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Article ; Online: Evaluation of corneal densitometry changes in patients with lichen planus.

Öncül, Hasan / Ayhan, Erhan

International journal of clinical practice

2021 Volume 75, Issue 7, Page(s) e14234

Abstract: Purpose: To investigate the corneal topography and densitometry changes in patients with lichen planus (LP).: Methods: Anterior segment parameters and corneal densitometry of patients with LP and age- and gender-matched individuals with healthy eyes ... ...

Abstract	Purpose: To investigate the corneal topography and densitometry changes in patients with lichen planus (LP). Methods: Anterior segment parameters and corneal densitometry of patients with LP and age- and gender-matched individuals with healthy eyes were evaluated using Scheimpflug corneal topography. A 12 mm corneal area was divided into 4 annular zones and 3 regions-in-depth anterior, central and posterior-for densitometry evaluation. Results: The study included 45 patients with LP and 50 individuals with healthy eyes. The two groups were similar in age and gender, and they showed no significant differences in anterior segment corneal topography parameters. Schirmer's I test results were significantly lower in the patients with LP than in the control group (P ˂ .001). The total corneal densitometry was higher in patients with LP than in the control group (P = .030). The anterior, central and posterior corneal densitometry in the 0-2 mm and 2-6 mm annular zones was higher in the LP group than in the control group. Correlation analysis between disease duration and corneal densitometry values showed a strong positive correlation in the anterior segment and a moderate positive correlation in the central and posterior segments (r = 0.632, P ˂ .001; r = 0.572, P ˂ .001; and r = 0.562, P ˂ .001, respectively). Conclusions: Corneal densitometry values were higher in patients with LP than in individuals with healthy eyes, even if the patients had a clinically transparent cornea. More studies are needed to evaluate the changes that may occur in corneal transparency in patients with LP and other autoimmune dermatologic diseases that may affect the eye.
Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14234
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Article ; Online: Lymphangioma Circumscriptum: Good Clinical Response to Isotretinoin Therapy.

Ayhan, Erhan

Pediatric dermatology

2016 Volume 33, Issue 3, Page(s) e208–9

Abstract: Lymphangioma circumscriptum (LC) is a superficial form of lymphatic malformation that can be difficult to treat. Therapeutic approaches to LC such as laser therapy, sclerotherapy, and surgical excision give varying results. This is the first description ... ...

Abstract	Lymphangioma circumscriptum (LC) is a superficial form of lymphatic malformation that can be difficult to treat. Therapeutic approaches to LC such as laser therapy, sclerotherapy, and surgical excision give varying results. This is the first description of a case of LC successfully treated with oral isotretinoin. Further studies are needed to confirm whether this is a reproducible treatment option.
MeSH term(s)	Administration, Oral ; Adolescent ; Biopsy, Needle ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Isotretinoin/therapeutic use ; Keratolytic Agents/therapeutic use ; Lymphangioma/diagnosis ; Lymphangioma/drug therapy ; Skin Neoplasms/diagnosis ; Skin Neoplasms/drug therapy ; Thigh ; Treatment Outcome
Chemical Substances	Keratolytic Agents ; Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	605539-4
ISSN	1525-1470 ; 0736-8046
ISSN (online)	1525-1470
ISSN	0736-8046
DOI	10.1111/pde.12839
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Zs.A 1882: Show issues

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Article ; Online: A case of multiple eccrine hidrocystoma successfully treated with oral oxybutynin.

Ayhan, Erhan

Dermatologic therapy

2015 Volume 28, Issue 3, Page(s) 107–109

MeSH term(s)	Administration, Oral ; Adult ; Antineoplastic Agents/administration & dosage ; Eccrine Glands/drug effects ; Eccrine Glands/pathology ; Female ; Hidrocystoma/diagnosis ; Hidrocystoma/drug therapy ; Humans ; Mandelic Acids/administration & dosage ; Muscarinic Antagonists/administration & dosage ; Sweat Gland Neoplasms/diagnosis ; Sweat Gland Neoplasms/drug therapy ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Mandelic Acids ; Muscarinic Antagonists ; oxybutynin (K9P6MC7092)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.12206
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Zs.A 5181: Show issues

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Article ; Online: Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients.

Öncül, Hasan / Ayhan, Erhan

Journal of cosmetic dermatology

2020 Volume 19, Issue 11, Page(s) 3032–3037

Abstract: Background: Vitiligo is one of the common pigmentary disorders affecting the ocular structures.: Aim: To determine the retinal nerve fiber layer (RNFL), retinal pigment epithelium (RPE), and choroidal thickness (CT) in vitiligo patients and to ... ...

Abstract	Background: Vitiligo is one of the common pigmentary disorders affecting the ocular structures. Aim: To determine the retinal nerve fiber layer (RNFL), retinal pigment epithelium (RPE), and choroidal thickness (CT) in vitiligo patients and to evaluate the relationship between choroidal thickness and vitiligo subtypes. Methods: The right eyes of 106 participants (51 vitiligo, 55 nonvitiligo) were included in the study. All of the participants underwent detailed eye examinations and spectral-domain optical coherence tomography (SD-OCT) examinations. CT was measured manually with enhanced depth imaging optical coherence tomography (Edi-OCT) (subfoveal [SubF], nasal n500 µm [N1], n1500 µm [N2]), and temporal (t500 µm [T1], t1500 µm [T2]). Results: In vitiligo patients, CT values were significantly lower in the SubF, N1, N2, T1, and T2 areas compared to the control group (P = .001, P = .011, P = .002, P = .005, P ˂ .001, respectively). Periorbital involvement did not affect CT (P = .355, P = .746, P = .443, P = .633, P = .558, respectively). However, in patients with periorbital region involvement, the CT was significantly reduced if the lesion had a universal character (P ˂ .001, P = .001, P = .011, P ˂ .001, P = .002, respectively). It was observed that RPE thickness decreased in vitiligo, but this difference was not statistically significant (P = .140). RNFL thickness was unaffected in all quadrants. A positive correlation (r = .286, r = .280, respectively) was observed between the Vitiligo Area Severity Index (VASI) and age and disease duration. A negative correlation (r = -.360, r = -.316, r = -.315, r = -.313, respectively) was found in the CT of the SubF, N1, N2, T1, and T2 areas. Conclusion: Vitiligo patients should be closely monitored for possible posterior ocular segment disorders.
MeSH term(s)	Choroid/diagnostic imaging ; Humans ; Nerve Fibers ; Retinal Pigment Epithelium/diagnostic imaging ; Tomography, Optical Coherence ; Vitiligo/diagnostic imaging
Language	English
Publishing date	2020-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.13367
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Article ; Online: The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study.

An, İsa / Aksoy, Mustafa / Ayhan, Erhan / Ozturk, Murat

International journal of clinical practice

2021 Volume 75, Issue 6, Page(s) e14114

Abstract: Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) ... ...

Abstract	Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients receiving secukinumab treatment for psoriasis vulgaris (PV). Materials and methods: In this retrospective study, we evaluated the laboratory results of 40 patients who were followed up with a diagnosis of PV and received secukinumab treatment in three different dermatology clinics between July 2018 and September 2019. Results: Neutrophil count and leukocyte count were significantly decreased after secukinumab treatment. (P < .001) There was no statistically significant difference between lymphocyte count, platelet count, MPV, NLR and PLR values before treatment and at the 4th month of treatment (P values .230, .065, .110, .915 and .365, respectively). Conclusion: In conclusion, it can be concluded that parameters such as NLR, PLR and MPV are not suitable parameters for monitoring the effects of secukinumab treatment on inflammation.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Biomarkers ; Humans ; Lymphocytes ; Mean Platelet Volume ; Neutrophils ; Psoriasis/drug therapy ; Retrospective Studies
Chemical Substances	Antibodies, Monoclonal, Humanized ; Biomarkers ; secukinumab (DLG4EML025)
Language	English
Publishing date	2021-02-28
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14114
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Article ; Online: Enhancing the appearance of vessels in dermoscopic images via a mobile photo editor application.

Ayhan, Erhan / Toprak, Serdar Ferit

Journal of the American Academy of Dermatology

2019 Volume 82, Issue 1, Page(s) e11–e12

MeSH term(s)	Cell Phone Use ; Dermoscopy/methods ; Humans ; Image Enhancement ; Mobile Applications ; Sensitivity and Specificity ; Skin/blood supply ; Skin/diagnostic imaging ; Skin Neoplasms/blood supply ; Skin Neoplasms/diagnostic imaging
Language	English
Publishing date	2019-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2019.05.008
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Zs.A 1540: Show issues

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Article ; Online: Dermoscopy of dermatofibromas: A new perspective.

Aytekin, Sema / Kaynak, Emre / Ayhan, Erhan

International journal of clinical practice

2021 Volume 75, Issue 10, Page(s) e14547

Abstract: Aim: In dermoscopic studies on dermatofibromas, some publications divide the appearance of lesions into standardised patterns, and some publications classify the clinical appearance of the lesions by comparing them with existing dermatological lesions. ... ...

Abstract	Aim: In dermoscopic studies on dermatofibromas, some publications divide the appearance of lesions into standardised patterns, and some publications classify the clinical appearance of the lesions by comparing them with existing dermatological lesions. This study aims to re-evaluate the dermoscopic findings and patterns of dermatofibromas from a different perspective. Materials and methods: In this study, 142 lesions of 72 patients were evaluated dermoscopically and their patterns were schematised. Results: In our study, a total of 15 patterns consisting of main and sub-patterns were created. The most common patterns we detected were pattern 1 (1a: 13.4%, 1b: 8.5%), pattern 8 (8a: 10.6%, 8b: 4.2%) and pattern 2 (2a: 9.2%, 2b: 4.2%), respectively. Conclusion: Patterns of DFs were reclassified while preserving basic patterns. We think that the new sub-patterns and schematisation with this study can contribute to a better understanding of DFs.
Language	English
Publishing date	2021-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14547
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Article ; Online: Effect of isotretinoin (13-cis-retinoic acid) on levels of soluble VEGF receptors (sVEGFR1, sVEGFR2, sVEGFR3) in patients with acne vulgaris.

Ayhan, Erhan / Aslan, Özgür / Araç, Eşref

The Journal of dermatological treatment

2020 Volume 32, Issue 8, Page(s) 936–940

Abstract: Background/aim: The effect of isotretinoin on soluble VEGFRs has not been previously investigated. This study evaluate the effects of isotretinoin (13-cis-retinoic acid) on soluble VEGFR1 (sVEGFR1), soluble VEGFR2 (sVEGFR2) and soluble VEGFR3 (sVEGFR3).! ...

Abstract	Background/aim: The effect of isotretinoin on soluble VEGFRs has not been previously investigated. This study evaluate the effects of isotretinoin (13-cis-retinoic acid) on soluble VEGFR1 (sVEGFR1), soluble VEGFR2 (sVEGFR2) and soluble VEGFR3 (sVEGFR3). Methods: The study included 38 patients (28 females, 10 males) receiving systemic isotretinoin treatment and 38 healthy individuals (28 females, 10 males) with similar age and gender characteristics. The blood samples of the patient group at third months and blood samples of the control group were compared in terms of sVEGFR1, sVEGFR2 and sVEGFR3 concentrations. Results: It was significant that sVEGFR1 was low and sVEGFR3 was high in patients receiving isotretinoin ( Conclusions: We think that the effect of isotretinoin on sVEGFR1, sVEGFR2 and sVEGFR3 may be secondary to its effects on the VEGF family. However, after clarifying the effect of isotretinoin on the VEGF family, we think that it can be used in some tumors and vascular diseases.
MeSH term(s)	Acne Vulgaris/drug therapy ; Female ; Humans ; Isotretinoin/therapeutic use ; Male ; Vascular Endothelial Growth Factor A
Chemical Substances	Vascular Endothelial Growth Factor A ; Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2020-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2020.1729331
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Article ; Online: Isotretinoin does not alter VEGF-A and VEGF-C levels: do retinoids behave differently in dose-dependent and/or

Ayhan, Erhan / Araç, Eşref / Aslan, Özgür

Cutaneous and ocular toxicology

2020 Volume 39, Issue 4, Page(s) 328–331

Abstract: Background: It is seen that various forms of retinoids have different results on VEGF-A and VEGF-C levels when tested at different dosages, in different diseases and under different conditions such as : Objective: To evaluate the effects of ... ...

Abstract	Background: It is seen that various forms of retinoids have different results on VEGF-A and VEGF-C levels when tested at different dosages, in different diseases and under different conditions such as Objective: To evaluate the effects of isotretinoin on VEGF-A and VEGF-C levels in humans. Methods: Blood samples at the third month of the patient group and blood samples of the control group were compared in terms of VEGF-A and VEGF-C concentrations. Results: No statistically significant difference was observed between the patient group and the control group in terms of VEGF-A and VEGF-C levels. Limitations: Most of the patients discontinued treatment and could not reach the required number, the study was converted to case-control. Conclusions: We think that 0.5 mg/kg/day isotretinoin has no effect on blood concentrations of VEGF-A and VEGF-C in humans. Therefore, there is a need for studies using isotretinoin in different doses and durations in humans in order to better evaluate its effects.
MeSH term(s)	Adolescent ; Adult ; Dermatologic Agents/pharmacology ; Dose-Response Relationship, Drug ; Female ; Humans ; Isotretinoin/pharmacology ; Male ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor C/blood ; Young Adult
Chemical Substances	Dermatologic Agents ; VEGFA protein, human ; VEGFC protein, human ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor C ; Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2020-08-09
Publishing country	England
Document type	Controlled Clinical Trial ; Journal Article
ZDB-ID	605635-0
ISSN	1556-9535 ; 1556-9527 ; 0731-3829
ISSN (online)	1556-9535
ISSN	1556-9527 ; 0731-3829
DOI	10.1080/15569527.2020.1802743
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Article ; Online: First clinical picture of a very rare disease: Primary cutaneous adenomyoepithelioma.

Ayhan, Erhan / Leblebici, Cem / An, Isa / Ozturk, Murat

Journal of cosmetic dermatology

2020 Volume 19, Issue 9, Page(s) 2444–2446

MeSH term(s)	Adenomyoepithelioma/pathology ; Adenomyoepithelioma/surgery ; Aged, 80 and over ; Female ; Humans ; Rare Diseases ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Thigh/pathology ; Thigh/surgery
Language	English
Publishing date	2020-04-12
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.13408
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