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Article ; Online: Symptomatic Isolated Mesenteric Artery Dissection: Insights from a Conservative Approach.

Choke, Edward / Aw, Darius Kang Lie

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2022

Language	English
Publishing date	2022-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2022.09.006
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 381: Show issues

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Article ; Online: Fenestrated Endovascular in situ Reconstruction of Femoral Arterial Bifurcation (FERFAB) of Common Femoral Artery Pseudoaneurysm.

Aw, Darius Kang Lie / Choke, Edward Tieng Chek / Tay, Jia Sheng

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2022 Volume 64, Issue 2-3, Page(s) 286

MeSH term(s)	Humans ; Femoral Artery/diagnostic imaging ; Femoral Artery/surgery ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/surgery ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Treatment Outcome
Language	English
Publishing date	2022-05-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2022.05.019
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 381: Show issues

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Article ; Online: MagicTouch PTA Sirolimus Coated Balloon for Femoropopliteal and Below the Knee Disease: 3 year outcomes of XTOSI trial.

Choke, Edward Tieng Chek / Peh, Eilane Yi Ling / Tang, Tjun Yip / Cheng, Shin Chuen / Tay, Jia Sheng / Aw, Darius Kang Lie / Vijaykumar, Kalpana

Annals of vascular surgery

2024

Abstract: Objectives: Sirolimus coated balloon (SCB) is a potential treatment option for peripheral arterial disease (PAD). There is currently no long term clinical data for this novel treatment for PAD. We present the 3 year results of the first-in-human study ... ...

Abstract	Objectives: Sirolimus coated balloon (SCB) is a potential treatment option for peripheral arterial disease (PAD). There is currently no long term clinical data for this novel treatment for PAD. We present the 3 year results of the first-in-human study of MagicTouch PTA SCB for treatment of PAD for both femoropopliteal and below the knee arteries (BTK). Methods: XTOSI pilot study is a prospective, single-arm, open-label, single centre trial evaluating MagicTouch PTA SCB for symptomatic PAD. Assessments through 3 years included freedom from clinically driven target lesion revascularization (CD-TLR), freedom from major amputation, amputation free survival (AFS), overall survival and ulcer free status. Results: At 3 years, the overall freedom from CD-TLR was 84.4%, freedom from major amputation was 86.1%, AFS was 63.3%, overall survival was 63.3% and ulcer free status in remaining survivors with intact limbs was 100%. For femoropoliteal lesions, at 3 years, the freedom from CD-TLR was 92.9%, freedom from major amputation was 93.3%, AFS was 70% and overall survival was 70%. For BTK lesions, at 3 years, the freedom from CD-TLR was 77.8%, freedom from major amputation was 81.0%, AFS was 58.6% and overall survival was 58.6%. Conclusions: SCB in the XTOSI pilot study showed promising clinical results sustained to 3 years and no long term safety concerns were raised. Randomized trials are currently ongoing to investigate the safety and efficacy of SCB for treatment of PAD.
Language	English
Publishing date	2024-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2023.12.096
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Zs.A 2882: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article: A case of severe polyarteritis nodosa with critical limb threatening ischemia-promising treatment with sirolimus drug-coated angioplasty.

Aw, Darius Kang Lie / Vijaykumar, Kalpana / Cheng, Shin Chuen / Tang, Tjun Yip / Tay, Jia Sheng / Choke, Edward Tieng Chek

Journal of vascular surgery cases and innovative techniques

2023 Volume 9, Issue 4, Page(s) 101266

Abstract: Polyarteritis nodosa (PAN) is a rare form of vasculitis. Acute limb ischemia is a rare presentation and complication of PAN. Plain old balloon angioplasty (POBA) is one of the treatment strategies for addressing PAN-related critical limb threatening ... ...

Abstract	Polyarteritis nodosa (PAN) is a rare form of vasculitis. Acute limb ischemia is a rare presentation and complication of PAN. Plain old balloon angioplasty (POBA) is one of the treatment strategies for addressing PAN-related critical limb threatening ischemia (CLTI). However, recurrence of stenosis and occlusion is frequent, making POBA a poor treatment choice, as evidenced in our described clinical case. Consequently, with consideration of sirolimus's anti-inflammatory and immunosuppressive properties, we used a sirolimus-coated balloon in the treatment of PAN-induced CLTI. A 37-year-old woman first presented with acute limb ischemia as her initial symptom. Diagnostic angiography demonstrated occlusion of her tibial vessels, and POBA was performed to restore perfusion. Later in the course of her illness, she developed foot gangrene despite multiple courses of immunosuppressive drugs and several attempts with POBA to achieve limb salvage. Because of her disease trajectory, a MagicTouch (Concept Medical) sirolimus-coated balloon was deployed to her anterior tibial artery during her third angioplasty. At 17 months after her last angioplasty, she remained ulcer free, and surveillance scans demonstrated occlusion-free tibial vessels. The use of sirolimus-coated balloon angioplasty is a promising treatment approach for successful limb salvage in patients with PAN vasculitis and CLTI.
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Case Reports
ISSN	2468-4287
ISSN	2468-4287
DOI	10.1016/j.jvscit.2023.101266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metastasis of primary lung carcinoma to breast: An unusual presentation.

Aw, Darius Kang Lie / Leong, Lester Chee Hao / Tan, Kiat Tee Benita

The breast journal

2018 Volume 24, Issue 3, Page(s) 406–407

MeSH term(s)	Adenocarcinoma of Lung/pathology ; Aged, 80 and over ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/secondary ; Female ; Humans ; Lung Neoplasms/pathology ; Mammography ; Tomography, X-Ray Computed ; Ultrasonography, Mammary
Language	English
Publishing date	2018-01-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.12956
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Zs.A 4483: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The Role and Effect of Multimodal Prehabilitation Before Major Abdominal Surgery: A Systemic Review and Meta-Analysis.

Jain, Sneha Rajiv / Kandarpa, Vasundhara Lakshmi / Yaow, Clyve Yu Leon / Tan, Winson JianHong / Ho, Leonard Ming Li / Sivarajah, Sharmini Su / Ng, Jia Lin / Chong, Cheryl Xi Zi / Aw, Darius Kang Lie / Foo, Fung Joon / Koh, Frederick Hong Xiang

World journal of surgery

2022 Volume 47, Issue 1, Page(s) 86–102

Abstract: Background: For patients undergoing abdominal surgery, multimodal prehabilitation, including nutrition and exercise interventions, aims to optimize their preoperative physical and physiological capacity. This meta-analysis aims to explore the impact of ... ...

Abstract	Background: For patients undergoing abdominal surgery, multimodal prehabilitation, including nutrition and exercise interventions, aims to optimize their preoperative physical and physiological capacity. This meta-analysis aims to explore the impact of multimodal prehabilitation on surgical and functional outcomes of abdominal surgery. Methods: Medline, Embase and CENTRAL were searched for articles about multimodal prehabilitation in major abdominal surgery. Primary outcomes were postoperative complications with a Clavien-Dindo score ≥3, and functional outcomes, measured by the 6-Minute Walking Test (6MWT). Secondary outcome measures included the quality-of-life measures. Pooled risk ratio (RR) and 95% confidence interval (CI) were estimated, with DerSimonian and Laird random effects used to account for heterogeneity. Results: Twenty-five studies were included, analysing 4,210 patients across 13 trials and 12 observational studies. Patients undergoing prehabilitation had significantly fewer overall complications (RR = 0.879, 95% CI 0.781-0.989, p = 0.034). There were no significant differences in the rates of wound infection, anastomotic leak and duration of hospitalization. The 6MWT improved preoperatively in patients undergoing prehabilitation (SMD = 33.174, 95% CI 12.674-53.673, p = 0.005), but there were no significant differences in the 6MWT at 4 weeks (SMD = 30.342, 95% CI - 2.707-63.391, p = 0.066) and 8 weeks (SMD = 24.563, 95% CI - 6.77-55.900, p = 0.104) postoperatively. Conclusions: As preoperative patient optimization shifts towards an interdisciplinary approach, evidence from this meta-analysis shows that multimodal prehabilitation improves the preoperative functional capacity and reduces postoperative complication rates, suggesting its potential in effectively optimizing the abdominal surgery patient. However, there is a large degree of heterogenicity between the prehabilitation interventions between included articles; hence results should be interpreted with caution.
MeSH term(s)	Humans ; Preoperative Exercise ; Quality of Life
Language	English
Publishing date	2022-10-02
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review ; Systematic Review
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-022-06761-0
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Zs.A 1336: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Unusual complication of bronchoscopy.

Aw, Darius Kang Lie / Tan, Matthew Zhen Wei / Yii, Anthony Chau Ang / Ng, Dorothy Hui Lin

Respiratory medicine case reports

2016 Volume 19, Page(s) 173–176

Abstract: In the last twenty years, the field of bronchoscopy has become increasingly more complex and invasive. It is now widely used in the management of pulmonary diseases and has the benefit of low mortality and complication rates. Overall incidence of ... ...

Abstract	In the last twenty years, the field of bronchoscopy has become increasingly more complex and invasive. It is now widely used in the management of pulmonary diseases and has the benefit of low mortality and complication rates. Overall incidence of complications and mortality reported ranges around 1% and 0.02% respectively. Common complications of bronchoscopy include pulmonary haemorrhage, desaturation, pneumothorax, and pulmonary oedema. However, facial and neck petechiae associated with subcutaneous hemorrhage post-bronchoscopy has not been reported before in the literature. We hereby report two novel cases of facial/neck petechiae post-bronchoscopy as a complication to be recognized by bronchoscopists. It is essential that bronchoscopists recognise such phenomenon as the clinical presentation is visually alarming to both the patient and clinician. It is usually self-resolving. However such presentation after bronchoscopy may trigger extensive and unnecessary investigations from the physician.
Language	English
Publishing date	2016-09-19
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2016.09.004
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Article: Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells

Aw, Darius Kang Lie / Sinha, Rohit A / Xie, Sherwin Ying / Yen, Paul M

Biochemical and biophysical research communications. 2014 May 16, v. 447

2014

Abstract: Insulin and glucagon signaling in the liver are major contributors to glucose homeostasis. Patients with Type 1 and Type 2 diabetes have impaired glycemic control due, in part, to dysregulation of the opposing actions of these hormones. While ... ...

Abstract	Insulin and glucagon signaling in the liver are major contributors to glucose homeostasis. Patients with Type 1 and Type 2 diabetes have impaired glycemic control due, in part, to dysregulation of the opposing actions of these hormones. While hyperglucagonemia is a common feature in diabetes, its precise role in insulin resistance is not well understood. Recently, metformin, an AMPK activator, was shown to regulate hepatic glucose output via inhibition of glucagon-induced cAMP/PKA signaling; however, the mechanism for how PKA inhibition leads to AMPK activation in human hepatic cells is not known. Here we show that glucagon impairs insulin-mediated AKT phosphorylation in human hepatic cell line Huh7. This impairment of AKT activation by glucagon is due to PKA-mediated inhibition of AMPK via increased inhibitory phosphorylation of AMPKSer173 and reduced activating phosphorylation of AMPKThr172. In contrast, metformin decreases PKA activity, leading to decreased pAMPKSer173 and increased pAMPKThr172. These data support a novel mechanism involving PKA-dependent AMPK phosphorylation that provides new insight into how glucagon and metformin modulate hepatic insulin resistance.
Keywords	cAMP-dependent protein kinase ; cyclic AMP ; glucagon ; glucose ; glycemic control ; homeostasis ; humans ; insulin ; insulin resistance ; liver ; metformin ; noninsulin-dependent diabetes mellitus ; patients ; phosphorylation
Language	English
Dates of publication	2014-0516
Size	p. 569-573.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2014.04.031
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.

Aw, Darius Kang Lie / Sinha, Rohit A / Xie, Sherwin Ying / Yen, Paul M

Biochemical and biophysical research communications

2014 Volume 447, Issue 4, Page(s) 569–573

Abstract	Insulin and glucagon signaling in the liver are major contributors to glucose homeostasis. Patients with Type 1 and Type 2 diabetes have impaired glycemic control due, in part, to dysregulation of the opposing actions of these hormones. While hyperglucagonemia is a common feature in diabetes, its precise role in insulin resistance is not well understood. Recently, metformin, an AMPK activator, was shown to regulate hepatic glucose output via inhibition of glucagon-induced cAMP/PKA signaling; however, the mechanism for how PKA inhibition leads to AMPK activation in human hepatic cells is not known. Here we show that glucagon impairs insulin-mediated AKT phosphorylation in human hepatic cell line Huh7. This impairment of AKT activation by glucagon is due to PKA-mediated inhibition of AMPK via increased inhibitory phosphorylation of AMPK(Ser173) and reduced activating phosphorylation of AMPK(Thr172). In contrast, metformin decreases PKA activity, leading to decreased pAMPK(Ser173) and increased pAMPK(Thr172). These data support a novel mechanism involving PKA-dependent AMPK phosphorylation that provides new insight into how glucagon and metformin modulate hepatic insulin resistance.
MeSH term(s)	AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Cell Line ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Gene Knockdown Techniques ; Glucagon/metabolism ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Hypoglycemic Agents/pharmacology ; Insulin/metabolism ; Insulin Resistance/physiology ; Metformin/pharmacology ; Phosphorylation ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Small Interfering/genetics ; Signal Transduction/drug effects
Chemical Substances	Hypoglycemic Agents ; Insulin ; RNA, Small Interfering ; Glucagon (9007-92-5) ; Metformin (9100L32L2N) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2014-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2014.04.031
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Zs.A 116: Show issues

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Article: Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells

Aw, Darius Kang Lie / Rohit A. SinhaauthorLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore / Sherwin Ying XieauthorLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore / Paul M. YenauthorLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, SingaporeSarah W. Stedman Nutrition and Metabolism Center, Department of Medicine, Duke University Medical Center, Durham, NC, USA

Language	English
Document type	Article
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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