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Article ; Online: Incidence and characteristics of rhegmatogenous retinal detachment during coronavirus-19 pandemic: A French study.

Vest, Agathe / Keilani, Chafik / Chaumet-Riffaud, Philippe / Barale, Pierre-Olivier / Tuil, Eric / Ayello-Scheer, Sarah / Koch, Edouard / Abada, Samir / Giocanti-Auregan, Audrey / Durand-Zaleski, Isabelle / Delbarre, Maxime / Froussart-Maille, Françoise / Beaugrand, Amélie / Tadayoni, Ramin / Sahel, José-Alain / Paques, Michel

European journal of ophthalmology

2022 Volume 32, Issue 6, Page(s) 3644–3649

Abstract: Purpose: To assess the impact of the Covid-19 pandemic and subsequent lockdown on the number and clinical characteristics of patients with retinal detachment (RD) in a French public university eye hospital.: Methods: Single-center, retrospective non- ... ...

Abstract	Purpose: To assess the impact of the Covid-19 pandemic and subsequent lockdown on the number and clinical characteristics of patients with retinal detachment (RD) in a French public university eye hospital. Methods: Single-center, retrospective non-interventional study. Patients consulting at the emergency room (ER) of Quinze-Vingts Hospital (France) for rhegmatogenous RD before and after instauration of the lockdown were reviewed. We compared the characteristics of patients with RD between the containment period (March17th - April27th,2020) and the period preceding the lockdown (February18th - March16th,2020). We compared the number of RD surgeries performed between the first month of lockdown (March17th - April19th,2020) and the corresponding period of 2019. Number of cases, delay between diagnosis and surgery, visual acuity was measured. Results: During the first month of lockdown, 59 RDs were operated on, compared to 107 in the corresponding period in 2019 (-44,8%). Mean time from first symptoms to surgery was significantly higher during the lockdown 12.7 (11.3) days vs 7.6 (7.8) days (p = 0.031) before. During the lockdown, the mean BCVA was lower albeit the difference did not reach statistical significance (1.16 (0.9) during pre-containment vs 1.5 (0.9) during containment; p = 0.09). Reasonsfor delayed consultation were: fear of Covid-19 (31%; p = 0.0001), absence of referral doctor (31%; p = 0.003) and difficulties in getting to public transport (10.3%;p = 0.859). Conclusion: Despite maintaining accessto emergency eye care facilitiesin our hospital, the lockdown affected visual health. Should the lockdown be reinstated, we postulate that a better information about eye care access for non-Covid emergencies may attenuate its effect on visual health.
MeSH term(s)	COVID-19/epidemiology ; Communicable Disease Control ; Humans ; Incidence ; Pandemics ; Retinal Detachment/epidemiology ; Retinal Detachment/etiology ; Retinal Detachment/surgery ; Retrospective Studies
Language	English
Publishing date	2022-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221080810
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Article ; Online: Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Keilani, Chafik / Augstburger, Edouard / Robin, Mathieu / Beaugrand, Amélie / Ores, Raphaëlle / Sahel, José-Alain / Ayello-Scheer, Sarah

Turkish journal of ophthalmology

2019 Volume 49, Issue 6, Page(s) 334–341

Abstract: Objectives: To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil- RMN3 (Oxane: Materials and methods: This was a retrospective, single-centre, comparative case series of 23 patients ... ...

Abstract	Objectives: To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil- RMN3 (Oxane Materials and methods: This was a retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria were RD with inferior PVR receiving Oxane Results: Twenty-three eyes were included: 16 eyes with Densiron Conclusion: Densiron
MeSH term(s)	Aged ; Endotamponade/methods ; Female ; Humans ; Male ; Middle Aged ; Retinal Detachment/etiology ; Retinal Detachment/physiopathology ; Retinal Detachment/surgery ; Retrospective Studies ; Silicone Oils/administration & dosage ; Treatment Outcome ; Visual Acuity/physiology ; Vitrectomy ; Vitreoretinopathy, Proliferative/complications
Chemical Substances	Silicone Oils ; densiron-68 ; oxane HD
Language	English
Publishing date	2019-12-28
Publishing country	Turkey
Document type	Comparative Study ; Journal Article
ZDB-ID	2586160-8
ISSN	2149-8709 ; 2147-2661 ; 1300-0659 ; 1300-0659 ; 2149-8695
ISSN (online)	2149-8709 ; 2147-2661 ; 1300-0659
ISSN	1300-0659 ; 2149-8695
DOI	10.4274/tjo.galenos.2019.24294
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Article ; Online: Improved performance and safety from Argus II retinal prosthesis post-approval study in France.

Delyfer, Marie-Noëlle / Gaucher, David / Mohand-Saïd, Saddek / Barale, Pierre-Olivier / Rezaigua-Studer, Fouzia / Ayello-Scheer, Sarah / Dollfus, Hélène / Dorn, Jessy D / Korobelnik, Jean-François / Sahel, José-Alain

Acta ophthalmologica

2020 Volume 99, Issue 7, Page(s) e1212–e1221

Abstract: Purpose: To evaluate the post-approval long-term outcomes of the Argus II Retinal Prosthesis, with a specific focus on its functional visual benefit in patients' daily activities.: Methods: Eighteen patients with bare light perception due to end- ... ...

Abstract	Purpose: To evaluate the post-approval long-term outcomes of the Argus II Retinal Prosthesis, with a specific focus on its functional visual benefit in patients' daily activities. Methods: Eighteen patients with bare light perception due to end-stage retinitis pigmentosa were included in a French prospective, multicentre, single-arm study and followed for 2 years. Visual benefit in patients' daily activities was monitored through the use of the Functional Low-vision Observer Rated Assessment (FLORA), and the final score at 2 years was the primary effectiveness outcome. Standardized visual assessments were also performed. Device- or procedure-related adverse events were recorded. Results: Seventeen subjects completed the study. Positive impacts of the Argus II system on functional vision and well-being were demonstrated for over 70% of subjects on the FLORA. Among the daily activities/tasks tested, finding doorways was one of the most statistically significantly improved tasks (p < 0.001), along with estimating the size of an obstacle (p < 0.001), visually locating a place setting on a dining table (p < 0.001) and visually locating people in a non-crowded setting (p < 0.001). Visual function was improved on most standardized tests. Only two device- or procedure-related serious adverse events were observed (one vitreous haemorrhage and one endophthalmitis, both resolved with treatment). No explantation was required. Conclusion: This first report of a completed post-approval study of Argus II with a two-year follow-up demonstrates the safety and effectiveness of the Argus II System in a real-world cohort of patients and further highlights its real functional benefit in implanted patients' daily activities.
MeSH term(s)	Device Approval ; Female ; Follow-Up Studies ; France/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Prosthesis Design ; Prosthesis Implantation/methods ; Retina/physiopathology ; Retina/surgery ; Retinitis Pigmentosa/epidemiology ; Retinitis Pigmentosa/physiopathology ; Retinitis Pigmentosa/surgery ; Time Factors ; Visual Acuity ; Visual Prosthesis/standards
Language	English
Publishing date	2020-12-23
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.14728
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Article ; Online: Indocyanine-green-guided targeted laser photocoagulation of capillary macroaneurysms in macular oedema: a pilot study.

Paques, Michel / Philippakis, Elise / Bonnet, Clémence / Falah, Sabrina / Ayello-Scheer, Sarah / Zwillinger, Stéphanie / Girmens, Jean-François / Dupas, Benedicte

The British journal of ophthalmology

2017 Volume 101, Issue 2, Page(s) 170–174

Abstract: Aims: In longstanding diabetic macular oedema (DME) or retinal vein occlusion (RVO), capillary macroaneurysms may develop. Indocyanine green angiography (ICGA) has been shown to optimise their detection. Here, we report the anatomical and functional ... ...

Abstract	Aims: In longstanding diabetic macular oedema (DME) or retinal vein occlusion (RVO), capillary macroaneurysms may develop. Indocyanine green angiography (ICGA) has been shown to optimise their detection. Here, we report the anatomical and functional outcome of the elective photocoagulation of capillary macroaneurysms. Methods: A retrospective, interventional, two-centre study. In eyes with chronic macular oedema and severe hard exsudates due to diabetic retinopathy or RVO, the presence of capillary macroaneurysms (defined by a diameter larger than 150 µm) was assessed by ICGA and optical coherence tomography (OCT). Capillary macroaneurysms were selectively photocoagulated, the presence of photothrombosis within the lumen being assessed by immediate OCT. Results: Four eyes from three patients with DME and five eyes from five patients with RVO were included. The median duration of visual loss was 4 years. Median initial visual acuity (VA) was 20/200. The median number of capillary macroaneurysms per eye was 2 (range, 1-8) and their median size was 410 µm (range, 154-603). Six months after photocoagulation, there was a significant reduction in macular thickness (mean±SD, 528 µm±200 vs 271 µm±152, p<0.05) and improvement of VA (mean log MAR, 0.82 vs 0.58, p<0.05). Conclusions: During macular oedema with severe hard exsudates due to DME or RVO, systematic detection of capillary macroaneurysms by ICGA followed by their OCT-controlled photocoagulation may be of interest. These results may contribute to re-evaluate the role of photocoagulation in the management of longstanding macular oedema.
MeSH term(s)	Adult ; Aged ; Aneurysm/surgery ; Capillaries/surgery ; Diabetic Retinopathy/complications ; Female ; Fluorescein Angiography/methods ; Humans ; Indocyanine Green/administration & dosage ; Laser Coagulation/methods ; Macular Edema/diagnosis ; Macular Edema/pathology ; Macular Edema/surgery ; Male ; Middle Aged ; Pilot Projects ; Retinal Vein Occlusion/complications ; Retinal Vessels/surgery ; Retrospective Studies
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2017-02
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2015-308142
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Article ; Online: Adapted Surgical Procedure for Argus II Retinal Implantation: Feasibility, Safety, Efficiency, and Postoperative Anatomic Findings.

Delyfer, Marie-Noëlle / Gaucher, David / Govare, Marc / Cougnard-Grégoire, Audrey / Korobelnik, Jean-François / Ajana, Soufiane / Mohand-Saïd, Saddek / Ayello-Scheer, Sarah / Rezaiguia-Studer, Fouzia / Dollfus, Hélène / Sahel, José-Alain / Barale, Pierre-Olivier

Ophthalmology. Retina

2017 Volume 2, Issue 4, Page(s) 276–287

Abstract: Purpose: To evaluate the feasibility, safety, and efficiency of an adapted surgical procedure used for postmarket Argus II implantations, so as to lower risks of postoperative hypotony or conjunctivoscleral erosion, and to describe the observed anatomic ...

Abstract	Purpose: To evaluate the feasibility, safety, and efficiency of an adapted surgical procedure used for postmarket Argus II implantations, so as to lower risks of postoperative hypotony or conjunctivoscleral erosion, and to describe the observed anatomic characteristics of the positioning of the implanted array. Design: Single-arm prospective multicenter clinical trial. Participants: Eighteen consecutive patients with end-stage retinitis pigmentosa. Methods: To protect the site of insertion of the cable of the device, a scleral flap was systematically added to the standardized implantation procedure. It was associated with temporalis fascia autograft, so as to cover the episcleral-fixed electronics case. Intraoperative and postoperative data at day 1, weeks 1 and 2, and months 1, 3, and 6 were collected. Postoperative distance between electrode-array and retina was measured on spectral-domain optical coherence tomography images. Position of the array was evaluated on fundus images between months 1 and 6. Main outcome measures: Feasibility of the modified surgical technique (time constraints, intraoperative complications), variations of intraocular pressure over time, postoperative ocular findings and adverse events, postoperative distance between the array and the retina, and rotation of the array between months 1 and 6 after implantation. Results: The adapted surgical technique was performed easily without associated specific complications. No cases of chronic hypotony or conjunctivoscleral erosion were reported. One serious device/procedure-related adverse event was recorded (sterile posterior uveitis), which resolved after vitrectomy. Postoperative distance between array and retina was variable: full apposition was achieved in 4 patients (22.22%), partial apposition observed in 9 patients (50.00%), and absence of strict apposition noted in 5 patients (27.78%, 4 of whom had posterior staphyloma). A statistically significant slight rotation of the array was observed between months 1 and 6 (P < 0.0001), occurring downwardly in 68.75% of cases. Conclusions: The combined use of scleral flap and temporalis fascia autograft was easily achieved and effective in preventing hypotony and conjunctival erosion in our study. Postoperative distance between semirigid array and retinal surface was variable, and increased in the case of preoperative staphyloma. A slight rotation of the device occurred over time. Further studies based on larger samples are needed to confirm our findings and determine their functional consequences.
Language	English
Publishing date	2017-10-26
Publishing country	United States
Document type	Journal Article
ISSN	2468-7219
ISSN (online)	2468-7219
DOI	10.1016/j.oret.2017.08.010
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Article ; Online: Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study).

Figueira, João / Fletcher, Emily / Massin, Pascale / Silva, Rufino / Bandello, Francesco / Midena, Edoardo / Varano, Monica / Sivaprasad, Sobha / Eleftheriadis, Haralabos / Menon, Geeta / Amaro, Miguel / Ayello Scheer, Sarah / Creuzot-Garcher, Catherine / Nascimento, João / Alves, Dalila / Nunes, Sandrina / Lobo, Conceição / Cunha-Vaz, José

Ophthalmology

2018 Volume 125, Issue 5, Page(s) 691–700

Abstract: Purpose: Comparison of the efficacy of ranibizumab (RBZ) 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP alone in the regression of the neovascularization (NV) area in subjects with high-risk proliferative diabetic ... ...

Abstract	Purpose: Comparison of the efficacy of ranibizumab (RBZ) 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP alone in the regression of the neovascularization (NV) area in subjects with high-risk proliferative diabetic retinopathy (HR-PDR) over a 12-month period. Design: Prospective, randomized, multicenter, open-label, phase II/III study. Participants: Eighty-seven participants (aged ≥18 years) with type 1/2 diabetes and HR-PDR (mean age, 55.2 years; 37% were female). Methods: Participants were randomized (1:1) to receive RBZ+PRP (n = 41) or PRP monotherapy (n = 46). The RBZ+PRP group received 3 monthly RBZ injections along with standard PRP. The PRP monotherapy group received standard PRP between day 1 and month 2; thereafter, re-treatments in both groups were at the investigators' discretion. Main outcome measures: The primary outcome was regression of NV total, on the disc (NVD) plus elsewhere (NVE), defined as any decrease in the area of NV from the baseline to month 12. Secondary outcomes included best-corrected visual acuity (BCVA) changes from baseline to month 12, time to complete NV regression, recurrence of NV, macular retinal thickness changes from baseline to month 12, need for treatment for diabetic macular edema, need for vitrectomy because of occurrence of vitreous hemorrhage, tractional retinal detachment or other complications of DR, and adverse events (AEs) related to treatments. Results: Seventy-seven participants (88.5%) completed the study. Overall baseline demographics were similar for both groups, except for age. At month 12, 92.7% of participants in the RBZ+PRP group presented NV total reduction versus 70.5% of the PRP monotherapy participants (P = 0.009). The number of participants with NVD and NVE reductions was higher with RBZ+PRP (93.3% and 91.4%, respectively) versus PRP (68.8% and 73.7%, respectively), significant only for NVE (P = 0.048). Complete NV total regression was observed in 43.9% in the RBZ+PRP group versus 25.0% in the PRP monotherapy group (P = 0.066). At month 12, the mean BCVA was 75.2 letters (20/32) in the RBZ+PRP group versus 69.2 letters (20/40) in the PRP monotherapy group (P = 0.104). In the RBZ+PRP group, the mean number of PRP treatments over month 12 was 3.5±1.3, whereas in the PRP monotherapy group, it was 4.6±1.5 (P = 0.001). No deaths or unexpected AEs were reported. Conclusions: Treatment with RBZ+PRP was more effective than PRP monotherapy for NV regression in HR-PDR participants over 12 months.
MeSH term(s)	Adult ; Aged ; Angiogenesis Inhibitors/therapeutic use ; Combined Modality Therapy ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/physiopathology ; Diabetic Retinopathy/surgery ; Diabetic Retinopathy/therapy ; Female ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Laser Coagulation/methods ; Male ; Middle Aged ; Prospective Studies ; Ranibizumab/therapeutic use ; Retinal Neovascularization/drug therapy ; Retinal Neovascularization/physiopathology ; Retinal Neovascularization/surgery ; Retinal Neovascularization/therapy ; Retreatment ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology
Chemical Substances	Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2018-02-01
Publishing country	United States
Document type	Clinical Trial, Phase II ; Clinical Trial, Phase III ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2017.12.008
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Article ; Online: ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion.

Rizzo, Stanislao / Barale, Pierre-Olivier / Ayello-Scheer, Sarah / Devenyi, Robert G / Delyfer, Marie-Noëlle / Korobelnik, Jean-François / Rachitskaya, Aleksandra / Yuan, Alex / Jayasundera, K Thiran / Zacks, David N / Handa, James T / Montezuma, Sandra R / Koozekanani, Dara / Stanga, Paulo E / da Cruz, Lyndon / Walter, Peter / Augustin, Albert J / Chizzolini, Marzio / Olmos de Koo, Lisa C /

Ho, Allen C / Kirchhof, Bernd / Hahn, Paul / Vajzovic, Lejla / Iezzi, Raymond / Gaucher, David / Arevalo, J Fernando / Gregori, Ninel Z / Grisanti, Salvatore / Özmert, Emin / Yoon, Young Hee / Kokame, Gregg T / Lim, Jennifer I / Szurman, Peter / de Juan, Eugene / Rezende, Flavio A / Salzmann, Joël / Richard, Gisbert / Huang, Suber S / Merlini, Francesco / Patel, Uday / Cruz, Cynthia / Greenberg, Robert J / Justus, Sally / Cinelli, Laura / Humayun, Mark S

Retina (Philadelphia, Pa.)

2020 Volume 40, Issue 2, Page(s) 303–311

Abstract: Purpose: To analyze and provide an overview of the incidence, management, and prevention of conjunctival erosion in Argus II clinical trial subjects and postapproval patients.: Methods: This retrospective analysis followed the results of 274 patients ...

Abstract	Purpose: To analyze and provide an overview of the incidence, management, and prevention of conjunctival erosion in Argus II clinical trial subjects and postapproval patients. Methods: This retrospective analysis followed the results of 274 patients treated with the Argus II Retinal Prosthesis System between June 2007 and November 2017, including 30 subjects from the US and European clinical trials, and 244 patients in the postapproval phase. Results were gathered for incidence of a serious adverse event, incidence of conjunctival erosion, occurrence sites, rates of erosion, and erosion timing. Results: Overall, 60% of subjects in the clinical trial subjects versus 83% of patients in the postapproval phase did not experience device- or surgery-related serious adverse events. In the postapproval phase, conjunctival erosion had an incidence rate of 6.2% over 5 years and 11 months. In 55% of conjunctival erosion cases, erosion occurred in the inferotemporal quadrant, 25% in the superotemporal quadrant, and 20% in both. Sixty percent of the erosion events occurred in the first 15 months after implantation, and 85% within the first 2.5 years. Conclusion: Reducing occurrence of conjunctival erosion in patients with the Argus II Retinal Prosthesis requires identification and minimization of risk factors before and during implantation. Implementing inverted sutures at the implant tabs, use of graft material at these locations as well as Mersilene rather than nylon sutures, and accurate Tenon's and conjunctiva closure are recommended for consideration in all patients.
MeSH term(s)	Conjunctiva/surgery ; Conjunctival Diseases/epidemiology ; Conjunctival Diseases/etiology ; Conjunctival Diseases/prevention & control ; Europe/epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Prosthesis Implantation/adverse effects ; Prosthesis Implantation/methods ; Retinitis Pigmentosa/surgery ; Retrospective Studies ; United States/epidemiology ; Visual Prosthesis/adverse effects
Language	English
Publishing date	2020-01-22
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000002394
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Article ; Online: Hypotony and the Argus II retinal prosthesis: causes, prevention and management.

Rizzo, Stanislao / Barale, Pierre-Olivier / Ayello-Scheer, Sarah / Devenyi, Robert G / Delyfer, Marie Noelle / Korobelnik, Jean-François / Rachitskaya, Aleksandra / Yuan, Alex / Jayasundera, K Thiran / Zacks, David N / Handa, James T / Montezuma, Sandra R / Koozekanani, Dara / Stanga, Paulo / da Cruz, Lyndon / Walter, Peter / Augustin, Albert J / Olmos de Koo, Lisa C / Ho, Allen C /

Kirchhof, Bernd / Hahn, Paul / Vajzovic, Lejla / Iezzi, Raymond / Gaucher, David / Arevalo, J Fernando / Gregori, Ninel Z / Wiedemann, Peter / Özmert, Emin / Lim, Jennifer I / Rezende, Flavio A / Huang, Suber S / Merlini, Francesco / Patel, Uday / Greenberg, Robert J / Justus, Sally / Bacherini, Daniela / Cinelli, Laura / Humayun, Mark S

The British journal of ophthalmology

2019 Volume 104, Issue 4, Page(s) 518–523

MeSH term(s)	Blindness/rehabilitation ; Ciliary Body/injuries ; Electrodes, Implanted ; Eye Injuries/etiology ; Humans ; Incidence ; Intraocular Pressure ; Ocular Hypotension/etiology ; Ocular Hypotension/prevention & control ; Prosthesis Implantation/adverse effects ; Retinitis Pigmentosa/therapy ; Retrospective Studies ; Sclerostomy/adverse effects ; Visual Prosthesis/adverse effects ; Wound Healing/physiology
Language	English
Publishing date	2019-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2019-314135
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