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Article: TTF1 Expression in Pulmonary Metastatic Rectal Adenocarcinoma.

Aversa, Sara / Bellan, Cristiana

Case reports in gastrointestinal medicine

2018 Volume 2018, Page(s) 6405125

Abstract: Thyroid transcription factor (TTF-1) is a tissue-specific nuclear transcription factor expressed developing thyroid, respiratory epithelium, and diencephalon. TTF-1 is thought to be expressed specifically in most thyroid tumors and in a significant ... ...

Abstract	Thyroid transcription factor (TTF-1) is a tissue-specific nuclear transcription factor expressed developing thyroid, respiratory epithelium, and diencephalon. TTF-1 is thought to be expressed specifically in most thyroid tumors and in a significant subset of pulmonary neoplasms. However, recent studies on its expression in extrapulmonary carcinomas have demonstrated that TTF-1 is not as specific for lung and thyroid carcinomas as was previously thought: positivity of this marker can be observed, although much less frequently, in some carcinomas arising in other organs, such as the ovaries, endometrium, colon, and breast, as well as in some tumors of the central nervous system. Case reports of patients with TTF-1-positive colon adenocarcinoma are present in medical literature, but there are only a few cases of TTF-1-positive rectal adenocarcinoma. We present the case of a patient with rectal adenocarcinoma with lung metastasis found to be TTF-1-positive on immunohistochemistry. A review of the available literature is also included.
Language	English
Publishing date	2018-12-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627636-7
ISSN	2090-6536 ; 2090-6528
ISSN (online)	2090-6536
ISSN	2090-6528
DOI	10.1155/2018/6405125
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Article ; Online: [

Filippi, Luca / Proietti, Ilaria / Petrozza, Vincenzo / Aversa, Sara / Fiorentino, Francesco / Potenza, Concetta / Bagni, Oreste / Schillaci, Orazio / Cantonetti, Maria

Cancer biotherapy & radiopharmaceuticals

2023 Volume 38, Issue 4, Page(s) 268–272

Abstract: A 73-year-old female patient, affected by mycosis fungoides (MF), discontinued mogamulizumab, after initial clinical benefit, due to the onset of generalized erythema. Follow-up positron emission computed tomography (PET/CTs) carried out at 3 weeks and 6 ...

Abstract	A 73-year-old female patient, affected by mycosis fungoides (MF), discontinued mogamulizumab, after initial clinical benefit, due to the onset of generalized erythema. Follow-up positron emission computed tomography (PET/CTs) carried out at 3 weeks and 6 months after therapy discontinuation showed, with respect to baseline PET/CT scan, a progressively increasing number of hypermetabolic enlarged lymph nodes suspected for a neoplastic involvement, but with histology indicative of an inflammatory reaction. After sequential therapy with corticosteroids and methotrexate, a complete remission was registered at
MeSH term(s)	Female ; Humans ; Aged ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Radiopharmaceuticals ; Positron-Emission Tomography/methods ; Mycosis Fungoides/diagnostic imaging ; Mycosis Fungoides/drug therapy ; Skin Neoplasms/diagnostic imaging ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; mogamulizumab (YI437801BE) ; Radiopharmaceuticals
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1315649-4
ISSN	1557-8852 ; 1084-9785
ISSN (online)	1557-8852
ISSN	1084-9785
DOI	10.1089/cbr.2022.0086
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Article: Chronic myeloproliferative neoplasms with concomitant

Frontiers in cell and developmental biology

2024 Volume 12, Page(s) 1391078

Abstract: Myeloproliferative neoplasms (MPNs) are subdivided into Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) and Ph-negative MPNs. ...

Abstract	Myeloproliferative neoplasms (MPNs) are subdivided into Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) and Ph-negative MPNs.
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2024.1391078
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Article ; Online: Cortical atrophy in chronic subdural hematoma from ultra-structures to physical properties.

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3400

Abstract: Several theories have tried to elucidate the mechanisms behind the pathophysiology of chronic subdural hematoma (CSDH). However, this process is complex and remains mostly unknown. In this study we performed a retrospective randomised analysis comparing ... ...

Abstract	Several theories have tried to elucidate the mechanisms behind the pathophysiology of chronic subdural hematoma (CSDH). However, this process is complex and remains mostly unknown. In this study we performed a retrospective randomised analysis comparing the cortical atrophy of 190 patients with unilateral CSDH, with 190 healthy controls. To evaluate the extent of cortical atrophy, CT scan images were utilised to develop an index that is the ratio of the maximum diameter sum of 3 cisterns divided by the maximum diameter of the skull at the temporal lobe level. Also, we reported, for the first time, the ultrastructural analyses of the CSDH using a combination of immunohistochemistry methods and transmission electron microscopy techniques. Internal validation was performed to confirm the assessment of the different degrees of cortical atrophy. Relative Cortical Atrophy Index (RCA index) refers to the sum of the maximum diameter of three cisterns (insular cistern, longitudinal cerebral fissure and cerebral sulci greatest) with the temporal bones' greatest internal distance. This index, strongly related to age in healthy controls, is positively correlated to the preoperative and post-operative maximum diameter of hematoma and the midline shift in CSDH patients. On the contrary, it negatively correlates to the Karnofsky Performance Status (KPS). The Area Under the Receiver Operating Characteristics (AUROC) showed that RCA index effectively differentiated cases from controls. Immunohistochemistry analysis showed that the newly formed CD-31 positive microvessels are higher in number than the CD34-positive microvessels in the CSDH inner membrane than in the outer membrane. Ultrastructural observations highlight the presence of a chronic inflammatory state mainly in the CSDH inner membrane. Integrating these results, we have obtained an etiopathogenetic model of CSDH. Cortical atrophy appears to be the triggering factor activating the cascade of transendothelial cellular filtration, inflammation, membrane formation and neovascularisation leading to the CSDH formation.
MeSH term(s)	Humans ; Hematoma, Subdural, Chronic/diagnostic imaging ; Retrospective Studies ; Physical Phenomena ; Filtration ; Neurodegenerative Diseases ; Inflammation ; Atrophy
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30135-8
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Article ; Online: Retinoblastoma Is Characterized by a Cold, CD8+ Cell Poor, PD-L1- Microenvironment, Which Turns Into Hot, CD8+ Cell Rich, PD-L1+ After Chemotherapy.

Miracco, Clelia / Toti, Paolo / Gelmi, Maria Chiara / Aversa, Sara / Baldino, Gennaro / Galluzzi, Paolo / De Francesco, Sonia / Petrelli, Federica / Sorrentino, Ester / Belmonte, Giuseppe / Galimberti, Daniela / Bracco, Sandra / Hadjistilianou, Theodora

Investigative ophthalmology & visual science

2021 Volume 62, Issue 2, Page(s) 6

Abstract: Purpose: To investigate the impact of chemotherapy (CHT) on human retinoblastoma (RB) tumor microenvironment (TME).: Cases and methods: Ninety-four RBs were studied, including 44 primary RBs treated by upfront surgery (Group 1) and 50 primary RBs ... ...

Abstract	Purpose: To investigate the impact of chemotherapy (CHT) on human retinoblastoma (RB) tumor microenvironment (TME). Cases and methods: Ninety-four RBs were studied, including 44 primary RBs treated by upfront surgery (Group 1) and 50 primary RBs enucleated after CHT (CHT), either intra-arterial (IAC; Group 2, 33 cases) or systemic (S-CHT; Group 3, 17 cases). Conventional and multiplexed immunohistochemistry were performed to make quantitative comparisons among the three groups, for the following parameters: tumor-infiltrating inflammatory cells (TI-ICs); programmed cell death protein 1 (PD-1) positive TI-ICs; Ki67 proliferation index; gliosis; PD-1 ligand (PD-L1) protein expression; vessel number. We also correlated these TME factors with the presence of histological high-risk factors (HHRF+) and RB anaplasia grade (AG). Results: After CHT, a decrease in both RB burden and Ki67 positivity was observed. In parallel, most subsets of TI-ICs, PD-1+ TI-ICs, gliosis, and PD-L1 protein expression significantly increased (P < 0.001, P = 0.02, P < 0.001, respectively). Vessel number did not significantly vary. Age, HHRFs+ and AG were significantly different between primary and chemoreduced RBs (P < 0.001, P = 0.006, P = 0.001, respectively) and were correlated with most TME factors. Conclusions: CHT modulates host antitumor immunity by reorienting the RB TME from anergic into an active, CD8+, PD-L1+ hot state. Furthermore, some clinicopathological characteristics of RB correlate with several factors of TME. Our study adds data in favor of the possibility of a new therapeutic scenario in human RB.
MeSH term(s)	B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Infant ; Infant, Newborn ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Male ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Retinal Neoplasms/immunology ; Retinal Neoplasms/metabolism ; Retinal Neoplasms/pathology ; Retinoblastoma/immunology ; Retinoblastoma/metabolism ; Retinoblastoma/pathology ; Retrospective Studies ; Time Factors ; Tumor Microenvironment/immunology
Chemical Substances	B7-H1 Antigen ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.62.2.6
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Article: ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output.

Terzuoli, Erika / Bellan, Cristiana / Aversa, Sara / Ciccone, Valerio / Morbidelli, Lucia / Giachetti, Antonio / Donnini, Sandra / Ziche, Marina

Cancers

2019 Volume 11, Issue 12

Abstract: Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In ... ...

Abstract	Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC cells, we demonstrate that ALDH3A1 isozyme overexpression and activity is closely associated with a highly aggressive mesenchymal and immunosuppressive profile. The contribution of ALDH3A1 to the stemness and immunogenic status of melanoma and NSCLC cells was evaluated by their ability to grow in 3D forming tumorspheres, and by the expression of markers for stemness, epithelial to mesenchymal transition (EMT), and inflammation. Furthermore, in specimens from melanoma and NSCLC patients, we investigated the expression of ALDH3A1, PD-L1, and cyclooxygenase-2 (COX-2) by immunohistochemistry. We show that cells engineered to overexpress the ALDH3A1 enzyme enriched the CSCs population in melanoma and NSCLC cultures, changing their transcriptome. In fact, we found increased expression of EMT markers, such as vimentin, fibronectin, and Zeb1, and of pro-inflammatory and immunosuppressive mediators, such as NFkB, prostaglandin E2, and interleukin-6 and -13. ALDH3A1 overexpression enhanced PD-L1 output in tumor cells and resulted in reduced proliferation of peripheral blood mononuclear cells when co-cultured with tumor cells. Furthermore, in tumor specimens from melanoma and NSCLC patients, ALDH3A1 expression was invariably correlated with PD-L1 and the pro-inflammatory marker COX-2. These findings link ALDH3A1 expression to tumor stemness, EMT and PD-L1 expression, and suggest that aldehyde detoxification is a redox metabolic pathway that tunes the immunological output of tumors.
Language	English
Publishing date	2019-12-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers11121963
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Article: Robot-assisted retroperitoneal lymphadenectomy in patient with type I papillary renal cancer recurrence after 5 years of follow-up.

Al Salhi, Yazan / Fuschi, Andrea / Velotti, Gennaro / Capone, Lorenzo / Aversa, Sara / de Nunzio, Cosimo / Porta, Natale / Petrozza, Vincenzo / Carbone, Antonio / Pastore, Antonio Luigi

Journal of surgical case reports

2020 Volume 2020, Issue 10, Page(s) rjaa336

Abstract: Papillary renal cell carcinoma (PRCC) is a rare cancer and is the second most frequent histologic type among all renal cell carcinoma, accounting for up to 15%. A 72-year-old man underwent a right radical nephrectomy 7 years ago with final histopathology ...

Abstract	Papillary renal cell carcinoma (PRCC) is a rare cancer and is the second most frequent histologic type among all renal cell carcinoma, accounting for up to 15%. A 72-year-old man underwent a right radical nephrectomy 7 years ago with final histopathology diagnosis of type 1 PRCC with negative surgical margins. Five years after surgery, computed tomography scan imaging showed the presence of multiple masses suspicious for node recurrences disease localized in the renal lodge, in the inter-aorto-caval space, at the iliac vessels bifurcation and right common iliac vessels. Patient underwent a robotic retroperitoneal lymphadenectomy. The histopathological examination confirmed the recurrence of type I papillary renal cancer in all the specimens. No further recurrences have been observed at 24-month follow-up after surgery. This report is the first describing a robot-assisted minimally invasive surgical excision for type I papillary renal cancer nodal and renal fossa recurrences.
Language	English
Publishing date	2020-10-10
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjaa336
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Article ; Online: Shear wave elastography in varicocele patients: Prospective study to investigate correlation with semen parameters and histological findings.

Fuschi, Andrea / Capone, Lorenzo / Abuorouq, Saleh / Al Salhi, Yazan / Velotti, Gennaro / Aversa, Sara / Carbone, Flavia / Maceroni, Piero / Petrozza, Vincenzo / Carbone, Antonio / Pastore, Antonio Luigi / Porta, Natale

International journal of clinical practice

2020 Volume 75, Issue 3, Page(s) e13699

Abstract: Aims: Shear wave elastosonography (SWE) is a non-invasive ultrasound imaging modality used to assess the mechanical properties of tissues such as rigidity and elasticity. In this prospective study, we investigated the effect of laparoscopic ... ...

Abstract	Aims: Shear wave elastosonography (SWE) is a non-invasive ultrasound imaging modality used to assess the mechanical properties of tissues such as rigidity and elasticity. In this prospective study, we investigated the effect of laparoscopic varicocelectomy on the elasticity, degree of fibrosis and function of the testes through SWE and we evaluated the correlation with semen parameters and histology findings. Methods: Male patients with monolateral left varicocele and progressive alteration of the semen quality were enrolled prospectively. Patients were evaluated before varicocelectomy, 3 and 6 months after surgery with semen analysis, ecocolordoppler US and SWE. In all patients, a left testicular biopsy was performed at the time of varicocelectomy and it was repeated after 6 months in 55% of patients in order to investigate the histological findings and to correlate with SWE results. Results: The study was conducted on 82 patients. SWE showed a statistically significant difference between left and right testicles. Three months after surgery the mean left testicular volume increased, mean left SWE features decreased, and sperm count increased (P values < .0001). The SWE parameters, testicular volume and semen analysis values showed a statistically significant positive correlation between the pre and postoperative results (P value < .0001). The histological alterations were significantly changed 6 months postoperative with a complete morphology recovery in accordance with SWE results. Conclusions: SWE showed a statistically significant positive correlation with testicular volume, semen analysis and histological findings. This study represents the first investigation that correlates the varicocele, the testis volume, the quality of the seminal fluid ant the histological findings with the ultrasound and SWE values.
MeSH term(s)	Elasticity Imaging Techniques ; Humans ; Male ; Prospective Studies ; Semen ; Semen Analysis ; Varicocele/diagnostic imaging ; Varicocele/surgery
Language	English
Publishing date	2020-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.13699
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Article: Use of miltefosine in a patient with mucosal leishmaniasis and HIV-coinfection: a challenge in long-term management.

Zanelli, Giacomo / Rossetti, Barbara / Gagliardini, Roberta / Paglicci, Lorenzo / Tordini, Giacinta / Miracco, Clelia / Aversa, Sara / Zammarchi, Lorenzo / Di Muccio, Trentina / Gramiccia, Marina / Montagnani, Francesca

Le infezioni in medicina

2019 Volume 27, Issue 4, Page(s) 452–455

Abstract: The management of mucosal leishmaniasis in immunocompromised patients is not standardized and limited data are available on the use of miltefosine for treatment and secondary prophylaxis. We describe a case of mucosal leishmaniasis in an HIV-coinfected ... ...

Abstract	The management of mucosal leishmaniasis in immunocompromised patients is not standardized and limited data are available on the use of miltefosine for treatment and secondary prophylaxis. We describe a case of mucosal leishmaniasis in an HIV-coinfected patient treated with miltefosine due to a severe allergic reaction to liposomal amphotericin B.
MeSH term(s)	Coinfection ; HIV Infections/complications ; Humans ; Leishmaniasis, Mucocutaneous/complications ; Leishmaniasis, Mucocutaneous/drug therapy ; Male ; Middle Aged ; Phosphorylcholine/analogs & derivatives ; Phosphorylcholine/therapeutic use ; Time Factors
Chemical Substances	Phosphorylcholine (107-73-3) ; miltefosine (53EY29W7EC)
Language	English
Publishing date	2019-10-31
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2041081-5
ISSN	1124-9390
ISSN	1124-9390
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Article ; Online: Correction to: IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications.

Granai, Massimo / Amato, Teresa / Di Napoli, Arianna / Santi, Raffaella / Vergoni, Federica / Di Stefano, Gioia / Mancini, Virginia / Kovalchuk, Sofya / Cencini, Emanuele / Carta, Alberto Giulio / Aversa, Sara / Ziepert, Marita / Cevenini, Gabriele / Lazzi, Stefano / Leoncini, Lorenzo / Bellan, Cristiana

Virchows Archiv : an international journal of pathology

2020 Volume 477, Issue 1, Page(s) 169

Abstract: This error was caused due to the author's oversight and this does not change the views or the results presented in the manuscript. ...

Abstract	This error was caused due to the author's oversight and this does not change the views or the results presented in the manuscript.
Language	English
Publishing date	2020-03-19
Publishing country	Germany
Document type	Journal Article ; Published Erratum
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-020-02794-9
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