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Article ; Online: Early neonatal outcomes in infants of mothers with organ transplantation under immunosuppressive treatment.

Çelik, Kıymet / Arayıcı, Sema / Zarif, Nurten Özkan / Kıhtır, Zeynep / Ongun, Hakan / Aydınlı, Bülent

2024 Volume 66, Issue 1, Page(s) 17–24

Abstract: Background: This study aimed to examine early clinical and laboratory findings in infants born to mothers who had organ transplants and received immunosuppressive treatment.: Methods: Between 2016 and 2023, the study examined infants of mothers who ... ...

Abstract	Background: This study aimed to examine early clinical and laboratory findings in infants born to mothers who had organ transplants and received immunosuppressive treatment. Methods: Between 2016 and 2023, the study examined infants of mothers who underwent organ transplantation and were receiving immunosuppressive treatment, and followed at the Department of Neonatology at Akdeniz University. Demographic, clinical, and laboratory characteristics of mothers and infants were recorded. On the first day of life, complete blood count values were examined, as well as potassium levels on the first, third, and seventh days, and creatinine levels on the third and seventh days. The tacrolimus blood level was calculated by taking the average of the tacrolimus blood values of the mother measured during the pregnancy. The infants were evaluated for any potential morbidities caused by intrauterine immunosuppressive drug exposure. Results: The study included 21 mothers (some with multiple pregnancies) and 27 infants. According to the findings of this study, 74% of these infants were born premature, 67% had low birth weight, and all were delivered via cesarean section. Prematurity was associated with the morbidities found in the infants. In the early period, lymphopenia was detected in 37%, neutropenia in 25.9%, thrombocytopenia in 11.1%, hyperkalemia in 18.5%, and creatinine elevation in 7.4%, all of which returned to normal within a few days. There was no significant relationship between maternal tacrolimus blood levels and infant potassium and creatinine levels. Conclusion: Apart from an increased risk of prematurity, low birth weight, and cesarean delivery, no effects were observed in these infants during the early period. However, long-term follow-up is necessary to monitor for any potential morbidities.
MeSH term(s)	Infant, Newborn ; Infant ; Pregnancy ; Humans ; Female ; Tacrolimus/adverse effects ; Mothers ; Cesarean Section ; Creatinine ; Immunosuppressive Agents/adverse effects ; Organ Transplantation ; Infant, Newborn, Diseases/drug therapy ; Potassium
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Creatinine (AYI8EX34EU) ; Immunosuppressive Agents ; Potassium (RWP5GA015D)
Language	English
Publishing date	2024-03-25
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2023.748
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Article ; Online: Rare Relationship Between the Right Hepatic Artery and Common Hepatic Duct in Living Donor Right Hepatectomy.

Kisaoglu, Abdullah / Avanaz, Ali / Demiryilmaz, Ismail / Sarıdemir Ünal, Demet / Özkan, Ömer / Aydinli, Bulent

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2022 Volume 21, Issue 1, Page(s) 63–65

Abstract: In living donor liver transplant, it is vital to perceive the hepatic artery anatomy and its variants. In the normal hepatic artery pattern, the common hepatic artery originates from the celiac artery to form the proper hepatic artery and gastroduodenal ... ...

Abstract	In living donor liver transplant, it is vital to perceive the hepatic artery anatomy and its variants. In the normal hepatic artery pattern, the common hepatic artery originates from the celiac artery to form the proper hepatic artery and gastroduodenal artery. The proper hepatic artery divides into right and left branches that supply the right and left lobes of the liver, respectively. Here, we report a rare variation of the right hepatic artery that was detected during a living liver right lobe hepatectomy. A 59-year-old man with alcoholic liver cirrhosis underwent living donor liver transplant. The patient's niece (a 47-year-old woman) volunteered to be a living donor. During the hilar dissection, we noticed that the anterior and posterior branches of the right hepatic artery passed through points anterior and posterior to the common hepatic duct, respectively. The right anterior hepatic artery and the right hepatic artery were divided separately. Although previously defined classifications have described anatomical variations of origin, branching, and course of hepatic artery, the topographical relationship of the anterior right hepatic artery and the posterior right hepatic artery versus the common hepatic duct has not been a matter of concern. Awareness must be maintained of this rare anatomical course of the right hepatic artery, especially in living liver right lobe donors. In the event of donors with rare variations, living donor liver transplant should be performed by an experienced team.
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Hepatectomy ; Hepatic Artery/diagnostic imaging ; Hepatic Artery/surgery ; Liver Transplantation/adverse effects ; Living Donors ; Hepatic Duct, Common ; Liver/anatomy & histology
Language	English
Publishing date	2022-05-23
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2022.0042
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Article ; Online: Evaluation of the effect and predictive role of vitamin D and vitamin D receptor expression in CD4 + , CD8 + , CD14 + , CD56 + cells on the development of chronic rejection and graft functions in kidney transplant patients.

Vural, Tuba / Yilmaz, Vural Taner / Koksoy, Sadi / Kisaoglu, Abdullah / Ozel, Deniz / Demiryilmaz, Ismail / Aydinli, Bulent / Kocak, Huseyin / Suleymanlar, Gultekin

International urology and nephrology

2023 Volume 55, Issue 10, Page(s) 2589–2598

Abstract: Purpose: It is known that vitamin D has positive effects on graft functions (reduce fibrosis, suppress excessive inflammatory response, improve graft functions). In our study, it was aimed to evaluate the effects and predictive roles of vitamin D, the ... ...

Abstract	Purpose: It is known that vitamin D has positive effects on graft functions (reduce fibrosis, suppress excessive inflammatory response, improve graft functions). In our study, it was aimed to evaluate the effects and predictive roles of vitamin D, the expression of vitamin D receptor (VDR) in lymphocytes, monocytes, natural killer cells on chronic rejection and graft functions in kidney transplant patients. Methods: Seventy one people were included in the study and analyses were made by dividing them into 3 groups. Group 1: Healthy control (n = 29), Group 2: Kidney transplant patients with stable kidney function (n = 17), and Group 3: Kidney transplant patients with chronic rejection diagnosis (n = 25). Serum 25-hydroxycholecalciferol, 1.25 dihydroxycholecalciferol levels and VDR percentages in CD4 + , CD8 + , CD14 + , CD56 + cells were measured in 3 groups. ROC analyses and logistic regression models were performed to predict rejection and long-term graft functions. Results: The percentage of VDR expression in CD4 + lymphocytes (p < 0.001) and CD14( +) monocytes (p < 0.001), 25-hydroxycholecalciferol and 1.25 dihydroxycholecalciferol levels were lower in group 3 was detected. In ROC analyses and logistic regression models, VDR expression in CD4( +)T lymphocytes was shown to have a statistically significant value in the development of chronic rejection (Odds ratio 0.86: 0.76-0.92; p = 0.001/AUC = 0.941, p < 0.001) and prediction of 5th-year graft functions (Odds ratio 0.93: 0.88-0.98; p = 0.017/AUC = 0.745, p = 0.007). Conclusion: In our study, it was shown that low vitamin D and VDR expression is associated with poor outcome and VDR expression in CD4( +)T lymphocytes is predictive in terms of graft function and rejection.
MeSH term(s)	Humans ; Kidney Transplantation ; Receptors, Calcitriol ; Vitamin D ; Calcifediol ; Graft Rejection/diagnosis ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Dihydroxycholecalciferols
Chemical Substances	Receptors, Calcitriol ; Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q) ; Dihydroxycholecalciferols
Language	English
Publishing date	2023-03-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-023-03550-z
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Article ; Online: The Factors Affecting Mortality After Pediatric Liver Transplantation and Long-Term Survival Outcomes: A Single Center Experience.

Avanaz, Ali / Ünal, Demet Sarıdemir / Kisaoglu, Abdullah / Yilmaz, Vural Taner / Moharer, Pooya Salehi / Demiryilmaz, Ismail / Aydinli, Bulent

Transplantation proceedings

2023 Volume 55, Issue 5, Page(s) 1182–1185

Abstract: Background: Liver transplantation (LT) is a treatment modality in the pediatric population for several diseases like biliary atresia, metabolic liver disease, hepatoblastoma, and so on. According to the Organ Procurement and Transplantation Network, 5- ... ...

Abstract	Background: Liver transplantation (LT) is a treatment modality in the pediatric population for several diseases like biliary atresia, metabolic liver disease, hepatoblastoma, and so on. According to the Organ Procurement and Transplantation Network, 5-year survival was reported as 85.4% to 93.5% by age after pediatric liver transplantation (PLT). This study aimed to evaluate our single-center experience of PLT by analyzing long-term results, comparing the outcomes with the literature, and identifying predictors of patient survival. Methods: The data of 40 patients who underwent LT at <18 years of age between June 2015 and June 2021 were studied retrospectively. Recipient characteristics such as age, sex, etiology of liver disease follow-up time, postoperative vascular and biliary complications, and donor characteristics were evaluated. Results: There were 20 (50%) girls and 20 (50%) boys, and the median age was 42 (IQR = 9-117) months. The most common indications of LT were biliary disorders (45%). A whole liver graft was used in 7 (17%), a right lobe graft in 9 (23%), a left lobe graft in 4 (10%), and a left lateral lobe graft in 20 (50%) of the recipients. The 1-, 3-, 5-, and 7-year survival rates were 85%, 82.1%, 82.1%, and 82.1%, respectively. The multivariate survival analysis revealed that the pediatric end-stage liver disease score, hepatic artery thrombosis, and portal vein thrombosis are associated with overall mortality. Conclusion: In conclusion, our long-term survival is similar to the literature, with satisfactory results. However, reducing the vascular complication rates can provide superior results on PLT.
MeSH term(s)	Male ; Female ; Child ; Humans ; Adult ; Liver Transplantation/methods ; End Stage Liver Disease/surgery ; Retrospective Studies ; Postoperative Complications/epidemiology ; Severity of Illness Index ; Liver Diseases/complications ; Thrombosis/complications ; Living Donors ; Graft Survival ; Treatment Outcome
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.01.036
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Article ; Online: Predictive Factors of BK Virus Development in Kidney Transplant Recipients and the Effect of Low-Dose Tacrolimus Plus Everolimus on Clinical Outcomes.

Yilmaz, Vural Taner / Kisaoglu, Abdullah / Avanaz, Ali / Dandin, Ozgur / Ozel, Deniz / Mutlu, Derya / Akkaya, Bahar / Aydinli, Bulent / Kocak, Huseyin

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2023 Volume 21, Issue 9, Page(s) 727–734

Abstract: Objectives: This study aimed to determine the predictive factors of BK virus viremia/nephropathy in kidney transplant recipients and to evaluate the effects of low-dose tacrolimus plus everolimus.: Materials and methods: This study included 3654 ... ...

Abstract	Objectives: This study aimed to determine the predictive factors of BK virus viremia/nephropathy in kidney transplant recipients and to evaluate the effects of low-dose tacrolimus plus everolimus. Materials and methods: This study included 3654 kidney transplant recipients. The patients were divided into 2 groups: group 1 were BK virus negative (n = 3525, 96.5%) and group 2 were BK virus positive (n = 129, viremia 3.5%, nephropathy 1%). Predictive factors were determined by receiver operating characteristic curve analysis and logistic regression models.We also divided and analyzed patients with BK virus viremia/nephropathy into 2 groups according to immunosuppressive changes. Group 2a had been switched to low-dose tacrolimus plus everolimus (n = 54, 41.9%), and group 2b had been switched to other immunosuppressive protocols (n = 75, 58.1%). Results: We found that use of anti-T-cell lymphocyte globulin and tacrolimus, deceased donor transplant, and rejection were predictive factors for BK virus viremia/nephropathy. In addition, patients who had low-dose calcineurin inhibitor plus mammalian target of rapamycin inhibitor regimens showed a low rate of BK virus development(only 6.2% of all cases). In Group 2a, both the BK polyomavirus-associated nephropathy rate (n = 23 [42.6%] vs n = 12 [16%] in group 2b; P = .001) and viral load (DNA > 104 copies/mL) (n = 49 [90.7%] vs n = 27 [36%] in group 2b; P = .001) were increased versus group 2b. Graft function, graft survival, viral clearance, and rejection rate were similar between the groups after protocol change. Conclusions: BK virus viremia/nephropathy rate was lower in patients who received low-dose calcineurin inhibitor plus mammalian target of rapamycin inhibitor protocols; the low-dose tacrolimus plus everolimus switch protocol after BK virus was more effective and safe than other protocols.
MeSH term(s)	Humans ; Tacrolimus/adverse effects ; Everolimus/adverse effects ; BK Virus ; Kidney Transplantation/adverse effects ; Calcineurin Inhibitors/adverse effects ; Viremia/diagnosis ; Viremia/drug therapy ; Immunosuppressive Agents/adverse effects ; Sirolimus/pharmacology ; Nephritis, Interstitial/etiology ; Polyomavirus Infections/diagnosis ; Polyomavirus Infections/drug therapy ; Tumor Virus Infections/diagnosis ; Tumor Virus Infections/drug therapy ; Transplant Recipients ; TOR Serine-Threonine Kinases
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Everolimus (9HW64Q8G6G) ; Calcineurin Inhibitors ; Immunosuppressive Agents ; Sirolimus (W36ZG6FT64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-10-26
Publishing country	Turkey
Document type	Journal Article ; Comment
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2023.0065
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Article ; Online: Evaluation of the relationship between de-novo DSA development and CXCR5+PD-1+CD8+ T cells and PD-1/PD-L1 mRNA expression in kidney transplant recipients.

Ekinci, Nurten Sayin / Yilmaz, Vural Taner / Kilinc, Yahya / Kocak, Huseyin / Darbas, Sule / Kisaoglu, Abdullah / Aydinli, Bulent / Uzuner, Sezin Yakut / Ucar, Fahri

Clinical transplantation

2023 Volume 37, Issue 11, Page(s) e15104

Abstract: Background and aims: The relationship between the Follicular Cytotoxic T cell subgroup and expression levels of PD1/PD-L1 genes and the development of donor specific antibody (DSA) is unknown. In this study, we aimed to examine CD8+CXCR5+PD-1+ ... ...

Abstract	Background and aims: The relationship between the Follicular Cytotoxic T cell subgroup and expression levels of PD1/PD-L1 genes and the development of donor specific antibody (DSA) is unknown. In this study, we aimed to examine CD8+CXCR5+PD-1+ follicular cytotoxic T cell levels and expression levels of PD1/PD-L1 genes in peripheral blood lymphocytes in de-novo DSA positive and negative kidney transplant recipients (KTR). Methods: In our study, expression of PD-1/ PD-L1 genes by Real-Time Quantitative PCR method and CD8+CXCR5+PD-1+ T cell expression levels by flow cytometric method were obtained from peripheral blood samples. 63 participants were included in the study (de-novo DSA positive recipients (n = 22, group 1), de-novo DSA negative recipients (n = 20, group 2) and healthy control (n = 21, group 3). All patients had negative PRA before kidney transplantation. Expression (%) levels of target cells were evaluated by flow cytometry method. IBM SPSS Statistics for Windows Version 22 and R.3.3.2 software were used to evaluate the data. Results: The demographic data of the groups were similar. PD-1 mRNA expression was higher in de-novo DSA positive KTR than negative (respectively, 1.03 ± .29/.82 ± .15, p: .001). CD8+CXCR5+PD-1+ T cell expression levels were found to be higher in the de-novo DSA positive group than in the negative group and similar to the healthy group (respectively, 3.06 ± 1.98/.52 ± .40, p:.001, 3.06 ± 1.98/2.78 ± .59, p:.62). The percentage of CD8+CXCR5+PD-1+ expressing T cells was significantly lower in the HLA-Class II+ group than other groups (HLA CI/II/ I+II, respectively, 3.63 ± 2.72/1.65 ± .50/3.68 ± 1.67, p: .04). Conclusions: In our study, a significant relationship was found between DSA formation and PD-1 mRNA level and CD8+CXCR5+PD-1+ follicular cytotoxic T cell in KTR.
MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; Programmed Cell Death 1 Receptor/genetics ; B7-H1 Antigen/genetics ; Antibodies ; CD8-Positive T-Lymphocytes ; Transplant Recipients ; Graft Rejection/etiology ; Receptors, CXCR5/genetics
Chemical Substances	Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; Antibodies ; CXCR5 protein, human ; Receptors, CXCR5
Language	English
Publishing date	2023-08-17
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15104
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Article ; Online: Preliminary Report of the ministry of health working group on standardization of living donor liver transplantation in Turkiye.

Umman, Veysel / Zeytunlu, Murat / Karasu, Zeki / Aydinli, Bulent / Kaciroglu, Fatih / Yavuz, Yusuf / Tekin, Ahmet / Emre, Sukru

Hepatology forum

2022 Volume 3, Issue 3, Page(s) 93–94

Abstract: Liver transplantation is successfully achieved all over the world and in Turkiye. Similar to many middle and far east countries, donation from deceased donors has not reached the desired level in Turkiye. Therefore, in Turkiye, living donors have been ... ...

Abstract	Liver transplantation is successfully achieved all over the world and in Turkiye. Similar to many middle and far east countries, donation from deceased donors has not reached the desired level in Turkiye. Therefore, in Turkiye, living donors have been frequently used for liver transplantation. Although Turkiye is the leading country in Europe and one of the top three countries in the world executing LDLT, nationwide standardization of LDLT protocols, including donor and recipient evaluation and acceptance criteria, donor and recipient follow-up and reporting rules, and routine periodic audits by the ministry of health authorities, has not been established. Therefore, we created a working group to study reviewing regulations of LDLT operation in Europe and the USA. The establishment and implementation of standardization of LDLT operation will serve to improve the donor and recipient outcomes while preventing incomplete or incorrect practices. The guide prepared on this subject is presented in the Appendix.
Language	English
Publishing date	2022-09-23
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2022.2021.0047
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Article ; Online: Management of reperfusion deficiency with indocyanine green fluorescence imaging during deceased donor liver transplantation in a pediatric recipient.

Kisaoglu, Abdullah / Demiryilmaz, Ismail / Dandin, Ozgur / Ozkan, Omer / Aydinli, Bulent

HPB : the official journal of the International Hepato Pancreato Biliary Association

2019 Volume 22, Issue 4, Page(s) 633

MeSH term(s)	Child ; Humans ; Indocyanine Green ; Liver Transplantation/adverse effects ; Living Donors ; Perfusion ; Tissue Donors ; Treatment Outcome
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2019-10-24
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2019.10.012
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Article: New markers for predictions of acute and chronic rejection and graft outcomes in kidney transplant recipients; HLA-G gene 3′UTR 14 bp polymorphism and sHLA-G

Darbas, Sule / Yilmaz, Vural Taner / Kocak, Huseyin / Kisaoglu, Abdullah / Demiryilmaz, Ismail / Aydinli, Bulent / Arslan, Habibe Sema / Ucar, Fahri

Gene. 2021 July 20, v. 790

2021

Abstract: The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients.The study was planned as a case- ... ...

Abstract	The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients.The study was planned as a case-control study involving two hundred fifty kidney transplant recipients. The case group consisted of 125 (female/male: 56/69) kidney transplant recipients diagnosed with acute (n = 52) and chronic rejection (n = 73). The control group consisted of one hundred twenty-five kidney transplant patients with no acute or chronic rejection matched by gender and age in the case group. The sHLA-G level in the recipient's plasma (at the time of rejection for the case, the same time as the case after the transplant for control) was analyzed by Enzyme-Linked Immunosorbent Assay (ELISA). HLA-G 3′ untranslated region (3′UTR) polymorphism of recipient and donor was determined using agarose gel electrophoresis and DNA sequencing method.In our study, it was shown that acute rejection rate increased 1.06 times and chronic rejection rate increased 1.14 times in kidney transplant recipients with low serum sHLA-G levels. The rejection patients with the HLA-G 14 bp del/del genotype had higher sHLA-G levels post-transplantation. The frequency of acute rejection was lower in patients with HLA-G 14 bp del/del polymorphism than those with ins/ins and ins/del polymorphisms.This study proposes that HLA-G 3′UTR polymorphism and sHLA-G level might be useful in prediction of rejection in kidney transplant recipients.
Keywords	DNA ; agar gel electrophoresis ; blood serum ; case-control studies ; enzyme-linked immunosorbent assay ; females ; genes ; genotype ; humans ; kidney transplant ; leukocytes ; males ; prediction
Language	English
Dates of publication	2021-0720
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2021.145712
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Regulatory B Cells Profile in Kidney Transplant Recipients With Chronic-Active Antibody-Mediated Rejection.

Guzel, Halil Goksel / Yilmaz, Vural Taner / Koksoy, Sadi / Kocak, Huseyin / Kisaoglu, Abdullah / Soylu, Mehmet / Akkaya, Bahar / Demiryilmaz, Ismail / Aydinli, Bülent / Suleymanlar, Gultekin

Transplantation proceedings

2023 Volume 55, Issue 5, Page(s) 1140–1146

Abstract: This study aims to reveal the relationship between regulatory B cell (Breg) subsets and chronic-active antibody-mediated rejection (c-aABMR) in renal transplant recipients. Our study involved 3 groups of participants: renal transplant recipients with ... ...

Abstract	This study aims to reveal the relationship between regulatory B cell (Breg) subsets and chronic-active antibody-mediated rejection (c-aABMR) in renal transplant recipients. Our study involved 3 groups of participants: renal transplant recipients with biopsy-proven c-aABMR as the chronic rejection group (c-aABMR, n = 23), recipients with stable graft functions as the patient control group (PC; n = 11), and healthy volunteers (HV; n = 11). Breg subsets, immature/transitional B cells, plasmablastic cells, B10 cells, and BR1 cells were isolated from venous blood samples by flow cytometry. The median values of Breg frequencies in the total lymphocyte population were analyzed. There were no significant differences between the study groups for immature and/or transitional B cell frequencies. Plasmablastic cell frequencies of the c-aABMR group (7.80 [2.10-27.40]) and the PC group (6.00 [1.80-55.50]) were similar, but both of these values were significantly higher than the HVs' (3.40 [1.20-8.50]), (respectively, P = .005 and P = .039). B10 cell frequencies were also similar, comparing the c-aABMR (4.20 [0.10-7.40]) and the PC groups (4.10 [0.10-5.90]), whereas the HVs (5.90 [2.90-8.50]) had the highest B10 cell frequency with an only statistical significance against the PC group (respectively, P = .09 and P = .028). The c-aABMR and the PC groups were similar regarding BR1 cell frequencies. However, the HV group significantly had the highest frequency of BR1 cells (5.50 [2.80-10.80]) than the other groups (P < .001 for both). We demonstrated that frequencies of B10 and BR1 cells were higher in HVs than in transplant recipients, regardless of rejection state. However, there was no significant relation between Breg frequencies and the c-aABMR state.
MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; B-Lymphocytes, Regulatory ; Transplant Recipients ; Antibodies ; Kidney ; Graft Rejection
Chemical Substances	Antibodies
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.03.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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