LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Axtmayer, Jossette"
  2. AU="Sato, Shusuke"
  3. AU="Debasis Mondal"
  4. AU="Hollingsworth, Neal A"
  5. AU=Restifo Nicholas P AU=Restifo Nicholas P
  6. AU="Farmer, Claire"
  7. AU="Hyeong, Seok-Ki"
  8. AU=Sathananthan A Henry
  9. AU="Ross D. Pollock"
  10. AU="Abouelkhair, Mohamed A"
  11. AU="Draia, Ahmed N"
  12. AU="Martins, Paulo"
  13. AU=Elliott P
  14. AU="Gill, J L"
  15. AU="Marmé, Dieter"
  16. AU=St John Ashley L
  17. AU="Macpherson, Catherine Fiona"
  18. AU=Malloy Giovanni S P
  19. AU="Bovino, Antonio"
  20. AU="Deseri, Luca"
  21. AU="Cunningham, C W"
  22. AU="Haas, Brian"
  23. AU="Raia, Anais"
  24. AU=Gollin Susanne M
  25. AU="Xie, Hong-Guang"
  26. AU="Ford, Paul Leicester"
  27. AU="Garver-Daniels, N. E."
  28. AU="De Pisapia, Nicola"
  29. AU="Inoue, Kazunori"
  30. AU="Tüzün, Funda"
  31. AU="McDonough, John"
  32. AU="Puche-Cañas, Emilio"
  33. AU="Rahim, Faraan O"
  34. AU="Barritt, Andrew W"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: An Unexpected Cause of Sepsis: Keep Pursuing the Source of Infection.

    Ramos-Rossy, Javier / Otero-Domínguez, Yomayra / Axtmayer, Jossette / Torres-Palacios, José / Cantres, Onix / Rodríguez-Cintrón, William

    Puerto Rico health sciences journal

    2019  Band 38, Heft 2, Seite(n) 118–119

    Abstract: An 86-year-old man was found with altered mental status, fever and aphasia. His physical exam revealed nuchal rigidity but no other meningeal signs. Because the patient's mental status was declining, he was intubated and placed in mechanical ventilation. ...

    Abstract An 86-year-old man was found with altered mental status, fever and aphasia. His physical exam revealed nuchal rigidity but no other meningeal signs. Because the patient's mental status was declining, he was intubated and placed in mechanical ventilation. His head CT scan was unremarkable, without evidence of mass effect. A lumbar puncture yielded cerebrospinal fluid that was remarkable for the presence of gram-positive cocci in pairs. His blood cultures showed gram-negative bacilli. Given the presence of these organisms, a polymicrobial infection was suspected. An abdomino pelvic CT scan showed a multi-septated abscess within the right hepatic lobe. CT-guided percutaneous drainage was performed and a specimen for culture obtained, which grew Klebsiella pneumoniae. After receiving intravenous antibiotics and supportive care, the patient showed clinical improvement. In this patient, there was a central nervous system infection secondary to bacteremia in the setting of an intrabdominal infection. The inquiring clinician should take note that whenever a polymicrobial infection is evidenced, more than one site of infection should be considered in the differential diagnosis.
    Mesh-Begriff(e) Aged, 80 and over ; Coinfection/complications ; Coinfection/diagnosis ; Coinfection/drug therapy ; Humans ; Male ; Meningitis, Bacterial/complications ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/drug therapy ; Sepsis/diagnosis ; Sepsis/drug therapy ; Sepsis/microbiology
    Sprache Englisch
    Erscheinungsdatum 2019-08-04
    Erscheinungsland Puerto Rico
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 639137-0
    ISSN 2373-6011 ; 0738-0658
    ISSN (online) 2373-6011
    ISSN 0738-0658
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 3093: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine.

    Yi, Kyung H / Axtmayer, Jossette / Gustin, John P / Rajpurohit, Anandita / Lauring, Josh

    Oncotarget

    2012  Band 4, Heft 1, Seite(n) 29–34

    Abstract: The phosphatidylinositol 3-kinase (PI3-kinase)-Akt-mTOR pathway is mutated at high frequency in human breast cancer, and this pathway is the focus of active drug discovery and clinical investigation. Trials of personalized cancer therapy seek to leverage ...

    Abstract The phosphatidylinositol 3-kinase (PI3-kinase)-Akt-mTOR pathway is mutated at high frequency in human breast cancer, and this pathway is the focus of active drug discovery and clinical investigation. Trials of personalized cancer therapy seek to leverage knowledge of cancer gene mutations by using mutations to guide the choice of targeted therapies. At the same time, cancer genome sequencing studies are identifying low frequency variants of unknown significance in known cancer genes, as well as genes of unknown function. We have performed functional analysis of six non-hotspot AKT1 pleckstrin homology domain mutants identified in recent large-scale breast cancer sequencing studies. Three of these mutants cause constitutive activation of Akt1 in the absence of growth factors, leading to phosphorylation of downstream target proteins. Like the hotspot E17K mutation, these mutants confer constitutive membrane localization of Akt1. Finally, the same three mutants showed oncogenic activity in a cellular transformation assay. The other three mutants were inactive in all assays. These findings validate novel driver mutations in AKT1, and extend the number and type of mutations that activate the PI3-kinase pathway in human breast cancers.
    Mesh-Begriff(e) Amino Acid Substitution ; Animals ; Binding Sites/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line ; Cell Membrane/metabolism ; Cell Transformation, Neoplastic/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Immunoblotting ; MCF-7 Cells ; Microscopy, Confocal ; Mutation ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
    Chemische Substanzen Green Fluorescent Proteins (147336-22-9) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2012-12-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.755
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang