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  1. Article ; Online: Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by

    Cheung, Bettina H / Alisoltani, Arghavan / Kochan, Travis J / Lebrun-Corbin, Marine / Nozick, Sophia H / Axline, Christopher M R / Bachta, Kelly E R / Ozer, Egon A / Hauser, Alan R

    mBio

    2023  , Page(s) e0212823

    Abstract: Gastrointestinal (GI) colonization ... ...

    Abstract Gastrointestinal (GI) colonization by
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02128-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence.

    Kochan, Travis J / Nozick, Sophia H / Valdes, Aliki / Mitra, Sumitra D / Cheung, Bettina H / Lebrun-Corbin, Marine / Medernach, Rachel L / Vessely, Madeleine B / Mills, Jori O / Axline, Christopher M R / Nelson, Julia A / VanGosen, Ethan M / Ward, Timothy J / Ozer, Egon A / van Duin, David / Chen, Liang / Kreiswirth, Barry N / Long, S Wesley / Musser, James M /
    Bulman, Zackery P / Wunderink, Richard G / Hauser, Alan R

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7962

    Abstract: Klebsiella pneumoniae has been classified into two types, classical K. pneumoniae (cKP) and hypervirulent K. pneumoniae (hvKP). cKP isolates are highly diverse and important causes of nosocomial infections; they include globally disseminated antibiotic- ... ...

    Abstract Klebsiella pneumoniae has been classified into two types, classical K. pneumoniae (cKP) and hypervirulent K. pneumoniae (hvKP). cKP isolates are highly diverse and important causes of nosocomial infections; they include globally disseminated antibiotic-resistant clones. hvKP isolates are sensitive to most antibiotics but are highly virulent, causing community-acquired infections in healthy individuals. The virulence phenotype of hvKP is associated with pathogenicity loci responsible for siderophore and hypermucoid capsule production. Recently, convergent strains of K. pneumoniae, which possess features of both cKP and hvKP, have emerged and are cause of much concern. Here, we screen the genomes of 2,608 multidrug-resistant K. pneumoniae isolates from the United States and identify 47 convergent isolates. We perform phenotypic and genomic characterization of 12 representative isolates. These 12 convergent isolates contain a variety of antimicrobial resistance plasmids and virulence plasmids. Most convergent isolates contain aerobactin biosynthesis genes and produce more siderophores than cKP isolates but not more capsule. Unexpectedly, only 1 of the 12 tested convergent isolates has a level of virulence consistent with hvKP isolates in a murine pneumonia model. These findings suggest that additional studies should be performed to clarify whether convergent strains are indeed more virulent than cKP in mouse and human infections.
    MeSH term(s) Humans ; Animals ; Mice ; Virulence/genetics ; Klebsiella pneumoniae ; Virulence Factors/genetics ; Anti-Bacterial Agents/pharmacology ; Plasmids ; Siderophores
    Chemical Substances Virulence Factors ; Anti-Bacterial Agents ; Siderophores
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43802-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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