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  1. Article ; Online: The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK.

    Wilmington, Rebekah / Abuawwad, Mahmoud / Holt, Guy / Anderson, Robyn / Aldafas, Rami / Awad, Sherif / Idris, Iskandar

    Obesity surgery

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-024-07120-9
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    Zs.A 3381: Show issues Location:
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  2. Article ; Online: The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK.

    Wilmington, Rebekah / Abuawwad, Mahmoud / Holt, Guy / Anderson, Robyn / Aldafas, Rami / Awad, Sherif / Idris, Iskandar

    Obesity surgery

    2024  Volume 34, Issue 3, Page(s) 850–854

    Abstract: Background: Current recommendations advocate the achievement of an optimal glucose control (HbA1c < 69 mmol/mol) prior to elective surgery to reduce risks of peri- and post-operative complications, but the relevance for this glycaemic threshold prior to ...

    Abstract Background: Current recommendations advocate the achievement of an optimal glucose control (HbA1c < 69 mmol/mol) prior to elective surgery to reduce risks of peri- and post-operative complications, but the relevance for this glycaemic threshold prior to Bariatric Metabolic Surgery (BMS) following a specialist weight management programme remains unclear.
    Methods: We undertook a retrospective cohort study of patients with type 2 diabetes mellitus (T2DM) who underwent BMS over a 6-year period (2016-2022) at a regional tertiary referral following completion of a specialist multidisciplinary weight management. Post-operative outcomes of interest included 30-day mortality, readmission rates, need for Intensive Care Unit (ICU) care and hospital length of stay (LOS) and were assessed according to HbA1c cut-off values of < 69 (N = 202) and > 69 mmol/mol (N = 67) as well as a continuous variable.
    Results: A total of 269 patients with T2D were included in this study. Patients underwent primary Roux en-Y gastric bypass (RYGB, n = 136), Sleeve Gastrectomy (SG, n = 124), insertion of gastric band (n = 4) or one-anastomosis gastric bypass (OAGB, n = 4). No significant differences in the rates of complications were observed between the two groups of pre-operative HbA1c cut-off values. No HbA1c threshold was observed for glycaemic control that would affect the peri- and post-operative complications following BMS.
    Conclusions: We observed no associations between pre-operative HbA1C values and the risk of peri- and post-operative complications. In the context of a specialist multidisciplinary weight management programme, optimising pre-operative HbA1C to a recommended target value prior to BMS may not translate into reduced risks of peri- and post-operative complications.
    MeSH term(s) Humans ; Obesity, Morbid/surgery ; Diabetes Mellitus, Type 2/surgery ; Diabetes Mellitus, Type 2/complications ; Glycated Hemoglobin ; Glycemic Control/adverse effects ; Retrospective Studies ; Bariatric Surgery/adverse effects ; Gastric Bypass/adverse effects ; Postoperative Complications/etiology ; Gastrectomy/adverse effects ; Referral and Consultation ; United Kingdom/epidemiology ; Treatment Outcome
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06964-x
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  3. Article ; Online: Depigmentation during vitiligo activity spares epithelial grafted areas.

    Awad, Sherif Shoukry

    Journal of cosmetic dermatology

    2016  Volume 15, Issue 4, Page(s) 383–386

    Abstract: Background: Vitiligo is a depigmenting disease characterized by episodes of stability and activity without a fixed sequence, and active phases demonstrate immune attacks toward vulnerable melanocytes. Epithelial grafts were introduced to treat ... ...

    Abstract Background: Vitiligo is a depigmenting disease characterized by episodes of stability and activity without a fixed sequence, and active phases demonstrate immune attacks toward vulnerable melanocytes. Epithelial grafts were introduced to treat recalcitrant vitiligo patches aiming to provide new generations of melanocytes.
    Aims: The aim of study was to evaluate the possible permanency of succeeded epithelial grafts during a coming activity episode.
    Methods: This study included 20 nonsegmental vitiligo cases. They were epithelial grafted, success was maintained with the use of UV sessions for a year, and further follow-up was allowed until new phases of activity developed.
    Results: The grafted areas, in all cases, were spared during the activity episodes in spite of the development of new depigmented lesions in other parts of skin neighboring the grafted areas or in remote sites.
    Conclusion: The permanency of epithelial grafts in spite of disease reactivity is a good sign and magnifies the value of surgical approaches in management of vitiligo. New genetically different melanocytes should have been provided and were able to resist the new immune attacks in spite of the yielding of other skin melanocytes.
    MeSH term(s) Autografts/immunology ; Combined Modality Therapy ; Epithelium/transplantation ; Follow-Up Studies ; Humans ; Melanocytes/immunology ; Postoperative Care ; Ultraviolet Therapy ; Vitiligo/physiopathology ; Vitiligo/therapy
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.12243
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  4. Article ; Online: Progressive bilateral symmetrical hyperpigmentation, induration, and hypertrichosis in a young female patient associated with other skeletal and systemic manifestations.

    Ahmed Touni, Ahmed / Shoukry Awad, Sherif

    International journal of dermatology

    2021  Volume 60, Issue 9, Page(s) 1094–1096

    MeSH term(s) Female ; Humans ; Hyperpigmentation/diagnosis ; Hypertrichosis
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15392
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  5. Article ; Online: Expression of immune checkpoints in active nonsegmental vitiligo: a pilot study.

    Awad, Sherif S / Touni, Ahmed A / Gabril, Manal Y

    International journal of dermatology

    2020  Volume 59, Issue 8, Page(s) 982–988

    Abstract: Background: Vitiligo is a depigmentary skin disfigurement resulting from destruction of melanocytes caused by a possible malfunctioning immunity. This destruction could be linked to an aberrant T-cell-mediated immune response. Cytotoxic T-lymphocyte- ... ...

    Abstract Background: Vitiligo is a depigmentary skin disfigurement resulting from destruction of melanocytes caused by a possible malfunctioning immunity. This destruction could be linked to an aberrant T-cell-mediated immune response. Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1) are immune checkpoints capable of downregulating T-cell immune functions.
    Objectives: To evaluate the pattern of expression of PD-1 and CTLA-4 in active vitiligo skin.
    Methods: Thirty nonsegmental vitiligo (NSV) patients had been included in this pilot study. Marginal, lesional, and nonlesional skin biopsies were obtained. PD-1 and CTLA-4 immunohistochemistry expression in the mononuclear inflammatory infiltrates were evaluated using digital images.
    Results: The marginal and lesional inflammatory infiltrates were significantly abundant when compared to nonlesional ones. The marginal infiltrates were significantly abundant when compared to the lesional ones. PD-1 and CTLA-4 were significantly expressed in the marginal and lesional infiltrates when compared to nonlesional skin. Moreover, the marginal expression of PD-1 was significantly higher than the lesional expression. However, no similar significant difference in CTLA-4 expression was found between the marginal and lesional infiltrates. Significant positive correlations were found between the expressions of PD-1 and CTLA-4 in marginal and lesional infiltrates.
    Conclusion: Programmed death-1 and CTLA-4 are expressed within the inflammatory infiltrate of active NSV. Further studies are required to confirm their significance in the development or limitation of the disease.
    MeSH term(s) Humans ; Melanocytes ; Pilot Projects ; Skin ; T-Lymphocytes ; Vitiligo
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.14983
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  6. Article ; Online: Repigmentation of poliosis after epithelial grafting for vitiligo.

    Awad, Sherif S

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2013  Volume 39, Issue 3 Pt 1, Page(s) 406–411

    Abstract: Background: Vitiligo is a disease of color loss from skin and possibly also from hair. The presence of white hair follicles is known to be a bad prognostic sign.: Objectives: To evaluate the possibility of repigmentation of white hair follicles after ...

    Abstract Background: Vitiligo is a disease of color loss from skin and possibly also from hair. The presence of white hair follicles is known to be a bad prognostic sign.
    Objectives: To evaluate the possibility of repigmentation of white hair follicles after epithelial grafting.
    Methods: Patients with recalcitrant vitiligo with loss of hair pigment were treated using Chinese cupping blisters or ultrathin Thiersch grafting after de-epithelialization of vitiliginous patches by dermabrasion. Phototherapy was used afterward to enhance success.
    Results: Repigmentation of the skin surface was obtained with as little as 1 to 2 months of phototherapy, as expected, and further follow-up of cases revealed the re-coloring of hair follicles after 4 to 11 months.
    Conclusion: Re-coloring of poliosis with vitiligo is possible but was unexpected because of the difference in mechanism and signaling required between hair bulb melanization and the surface skin. One likely mechanism to explain this change is that melanocyte stem cells are stimulated and migrate to supply hair bulbs with new mature melanocytes. Epithelial grafting of vitiligo with poliosis in hairy areas should be a treatment of choice when white hair tufts cause cosmetic disfigurement.
    MeSH term(s) Adolescent ; Adult ; Child ; Dermabrasion ; Epithelium/transplantation ; Female ; Hair Color ; Hair Diseases/etiology ; Hair Diseases/surgery ; Humans ; Male ; Phototherapy ; Skin Pigmentation ; Vitiligo/complications ; Vitiligo/surgery
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1111/dsu.12082
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  7. Article ; Online: Dermabrasion may repigment vitiligo through stimulation of melanocyte precursors and elimination of hyperkeratosis.

    Awad, Sherif Shoukry

    Journal of cosmetic dermatology

    2012  Volume 11, Issue 4, Page(s) 318–322

    Abstract: Background: The observation of successful repigmentation of recalcitrant vitiligo patches in spite of rejection of epithelial grafts from the dermabraded skin presented a query about possible efficiency of dermabrasion itself in the repigmentation ... ...

    Abstract Background: The observation of successful repigmentation of recalcitrant vitiligo patches in spite of rejection of epithelial grafts from the dermabraded skin presented a query about possible efficiency of dermabrasion itself in the repigmentation process.
    Objectives: The aim of this work is to investigate the possible effectiveness of dermabrasion alone in managing stable vitiligo.
    Methods: Ten patients with vitiligo were candidates in this study. Superficial dermabrasion was carried out using proper diamond fraises. Biopsy was obtained after 10 days of the procedure and examined pathologically. The patients were followed up for 3 months.
    Results: Dermabrasion was able to repigment vitiliginous patches completely in six patients and partially in two patients, while two cases failed to repigment at all. Spindle melanocyte precursors were demonstrated in the epidermis 10 days after abrasion with regaining normal thickness of keratin layers.
    Conclusion: Dermabrasion can repigment vitiligo through stimulation of melanocyte stem cells and elimination of hyperkeratosis.
    MeSH term(s) Adult ; Aged ; Dermabrasion ; Epidermis/cytology ; Epidermis/surgery ; Face ; Female ; Humans ; Male ; Melanocytes ; Middle Aged ; Neck ; Scalp ; Skin/cytology ; Skin Pigmentation/physiology ; Stem Cells/cytology ; Vitiligo/surgery ; Young Adult
    Language English
    Publishing date 2012-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.12010
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  8. Article ; Online: Evaluation of Liver Function Tests and Risk Score Assessment to Screen Patients for Significant Liver Disease Prior to Bariatric and Metabolic Surgery.

    Antipass, Anthony / Austin, Andrew / Awad, Sherif / Hughes, David / Idris, Iskandar

    Obesity surgery

    2020  Volume 30, Issue 7, Page(s) 2840–2843

    Abstract: Bariatric and metabolic surgery is associated with significant improvement in obesity-related comorbidities, but for patients with non-alcoholic fatty liver disease (NAFLD), clinical outcomes are dependent on the severity of liver disease, i.e. ... ...

    Abstract Bariatric and metabolic surgery is associated with significant improvement in obesity-related comorbidities, but for patients with non-alcoholic fatty liver disease (NAFLD), clinical outcomes are dependent on the severity of liver disease, i.e. improvement of NAFLD in most patients but increased risks of fulminant hepatic failure and/or bleeding varices in patients with more advanced cirrhosis. Our study showed that absolute values of liver enzymes were poor indicator of risk of liver fibrosis. The use of AST/ALT ratio, Fib 4 or NAFLD scores were appropriate screening tools, with each risk score appearing to pick out a certain phenotype of patients based on age, BMI or individual values of ALT, AST or platelet count. There is lack of agreement in some cases between FIB-4 scores and NAFLD scores when ruling out patients at high risk of liver fibrosis. Meticulous screening of patients at risk of liver fibrosis is crucial in order to reduce the risk of liver-related complications following bariatric and metabolic surgery.
    MeSH term(s) Bariatric Surgery ; Humans ; Liver Cirrhosis/etiology ; Liver Function Tests ; Non-alcoholic Fatty Liver Disease ; Obesity, Morbid/surgery ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-020-04486-4
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  9. Article ; Online: Correction to: Evaluation of Liver Function Tests and Risk Score Assessment to Screen Patients for Significant Liver Disease Prior to Bariatric and Metabolic Surgery.

    Antypas, Antony / Austin, Andrew / Awad, Sherif / Hughes, David / Idris, Iskandar

    Obesity surgery

    2020  Volume 30, Issue 10, Page(s) 4176

    Abstract: The name of author Anthony Antypas was misspelled in the original article. It is correct here. ...

    Abstract The name of author Anthony Antypas was misspelled in the original article. It is correct here.
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-020-04878-6
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  10. Article ; Online: Effectiveness and Safety of Chinese Cups in the Treatment of Halo Nevi.

    Abdel Aziz, Rasha T A / Awad, Sherif S / Mohammed, Sahar S

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2019  Volume 47, Issue 1, Page(s) 150–151

    MeSH term(s) Adolescent ; Adult ; Child ; Cupping Therapy ; Female ; Humans ; Male ; Nevus, Halo/therapy ; Vitiligo/therapy
    Language English
    Publishing date 2019-12-13
    Publishing country United States
    Document type Letter
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000002288
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