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  1. Article ; Online: Change Is Incremental but Worth Fighting for: Breaking the Silence About HIV Intersectional Stigma.

    Ayala, George

    American journal of public health

    2022  Volume 112, Issue S4, Page(s) S333

    MeSH term(s) HIV Infections/prevention & control ; Humans ; Social Stigma
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2022.306746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.279: Show issues Location:
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  2. Article ; Online: Neuroepithelial Interactions in Cancer.

    Ayala, Gustavo

    Annual review of pathology

    2022  Volume 18, Page(s) 493–514

    Abstract: Nerves not only regulate the homeostasis and energetic metabolism of normal epithelial cells but also are critical for cancer, as cancer recapitulates the biology of neural regulation of epithelial tissues. Cancer cells rarely develop in denervated ... ...

    Abstract Nerves not only regulate the homeostasis and energetic metabolism of normal epithelial cells but also are critical for cancer, as cancer recapitulates the biology of neural regulation of epithelial tissues. Cancer cells rarely develop in denervated organs, and denervation affects tumorigenesis, in vivo and in humans. Axonogenesis occurs to supply the new malignant epithelial growth with nerves. Neurogenesis happens later, first in ganglia around organs or the spinal column and subsequently through recruitment of neuroblasts from the central nervous system. The hallmark of this stage is regulation of homeostasis and energetic metabolism. Perineural invasion is the most efficient interaction between cancer cells and nerves. The hallmark of this stage is increased proliferation and decreased apoptosis. Finally, carcinoma cells transdifferentiate into a neuronal profile in search of neural independence. The latter is the last stage in neuroepithelial interactions. Treatments for cancer must address the biology of neural regulation of cancer.
    MeSH term(s) Humans ; Neoplasms ; Neurons
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathmechdis-031521-023248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HIV Is a Story First Written on the Bodies of Gay and Bisexual Men.

    Ayala, George / Spieldenner, Andrew

    American journal of public health

    2021  Volume 111, Issue 7, Page(s) 1240–1242

    MeSH term(s) Acquired Immunodeficiency Syndrome/epidemiology ; Anti-Retroviral Agents/therapeutic use ; Bisexuality ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/ethnology ; Health Services Accessibility ; Homosexuality, Male ; Human Rights ; Humans ; Male ; Sexual and Gender Minorities ; Socioeconomic Factors ; United States/epidemiology
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2021.306348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Relationship between neck kinematics and neck dissability index. An approach based on functional regression.

    Aragón-Basanta, Elisa / Venegas, William / Ayala, Guillermo / Page, Alvaro / Serra-Añó, Pilar

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 215

    Abstract: Numerous studies use numerical variables of neck movement to predict the level of severity of a pathology. However, the correlation between these numerical variables and disability levels is low, less than 0.4 in the best cases, even less in subjects ... ...

    Abstract Numerous studies use numerical variables of neck movement to predict the level of severity of a pathology. However, the correlation between these numerical variables and disability levels is low, less than 0.4 in the best cases, even less in subjects with nonspecific neck pain. This work aims to use Functional Data Analysis (FDA), in particular scalar-on-function regression, to predict the Neck Disability Index (NDI) of subjects with nonspecific neck pain using the complete movement as predictors. Several functional regression models have been implemented, doubling the multiple correlation coefficient obtained when only scalar predictors are used. The best predictive model considers the angular velocity curves as a predictor, obtaining a multiple correlation coefficient of 0.64. In addition, functional models facilitate the interpretation of the relationship between the kinematic curves and the NDI since they allow identifying which parts of the curves most influence the differences in the predicted variable. In this case, the movement's braking phases contribute to a greater or lesser NDI. So, it is concluded that functional regression models have greater predictive capacity than usual ones by considering practically all the information in the curve while allowing a physical interpretation of the results.
    MeSH term(s) Humans ; Neck Pain/diagnosis ; Biomechanical Phenomena ; Disability Evaluation ; Multivariate Analysis ; Physical Examination
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50562-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Small Felids Coexist in Mixed-Use Landscape in the Bolivian Amazon.

    Anderson, Courtney / Zuckerwise, Amelia / Wallace, Robert B / Ayala, Guido / Viscarra, Maria / Schmitz, Oswald J

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 5

    Abstract: In the face of global species loss, it is paramount to understand the effects of human activity on vulnerable species, particularly in highly diverse, complex systems. The Greater Madidi Landscape in the Bolivian Amazon includes several biodiverse ... ...

    Abstract In the face of global species loss, it is paramount to understand the effects of human activity on vulnerable species, particularly in highly diverse, complex systems. The Greater Madidi Landscape in the Bolivian Amazon includes several biodiverse protected areas that were created with the goal of sustaining healthy and diverse ecosystems while not impeding the livelihoods of local indigenous peoples. In this study, we sought to use camera trap data and single-species occupancy analysis to assess the impacts of different forms of human activity on four species of small felids: ocelots (
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14050697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes.

    Fernández-Coto, Diana Lashidua / Gil, Jeovanis / Ayala, Guadalupe / Encarnación-Guevara, Sergio

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Glioblastoma, a type of cancer affecting the central nervous system, is characterized by its poor prognosis and the dynamic alteration of its metabolic phenotype to fuel development and progression. Critical to cellular metabolism, mitochondria play a ... ...

    Abstract Glioblastoma, a type of cancer affecting the central nervous system, is characterized by its poor prognosis and the dynamic alteration of its metabolic phenotype to fuel development and progression. Critical to cellular metabolism, mitochondria play a pivotal role, where the acetylation of lysine residues on mitochondrial enzymes emerges as a crucial regulatory mechanism of protein function. This post-translational modification, which negatively impacts the mitochondrial proteome's functionality, is modulated by the enzyme sirtuin 3 (SIRT3). Aiming to elucidate the regulatory role of SIRT3 in mitochondrial metabolism within glioblastoma, we employed high-resolution mass spectrometry to analyze the proteome and acetylome of two glioblastoma cell lines, each exhibiting distinct metabolic behaviors, following the chemical inhibition of SIRT3. Our findings reveal that the protein synthesis machinery, regulated by lysine acetylation, significantly influences the metabolic phenotype of these cells. Moreover, we have shed light on potential novel SIRT3 targets, thereby unveiling new avenues for future investigations. This research highlights the critical function of SIRT3 in mitochondrial metabolism and its broader implications for cellular energetics. It also provides a comparative analysis of the proteome and acetylome across glioblastoma cell lines with opposing metabolic phenotypes.
    MeSH term(s) Humans ; Sirtuin 3/metabolism ; Proteome/metabolism ; Lysine/metabolism ; Glioblastoma/metabolism ; Mitochondria/metabolism ; Protein Processing, Post-Translational ; Phenotype ; Acetylation ; Mitochondrial Proteins/metabolism
    Chemical Substances Sirtuin 3 (EC 3.5.1.-) ; Proteome ; Lysine (K3Z4F929H6) ; Mitochondrial Proteins
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Impact of Delivering a Healthy Lifestyle Intervention:

    Madanat, H / Martinez, A / Molina, M / Ayala, G X

    Journal of health science & education

    2023  Volume 1, Issue 3, Page(s) 1–7

    Abstract: Background: Community health workers, : Objectives: This study assessed whether : Methods: Volunteer : Results: Repeated measures ANOVAs showed statistically significant decreases from baseline to 6 months for systolic blood pressure (p ≤ 0.05), ...

    Abstract Background: Community health workers,
    Objectives: This study assessed whether
    Methods: Volunteer
    Results: Repeated measures ANOVAs showed statistically significant decreases from baseline to 6 months for systolic blood pressure (p ≤ 0.05), diastolic blood pressure (p ≤ 0.001) and body mass index (p ≤ 0.05). Changes in self-reported measures were not statistically significant although trends were observed with increases in water consumption.
    Conclusions: Findings from this study suggest positive effects associated with delivery of a PA intervention. This is one of the first studies to focus on a cohort of
    Language English
    Publishing date 2023-06-27
    Publishing country Trinidad and Tobago
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fostering student and faculty scholarship in an accelerated three-year medical school.

    Kasselman, Lora J / Ayala, Gladys / Shelov, Steven / Nonaillada, Jeannine

    MedEdPublish (2016)

    2022  Volume 12, Page(s) 45

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-06-23
    Document type Journal Article
    ISSN 2312-7996
    ISSN (online) 2312-7996
    DOI 10.12688/mep.19142.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Addressing HIV-Related Intersectional Stigma and Discrimination to Improve Public Health Outcomes: An

    Dale, Sannisha K / Ayala, George / Logie, Carmen H / Bowleg, Lisa

    American journal of public health

    2022  Volume 112, Issue S4, Page(s) S335–S337

    MeSH term(s) HIV Infections/prevention & control ; Humans ; Public Health ; Social Stigma
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2022.306738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterization of aTiO

    Ureiro-Cueto, Guadalupe / Rodil, Sandra E / Santana-Vázquez, Maricela / Hoz-Rodriguez, Lia / Arzate, Higinio / Montoya-Ayala, Gonzalo

    Journal of biomedical materials research. Part A

    2024  

    Abstract: Functionalization of Titanium implants using adequate organic molecules is a proposed method to accelerate the osteointegration process, which relates to topographical, chemical, mechanical, and physical features. This study aimed to assess the potential ...

    Abstract Functionalization of Titanium implants using adequate organic molecules is a proposed method to accelerate the osteointegration process, which relates to topographical, chemical, mechanical, and physical features. This study aimed to assess the potential of a peptide derived from cementum attachment protein (CAP-p15) adsorbed onto aTiO
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37676
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