh Gas Flow.

Edwards, Christopher M / Rahn, Nicholas / El Ayadi, Hamza / Hendricks, Christina / Austin, Thomas M / Gravenstein, Nikolaus

Cureus

2023 Volume 15, Issue 3, Page(s) e36207

Abstract: Introduction: The environmental impact of inhaled anesthetics is a subject of increasing research. However, little attention has been paid to optimizing high-concentration volatile anesthetics during the inhalational (mask) inductions that begin most ... ...

Abstract	Introduction: The environmental impact of inhaled anesthetics is a subject of increasing research. However, little attention has been paid to optimizing high-concentration volatile anesthetics during the inhalational (mask) inductions that begin most pediatric anesthetics. Methods: The performance of the GE Datex Ohmeda TEC 7 sevoflurane vaporizer was analyzed at different fresh gas flow (FGF) rates and two clinically relevant ambient temperatures. We found that an FGF rate of 5 liters per minute (LPM) is likely optimal for inhalational inductions, rapidly achieving dialed sevoflurane concentrations at the elbow of an unprimed pediatric breathing circuit while minimizing waste associated with higher FGF rates. We began educating our department regarding these findings, first with QR code labels on anesthetic workstations, then with targeted e-mails to pediatric anesthesia teams. We analyzed peak induction FGF in 100 consecutive mask inductions at our ambulatory surgery center at three different periods - baseline, post-labels, and post-emails - to assess the efficacy of these educational interventions. We also analyzed the time from induction to the start of myringotomy tube placement in a subset of these cases to determine if reducing mask induction FGF was associated with any change in the speed of induction. Results: Our institution's median peak FGF during inhalational inductions decreased from 9.2 LPM at baseline to 8.0 LPM after labels were placed on anesthetic workstations to 4.9 LPM after targeted e-mails. There was no associated decrease in the speed of induction. Conclusion: Total fresh gas flow can be limited to 5 LPM during pediatric inhalational inductions, decreasing anesthetic waste and environmental impact without slowing the speed of induction. Educational labels on anesthetic workstations and direct e-mails to clinicians were effectively used in our department to enact change in this practice.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36207
Database	MEDical Literature Analysis and Retrieval System OnLINE

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