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  1. Article ; Online: Concordance for changes in allergic asthma domain variables after short-term corticosteroid therapy.

    Silkoff, Philip E / Sarno, Mark / Ssenyange, Solomon / Balasubramanyam, Vivek / Awabdy, Brian / Leard, Ryan

    BMC pulmonary medicine

    2020  Volume 20, Issue 1, Page(s) 139

    Abstract: Background: Asthma is a complex syndrome with multiple domains including symptoms, lung function, asthma control, and airway inflammation. A study of Fenom PRO™, a novel monitor for exhaled nitric oxide (FeNO), provided an opportunity to look at ... ...

    Abstract Background: Asthma is a complex syndrome with multiple domains including symptoms, lung function, asthma control, and airway inflammation. A study of Fenom PRO™, a novel monitor for exhaled nitric oxide (FeNO), provided an opportunity to look at concordance/discordance (C/D) for changes in multiple asthma domains over a 2-week period after corticosteroid therapy.
    Methods: Non-steroid-treated adults and children with uncontrolled asthma had asthma domain measures, (FeNO), forced expired volume in 1 s (FEV
    Results: There was a highly significant fall in mean FeNO of 51.7% over 2 weeks (p < 0.0001) accompanied by significant improvements in mean FEV
    Conclusion: This data demonstrates that the concordance between changes in the asthma domains is often substantially less than 100%. Reasons for this may include different time courses for change of the separate domains, the degree of abnormality for each domain at baseline, as well as intrinsic limitations of each parameter.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones/administration & dosage ; Adult ; Aged ; Asthma/drug therapy ; Asthma/metabolism ; Asthma/physiopathology ; Breath Tests ; Child ; Exhalation ; Female ; Humans ; Male ; Middle Aged ; Nitric Oxide/analysis ; Prospective Studies ; Respiratory Function Tests ; Spirometry ; United States ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-020-1166-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical precision, accuracy, number and durations of exhalations for a novel electrochemical monitor for exhaled nitric oxide.

    Silkoff, Philip E / Awabdy, Brian / Sarno, Mark / Ssenyange, Solomon / Balsubramanyam, Vivek / Leard, Ryan

    Journal of breath research

    2019  Volume 14, Issue 1, Page(s) 16011

    Abstract: Background: Exhaled nitric oxide (FeNO) is a validated marker of eosinophilic inflammation. Fenom Pro: Methods: Clinical precision, 6 versus 10 s exhalations, the first versus the average of the first two valid exhalation methods comparison were ... ...

    Abstract Background: Exhaled nitric oxide (FeNO) is a validated marker of eosinophilic inflammation. Fenom Pro
    Methods: Clinical precision, 6 versus 10 s exhalations, the first versus the average of the first two valid exhalation methods comparison were evaluated for Fenom Pro
    Results: The intent-to-treat population (n = 126) consisted of 83 adults, and 43 pediatric subjects with 16 subjects under 12 years of age. Clinical precision for 10 s exhalations on Fenom Pro
    Conclusion: Fenom Pro
    MeSH term(s) Adult ; Breath Tests/methods ; Child ; Child, Preschool ; Electrochemistry/instrumentation ; Exhalation ; Female ; Humans ; Intention to Treat Analysis ; Luminescent Measurements ; Male ; Monitoring, Physiologic/instrumentation ; Nitric Oxide/analysis ; Regression Analysis ; Reproducibility of Results
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2019-12-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/ab5422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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