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Article: The unusual finding of peripheral lymphadenopathy among confirmed Lassa fever patients in Nigeria.

Owhin, Sampson O / Abejegah, Chukuyem / Olatunde, Lanre O / Adedosu, Nelson A / Ayodeji, Olufemi O / Folorunso, Timothy R / Azegbeobor, Joachim / Akhideno, Peter E / Akpede, George O / Ayeyemi, Joseph A / Olowosusi, Oyebanji Z / Erameh, Cyril / Ahmed, Liasu A

Future science OA

2023 Volume 9, Issue 6, Page(s) FSO860

Abstract: Lassa fever is a viral haemorrhagic fever belonging to the arenaviridae family that is well known to be endemic to West Africa. The clinical presentation of the disease ranges from asymptomatic to fulminant illness. Lymphadenopathy a clinical ... ...

Abstract	Lassa fever is a viral haemorrhagic fever belonging to the arenaviridae family that is well known to be endemic to West Africa. The clinical presentation of the disease ranges from asymptomatic to fulminant illness. Lymphadenopathy a clinical manifestation of inflammation, infection, or malignancy has not been widely reported in Lassa fever disease. We report two cases of Lassa fever disease presenting with lymphadenopathy.
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Case Reports
ISSN	2056-5623
ISSN	2056-5623
DOI	10.2144/fsoa-2022-0086
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Article ; Online: Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice.

Adesina, Adetunji Samuel / Oyeyiola, Akinlabi / Obadare, Adeoba / Igbokwe, Joseph / Abejegah, Chukwuyem / Akhilomen, Patience / Bangura, Umaru / Asogun, Danny / Tobin, Ekaete / Ayodeji, Olufemi / Osoniyi, Omolaja / Davis, Chris / Thomson, Emma C / Pahlmann, Meike / Günther, Stephan / Fichet-Calvet, Elisabeth / Olayemi, Ayodeji

Emerging microbes & infections

2023 Volume 12, Issue 1, Page(s) 2219350

Abstract: We phylogenetically compared sequences of the zoonotic Lassa virus (LASV) obtained ... ...

Abstract	We phylogenetically compared sequences of the zoonotic Lassa virus (LASV) obtained from
MeSH term(s)	Humans ; Mice ; Animals ; Lassa virus/genetics ; Nigeria/epidemiology ; Phylogeny ; Lassa Fever/epidemiology ; Lassa Fever/veterinary ; Murinae
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2023.2219350
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Article ; Online: Immunological insights into COVID-19 in Southern Nigeria.

Ugwu, Chinedu A / Alao, Oluwasina / John, Oluwagboadurami G / Akinnawo, Blossom / Ajayi, Israel / Odebode, Ooreofe / Bejide, Ifeoluwa / Campbell, Allan / Campbell, Julian / Adole, Jolly A / B Olawoye, Idowu / Akano, Kazeem / Okolie, Johnson / Eromon, Philomena / Olaitan, Peter / Olagunoye, Ajibola / Adebayo, Ibukun / Adebayo, Victor / Babalola, Elizabeth /

Abioye, Omowumi / Ajayi, Nnennaya / Ogah, Emeka / Ukwaja, Kingsley / Okoro, Sylvanus / Oje, Ogbonnaya / Kingsley, Ojide Chiedozie / Eke, Matthew / Onyia, Venatius / Achonduh-Atijegbe, Olivia / Ewah, Friday Elechi / Obasi, Mary / Igwe, Violet / Ayodeji, Olufemi / Chukwuyem, Abejegah / Owhin, Sampson / Oyejide, Nicholas / Abah, Sylvester / Ingbian, Winifred / Osoba, Moyosoore / Alebiosu, Ahmed / Nadesalingam, Angalee / Aguinam, Ernest T / Carnell, George / Krause, Nina / Chan, Andrew / George, Charlotte / Kinsley, Rebecca / Tonks, Paul / Temperton, Nigel / Heeney, Jonathan / Happi, Christian

Frontiers in immunology

2024 Volume 15, Page(s) 1305586

Abstract: Introduction: One of the unexpected outcomes of the COVID-19 pandemic was the relatively low levels of morbidity and mortality in Africa compared to the rest of the world. Nigeria, Africa's most populous nation, accounted for less than 0.01% of the ... ...

Abstract	Introduction: One of the unexpected outcomes of the COVID-19 pandemic was the relatively low levels of morbidity and mortality in Africa compared to the rest of the world. Nigeria, Africa's most populous nation, accounted for less than 0.01% of the global COVID-19 fatalities. The factors responsible for Nigeria's relatively low loss of life due to COVID-19 are unknown. Also, the correlates of protective immunity to SARS-CoV-2 and the impact of pre-existing immunity on the outcome of the COVID-19 pandemic in Africa are yet to be elucidated. Here, we evaluated the natural and vaccine-induced immune responses from vaccinated, non-vaccinated and convalescent individuals in Southern Nigeria throughout the three waves of the COVID-19 pandemic in Nigeria. We also examined the pre-existing immune responses to SARS-CoV-2 from samples collected prior to the COVID-19 pandemic. Methods: We used spike RBD and N- IgG antibody ELISA to measure binding antibody responses, SARS-CoV-2 pseudotype assay protocol expressing the spike protein of different variants (D614G, Delta, Beta, Omicron BA1) to measure neutralizing antibody responses and nucleoprotein (N) and spike (S1, S2) direct ex vivo interferon gamma (IFNγ) T cell ELISpot to measure T cell responses. Result: Our study demonstrated a similar magnitude of both binding (N-IgG (74% and 62%), S-RBD IgG (70% and 53%) and neutralizing (D614G (49% and 29%), Delta (56% and 47%), Beta (48% and 24%), Omicron BA1 (41% and 21%)) antibody responses from symptomatic and asymptomatic survivors in Nigeria. A similar magnitude was also seen among vaccinated participants. Interestingly, we revealed the presence of preexisting binding antibodies (N-IgG (60%) and S-RBD IgG (44%)) but no neutralizing antibodies from samples collected prior to the pandemic. Discussion: These findings revealed that both vaccinated, non-vaccinated and convalescent individuals in Southern Nigeria make similar magnitude of both binding and cross-reactive neutralizing antibody responses. It supported the presence of preexisting binding antibody responses among some Nigerians prior to the COVID-19 pandemic. Lastly, hybrid immunity and heterologous vaccine boosting induced the strongest binding and broadly neutralizing antibody responses compared to vaccine or infection-acquired immunity alone.
MeSH term(s)	Humans ; Antibodies, Neutralizing ; Broadly Neutralizing Antibodies ; COVID-19/immunology ; Enzyme-Linked Immunospot Assay ; Immunoglobulin G ; Nigeria ; Pandemics ; SARS-CoV-2 ; West African People
Chemical Substances	Antibodies, Neutralizing ; Broadly Neutralizing Antibodies ; Immunoglobulin G
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1305586
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Article: Association of hypoalbuminemia and reversal of albumin-to-globulin ratio with morbidity outcome among hospitalized Lassa fever infected patients at a dedicated treatment center in Ondo state, south-western Nigeria.

Owhin, Sampson Omagbemi / Abejegah, Chukwuyem / Fasipe, Olumuyiwa John / Oke, Clement / Abidoye, Abiodun / Osagbaekhoe, Austine / Awe, Abimbola / Etafo, Ijeoma / Iredia, Evbaruese / Ayodeji, Olufemi / Olatunde, Lanre / Ojo, Olalekan / Alabi, Josephine / Akhideno, Peter Ehizokhale / Ejiyere, Harrison / Stephen Adeke, Azuka / Azegbeobor, Joachim / Ahmed, Liasu

Future science OA

2020 Volume 6, Issue 10, Page(s) FSO620

Abstract: Background: As of this present moment, there is paucity of data on report concerning the association between hypoalbuminaemia or reversal of albumin-to-globulin ratio and morbidity outcome in Lassa fever (LF) infection as a crucial determinant ... ...

Abstract	Background: As of this present moment, there is paucity of data on report concerning the association between hypoalbuminaemia or reversal of albumin-to-globulin ratio and morbidity outcome in Lassa fever (LF) infection as a crucial determinant prognostic-predictor factor for treatment-survival outcome. Aim: This study was designed to determine the association between hypoalbuminaemia, reversal of albumin-to-globulin ratio and morbidity outcome among confirmed LF infected patients. Methodology: This was a descriptive retrospective study involving the assessment of records of confirmed LF infected patients that were managed at the center from November 2018 to October 2019. Results: Out of 83 recruited participants with complete records, 66 (79.5%) had hypoalbuminaemia, 74 (89.2%) had reversal of albumin-to-globulin ratio. A higher mean value of total white blood cell (WBC) count was observed among patients with hypoalbuminaemia (p < 0.0001) and reversal of albumin-to-globulin ratio (p < 0.0001) when compared to patients with normal values, respectively. Also, this study showed statistically significant associations between serum albumin level versus total WBC count (p < 0.0001), acute kidney injury (AKI; p = 0.009), bleeding diathesis (p < 0.0001), and occurrence of pregnancy miscarriage (p < 0.0001). Conclusion: There is a baseline hypoalbuminaemia and reversal of albumin-to-globulin ratio among confirmed LF infected patients. Based on these findings, the serum level of albumin and albumin-to-globulin ratio at presentation may serve as simple early biomarkers to identify patients at high risk for a complicated clinical course of disease. This study also reveals that those hospitalized LF infected patients with hypoalbuminemia and/or reversal of albumin-to-globulin ratio tend to have leucocytosis and experience prolonged duration of illness.
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article
ISSN	2056-5623
ISSN	2056-5623
DOI	10.2144/fsoa-2020-0075
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Article ; Online: A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)-Study protocol.

Penfold, Suzanne / Adegnika, Ayola Akim / Asogun, Danny / Ayodeji, Olufemi / Azuogu, Benedict N / Fischer, William A / Garry, Robert F / Grant, Donald Samuel / Happi, Christian / N'Faly, Magassouba / Olayinka, Adebola / Samuels, Robert / Sibley, Jefferson / Wohl, David A / Accrombessi, Manfred / Adetifa, Ifedayo / Annibaldis, Giuditta / Camacho, Anton / Dan-Nwafor, Chioma /

Deha, Akpénè Ruth Esperencia / DeMarco, Jean / Duraffour, Sophie / Goba, Augustine / Grais, Rebecca / Günther, Stephan / Honvou, Énagnon Junior Juvénal Prince / Ihekweazu, Chikwe / Jacobsen, Christine / Kanneh, Lansana / Momoh, Mambu / Ndiaye, Aminata / Nsaibirni, Robert / Okogbenin, Sylvanus / Ochu, Chinwe / Ogbaini, Ephraim / Logbo, Énagnon Parsifal Marie Alexandre / Sandi, John Demby / Schieffelin, John S / Verstraeten, Thomas / Vielle, Nathalie J / Yadouleton, Anges / Yovo, Emmanuel Koffi

PloS one

2023 Volume 18, Issue 3, Page(s) e0283643

Abstract: Background: Lassa fever (LF), a haemorrhagic illness caused by the Lassa fever virus (LASV), is endemic in West Africa and causes 5000 fatalities every year. The true prevalence and incidence rates of LF are unknown as infections are often asymptomatic, ...

Abstract	Background: Lassa fever (LF), a haemorrhagic illness caused by the Lassa fever virus (LASV), is endemic in West Africa and causes 5000 fatalities every year. The true prevalence and incidence rates of LF are unknown as infections are often asymptomatic, clinical presentations are varied, and surveillance systems are not robust. The aim of the Enable Lassa research programme is to estimate the incidences of LASV infection and LF disease in five West African countries. The core protocol described here harmonises key study components, such as eligibility criteria, case definitions, outcome measures, and laboratory tests, which will maximise the comparability of data for between-country analyses. Method: We are conducting a prospective cohort study in Benin, Guinea, Liberia, Nigeria (three sites), and Sierra Leone from 2020 to 2023, with 24 months of follow-up. Each site will assess the incidence of LASV infection, LF disease, or both. When both incidences are assessed the LASV cohort (nmin = 1000 per site) will be drawn from the LF cohort (nmin = 5000 per site). During recruitment participants will complete questionnaires on household composition, socioeconomic status, demographic characteristics, and LF history, and blood samples will be collected to determine IgG LASV serostatus. LF disease cohort participants will be contacted biweekly to identify acute febrile cases, from whom blood samples will be drawn to test for active LASV infection using RT-PCR. Symptom and treatment data will be abstracted from medical records of LF cases. LF survivors will be followed up after four months to assess sequelae, specifically sensorineural hearing loss. LASV infection cohort participants will be asked for a blood sample every six months to assess LASV serostatus (IgG and IgM). Discussion: Data on LASV infection and LF disease incidence in West Africa from this research programme will determine the feasibility of future Phase IIb or III clinical trials for LF vaccine candidates.
MeSH term(s)	Humans ; Cohort Studies ; Immunoglobulin G ; Incidence ; Lassa Fever/epidemiology ; Lassa Fever/diagnosis ; Lassa virus ; Liberia ; Prospective Studies ; Multicenter Studies as Topic
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283643
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Article ; Online: Increase in Lassa Fever Cases in Nigeria, January-March 2018.

Emerging infectious diseases

2019 Volume 25, Issue 5, Page(s) 1026–1027

Abstract: We reviewed data pertaining to the massive wave of Lassa fever cases that occurred in Nigeria in 2018. No new virus strains were detected, but in 2018, the outbreak response was intensified, additional diagnostic support was available, and surveillance ... ...

Abstract	We reviewed data pertaining to the massive wave of Lassa fever cases that occurred in Nigeria in 2018. No new virus strains were detected, but in 2018, the outbreak response was intensified, additional diagnostic support was available, and surveillance sensitivity increased. These factors probably contributed to the high case count.
MeSH term(s)	Animals ; Disease Outbreaks ; History, 21st Century ; Humans ; Incidence ; Lassa Fever/diagnosis ; Lassa Fever/epidemiology ; Lassa Fever/history ; Lassa Fever/virology ; Lassa virus/classification ; Lassa virus/genetics ; Lassa virus/isolation & purification ; Nigeria/epidemiology ; Public Health Surveillance ; Seasons
Language	English
Publishing date	2019-05-17
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2505.181247
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Article ; Online: Epidemiologic and Clinical Features of Lassa Fever Outbreak in Nigeria, January 1-May 6, 2018.

Ilori, Elsie A / Furuse, Yuki / Ipadeola, Oladipupo B / Dan-Nwafor, Chioma C / Abubakar, Anwar / Womi-Eteng, Oboma E / Ogbaini-Emovon, Ephraim / Okogbenin, Sylvanus / Unigwe, Uche / Ogah, Emeka / Ayodeji, Olufemi / Abejegah, Chukwuyem / Liasu, Ahmed A / Musa, Emmanuel O / Woldetsadik, Solomon F / Lasuba, Clement L P / Alemu, Wondimagegnehu / Ihekweazu, Chikwe

Emerging infectious diseases

2019 Volume 25, Issue 6, Page(s) 1066–1074

Abstract: Lassa fever (LF) is endemic to Nigeria, where the disease causes substantial rates of illness and death. In this article, we report an analysis of the epidemiologic and clinical aspects of the LF outbreak that occurred in Nigeria during January 1-May 6, ... ...

Abstract	Lassa fever (LF) is endemic to Nigeria, where the disease causes substantial rates of illness and death. In this article, we report an analysis of the epidemiologic and clinical aspects of the LF outbreak that occurred in Nigeria during January 1-May 6, 2018. A total of 1,893 cases were reported; 423 were laboratory-confirmed cases, among which 106 deaths were recorded (case-fatality rate 25.1%). Among all confirmed cases, 37 occurred in healthcare workers. The secondary attack rate among 5,001 contacts was 0.56%. Most (80.6%) confirmed cases were reported from 3 states (Edo, Ondo, and Ebonyi). Fatal outcomes were significantly associated with being elderly; no administration of ribavirin; and the presence of a cough, hemorrhaging, and unconsciousness. The findings in this study should lead to further LF research and provide guidance to those preparing to respond to future outbreaks.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Disease Outbreaks ; Female ; Geography, Medical ; History, 21st Century ; Humans ; Infant ; Infant, Newborn ; Lassa Fever/diagnosis ; Lassa Fever/epidemiology ; Lassa Fever/history ; Lassa Fever/virology ; Lassa virus ; Male ; Middle Aged ; Mortality ; Nigeria/epidemiology ; Odds Ratio ; Prevalence ; Public Health Surveillance ; Seasons ; Symptom Assessment ; Young Adult
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2506.181035
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Article ; Online: Increase in Lassa Fever Cases in Nigeria, January–March 2018

2019

Abstract	We reviewed data pertaining to the massive wave of Lassa fever cases that occurred in Nigeria in 2018. No new virus strains were detected, but in 2018, the outbreak response was intensified, additional diagnostic support was available, and surveillance sensitivity increased. These factors probably contributed to the high case count. Peer Reviewed
Keywords	Ebonyi ; Edo ; Lassa fever ; Lassa virus ; Nigeria ; Ondo ; epidemiology ; hemorrhagic fever ; outbreak ; surveillance ; surveillance capacity ; viruses ; zoonoses ; 610 Medizin und Gesundheit ; ddc:610
Language	English
Publishing date	2019-02-26
Publisher	Robert Koch-Institut
Publishing country	de
Document type	Article ; Online
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Article ; Online: Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.

Olawoye, Idowu B / Oluniyi, Paul E / Oguzie, Judith U / Uwanibe, Jessica N / Kayode, Tolulope A / Olumade, Testimony J / Ajogbasile, Fehintola V / Parker, Edyth / Eromon, Philomena E / Abechi, Priscilla / Sobajo, Tope A / Ugwu, Chinedu A / George, Uwem E / Ayoade, Femi / Akano, Kazeem / Oyejide, Nicholas E / Nosamiefan, Iguosadolo / Fred-Akintunwa, Iyanuoluwa / Adedotun-Sulaiman, Kemi /

Brimmo, Farida B / Adegboyega, Babatunde B / Philip, Courage / Adeleke, Richard A / Chukwu, Grace C / Ahmed, Muhammad I / Ope-Ewe, Oludayo O / Otitoola, Shobi G / Ogunsanya, Olusola A / Saibu, Mudasiru F / Sijuwola, Ayotunde E / Ezekiel, Grace O / John, Oluwagboadurami G / Akin-John, Julie O / Akinlo, Oluwasemilogo O / Fayemi, Olanrewaju O / Ipaye, Testimony O / Nwodo, Deborah C / Omoniyi, Abolade E / Omwanghe, Iyobosa B / Terkuma, Christabel A / Okolie, Johnson / Ayo-Ale, Olubukola / Ikponmwosa, Odia / Benevolence, Ebo / Naregose, Grace O / Patience, Akhilomen E / Blessing, Osiemi / Micheal, Airende / Jacqueline, Agbukor / Aiyepada, John O / Ebhodaghe, Paulson / Racheal, Omiunu / Rita, Esumeh / Rosemary, Giwa E / Solomon, Ehikhametalor / Anieno, Ekanem / Edna, Yerumoh / Chris, Aire O / Donatus, Adomeh I / Ogbaini-Emovon, Ephraim / Tatfeng, Mirabeau Y / Omunakwe, Hannah E / Bob-Manuel, Mienye / Ahmed, Rahaman A / Onwuamah, Chika K / Shaibu, Joseph O / Okwuraiwe, Azuka / Ataga, Anthony E / Bock-Oruma, Andrew / Daramola, Funmi / Yusuf, Ibrahim F / Fajola, Akinwumi / Ntia, Nsikak-Abasi / Ekpo, Julie J / Moses, Anietie E / Moore-Igwe, Beatrice W / Fakayode, Oluwatosin E / Akinola, Monilade / Kida, Ibrahim M / Oderinde, Bamidele S / Wudiri, Zara W / Adeyemi, Oluwapelumi O / Akanbi, Olusola A / Ahumibe, Anthony / Akinpelu, Afolabi / Ayansola, Oyeronke / Babatunde, Olajumoke / Omoare, Adesuyi A / Chukwu, Chimaobi / Mba, Nwando G / Omoruyi, Ewean C / Olisa, Olasunkanmi / Akande, Olatunji K / Nwafor, Ifeanyi E / Ekeh, Matthew A / Ndoma, Erim / Ewah, Richard L / Duruihuoma, Rosemary O / Abu, Augustine / Odeh, Elizabeth / Onyia, Venatius / Ojide, Chiedozie K / Okoro, Sylvanus / Igwe, Daniel / Ogah, Emeka O / Khan, Kamran / Ajayi, Nnennaya A / Ugwu, Collins N / Ukwaja, Kingsley N / Ugwu, Ngozi I / Abejegah, Chukwuyem / Adedosu, Nelson / Ayodeji, Olufemi / Liasu, Ahmed A / Isamotu, Rafiu O / Gadzama, Galadima / Petros, Brittany A / Siddle, Katherine J / Schaffner, Stephen F / Akpede, George / Erameh, Cyril Oshomah / Baba, Marycelin M / Oladiji, Femi / Audu, Rosemary / Ndodo, Nnaemeka / Fowotade, Adeola / Okogbenin, Sylvanus / Okokhere, Peter O / Park, Danny J / Mcannis, Bronwyn L / Adetifa, Ifedayo M / Ihekweazu, Chikwe / Salako, Babatunde L / Tomori, Oyewale / Happi, Anise N / Folarin, Onikepe A / Andersen, Kristian G / Sabeti, Pardis C / Happi, Christian T

Nature communications

2023 Volume 14, Issue 1, Page(s) 811

Abstract: Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated ... ...

Abstract	Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Nigeria/epidemiology ; SARS-CoV-2/genetics
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36449-5
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