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Article ; Online: Evaluation of medication errors in pediatric patients using antibiotics.

Özdemir, Nesligül / Kara, Emre / Büyükçam, Ayşe / Aykaç, Kübra / Çeliker, Ayçe / Demirkan, Kutay / Kara, Ateş

2022 Volume 63, Issue 6, Page(s) 970–977

Abstract: Background: Medication errors are frequently seen in pediatric patients. Medication error studies on pediatric cases were found to not only be limited but also the collaboration of clinical pharmacists and physicians on this topic was not published in ... ...

Abstract	Background: Medication errors are frequently seen in pediatric patients. Medication error studies on pediatric cases were found to not only be limited but also the collaboration of clinical pharmacists and physicians on this topic was not published in Turkey. This study aimed to identify drug-related problems, especially in antibiotics. Methods: This study was a point prevalence study with pediatric inpatients that used at least one antibiotic at a pediatric tertiary care reference hospital on November 16, 2016. Medications of patients were evaluated by clinical pharmacists in terms of drug-related problems and by physicians in terms of correct indications. Results: Eighty-nine hospitalized patients were using antibiotics at the time of the study. The median age was 42 months (range: 1-226 months), and 49 (55.1%) of the patients were male. Clinical pharmacists detected a total of 210 potential drug-drug interactions in 46 (51.7%) patients. Approximately 48.5% of the patients in pediatric wards and 52.4% of the patients in surgical wards had at least one potential drug-drug interaction. A total of 39 medication errors were identified in 36 patients` drug orders. Most of the errors (51.3%) were due to dosing and administration time errors (35.9%). The number of errors per patient in surgical services was higher (0.47) than the pediatric services (0.42). Forty-three percent of errors were antimicrobial-related, and 70.5% of them were classified as dosing errors. Conclusions: Evaluation of patients` drug usage by a clinical pharmacist in terms of drug-related problems such as drug interactions, side effects and prescribing errors leads to better pharmaceutical care.
MeSH term(s)	Adolescent ; Anti-Bacterial Agents/adverse effects ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions ; Female ; Humans ; Infant ; Male ; Medication Errors ; Pharmacists ; Pharmacy Service, Hospital
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-01-13
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2021.06.004
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Article ; Online: Methylprednisolone use in children with severe pneumonia caused by severe acute respiratory syndrome coronavirus 2.

Ozsurekci, Yasemin / Aykac, Kubra / Demir, Osman Oguz / Ilbay, Sare / Kesici, Selman / Karakaya, Jale / Cengiz, Ali Bulent

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15603

Abstract: Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population.: ... ...

Abstract	Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population. Methods: We conducted a retrospective study and included patients (aged < 18 years) with severe COVID-19 pneumonia and/or acute respiratory distress syndrome (ARDS) who received standard doses (2-4 mg/kg/day) and high doses (>250 mg/day) of methylprednisolone (MPZ). We adjusted for patients on steroid treatments with a propensity score and compared the side effects of different MPZ doses and patient survival. Results: Fifty-nine patients were included: 61% were male, the median age was 8, interquartile range (IQR) 2-15) years. The overall survival was 84.4% in patients treated with standard-dose MPZ (n = 45, 76.3%) and 92.2% in patients treated with high-dose MPZ (n = 14, 23.7%; p = 0.67). The demographic, clinical, and laboratory data did not differ significantly after propensity score matching, apart from bradycardia, which was a prominent feature of the high-dose group. The clinical and radiological response rates on day 7 were higher and the need for invasive mechanical ventilation (IMV) was lower in the high-dose group. Conclusion: The patients with high-dose MPZ had better clinical and radiological responses than those with standard-dose MPZ, although the mortality rate did not differ between standard and high-dose regimens of MPZ.
MeSH term(s)	Humans ; Male ; Child ; Child, Preschool ; Adolescent ; Female ; SARS-CoV-2 ; COVID-19 ; Methylprednisolone/therapeutic use ; Retrospective Studies ; Respiratory Distress Syndrome/drug therapy ; Respiration, Artificial
Chemical Substances	Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2023-08-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15603
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Zs.A 848: Show issues

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Article ; Online: The comparison of COVID-19 vs seasonal influenza in children.

Yayla, Burcu Ceylan Cura / Aykac, Kubra / Boluk, Oguz / Fidanci, Ilknur / Tasar, Medine Aysin / Pamuk, Utku / Karakoc, Ayse Esra / Karakaya, Jale / Ozsurekci, Yasemin

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15684

Abstract: Background: Influenza in children has been well described, whereas there has been a paucity of pediatric data regarding COVID-19. It is crucial for clinicians to differentiate cases of COVID-19 from cases of influenza because of the upcoming influenza ... ...

Abstract	Background: Influenza in children has been well described, whereas there has been a paucity of pediatric data regarding COVID-19. It is crucial for clinicians to differentiate cases of COVID-19 from cases of influenza because of the upcoming influenza season in the new pandemic era. Methods: This retrospective study included pediatric patients who were diagnosed with laboratory-confirmed COVID-19 between March and September 2020, or seasonal influenza between October 2019 and March 2020. Results: A total of 315 children were included in this study; 151 were diagnosed with influenza and 164 had confirmed COVID-19. The median age of patients with COVID-19 was 10 years (interquartile range [IQR]: 3-15 years), whereas the median age of patients with influenza was 4 years (IQR: 1-6 years) (p = 0.001). In the COVID-19 group, 6.3% of patients had underlying diseases, the most frequent being neurological conditions (3%). In the influenza group, 20.9% of patients had an underlying disease, the most frequent being asthma (14.5%). Fever (odds ratio [OR]: 20.476; 95% confidence interval [CI]: 2.438-171.995; p = 0.005), dyspnea/tachypnea (OR 13.950; 95% CI: 2.607-74.634; p = 0.002), and increased C-reactive protein (CRP) (OR: 7.650; 95% CI: 2.094-27.955; p = 0.002) were main predictors of influenza diagnosis in comparison to COVID-19. Lymphopenia was detected in 43.2% of patients with influenza and 19.9% of patients with COVID-19 (p = 0.001). Conclusions: The accurate differentiation between "influenza or COVID-19" seems possible by evaluating a combination of factors including cough, fever, vomiting, leucopenia, lymphopenia, pneumonia, in pediatric patients with high CRP as well as age.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Adolescent ; Infant ; COVID-19/diagnosis ; COVID-19/epidemiology ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Seasons ; Retrospective Studies ; SARS-CoV-2 ; Lymphopenia/epidemiology
Language	English
Publishing date	2023-12-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15684
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Zs.A 848: Show issues

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Article ; Online: Immunogenicity and Protective Capacity of CpG ODN Adjuvanted Alum Adsorbed Bivalent Meningococcal Outer Membrane Vesicle Vaccine.

Canavar Yildirim, Tugce / Ozsurekci, Yasemin / Yildirim, Muzaffer / Evcili, Irem / Yazar, Volkan / Aykac, Kubra / Guler, Ulku / Salih, Bekir / Gursel, Mayda / Gursel, Ihsan

International immunology

2024

Abstract: Invasive meningococcal disease (IMD) is caused by Neisseria meningitidis, with the main serogroups responsible for the disease being A, B, C, W, X, and Y. To date, several vaccines targeting N.meningitidis have been developed albeit with a short-lived ... ...

Abstract	Invasive meningococcal disease (IMD) is caused by Neisseria meningitidis, with the main serogroups responsible for the disease being A, B, C, W, X, and Y. To date, several vaccines targeting N.meningitidis have been developed albeit with a short-lived protection. Given that MenW and MenB are the most common causes of IMD in Europe, Turkey, and Middle East, we aimed to develop an outer membrane vesicle (OMV) based bivalent vaccine as the heterologous antigen source. Herein, we compared the immunogenicity, and breadth of serum bactericidal assays (SBA) based protective coverage of OMV vaccine to X serotype with existing commercial meningococcal conjugate and polysaccharide (PS) vaccines in a murine model. BALB/c mice were immunized with preclinical batches of the W+B OMV vaccine, either adjuvanted with Alum, CpG ODN or their combinations and compared with a MenACYW conjugate vaccine (NimenrixTM, Pfizer) and a MenB OMV-based vaccine (Bexsero®, GSK), The immune responses were assessed through ELISA and SBA. Antibody responses and SBA titers were significantly higher in the W+B OMV vaccine when adjuvanted with Alum or CpG ODN, as compared to the control groups. Moreover, the SBA titers were not only significantly higher than those achieved with available conjugated ACYW vaccines but also on par with the 4CMenB vaccines. In conclusion, the W+B OMV vaccine demonstrated the capacity to elicit robust antibody responses, surpassing or matching the levels induced by licensed meningococcal vaccines. Consequently, the W+B OMV vaccine could potentially serve as a viable alternative or supplement to existing meningococcal vaccines.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxae016
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: MyD88 in osteoclast- and osteoblast-lineages differentially controls bone remodeling in homeostasis and malaria.

Alshaweesh, Jalal / Dash, Rashmi / Lee, Michelle S J / Kahyaoglu, Pinar / Erci, Ece / Xu, Mengling / Matsuo-Dapaah, Julia / Del Rosario Zorrilla, Camila / Aykac, Kubra / Ekemen, Suheyla / Kobiyama, Kouji / Ishii, Ken J / Coban, Cevayir

International immunology

2024

Abstract: Chronic bone loss is an under-recognized complication of malaria, the underlying mechanism of which remains incompletely understood. We have previously shown that persistent accumulation of Plasmodium products in the bone marrow leads to chronic ... ...

Abstract	Chronic bone loss is an under-recognized complication of malaria, the underlying mechanism of which remains incompletely understood. We have previously shown that persistent accumulation of Plasmodium products in the bone marrow leads to chronic inflammation in osteoblast (OB) and osteoclast (OC) precursors causing bone loss through MyD88, an adaptor molecule for diverse inflammatory signals. However, the specific contribution of MyD88 signaling in OB or OC precursors in malaria-induced bone loss remains elusive. To assess the direct cell-intrinsic role of MyD88 signaling in adult bone metabolism under physiological and infection conditions, we used the Lox-Cre system to specifically deplete MyD88 in the OB or OC lineages. Mice lacking MyD88 primarily in the maturing OBs showed a comparable decrease in trabecular bone density by microcomputed tomography (µCT) to that of controls after PyNL infection. In contrast, mice lacking MyD88 in OC precursors showed significantly less trabecular bone loss than controls, suggesting that malaria-mediated inflammatory mediators are primarily controlled by MyD88 in the OC lineage. Surprisingly, however, depletion of MyD88 in OB, but not in OC precursors, resulted in reduced bone mass with decreased bone formation rates in the trabecular areas of femurs under physiological conditions. Notably, IGF-1, a key molecule for OB differentiation, was significantly lower locally and systemically when MyD88 was depleted in OBs. Thus, our data demonstrate an indispensable intrinsic role for MyD88 signaling in OB differentiation and bone formation, while MyD88 signaling in OC lineages plays a partial role in controlling malaria-induced inflammatory mediators and following bone pathology. These findings may lead to the identification of novel targets for specific intervention of bone pathologies, particularly in malaria-endemic regions.
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxae023
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 70: Show issues

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Article ; Online: Characteristics and Management of Children With COVID-19 in a Tertiary Care Hospital in Turkey.

Yayla, Burcu Ceylan Cura / Aykac, Kubra / Ozsurekci, Yasemin / Ceyhan, Mehmet

Clinical pediatrics

2020 Volume 60, Issue 3, Page(s) 170–177

Abstract: Introduction: Limited data are available for pediatric patients with coronavirus disease 2019 (COVID-19), especially with regard to disease management strategies.: Objective: To assess the children with COVID-19.: Method: We conducted a ... ...

Abstract	Introduction: Limited data are available for pediatric patients with coronavirus disease 2019 (COVID-19), especially with regard to disease management strategies. Objective: To assess the children with COVID-19. Method: We conducted a retrospective review of the medical records of pediatric patients on March 11 and May 23, 2020. Results: We evaluated 77 COVID-19 pediatric patients, of whom 45.5% were male, with a median age of 8 years (interquartile range [IQR] = 2-13), and 6.4% had underlying diseases. Patients were classified according to severity, with the percentages of asymptomatic, mild, moderate, and critical/severe cases determined to be 24.7%, 41.6%, 29.9%, and 3.9%, respectively. Extracorporeal membrane oxygenation and mechanic ventilation were only required for 1 patient. Targeted therapies were used in 3 patients. Conclusion: The disease course of COVID-19 appears to be milder in children than in adults, and the treatment course primarily consists of supportive care.
MeSH term(s)	Adolescent ; Amides ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/physiopathology ; Child ; Child, Preschool ; Female ; Humans ; Hydroxychloroquine ; Immunoglobulins, Intravenous/therapeutic use ; Lung/pathology ; Lung/physiopathology ; Male ; Pediatrics/methods ; Pyrazines ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Tertiary Care Centers ; Treatment Outcome ; Turkey
Chemical Substances	Amides ; Antiviral Agents ; Immunoglobulins, Intravenous ; Pyrazines ; Hydroxychloroquine (4QWG6N8QKH) ; favipiravir (EW5GL2X7E0)
Keywords	covid19
Language	English
Publishing date	2020-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922820966306
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Zs.A 454: Show issues

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Article ; Online: Oxidative Stress Related Diseases in Newborns.

Ozsurekci, Yasemin / Aykac, Kubra

Oxidative medicine and cellular longevity

2016 Volume 2016, Page(s) 2768365

Abstract: We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced ... ...

Abstract	We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced reactive oxygen/nitrogen species and the lack of protective ability of antioxidants. From that point of view, free radical-induced damage caused by oxidative stress seems to be a probable contributing factor to the pathogenesis of many newborn diseases, such as respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity. We share the hope that the new understanding of the concept of oxidative stress and its relation to newborn diseases that has been made possible by new diagnostic techniques will throw light on the treatment of those diseases.
MeSH term(s)	Antioxidants ; Female ; Humans ; Infant, Newborn ; Infant, Premature, Diseases/etiology ; Male ; Oxidative Stress/physiology ; Respiratory Distress Syndrome, Newborn/etiology
Chemical Substances	Antioxidants
Language	English
Publishing date	2016-06-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2016/2768365
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Article ; Online: Future Directions and Molecular Basis of Ventilator Associated Pneumonia.

Aykac, Kubra / Ozsurekci, Yasemin / Tanir Basaranoglu, Sevgen

Canadian respiratory journal

2017 Volume 2017, Page(s) 2614602

Abstract: Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care ...

Abstract	Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care units. Although it is still not well understood, understanding molecular pathogenesis is essential for preventing and treating pneumonia. A lot of microbes are detected as a causative agent of VAP. The most common isolated VAP pathogens in pediatric patients are
MeSH term(s)	Animals ; Humans ; Pneumonia, Ventilator-Associated/microbiology
Language	English
Publishing date	2017
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	1213103-9
ISSN	1916-7245 ; 1198-2241
ISSN (online)	1916-7245
ISSN	1198-2241
DOI	10.1155/2017/2614602
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Zs.A 4140: Show issues

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Article: Evaluation of Tubular Dysfunction Using Urine Biomarkers in Children with COVID-19.

Taş, Nesrin / Uslu Gökçeoğlu, Arife / Aykaç, Kübra / Cura Yayla, Burcu Ceylan / Şeneş, Mehmet / Demirkapı, Leyla / Çolak Samsun, Emel

Turkish archives of pediatrics

2021 Volume 57, Issue 1, Page(s) 99–103

Abstract: Objective: The coronavirus disease pandemic is a major problem that the world has been facing since December 2019. It mainly affects the respiratory system; however, the disease can affect the kidneys to different degrees. This study aimed to determine ... ...

Abstract	Objective: The coronavirus disease pandemic is a major problem that the world has been facing since December 2019. It mainly affects the respiratory system; however, the disease can affect the kidneys to different degrees. This study aimed to determine the changes in tubular dysfunction and inflammation parameters in children with coronavirus disease using urine biomarkers. Materials and methods: We included 36 children who tested positive for severe acute respiratory syndrome coronavirus 2 on real-time reverse transcriptase-polymerase chain reaction using respiratory specimens. Coronavirus disease-positive and -negative period parameters were evaluated. For measurement of interleukin-1β, interleukin-6, and urine β2 microglobulin levels, patients' urine samples were collected at diagnosis and 1 month after discharge. Additionally, routine urine and hematological parameters were evaluated concurrently. Results: For all patients, the median urine β2 microglobulin, serum urea, and lactate dehydrogenase levels were significantly higher in the coronavirus disease-positive period than in the coronavirus disease-negative period (P < .05). Further, serum platelet count was significantly lower in the coronavirus disease-positive period than in the coronavirus disease-negative period (P < .05). However, there was no difference in serum creatinine, interleukin-6, or interleukin-1β levels between the 2 periods (P > .05). Conclusion: Our results suggest kidney involvement and tubular dysfunction in patients with asymptomatic, mild, and moderate infections. Furthermore, interleukin-1β and interleukin-6 levels were high in the urine, even in non-critically ill patients. We believe that these findings contribute to the accumulation of evidence on continued inflammation in the kidney.
Language	English
Publishing date	2021-12-18
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2022.21248
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Article ; Online: Adhesion molecules as diagnostic and severity biomarkers in pediatric community-acquired pneumonia.

Tanır Basaranoglu, Sevgen / Ozsurekci, Yasemin / Aykac, Kubra / Iyigun, Irem / Satirer, Ozlem / Akin, Mustafa Senol / Ceyhan, Mehmet

The clinical respiratory journal

2021 Volume 15, Issue 5, Page(s) 522–529

Abstract: Background: Discrimination of the cases with severe and mild pneumonia is crucial due to the requirement of hospitalization, additional management, and treatment protocols. We aimed to analyze the role of IL6 (Interleukin), IL8, IL10, VCAM-1 (soluble ... ...

Abstract	Background: Discrimination of the cases with severe and mild pneumonia is crucial due to the requirement of hospitalization, additional management, and treatment protocols. We aimed to analyze the role of IL6 (Interleukin), IL8, IL10, VCAM-1 (soluble Vascular Cell Adhesion Molecule), and sSELE (soluble E-selectin) in the diagnosis and prognostic evaluation of community-acquired pneumonia (CAP). Methods: Pediatric patients with severe pneumonia (SP) were hospitalized and patients with mild disease (MP) were treated in the community. IL6, IL8, IL10, VCAM-1, and sSELE levels of the patients were investigated and compared with the age- and gender-matched healthy subjects. Results: A total of 113 patients fulfilling the criteria for a diagnosis of CAP were enrolled in the study, 62 (54.8%) of which had SP and 51 (45%) had MP. MP and SP groups were significantly different in terms of IL8, IL10, and sSELE levels. Patients with SP and MP had significantly different WBC, ESR, and CRP values, as well. Conclusions: Besides classical acute phase parameters, inflammatory response parameters such as IL6 and VCAM-1 levels may be helpful in diagnosis of pneumonia. In terms of determination of disease severity in pediatric CAP, systemic inflammatory markers like IL8 and IL10 and adhesion molecules like sSELE seem useful in clinical settings.
MeSH term(s)	Biomarkers ; C-Reactive Protein ; Child ; Community-Acquired Infections ; Humans ; Pneumonia ; Prognosis
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13334
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