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Article ; Online: Positive impacts of COVID-19 on social life and environment

Ayesha Bibi / Ghulam Murtaza

Journal of Family Medicine and Primary Care, Vol 12, Iss 9, Pp 2188-

2023 Volume 2189

Keywords	Medicine ; R
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rare presentation of thrombosis with bleeding in Behcet's disease.

Meisel, Talia / Mian, Sundus / Nguyen, Andy / Ayesha, Bibi

BMJ case reports

2023 Volume 16, Issue 12

Abstract: Behcet's disease (BD) is a rare autoimmune and autoinflammatory disease characterised by recurrent oral and genital aphthous ulcers as well as gastrointestinal, ocular, neurological, articular and vascular inflammation. Patients are at risk for both ... ...

Abstract	Behcet's disease (BD) is a rare autoimmune and autoinflammatory disease characterised by recurrent oral and genital aphthous ulcers as well as gastrointestinal, ocular, neurological, articular and vascular inflammation. Patients are at risk for both thrombotic events and bleeding, so providers are often challenged in deciding whether to start patients on anticoagulation. We report a rare, complex case of a patient with BD who presented with massive gastrointestinal bleeding. This case report highlights the management of recurrent thrombosis due to protein C and S deficiency in a patient with BD who also presents with acute gastrointestinal bleeding.
MeSH term(s)	Humans ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Thrombosis/diagnostic imaging ; Thrombosis/drug therapy ; Thrombosis/etiology ; Gastrointestinal Hemorrhage ; Acute Disease
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-256329
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of Gene Polymorphisms in Human Male Infertility

Anam Sohail / Adina Arshad / Tamjeed Tariq / Ayesha Bibi / Shaista Aslam / Muhammad Irfan

American Journal of Men's Health, Vol

A Meta-Analysis

2023 Volume 17

Abstract: The present meta-analysis is performed to determine the association of C1236T and C3435T polymorphisms in the MDR1 gene. Google Scholar, PubMed, and Science Direct were searched. A total of 47 studies were retrieved, of which only three case–control ... ...

Abstract	The present meta-analysis is performed to determine the association of C1236T and C3435T polymorphisms in the MDR1 gene. Google Scholar, PubMed, and Science Direct were searched. A total of 47 studies were retrieved, of which only three case–control studies, consisting of 490 cases and 423 controls, met the selection criteria. Odds ratios (ORs) for MDR1 C1236T were as follows: Allelic model (T vs. C): OR = 1.06 [0.83, 1.35]; Additive model (TT vs. CC): OR = 0.91 [0.53, 1.56]; Dominant model (TT+CT vs. CC): OR = 0.83 [0.55, 1.24]; and Recessive model (TT vs. CT+CC): OR = 1.43 [0.95, 2.17]. However, for MDR1 C3435T: Allelic model (T vs. C): OR = 1.06 [0.83, 1.35]; Additive model (TT vs. CC): OR = 1.18 [0.75, 1.88]; Dominant model (TT+CT vs. CC): OR = 1.42 [0.99, 2.04]; and Recessive model (TT vs. CT+CC): OR = 0.90 [0.61, 1.33]. None of the four models presented a significant association of either polymorphism with the risk of infertility in men ( p >.05). The present study indicates that MDR1 gene polymorphisms might not be a risk factor for male infertility. Further studies with a larger sample size are needed to be conducted to confirm the findings of the present study.
Keywords	Medicine ; R
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of A2756G and A66G Polymorphisms With Male Infertility

Tamjeed Tariq / Adina Arshad / Ayesha Bibi / Shaista Aslam / Anam Sohail / Bilal Ishaq / Muhammad Irfan

American Journal of Men's Health, Vol

An Updated Meta-Analysis

2023 Volume 17

Abstract: The objective of the present study was to find out the association of folate genes MTR A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of Google Scholar, PubMed, and Science Direct were searched to find relevant ... ...

Abstract	The objective of the present study was to find out the association of folate genes MTR A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of Google Scholar, PubMed, and Science Direct were searched to find relevant studies. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Review Manager 5.4 was used for statistical analysis. Nineteen case-control studies were included in this meta-analysis which comprised 3621 cases and 3327 controls. Pooled analysis revealed that there is a significant association between MTR A2756G polymorphism with male infertility except for the dominant model. The ORs and 95% CI for each genetic model were as follows: 1.21 [1.03–1.42] for the allele model (G vs. A), 2.31 [1.38–3.96] for the additive model (GG vs. AA), 1.17 [0.98–1.38] for the dominant model (GG+AG vs. AA) and 2.10 [1.55–2.86] for the recessive model (GG vs. AG+AA). MTRR A66G has no noticeable association with male infertility. The current meta-analysis suggests that MTR A2756G polymorphism might be a potential risk factor for male infertility. In the future, the sample size should be increased to confirm the present results.
Keywords	Medicine ; R
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study.

Korogodina, Anna / Kaur, Navneet / Xie, Xianhong / Mehta, Adhya / Cleven, Krystal L / Ayesha, Bibi / Kumthekar, Anand

Advances in rheumatology (London, England)

2024 Volume 64, Issue 1, Page(s) 1

Abstract: Background: Interstitial lung disease (ILD) remains one of the most important causes of morbidity and mortality in patients with Connective Tissue Diseases (CTD). This study evaluated the impact of hospitalization on mortality in an ethnically and ... ...

Abstract	Background: Interstitial lung disease (ILD) remains one of the most important causes of morbidity and mortality in patients with Connective Tissue Diseases (CTD). This study evaluated the impact of hospitalization on mortality in an ethnically and racially diverse cohort of CTD-ILD patients. Methods: We conducted a medical records review study at Montefiore Medical Center, Bronx, NY. We included 96 patients and collected data on demographic characteristics, reasons for hospitalization, length of stay, immunosuppressant therapy use, and mortality. We stratified our patients into two cohorts: hospitalized and non-hospitalized. The hospitalized cohort was further subdivided into cardiopulmonary and non-cardiopulmonary admissions. Two-sample tests or Wilcoxon's rank sum tests for continuous variables and Chi-square or Fisher's exact tests for categorical variables were used for analyses as deemed appropriate. Results: We identified 213 patients with CTD-ILD. Out of them, 96 patients met the study's inclusion criteria. The majority of patients were females (79%), and self-identified as Hispanic (54%) and Black (40%). The most common CTDs were rheumatoid arthritis (RA) (29%), inflammatory myositis (22%), and systemic sclerosis (15%). The majority (76%) of patients required at least one hospitalization. In the non-hospitalized group, no deaths were observed, however we noted significant increase of mortality risk in hospitalized group (p = 0.02). We also observed that prolonged hospital stay (> 7 days) as well as older age and male sex were associated with increased mortality. Conclusions: Prolonged (> 7 days) hospital stay and hospitalization for cardiopulmonary causes, as well as older age and male sex were associated with an increased mortality risk in our cohort of CTD-ILD patients.
MeSH term(s)	Female ; Humans ; Male ; Connective Tissue Diseases/complications ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/therapy ; Scleroderma, Systemic/complications ; Hospitalization ; Medical Records
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ISSN	2523-3106
ISSN (online)	2523-3106
DOI	10.1186/s42358-023-00343-x
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Article ; Online: Impacts of Omega-3 Fatty Acids, Natural Elixirs for Neuronal Health, on Brain Development and Functions.

Rao, Archana S / Nair, Ajay / Nivetha, K / Ayesha, Bibi / Hardi, Kapadia / Divya, Vora / Veena, S M / Anantharaju, K S / More, Sunil S

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2761, Page(s) 209–229

Abstract: Omega-3 fatty acids play a seminal role in maintaining the structural and functional integrity of the nervous system. These specialized molecules function as precursors for many lipid-based biological messengers. Also, studies suggest the role of these ... ...

Abstract	Omega-3 fatty acids play a seminal role in maintaining the structural and functional integrity of the nervous system. These specialized molecules function as precursors for many lipid-based biological messengers. Also, studies suggest the role of these fatty acids in regulating healthy sleep cycles, cognitive ability, brain development, etc. Dietary intake of essential poly unsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are foundational to the optimal working of the nervous system. Besides regulating health, these biomolecules have great therapeutic value in treating several diseases, particularly nervous system diseases and disorders. Many recent studies conclusively demonstrated the beneficial effects of Omega-3 fatty acids in treating depression, neuropsychiatric disorders, neurodegenerative disorders, neurochemical disorders, and many other illnesses associated with the nervous system. This chapter summates the multifaceted role of poly unsaturated fatty acids, especially Omega-3 fatty acids (EPA and DHA), in the neuronal health and functioning. The importance of dietary intake of these essential fatty acids, their recommended dosages, bioavailability, the mechanism of their action, and therapeutic values are extensively discussed.
MeSH term(s)	Fatty Acids, Omega-3/pharmacology ; Eicosapentaenoic Acid/pharmacology ; Docosahexaenoic Acids/pharmacology ; Fatty Acids, Unsaturated ; Fatty Acids ; Brain
Chemical Substances	Fatty Acids, Omega-3 ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Docosahexaenoic Acids (25167-62-8) ; Fatty Acids, Unsaturated ; Fatty Acids
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3662-6_15
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 IgG-related autoimmune inflammatory necrotizing myositis.

Veyseh, Maedeh / Koyoda, Sai / Ayesha, Bibi

BMJ case reports

2021 Volume 14, Issue 4

Abstract: The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected millions of people around the globe. The most common presentation of COVID-19 is fever and upper and lower respiratory tract infection. Myalgia is fairly common in the prodromal phase of ... ...

Abstract	The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected millions of people around the globe. The most common presentation of COVID-19 is fever and upper and lower respiratory tract infection. Myalgia is fairly common in the prodromal phase of the viral illness which self-resolves. There is very scant literature on autoimmune myositis triggered by COVID-19 infection. We report a case of SARS-CoV-2 infection, who presented with progressive muscle weakness with rhabdomyolysis and necrotizing autoimmune myopathy on muscle biopsy. This case report imposes awareness of musculoskeletal autoimmune processes triggered by COVID-19 which requires clinical suspicion for early diagnosis and initiation of treatment.
MeSH term(s)	Antibodies, Viral/blood ; Autoimmune Diseases/therapy ; Autoimmune Diseases/virology ; COVID-19/complications ; Diagnosis, Differential ; Female ; Humans ; Immunoglobulin G/blood ; Middle Aged ; Muscle Weakness/virology ; Myalgia/virology ; Myositis/therapy ; Myositis/virology ; Necrosis/virology ; Prednisone/therapeutic use ; Rhabdomyolysis/virology
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2021-04-13
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-239457
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Article ; Online: When sarcoidosis mimics immunodeficiency.

Kaur, Navneet / Kumthekar, Anand / Ayesha, Bibi

BMJ case reports

2021 Volume 14, Issue 7

Abstract: Sarcoidosis is a granulomatous disease with a wide spectrum of clinical manifestations. A 28-year-old previously healthy woman presented with multifocal pneumonia, mediastinal lymphadenopathy which was thought to be caused by actinomyces infection. ... ...

Abstract	Sarcoidosis is a granulomatous disease with a wide spectrum of clinical manifestations. A 28-year-old previously healthy woman presented with multifocal pneumonia, mediastinal lymphadenopathy which was thought to be caused by actinomyces infection. Despite antibiotics, she developed cavitary lung lesions and had worsening lymphadenopathy prompting evaluation for alternative aetiologies like malignancy, autoimmune or immunodeficiency disorders. Further workup also revealed low CD4, CD8 cell counts, elevated soluble interleukin-2 levels. Over the due course of time, she developed granulomatous pan-uveitis, classical skin lesions leading to the diagnosis of sarcoidosis. Our case highlights the rare manifestations of sarcoidosis which can mimic immunodeficiency disorders especially when these patients develop secondary infections. Our goal is to raise awareness among clinicians about these atypical presentations of sarcoidosis which can lead to substantial delay in diagnosis thus leading to progression of the disease in the absence of appropriate treatment.
MeSH term(s)	Adult ; Female ; Granuloma/diagnosis ; Humans ; Immunologic Deficiency Syndromes ; Lymphadenopathy/diagnosis ; Lymphadenopathy/etiology ; Sarcoidosis/diagnosis ; Skin Diseases
Language	English
Publishing date	2021-07-14
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-243557
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Article ; Online: The Comparison of Symphysis Morphology in Normodivergent Patients of Short and Normal Mandible

Erum Behroz Khan / Hunny Kumari / Ayesha Bibi / Danish Ali Mottani / Sarvaich Kumar

Journal of the Dow University of Health Sciences, Vol 15, Iss

2022 Volume 1

Abstract: Objective: To compare the morphological symphysis in normodivergent patients of short and normal mandible attending outpatient department of large public sector dental hospital of Karachi, Pakistan. Methods: This was a prospective observational study ... ...

Abstract	Objective: To compare the morphological symphysis in normodivergent patients of short and normal mandible attending outpatient department of large public sector dental hospital of Karachi, Pakistan. Methods: This was a prospective observational study that was carried out at the outpatient department of the orthodontics, Sindh Institute of Oral Health Sciences, from June-2020 to December-2020. The study included 70 (35 in each group) patients with a normal angle MMA over the range of 25.5° ± 5.3°. McNamara analysis has been carried out including all the patients and dividing into two group's i.e., normal mandible and short mandible. On cephalogram, perpendicular distance from Pog to B-Me line, angle symphysis vertical dimension (B-B1-Gn), and angle symphysis convexity (B-Pog-Me), were measured for all patients. Results: Of 70 patients, there were 24 (34.3%) males and 46 (65.7) females. Patients were equally divided into two groups, i.e., short 35 (50.0%) and normal mandible 35 (50.0%). The mean angle of symphysis convexity, symphysis vertical dimension, and anterior prominence of symphysis of participants were 124.6 ± 42.8, 49.9 ± 4.7, and 4.1 ± 1.1 respectively. Patients of short mandibular were found significantly higher in symphysis convexity as compared to patients of normal mandibular, i.e., 136.54 ± 3.55 and 112.74 ± 58.53 respectively, (p- value= 0.022). Conclusion: Symphysis convexity was found greater in short mandible patients showing that in short mandible patients, symphysis was flatter anteriorly, less convex, and less prominent.
Keywords	Symphysis ; morphy ; orthodontics ; mandible ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Dow University of Health Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Comparison of Symphysis Morphology in Normodivergent Patients of Short and Normal Mandible

Erum Behroz Khan / Hunny Kumari / Ayesha Bibi / Danish Ali Mottani / Sarvaich Kumar

Journal of the Dow University of Health Sciences, Vol 15, Iss

2022 Volume 1

Abstract	Objective: To compare the morphological symphysis in normodivergent patients of short and normal mandible attending outpatient department of large public sector dental hospital of Karachi, Pakistan. Methods: This was a prospective observational study that was carried out at the outpatient department of the orthodontics, Sindh Institute of Oral Health Sciences, from June-2020 to December-2020. The study included 70 (35 in each group) patients with a normal angle MMA over the range of 25.5° ± 5.3°. McNamara analysis has been carried out including all the patients and dividing into two group's i.e., normal mandible and short mandible. On cephalogram, perpendicular distance from Pog to B-Me line, angle symphysis vertical dimension (B-B1-Gn), and angle symphysis convexity (B-Pog-Me), were measured for all patients. Results: Of 70 patients, there were 24 (34.3%) males and 46 (65.7) females. Patients were equally divided into two groups, i.e., short 35 (50.0%) and normal mandible 35 (50.0%). The mean angle of symphysis convexity, symphysis vertical dimension, and anterior prominence of symphysis of participants were 124.6 ± 42.8, 49.9 ± 4.7, and 4.1 ± 1.1 respectively. Patients of short mandibular were found significantly higher in symphysis convexity as compared to patients of normal mandibular, i.e., 136.54 ± 3.55 and 112.74 ± 58.53 respectively, (p- value= 0.022). Conclusion: Symphysis convexity was found greater in short mandible patients showing that in short mandible patients, symphysis was flatter anteriorly, less convex, and less prominent.
Keywords	Symphysis ; morphy ; orthodontics ; mandible ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Dow University of Health Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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