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  1. Article ; Online: Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum of Prostate Cancer Patients.

    Aykanli, Emre / Arisan, Serdar / Arisan, Elif Damla / Yavuzsan, Abdullah Hizir

    Urology journal

    2024  Volume 21, Issue 3, Page(s) 182–188

    Abstract: Purpose: Considering the inadequacy of PSA measurement in the diagnosis of prostate cancer, it is aimed to establish a potential liquid biopsy diagnostic panel.: Materials and methods: 39 patients who underwent TRUS-biopsy and 15 healthy volunteers ... ...

    Abstract Purpose: Considering the inadequacy of PSA measurement in the diagnosis of prostate cancer, it is aimed to establish a potential liquid biopsy diagnostic panel.
    Materials and methods: 39 patients who underwent TRUS-biopsy and 15 healthy volunteers were included. Approximately 15 ml of venous blood samples taken from healthy volunteers and patients before biopsy were separated as plasma. Hypermethylation status of GSTP1 and RASSF1:RASSF2 genes was revealed in cfDNA materials collected from plasma samples. Correlation of this epigenetic change detected in PCa, BPH and healthy volunteer groups with pathology results was examined.
    Results: Pathology reports of 39 patients included were 13 PCa, 3 ASAP, 3 HGPIN, and 20 BPH. In total, 3 of the patients with PCa had positive GSTP1, 4 had RASSF1 and 9 had positive RASSF2 methylation. It was seen that RASSF2 had the highest sensitivity (69%), specificity (39%) and NPV (80%), while RASSF1 had the highest PPV (30%). When the binary combinations of genes were examined it was observed that the GSTP1:RASSF1 combination had the highest sensitivity (46%), specificity (76%) and NPV (82%). When the methylation of all three genes was examined, it was observed that the sensitivity was quite low (8%), but the specificity (83%) increased significantly.
    Conclusion: Although we observed that the GSTP1 and RASSF1 methylation positivity rates that we examined in our study were higher in patients without prostate cancer, we found that the RASSF2 methylation rate was higher in patients with prostate cancer. randomized controlled studies are needed.
    MeSH term(s) Humans ; Male ; Glutathione S-Transferase pi/genetics ; Glutathione S-Transferase pi/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/diagnosis ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/blood ; DNA Methylation ; Aged ; Middle Aged ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics
    Chemical Substances Glutathione S-Transferase pi (EC 2.5.1.18) ; RASSF1 protein, human ; Tumor Suppressor Proteins ; GSTP1 protein, human (EC 2.5.1.18) ; RASSF2 protein, human ; Biomarkers, Tumor
    Language English
    Publishing date 2024-05-06
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2251940-3
    ISSN 1735-546X ; 1735-1308
    ISSN (online) 1735-546X
    ISSN 1735-1308
    DOI 10.22037/uj.v20i.8014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Factors predicting duration and success of semirigid ureteroscopy for ureteral stones in different localizations.

    Guner, Ekrem / Danacioglu, Yavuz Onur / Akkas, Fatih / Ugur, Ramazan / Polat, Salih / Aykanli, Emre / Yavuzsan, Abdullah Hizir / Sam, Emre / Simsek, Abdulmuttalip

    Archivos espanoles de urologia

    2021  Volume 74, Issue 3, Page(s) 335–342

    Abstract: Objective: In this study, we aimed to determine the factors predicting the duration and successof semirigid ureteroscopy performed for the treatment of ureteral stones in different localizations. MATERIALS AND METHODS: Medical records of the patients ... ...

    Title translation Factores predictores de la duración y éxito de la ureteroscopia semirígida para litiasis ureterales en diferentes localizaciones.
    Abstract Objective: In this study, we aimed to determine the factors predicting the duration and successof semirigid ureteroscopy performed for the treatment of ureteral stones in different localizations. MATERIALS AND METHODS: Medical records of the patients whom under went semirigid ureteroscopy for urolithiasis in our centre between January 2015 and December 2019 were retrospectively reviewed. The study group composed of 170 patients and divided into three subgroups; of which 54 in proximal ureter (31.8%), 51 in the mid (30 %) and 65 (38.2%) in the distal ureter. Predictive factors of semirigid ureteroscopy duration and success were determined by performance of correlation analysis and multivariate analysis.
    Results: Overall stone-free rate was calculated as 78.8%. Success rates for proximal, mid and distal ureteral stones were 72.2% (39/54 patients), 74.5% (38/51 patients) and 87.7% (57/65 patients), respectively. Complications were present in 19 patients (11.2%). Multivariate analysis indicated that stone diameter and stone burden independently affected the stone-free rate. Statistically significant negative correlation was determined between success of the procedure and stone diameter, stone burden, impaction and more proximal stone localization. While there was a statistically significant positive correlation between duration of procedure and stone burden, diameter, impaction, historyof ipsilateral ureteroscopy and more proximal stone localization, there was negative correlation between duration of procedure and stone-free status. CONCLUSION: We conclude that stone diameter, stone burden, impaction and more proximal stone localization are common factors affecting both duration and success of semirigid ureteroscopy. In addition, stone size and stone burden were determined as independent markers of stone-free status.
    MeSH term(s) Humans ; Lithotripsy ; Retrospective Studies ; Treatment Outcome ; Ureter ; Ureteral Calculi/surgery ; Ureteroscopy ; Urolithiasis
    Language Spanish
    Publishing date 2021-04-05
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 211673-x
    ISSN 0004-0614
    ISSN 0004-0614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1312: Show issues Location:
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  3. Article ; Online: The fate of paratesticular masses: 13 years' experience in a tertiary referral centre.

    Demirel, Huseyin Cihan / Tokuç, Emre / Eryilmaz, Ozlem Ton / Aykanli, Emre / Yavuzsan, Abdullah Hizir / Ozagari, Ayse Aysim / Kirecci, Sinan Levent / Horasanli, Kaya

    Aktuelle Urologie

    2021  Volume 55, Issue 2, Page(s) 148–153

    Abstract: Objective: Paratesticular neoplasms exhibit different behaviours, depending on the embryological tissue of origin. Treatment modalities can depend on the differential diagnosis. The aim of this study is to present the clinical, morphological and ... ...

    Title translation Das Schicksal paratestikulärer Massen: 13 Jahre Erfahrung eines tertiären Überweisungszentrums.
    Abstract Objective: Paratesticular neoplasms exhibit different behaviours, depending on the embryological tissue of origin. Treatment modalities can depend on the differential diagnosis. The aim of this study is to present the clinical, morphological and histopathological features of patients with paratesticular masses and their follow-ups and is intended to increase awareness of the issues.
    Methodology: We included 31 excisions of paratesticular masses, after radiological diagnosis as paratesticular mass in our hospital between 2007-2020. Information on treatment modalities, tumour recurrence, metastasis, and survival rates were obtained from hospital archives. All patients were evaluated by taking patients' history, physical examination, scrotal ultrasound, chest radiography, and serum tumour markers. Treatment modality was selected according to intraoperative findings. Haematoxylin-eosin sections were examined, and immunohistochemical analyses were performed for smooth muscle actin, desmin, Ki67, CD34, S100, and myogenin. Ten high-power fields were counted to document Ki67 and p53 nuclear positivity rates.
    Results: A total of 31 operations were performed with recurrence in three patients. Histomorphological and immunohistochemical examination revealed eleven malignant masses; eight rhabdomyosarcomas, a leiomyosarcoma, a liposarcoma and a large B cell lymphoma. Other excised masses were benign and infective lesions.
    Conclusion: Paratesticular masses are heterogeneous tumours that follow different clinical courses. Clinicians must be aware of this histological diversity in order to plan a treatment pathway. This study is one of the largest published series, with a long follow-up period. It shows that the most critical features in determining prognosis are histopathological subtype and tumour grade.
    MeSH term(s) Male ; Humans ; Testicular Neoplasms/diagnosis ; Testicular Neoplasms/surgery ; Tertiary Care Centers ; Ki-67 Antigen ; Neoplasm Recurrence, Local ; Genital Neoplasms, Male/diagnosis ; Genital Neoplasms, Male/surgery ; Genital Neoplasms, Male/pathology
    Chemical Substances Ki-67 Antigen
    Language English
    Publishing date 2021-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-1345-6808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 676: Show issues Location:
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  4. Article: Plication without degloving - Safe and effective approach for correcting lateral and dorsal penile curvature: Case series.

    Demirel, Hüseyin Cihan / Yeşildal, Cumhur / Ilgi, Musab / Albayrak, Ahmet Tevfik / Aykanlı, Emre / Kireççi, Sinan Levent

    Urology annals

    2019  Volume 11, Issue 2, Page(s) 217–218

    Abstract: Penile curvature deformities are often manageable with surgical reconstruction methods. We aimed to show the safety and efficacy of ventral and dorsal plication techniques without degloving in our two patients who have penile curvature. Two young adults, ...

    Abstract Penile curvature deformities are often manageable with surgical reconstruction methods. We aimed to show the safety and efficacy of ventral and dorsal plication techniques without degloving in our two patients who have penile curvature. Two young adults, aged 20 and 23 years, presented to our clinic with lateral and dorsal penile curvatures. This problem has been sustaining since their teenage. Following the required preparations, two surgical techniques were used, namely Nesbit and Lue's "16-dot" technique. Patients completed a satisfaction survey at a mean of 6 months later the surgery. Although both patients reported a subjective decrease in penile length, their satisfaction rate was high. Penile plication without degloving is a safe and effective technique for correcting dorsal and lateral penile curvatures.
    Language English
    Publishing date 2019-02-28
    Publishing country India
    Document type Case Reports
    ISSN 0974-7796
    ISSN 0974-7796
    DOI 10.4103/UA.UA_181_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The fate of paratesticular masses: 13 years’ experience in a tertiary referral centre

    Demirel, Huseyin Cihan / Tokuç, Emre / Eryilmaz, Ozlem Ton / Aykanli, Emre / Yavuzsan, Abdullah Hizir / Ozagari, Ayse Aysim / Kirecci, Sinan Levent / Horasanli, Kaya

    Aktuelle Urologie

    2021  Volume 55, Issue 02, Page(s) 148–153

    Abstract: Objective: Paratesticular neoplasms exhibit different behaviours, depending on the embryological tissue of origin. Treatment modalities can depend on the differential diagnosis. The aim of this study is to present the clinical, morphological and ... ...

    Abstract Objective: Paratesticular neoplasms exhibit different behaviours, depending on the embryological tissue of origin. Treatment modalities can depend on the differential diagnosis. The aim of this study is to present the clinical, morphological and histopathological features of patients with paratesticular masses and their follow-ups and is intended to increase awareness of the issues.
    Methodology: We included 31 excisions of paratesticular masses, after radiological diagnosis as paratesticular mass in our hospital between 2007–2020. Information on treatment modalities, tumour recurrence, metastasis, and survival rates were obtained from hospital archives. All patients were evaluated by taking patients’ history, physical examination, scrotal ultrasound, chest radiography, and serum tumour markers. Treatment modality was selected according to intraoperative findings. Haematoxylin-eosin sections were examined, and immunohistochemical analyses were performed for smooth muscle actin, desmin, Ki67, CD34, S100, and myogenin. Ten high-power fields were counted to document Ki67 and p53 nuclear positivity rates.
    Results: A total of 31 operations were performed with recurrence in three patients. Histomorphological and immunohistochemical examination revealed eleven malignant masses; eight rhabdomyosarcomas, a leiomyosarcoma, a liposarcoma and a large B cell lymphoma. Other excised masses were benign and infective lesions.
    Conclusion: Paratesticular masses are heterogeneous tumours that follow different clinical courses. Clinicians must be aware of this histological diversity in order to plan a treatment pathway. This study is one of the largest published series, with a long follow-up period. It shows that the most critical features in determining prognosis are histopathological subtype and tumour grade.
    Keywords Orchiectomy ; Paratestis ; Scrotum ; Sarcoma ; Tumor ; Orchiektomie ; Paratestis ; Hodensack ; Sarkom ; Tumor
    Language English
    Publishing date 2021-04-14
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-1345-6808
    Database Thieme publisher's database

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  6. Article: Genital Self-mutilation Case in High-level Educated Person.

    Ilgi, Musab / Kutsal, Cemil / Abdullayev, Elshad / Aykanlı, Emre / Kirecci, Sinan Levent

    Urology case reports

    2016  Volume 10, Page(s) 19–22

    Abstract: Self-mutilation is the deliberate direct injuring of body tissue, often done without suicidal intention. Genital self-mutilation is a very rare event and self-harm of the penis, especially in the genital system is exceedingly rare. Generally, this kind ... ...

    Abstract Self-mutilation is the deliberate direct injuring of body tissue, often done without suicidal intention. Genital self-mutilation is a very rare event and self-harm of the penis, especially in the genital system is exceedingly rare. Generally, this kind of behavior is related to psychotic disorders but can sometimes be seen in non-psychotic people due to bizarre autoerotic acts, a desire for to change sex or religious beliefs that view sexual intercourse as a sin. Our case was the reported genital self-mutilation as a result of the bizarre sexual arousal of a young man who is employed as an architect.
    Language English
    Publishing date 2016-11-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2016.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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