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Book ; Thesis: Evolution of polyploid Brassica genomes

Axelsson, Tomas

genome structure and the evolution of duplicated genes

(Acta Universitatis Agriculturae Sueciae : Agraria ; 229)

2000

Author's details	Tomas Axelsson
Series title	Acta Universitatis Agriculturae Sueciae : Agraria ; 229 Acta Universitatis Agriculturae Sueciae Acta Universitatis Agriculturae Sueciae ; Agraria
Collection	Acta Universitatis Agriculturae Sueciae Acta Universitatis Agriculturae Sueciae ; Agraria
Keywords	Kohl ; Genanalyse ; Duplikation
Subject	Verdopplung ; Verdoppelung ; Genduplikation ; Gen ; Genetischer Test ; Gentest ; Genomanalyse ; Genom ; Genetische Analyse ; Gendiagnostik ; Genomsequenzierung ; Brassica
Language	English
Size	Getr. Zählung : Ill., graph. Darst.
Publishing place	Uppsala
Publishing country	Sweden
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Uppsala, Swedish Univ. of Agricultural Sciences, Diss., 2000
HBZ-ID	HT012887880
ISBN	91-576-5768-8 ; 978-91-576-5768-8
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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008/2468	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Patient-specific targeted analysis of circulating tumour DNA in plasma is feasible and may be a potential biomarker in UTUC.

Mu, Ninni / Jylhä, Cecilia / Axelsson, Tomas / Sydén, Filip / Brehmer, Marianne / Tham, Emma

World journal of urology

2023 Volume 41, Issue 12, Page(s) 3421–3427

Abstract: Purpose: The prognosis of upper urinary tract urothelial carcinoma (UTUC) is associated with tumour grade (G) and stage. Despite preoperative risk stratification and radical treatment, recurrence and progression are common. Thus, prognostic and ... ...

Abstract	Purpose: The prognosis of upper urinary tract urothelial carcinoma (UTUC) is associated with tumour grade (G) and stage. Despite preoperative risk stratification and radical treatment, recurrence and progression are common. Thus, prognostic and monitoring biomarkers are needed. This feasibility study aimed to investigate if targeted analyses on circulating tumour DNA (ctDNA) in plasma could identify tumour-specific gene variants, and thus have potential for further evaluation as a biomarker in UTUC. Methods: Nine UTUC patients with genetically characterised tumours were included in this prospective pilot study. Two tumour-specific variants were chosen for targeted analyses with multiplex droplet digital PCR on cell-free DNA (cfDNA) from plasma at diagnosis or from recurrence. Results: Of six patients with diagnostic plasma samples, ctDNA was detected in four with G2 or G3 tumours and tumours > 300m Conclusion: Our early findings demonstrate that ctDNA in plasma can be detected by targeted analysis in patients with UTUC. However, further studies are needed to determine its role as a potential biomarker.
MeSH term(s)	Humans ; Urinary Bladder Neoplasms/pathology ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/genetics ; Carcinoma, Transitional Cell/surgery ; Circulating Tumor DNA ; Pilot Projects ; Prospective Studies ; Prognosis ; Biomarkers ; Biomarkers, Tumor/genetics ; Neoplasm Recurrence, Local/pathology
Chemical Substances	Circulating Tumor DNA ; Biomarkers ; Biomarkers, Tumor
Language	English
Publishing date	2023-09-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04583-w
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Article ; Online: An epidemiological and clinicopathological study of type 1 vs. type 2 morphological subtypes of papillary renal cell carcinoma- results from a nation-wide study covering 50 years in Iceland.

Runarsson, Thorri Geir / Bergmann, Andreas / Erlingsdottir, Gigja / Petursdottir, Vigdis / Heitmann, Leon Arnar / Johannesson, Aevar / Asbjornsson, Viktor / Axelsson, Tomas / Hilmarsson, Rafn / Gudbjartsson, Tomas

BMC urology

2024 Volume 24, Issue 1, Page(s) 105

Abstract: Introduction: Papillary renal cell carcinoma (pRCC) is the second most common histology of renal cell carcinoma (RCC), accounting for 10-15% of cases. Traditionally, pRCC is divided into type 1 and type 2, although this division is currently debated as ... ...

Abstract	Introduction: Papillary renal cell carcinoma (pRCC) is the second most common histology of renal cell carcinoma (RCC), accounting for 10-15% of cases. Traditionally, pRCC is divided into type 1 and type 2, although this division is currently debated as a prognostic factor of survival. Our aim was to investigate the epidemiology and survival of the pRCC subtypes in a whole nation cohort of patients during a 50-year period. Materials and methods: A Population based retrospective study including consecutive cases of RCC in Iceland from 1971-2020. Comparisons were made between histological classifications of RCC, with emphasis on pRCC subtypes (type 1 vs. 2) for outcome estimation. Changes in RCC incidence were analyzed in 5-year intervals after age standardization. The Kaplan-Meier method and Cox regression were used for outcome analysis. Results: A total of 1.725 cases were identified, with 74.4%, 2.1% and 9.2% having clear cell (ccRCC), chromophobe (chRCC), and pRCC, respectively. The age standardized incidence (ASI) of pRCC was 1.97/100.000 for males and 0.5/100.000 for females, and the proportion of pRCC increased from 3.7% to 11.5% between the first and last intervals of the study (p < 0.001). Age standardized cancer specific mortality (ASCSM) of pRCC was 0.6/100.000 and 0.19/100.000 for males and females, respectively. The annual average increase in ASI was 3.6% for type 1 pRCC, but the ASI for type 2 pRCC and ASCSM for both subtypes did not change significantly. Male to female ratio was 4.4 for type 1 pRCC and 2.3 for type 2. The average tumor size for type 1 and 2 was 58.8 and 73.7 mm, respectively. Metastasis at diagnosis was found in 8.7% in the type 1 pRCC, compared to 30.0% of patients with type 2 pRCC (p < 0.001). Estimated 5-year cancer-specific survival (CSS) were 94.4%, 80.7%, and 69.3% for chRCC, pRCC and ccRCC, respectively (p < 0.001). For the pRCC subtypes, type 1 was associated with better 5-year CSS than type 2 (86.3% vs. 66.0%, p < 0.001), although this difference was not significant after adjusting for cancer stage and grading. Conclusions: pRCC histology was slightly less common in Iceland than in other countries. Males are more than three times more likely to be diagnosed with pRCC, compared to other RCC histologies. The subtype of pRCC was not found to be an independent risk factor for worse survival, and as suggested by the most recent WHO Classification of Urinary Tumors, grade and TNM-stage seem to be the most important factors for estimation of survival for pRCC patients.
MeSH term(s)	Humans ; Iceland/epidemiology ; Carcinoma, Renal Cell/epidemiology ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/classification ; Kidney Neoplasms/pathology ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/mortality ; Kidney Neoplasms/classification ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Survival Rate ; Incidence ; Time Factors ; Young Adult ; Aged, 80 and over
Language	English
Publishing date	2024-05-13
Publishing country	England
Document type	Journal Article ; Comparative Study
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-024-01494-9
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Article ; Online: Consultation on UTUC II Stockholm 2022: diagnostics, prognostication, and follow-up-where are we today?

Sydén, Filip / Baard, Joyce / Bultitude, Matthew / Keeley, Francis Xavier / Rouprêt, Morgan / Thomas, Kay / Axelsson, Tómas Andri / Jaremko, Georg / Jung, Helene / Malm, Camilla / Proietti, Silvia / Osther, Palle Jørn Sloth / Brehmer, Marianne

World journal of urology

2023 Volume 41, Issue 12, Page(s) 3395–3403

Abstract: Purpose: To summarise the current knowledge regarding diagnostics, prognostication and follow-up in upper tract urothelial carcinoma (UTUC).: Methods: A scoping review combined with expert opinion was applied to provide an overview of the current ... ...

Abstract	Purpose: To summarise the current knowledge regarding diagnostics, prognostication and follow-up in upper tract urothelial carcinoma (UTUC). Methods: A scoping review combined with expert opinion was applied to provide an overview of the current research field. Based on the published literature and the experts' own experience and opinions, consensus was reached through presentations and discussions at the meeting Consultation on UTUC II in Stockholm 2022. Results: The strongest prognostic factors in UTUC are tumour grade and stage. They are correlated, and grade is used for indirect staging. The diagnostic examinations should include multiphase computed tomography urography (CTU) with corticomedullary phase, and urethrocystoscopy with cytology. If there is no clear diagnosis for clinical decision-making, ureterorenoscopy (URS) with focal cytology and biopsies should be performed. Both WHO classification systems (1973/1999 and 2004/2016) should be used. Novel biomarker tests are not yet widespread nor recommended for the detection of UTUC. Long-term, regular follow-up, including URS in patients who have had organ-sparing treatment, is important to check for tumour recurrences, intravesical recurrences, metastases and progression of the tumour. Conclusion: Proper diagnostics with correct grading of UTUC are necessary for appropriate treatment decisions. The diagnostics should include CTU with corticomedullary phase, urine or bladder cytology, URS with focal barbotage cytology, and biopsies when needed for proper diagnosis and risk stratification. Regular, long-term follow-ups are fundamental, due to the high rate of recurrence and risk of progression.
MeSH term(s)	Humans ; Carcinoma, Transitional Cell/pathology ; Urinary Bladder Neoplasms/diagnosis ; Kidney Neoplasms/pathology ; Follow-Up Studies ; Ureteral Neoplasms/pathology ; Neoplasm Recurrence, Local/diagnosis
Language	English
Publishing date	2023-08-04
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04530-9
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Article ; Online: Long-term outcomes after coronary artery bypass surgery in patients with diabetes.

Axelsson, Tomas Andri / Adalsteinsson, Jonas A / Arnadottir, Linda O / Helgason, Dadi / Johannesdottir, Hera / Helgadottir, Solveig / Orrason, Andri Wilberg / Andersen, Karl / Gudbjartsson, Tomas

Interactive cardiovascular and thoracic surgery

2020 Volume 30, Issue 5, Page(s) 685–690

Abstract: Objectives: Our aim was to investigate the outcome of patients with diabetes undergoing coronary artery bypass grafting (CABG) surgery in a whole population with main focus on long-term mortality and complications.: Methods: This was a nationwide ... ...

Abstract	Objectives: Our aim was to investigate the outcome of patients with diabetes undergoing coronary artery bypass grafting (CABG) surgery in a whole population with main focus on long-term mortality and complications. Methods: This was a nationwide retrospective analysis of all patients who underwent isolated primary CABG in Iceland between 2001 and 2016. Overall survival together with the composite end point of major adverse cardiac and cerebrovascular events was compared between patients with diabetes and patients without diabetes during a median follow-up of 8.5 years. Multivariable regression analyses were used to evaluate the impact of diabetes on both short- and long-term outcomes. Results: Of a total of 2060 patients, 356 (17%) patients had diabetes. Patients with diabetes had a higher body mass index (29.9 vs 27.9 kg/m2) and more often had hypertension (83% vs 62%) and chronic kidney disease (estimated glomerular filtration rate ≤60 ml/min/1.73 m2, 21% vs 14%). Patients with diabetes had an increased risk of operative mortality [odds ratio 2.52, 95% confidence interval (CI) 1.27-4.80] when adjusted for confounders. 5-Year overall survival (85% vs 91%, P < 0.001) and 5-year freedom from major adverse cardiac and cerebrovascular events were also inferior for patients with diabetes (77% vs 82%, P < 0.001). Cox regression analysis adjusting for potential confounders showed that the diagnosis of diabetes significantly predicted all-cause mortality [hazard ratio (HR) 1.87, 95% CI 1.53-2.29] and increased risk of major adverse cardiac and cerebrovascular events (HR 1.47, 95% CI 1.23-1.75). Conclusions: Patients with diabetes have significantly lower survival after CABG, both within 30 days and during long-term follow-up.
MeSH term(s)	Aged ; Comorbidity ; Coronary Artery Bypass/methods ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/surgery ; Diabetes Mellitus/epidemiology ; Female ; Follow-Up Studies ; Forecasting ; Humans ; Iceland/epidemiology ; Incidence ; Male ; Postoperative Complications/epidemiology ; Retrospective Studies ; Survival Rate/trends ; Treatment Outcome
Language	English
Publishing date	2020-03-03
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivaa009
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Zs.A 5730: Show issues

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Article: Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.

Cancers

2022 Volume 14, Issue 7

Abstract: Background: Ovarian cancer is the eighth most common cancer among women and has a 5-year survival of only 30-50%. The survival is close to 90% for patients in stage I but only 20% for patients in stage IV. The presently available biomarkers have ... ...

Abstract	Background: Ovarian cancer is the eighth most common cancer among women and has a 5-year survival of only 30-50%. The survival is close to 90% for patients in stage I but only 20% for patients in stage IV. The presently available biomarkers have insufficient sensitivity and specificity for early detection and there is an urgent need to identify novel biomarkers. Methods: We employed the Explore PEA technology for high-precision analysis of 1463 plasma proteins and conducted a discovery and replication study using two clinical cohorts of previously untreated patients with benign or malignant ovarian tumours ( Results: The discovery analysis identified 32 proteins that had significantly higher levels in malignant cases as compared to benign diagnoses, and for 28 of these, the association was replicated in the second cohort. Multivariate modelling identified three highly accurate models based on 4 to 7 proteins each for separating benign tumours from early-stage and/or late-stage ovarian cancers, all with AUCs above 0.96 in the replication cohort. We also developed a model for separating the early-stage from the late-stage achieving an AUC of 0.81 in the replication cohort. These models were based on eleven proteins in total (ALPP, CXCL8, DPY30, IL6, IL12, KRT19, PAEP, TSPAN1, SIGLEC5, VTCN1, and WFDC2), notably without MUCIN-16. The majority of the associated proteins have been connected to ovarian cancer but not identified as potential biomarkers. Conclusions: The results show the ability of using high-precision proteomics for the identification of novel plasma protein biomarker candidates for the early detection of ovarian cancer.
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14071757
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Article ; Online: Tall cell variant of papillary thyroid carcinoma: a population-based study in Iceland.

Axelsson, Tomas A / Hrafnkelsson, Jon / Olafsdottir, Elinborg J / Jonasson, Jon G

Thyroid : official journal of the American Thyroid Association

2015 Volume 25, Issue 2, Page(s) 216–220

Abstract: Background: The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is an aggressive variant of PTC that is believed to have worse outcomes than classical PTC. The objective of this study was to investigate the incidence, survival, and disease ... ...

Abstract	Background: The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is an aggressive variant of PTC that is believed to have worse outcomes than classical PTC. The objective of this study was to investigate the incidence, survival, and disease recurrence of patients with TCV and compare them with other PTC in a whole population. Methods: Information on all thyroid carcinomas diagnosed in Iceland from 1990 to 2009 was obtained from the Icelandic Cancer Registry. PTC diagnosed postmortem was excluded. The date of diagnosis, sex, and age at diagnosis were registered. All histopathology material was re-evaluated, and papillary thyroid tumors classified as either TCV or other types of PTC. Tumors were classified as TCV if >50% of cells were tall (height > twice the width). TNM stage was determined for all the cases. Endpoints were thyroid cancer-specific death and thyroid cancer recurrence. Results: Out of 376 patients diagnosed with PTC in the study period, 49 (13%) were classified as TCV. Patients with TCV were older (66 years vs. 49 years, p<0.001), more often had pT4 tumors (71% vs. 15%, p<0.001), had higher rates of nodal metastasis (51% vs. 22%, p<0.001), and more often distant metastasis (14% vs. 2%, p<0.001). The age-adjusted incidence of TCV for men was 0.5/100,000 [confidence interval (CI) 0.3-0.7] and for women 0.7/100,000 [CI 0.4-1.0] between 1990 and 2009. The five-year disease-specific survival for TCV was 83% [CI 68-91] compared to 98% [CI 96-99] for other PTC respectively (p<0.001). In multivariate analysis, TCV histology was an independent risk factor for recurrence (hazard ratio (HR) 3.18 [CI 1.48-6.84]) but not for disease specific survival (HR 1.86 [CI 0.77-4.73]). Conclusions: TCV comprises 13% of all diagnosed PTC in Iceland with an incidence of 0.5/100,000 for men and 0.7/100,000 for women. Patients diagnosed with TCV have worse five-year disease-specific survival than patients with other PTC. TCV histology is an independent risk factor for disease recurrence but not for disease-specific survival.
MeSH term(s)	Adolescent ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Carcinoma, Papillary/epidemiology ; Carcinoma, Papillary/mortality ; Carcinoma, Papillary/pathology ; Female ; Humans ; Iceland/epidemiology ; Incidence ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Sex Factors ; Survival Rate ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/mortality ; Thyroid Neoplasms/pathology ; Young Adult
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2014.0075
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Zs.A 3307: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Next generation pan-cancer blood proteome profiling using proximity extension assay.

Álvez, María Bueno / Edfors, Fredrik / von Feilitzen, Kalle / Zwahlen, Martin / Mardinoglu, Adil / Edqvist, Per-Henrik / Sjöblom, Tobias / Lundin, Emma / Rameika, Natallia / Enblad, Gunilla / Lindman, Henrik / Höglund, Martin / Hesselager, Göran / Stålberg, Karin / Enblad, Malin / Simonson, Oscar E / Häggman, Michael / Axelsson, Tomas / Åberg, Mikael /

Nordlund, Jessica / Zhong, Wen / Karlsson, Max / Gyllensten, Ulf / Ponten, Fredrik / Fagerberg, Linn / Uhlén, Mathias

Nature communications

2023 Volume 14, Issue 1, Page(s) 4308

Abstract: A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. ... ...

Abstract	A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types. Plasma profiles of 1463 proteins from more than 1400 cancer patients are measured in minute amounts of blood collected at the time of diagnosis and before treatment. An open access Disease Blood Atlas resource allows the exploration of the individual protein profiles in blood collected from the individual cancer patients. We also present studies in which classification models based on machine learning have been used for the identification of a set of proteins associated with each of the analyzed cancers. The implication for cancer precision medicine of next generation plasma profiling is discussed.
MeSH term(s)	Humans ; Proteome/metabolism ; Neoplasms/diagnosis ; Neoplasms/metabolism ; Hematologic Neoplasms ; Precision Medicine ; Machine Learning
Chemical Substances	Proteome
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39765-y
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Article ; Online: Is emergency and salvage coronary artery bypass grafting justified? The Nordic Emergency/Salvage coronary artery bypass grafting study.

Axelsson, Tomas A / Mennander, Ari / Malmberg, Markus / Gunn, Jarmo / Jeppsson, Anders / Gudbjartsson, Tomas

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2016 Volume 49, Issue 5, Page(s) 1451–1456

Abstract: Objectives: According to the EuroSCORE-II criteria, patients undergoing emergency coronary artery bypass grafting (CABG) are operated on before the beginning of the next working day after decision to operate while salvage CABG patients require ... ...

Abstract	Objectives: According to the EuroSCORE-II criteria, patients undergoing emergency coronary artery bypass grafting (CABG) are operated on before the beginning of the next working day after decision to operate while salvage CABG patients require cardiopulmonary resuscitation en route to the operating theatre. The objective of this multicentre study was to investigate the efficacy of emergency and salvage CABG. Methods: A retrospective analysis of all patients that underwent emergency or salvage CAGB at four North-European university hospitals from 2006 to 2014. Results: A total of 614 patients; 580 emergency and 34 salvage CABG patients (mean age 67 ± 10 years, 56% males) were included. All patients had an acute coronary syndrome: 234 (38%) had an ST segment elevation myocardial infarction (STEMI) and 289 (47%) had a non-STEMI. Haemodynamic instability requiring inotropic drugs and/or intra-aortic balloon pump preoperatively occurred in 87 (14%) and 82 (13%) of the patients, respectively. Three hundred and thirty-one patient (54%) were transferred to the operating room immediately after angiography and 205 (33%) had a failure of an attempted percutaneous coronary intervention. Cardiopulmonary resuscitation within 1 h before the operation was performed in 49 patients (8%), and 9 patients (1%) received cardiac massage during sternotomy. Hospital mortality for emergency and salvage operations was 13 and 41%, respectively. Early complications included reoperation for bleeding (15%), postoperative stroke (6%) and de novo dialysis for acute kidney injury (6%). Overall 5-year survival rate was 79% for emergency operations and 46% for salvage operations. Only one out of 9 patients receiving cardiac massage during sternotomy survived. Conclusions: Early mortality in patients undergoing emergent and salvage CABG is substantial, especially in salvage patients. Long-term survival is acceptable in both emergent and salvage patients. Life-saving emergency and salvage CABG is justified in most patients but salvage patients have dismal prognosis if cardiac massage is needed during sternotomy.
MeSH term(s)	Aged ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/mortality ; Coronary Artery Bypass/statistics & numerical data ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2016-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezv388
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Zs.A 2303: Show issues

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Article ; Online: Acute coronary angiography after coronary artery bypass grafting.

Hultgren, Karin / Andreasson, Anders / Axelsson, Tomas A / Albertsson, Per / Lepore, Vincenzo / Jeppsson, Anders

Scandinavian cardiovascular journal : SCJ

2016 Volume 50, Issue 2, Page(s) 123–127

Abstract: Objectives: Coronary angiography is the golden standard when myocardial ischemia after CABG occurs. We summarize our experience of acute coronary angiography after CABG.: Design: All 4446 patients (mean age 68 ± 9 years, 22% women) who underwent CABG ...

Abstract	Objectives: Coronary angiography is the golden standard when myocardial ischemia after CABG occurs. We summarize our experience of acute coronary angiography after CABG. Design: All 4446 patients (mean age 68 ± 9 years, 22% women) who underwent CABG 2007 to 2012 were included in this retrospective observational study. Incidence, indications, findings, measures of acute angiography after CABG was assessed. Outcome variables were compared between patients who underwent angiography and those who did not. Results: Eighty-seven patients (2%) underwent acute coronary angiography. Patients undergoing angiography had ECG changes (92%), echocardiographic alterations (48%), hemodynamic instability (28%), angina (15%), and/or arrhythmia (13%). Positive findings were detected in 69% of the cases. Only ECG changes as indication for angiography had a moderate association with positive findings, but the precision increased if other sign(s) of ischemia were present. Thirty-day mortality (7% versus 2%, p = 0.002) was higher and long-term-cumulative survival lower (77% versus 87% at five years, p = 0.043) in angiography patients. Conclusions: Acute angiography is a rare event after CABG. Postoperative myocardial ischemia leading to acute coronary angiography is associated with increased short-term and long-term mortality.
MeSH term(s)	Aged ; Coronary Angiography/adverse effects ; Coronary Angiography/mortality ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/mortality ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/mortality ; Coronary Artery Disease/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Registries ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1379906-x
ISSN	1651-2006 ; 1401-7431
ISSN (online)	1651-2006
ISSN	1401-7431
DOI	10.3109/14017431.2016.1143112
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