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Article ; Online: EFFICACY OF LEMON GRASS (CYMBOPOGON CITRATUS) ON THE HIDE BEETLE (DERMESTES MACULATUS) IN SMOKE-DRIED AFRICAN CATFISH (CLARIAS GARIEPINUS) IN JOS NORTH LGA OF PLATEAU STATE, NIGERIA

Ishaya M. / John W.C. / Oke O. / Chomini M.S. / Oladejo A.O. / Ihum T.A. / Olorundare O.O. / Ukanyirioha C.J. / Ayorinde J.O. / Sikiru G.K.

Russian Journal of Agricultural and Socio-Economic Sciences, Vol 116, Iss 8, Pp 73-

2021 Volume 78

Abstract: Fish losses to Dermestes maculatus infestation is one of the biggest problems of fish farming, hence this study was carried out to evaluate the efficacy of Cymbopogon citratus against Dermestes maculatus fed on smoke-dried Catfish. Fresh and Dermestes ... ...

Abstract	Fish losses to Dermestes maculatus infestation is one of the biggest problems of fish farming, hence this study was carried out to evaluate the efficacy of Cymbopogon citratus against Dermestes maculatus fed on smoke-dried Catfish. Fresh and Dermestes maculatus infested samples of Catfish were procured. The fresh Catfish were smoked traditionally and then oven dried at 60°C for 1hour to remove excess moisture. Twenty-eight of un-infested Catfish were placed in 1000mL plastic jars and Cymbopogon citratus powder was added at the rate of 2.5g, 5.0g, 7.5g, and 10.0g. The fish and the powder were thoroughly mixed and six newly emerged adults were introduced into each jar, while to a different set of experiment, six 3rd-4th instar larvae of Dermestes maculatus were introduced into each jars and then covered with muslin cloth. The experiments were arranged in a Completely Randomized Design with each treatment replicated three times. Data on mortality of the larval Demestes maculatus was collected for 21 days while data on adult mortality was collected for 7 days at 48 hours interval. The data were subjected to ANOVA and means were separated using Duncan multiple range test. Cymbopogon citratus powder showed significant effects on Dermestes maculatus larvae and adult, where the highest mortality was recorded at the following doses of 2.5 and 5.0g (72.2% and77.8% respectively) for the larvae and 5.0 and 10.0g (22.2% and 16.7%) for the adults. This study revealed that Cymbopogon citratus has insecticidal potentials and therefore, be used to preserve Catfish shelve life.
Keywords	demestes maculatus ; cymbopogon citratus ; catfish ; clarias gariepinus ; lemongrass ; mortality ; larva ; Agriculture (General) ; S1-972
Subject code	590
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Russian Journal of Agricultural and Socio-Economic Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COMPARATIVE EFFECTS OF GARLIC (ALLIUM SATIVUM) BULB AND BULB COAT POWDER ON MAIZE WEEVILS (SITOPHILUS ZEAMAIS)

Ishaya M. / John W.C. / Oke O. / Chomini M.S. / Oladejo A.O. / Ihum T.A. / Olorundare O.O. / Ukanyirioha C.J. / Ayorinde J.O. / Sikiru G.K.

Russian Journal of Agricultural and Socio-Economic Sciences, Vol 116, Iss 8, Pp 91-

2021 Volume 95

Abstract: In Nigeria, maize serves as a staple food and a good source of carbohydrates, protein, vitamin B and minerals, hence, the need to protect it against Sitophilus zeamais. This study was conducted to determine the phytochemical properties and insecticidal ... ...

Abstract	In Nigeria, maize serves as a staple food and a good source of carbohydrates, protein, vitamin B and minerals, hence, the need to protect it against Sitophilus zeamais. This study was conducted to determine the phytochemical properties and insecticidal potentials of Allium sativum bulb and bulb coat powders against Sitophilus zeamais. Allium sativum bulb and bulb coat were collected, dried, and pulverized into fine powder. A 0, 2.0, 3.0, 4.0, and 5.0g of the plant powder were used. Each treatment had 16 newly emerged maize weevils. The weevils were mixed with 250g un-infested maize grains in 500ml bottles and kept at room temperature. Mortality was observed for 7 days at 24 hours intervals post treatment. The experiment was laid out in a Completely Randomized Design and treatments were replicated three times. Data obtained were analyzed using a one-way ANOVA and means were separated using Duncan multiple Range test. The results revealed that both parts showed significant percentage mortality (P ≤ 0.05). The results showed that as the dosage of the bulb powder increased from 2 - 5g, percentage mortality increased from 16-32.8%. For bulb coat powder, percentage mortality increased from 16.5-32.1%. The control showed mortality of 3.0 and 2.8% for the bulb and bulb coat powders, which were significantly different (P < 0.05) from the mortality in treated maize. The most effective dosage for both powders is 5g. Based on the results obtained, Garlic bulb and garlic bulb coat could be used in the management of Sitophilus zeamais infestation.
Keywords	garlic bulb ; garlic bulb coat ; sitophilus zeamais ; mortality ; dosages ; phytochemical ; Agriculture (General) ; S1-972
Subject code	630 ; 310
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Russian Journal of Agricultural and Socio-Economic Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of material properties and speed of compression on microbial survival and tensile strength in diclofenac tablet formulations.

Ayorinde, J O / Itiola, O A / Odeniyi, M A

Archives of pharmacal research

2013 Volume 36, Issue 3, Page(s) 273–281

Abstract: A work has been done to study the effects of material properties and compression speed on microbial survival and tensile strength in diclofenac tablet formulations. Tablets were produced from three formulations containing diclofenac and different ... ...

Abstract	A work has been done to study the effects of material properties and compression speed on microbial survival and tensile strength in diclofenac tablet formulations. Tablets were produced from three formulations containing diclofenac and different excipients (DC, DL and DDCP). Two types of machines (Hydraulic hand press and single punch press), which compress the tablets at different speeds, were used. The compression properties of the tablets were analyzed using Heckel and Kawakita equations. A 3-dimensional plot was produced to determine the relationship between the tensile strength, compression speed and percentage survival of Bacillus subtilis in the diclofenac tablets. The mode of consolidation of diclofenac was found to depends on the excipient used in the formulation. DC deformed mainly by plastic flow with the lowest Py and Pk values. DL deformed plastically at the initial stage, followed by fragmentation at the later stage of compression, whereas DDCP deformed mainly by fragmentation with the highest Py and Pk values. The ranking of the percentage survival of B. subtilis in the formulations was DDCP > DL > DC, whereas the ranking of the tensile strength of the tablets was DDCP > DL > DC. Tablets produced on a hydraulic hand press with a lower compression speed had a lower percentage survival of microbial contaminants than those produced on a single punch press, which compressed the tablets at a much higher speed. The mode of consolidation of the materials and the speed at which tablet compression is carried out have effects on both the tensile strength of the tablets and the extent of destruction of microbial contaminants in diclofenac tablet formulations.
MeSH term(s)	Bacillus subtilis/isolation & purification ; Bacillus subtilis/physiology ; Chemistry, Pharmaceutical/methods ; Chemistry, Pharmaceutical/standards ; Compressive Strength ; Diclofenac/chemical synthesis ; Diclofenac/standards ; Drug Contamination/prevention & control ; Tablets ; Tensile Strength ; Time Factors
Chemical Substances	Tablets ; Diclofenac (144O8QL0L1)
Language	English
Publishing date	2013-03
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-013-0027-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 vaccine breakthrough infections among fully vaccinated Health Care Workers in Lagos, Nigeria

Oladele, David Ayoola / Salako, Abideen / Ayorinde, James / Onwuamah, Chika / Usman, Olagoke / Abubakar, Rufai / Liboro, Gideon / Odubela, Oluwatosin / Mogaji, Sunday / Ige, Fehintola / Ohihoin, Gregory / Ezechi, Oliver / Audu, Rosemary / Adegbola, Richard A. / Dada, Adedamola / Salako, Tunde

medRxiv

Abstract: Background Access to vaccines has contributed to the control of COVID-19. However, evaluation of the effectiveness of the vaccines in a setting where the vaccines were not originally tested is critically important. This study evaluates the clinical and ... ...

Abstract	Background Access to vaccines has contributed to the control of COVID-19. However, evaluation of the effectiveness of the vaccines in a setting where the vaccines were not originally tested is critically important. This study evaluates the clinical and laboratory characteristics of COVID-19 vaccine breakthrough infections among healthcare workers (HCWs). Methods A multicentre prospective study among HCWs who had two doses of the Oxford/AstraZeneca ChAdOx1-S [recombinant] (AZD1222) vaccine were followed up 24 weeks. Nasopharyngeal and oropharyngeal specimens were tested using RT-PCR for SARS-CoV-2 and positive samples were subjected to whole genome sequencing for variant assignment. Result A total of 369 HCWs were enrolled; of which 24 (6.5%) had breakthrough infections. There was equal sex distribution among the breakthrough cases. The majority were aged between 30 to 39years (37.5%), and had mild symptoms of cough, fever, headache, and nausea/vomiting (58%), with no hospitalization. Among the 24 breakthrough cases whose whole genomes were successfully sequenced, three were confirmed to be Delta B.1.617.2 variant during the 3 rd wave and an additional three were confirmed as omicron B.1.1.529 variant during the 4 th wave. Conclusion We reported vaccine breakthrough cases among fully vaccinated HCWs with the majority presenting with mild illness. Both delta and omicron variants were identified during the different epidemiologic spectrums of SARS-CoV-2. Therefore, there is a need to scale up vaccination for all front-line health workers and high-risk populations in developing countries.
Keywords	covid19
Language	English
Publishing date	2022-06-22
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.06.22.22276765
Database	COVID19

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Article: Effects of material properties and speed of compression on microbial survival and tensile strength in diclofenac tablet formulations

Ayorinde, J. O / Itiola, O. A / Odeniyi, M. A

Archives of pharmacal research. 2013 Mar., v. 36, no. 3

2013

Abstract	A work has been done to study the effects of material properties and compression speed on microbial survival and tensile strength in diclofenac tablet formulations. Tablets were produced from three formulations containing diclofenac and different excipients (DC, DL and DDCP). Two types of machines (Hydraulic hand press and single punch press), which compress the tablets at different speeds, were used. The compression properties of the tablets were analyzed using Heckel and Kawakita equations. A 3-dimensional plot was produced to determine the relationship between the tensile strength, compression speed and percentage survival of Bacillus subtilis in the diclofenac tablets. The mode of consolidation of diclofenac was found to depends on the excipient used in the formulation. DC deformed mainly by plastic flow with the lowest Py and Pₖ values. DL deformed plastically at the initial stage, followed by fragmentation at the later stage of compression, whereas DDCP deformed mainly by fragmentation with the highest Py and Pₖ values. The ranking of the percentage survival of B. subtilis in the formulations was DDCP > DL > DC, whereas the ranking of the tensile strength of the tablets was DDCP > DL > DC. Tablets produced on a hydraulic hand press with a lower compression speed had a lower percentage survival of microbial contaminants than those produced on a single punch press, which compressed the tablets at a much higher speed. The mode of consolidation of the materials and the speed at which tablet compression is carried out have effects on both the tensile strength of the tablets and the extent of destruction of microbial contaminants in diclofenac tablet formulations.
Keywords	Bacillus subtilis ; equations ; equipment ; microbial contamination ; tensile strength
Language	English
Dates of publication	2013-03
Size	p. 273-281.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	447623-2
ISSN	0253-6269
ISSN	0253-6269
DOI	10.1007/s12272-013-0027-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparative performance of SARS-CoV-2 real-time PCR diagnostic assays on samples from Lagos, Nigeria.

PloS one

2021 Volume 16, Issue 2, Page(s) e0246637

Abstract: A key element in containing the spread of the SARS-CoV-2 infection is quality diagnostics which is affected by several factors. We now report the comparative performance of five real-time diagnostic assays. Nasopharyngeal swab samples were obtained from ... ...

Abstract	A key element in containing the spread of the SARS-CoV-2 infection is quality diagnostics which is affected by several factors. We now report the comparative performance of five real-time diagnostic assays. Nasopharyngeal swab samples were obtained from persons seeking a diagnosis for SARS-CoV-2 infection in Lagos, Nigeria. The comparison was performed on the same negative, low, and high-positive sample set, with viral RNA extracted using the Qiagen Viral RNA Kit. All five assays are one-step reverse transcriptase real-time PCR assays. Testing was done according to each assay's manufacturer instructions for use using real-time PCR platforms. 63 samples were tested using the five qPCR assays, comprising of 15 negative samples, 15 positive samples (Ct = 16-30; one Ct = 35), and 33 samples with Tib MolBiol E-gene Ct value ranging from 36-41. All assays detected all high positive samples correctly. Three assays correctly identified all negative samples while two assays each failed to correctly identify one different negative sample. The consistent detection of positive samples at different Ct/Cq values gives an indication of when to repeat testing and/or establish more stringent in-house cut-off value. The varied performance of different diagnostic assays, mostly with emergency use approvals, for a novel virus is expected. Comparative assays' performance reported may guide laboratories to determine both their repeat testing Ct/Cq range and/or cut-off value.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/virology ; COVID-19 Nucleic Acid Testing/methods ; Humans ; Nigeria/epidemiology ; RNA, Viral/analysis ; RNA, Viral/genetics ; Retrospective Studies ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Comparative Study ; Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0246637
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Antibody responses to AZD1222 vaccination in West Africa

Abdullahi, Adam / Oladele, David / Kemp, Steven / Ayorinde, James / Salako, Abideen / Ige, Fehintola / Fink, Douglas / Onwuamah, Chika / Osuolale, Qosim / Abubakar, Rufai / Okuruawe, Azuka / Liboro, Gideon / Odubela, Oluwatosin / Ohihoin, Gregory / Ezechi, Oliver / Usman, Olagoke / Mogaji, Sunfay / Dada, Adedamola / Ebrahimi, Soraya /

Gutierrez, Lourdes Ceron / Aliyu, Sani H / Doffinger, Rainer / Audu, Rosemary / Adegbola, Richard / Mlcochova, Petra / Salako, Babatunde Lawal / Gupta, Ravindra K

medRxiv

Abstract: Background: There are no data on vaccine elicited neutralising antibody responses for the most widely used vaccine, AZD1222, in African populations following scale up. Here, we measured i. baseline SARS-CoV-2 seroprevalence and levels of protective ... ...

Abstract	Background: There are no data on vaccine elicited neutralising antibody responses for the most widely used vaccine, AZD1222, in African populations following scale up. Here, we measured i. baseline SARS-CoV-2 seroprevalence and levels of protective antibodies prior to vaccination rollout using both flow cytometric based analysis of binding antibodies to nucleocapsid (N), coupled with virus neutralisation approaches and ii. neutralizing antibody responses to VOC prior to vaccination (January 2021) and after two-doses of AZD1222 vaccine administered between June and July 2021 in Lagos, Nigeria, during a period when the Delta variant was also circulating. Methods: Health workers at multiple sites in Lagos were recruited to the study. For binding antibody measurement, IgG antibodies against SARS-COV-2 Wuhan-1 receptor-binding domain (RBD), trimeric spike protein (S), nucleocapsid protein (N) and Omicron S1 were measured using the Luminex-based SARS-CoV-2-IgG assay by flow cytometry. For plasma neutralising antibody measurement, SARS-CoV-2 lentiviral pseudovirus (PV) were prepared by transfecting 293T cells with Wuhan-614G wild type (WT), B.1.617.2 (Delta) and BA.1 (Omicron) plasmids in conjunction with HIV-1 expression vectors and luciferase encoding genome flanked by LTRs. We performed serial plasma dilutions from each time point and mixed plasma with PV before infecting HeLa-ACE2 cell lines, reading out luminescence and calculating ID50 (dilution of sera required to inhibit 50% of PV infection). Results: Our study population who received at least one dose of vaccine comprised 140 participants with a median age of 40 (interquartile range: 33, 48). 62/140 (44%) participants were anti-N IgG positive prior to administration of first vaccine dose. 49 had plasma samples available at baseline prior to vaccination and at two follow-up timepoints post vaccination for neutralization assays. Half of the participants, 25/49 (51%) were IgG anti-N positive at baseline. Of the 24 individuals anti-N Ab negative at baseline, 12/24 had ID50 above the cut-off of 20. In these individuals, binding antibodies to S were also detectable, and neutralisation correlated with IgG anti-S. Overall, neutralizing Ab titres to WT 1 month after second dose were 2579 and at 3 months post second-dose were 1695. As expected, lower levels of neutralization were observed against the Delta GMT 549 and Omicron variants 269 at 1 month. Positive anti-N IgG Ab status at baseline was associated with significantly higher titres of neutralizing antibodies following vaccination across all tested VOC. Those with anti-N Abs present at baseline did not experience waning of responses between months 1 and 3 post second dose. When data were analysed for negative anti-N IgG status at any timepoint, there was a significant decline in neutralization and binding antibodies between 1 month and 3 months post second-dose. The GMT in these individuals for Delta and Omicron was approximately 100, nearly a log lower in comparison to WT. We tested anti-N IgG in subjects who were anti-N IgG negative at baseline (n=78) and became positive between 1- and 3-months post second dose and found 7/49 (14%) with de-novo infection, with one additional participant demonstrating both reinfection and breakthrough infection to yield a total breakthrough rate of 8/49 (16%). Neutralising and binding Ab titres 1 month post vaccine, prior to breakthrough, did not appear to be associated with breakthrough infection. Neutralizing titres were higher at the last time point in individuals who had experienced vaccine breakthrough infection (with no evidence of infection prior to vaccine), indicating a boosting effect of infection in addition to vaccine. We noted that the increase in titres against Delta PV observed in breakthrough was significantly greater than the increase for WT and Omicron PVs, coincident with in the Delta wave of infection during the sampling period. Conclusions: AZD1222 is immunogenic in this real world west African cohort with significant background seroprevalence and incidence of breakthrough infection over a short time period. Prior infection and breakthrough infection induced higher anti-SARS-CoV-2 Ab responses at 3 months post vaccine against all widely circulating VOC. However, responses to Omicron BA.1 were reduced at three months regardless of prior exposure. Given that data suggesting that mRNA vaccine booster third doses induce broader, more potent responses with reduced mortality in the elderly, further doses after AZD1222 should be considered for those at high risk.
Keywords	covid19
Language	English
Publishing date	2022-05-05
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.05.04.22274668
Database	COVID19

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Article ; Online: SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa.

Abdullahi, Adam / Oladele, David / Owusu, Michael / Kemp, Steven A / Ayorinde, James / Salako, Abideen / Fink, Douglas / Ige, Fehintola / Ferreira, Isabella A T M / Meng, Bo / Sylverken, Augustina Angelina / Onwuamah, Chika / Boadu, Kwame Ofori / Osuolale, Kazeem / Frimpong, James Opoku / Abubakar, Rufai / Okuruawe, Azuka / Abdullahi, Haruna Wisso / Liboro, Gideon /

Agyemang, Lawrence Duah / Ayisi-Boateng, Nana Kwame / Odubela, Oluwatosin / Ohihoin, Gregory / Ezechi, Oliver / Kamasah, Japhet Senyo / Ameyaw, Emmanuel / Arthur, Joshua / Kyei, Derrick Boakye / Owusu, Dorcas Ohui / Usman, Olagoke / Mogaji, Sunday / Dada, Adedamola / Agyei, George / Ebrahimi, Soraya / Gutierrez, Lourdes Ceron / Aliyu, Sani H / Doffinger, Rainer / Audu, Rosemary / Adegbola, Richard / Mlcochova, Petra / Phillips, Richard Odame / Solako, Babatunde Lawal / Gupta, Ravindra K

Nature communications

2022 Volume 13, Issue 1, Page(s) 6131

Abstract: Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior to vaccination rollout ... ...

Abstract	Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior to vaccination rollout using binding antibodies analysis coupled with pseudotyped virus neutralisation assays in two cohorts from West Africa: Nigerian healthcare workers (n = 140) and a Ghanaian community cohort (n = 527) pre and post vaccination. We found 44 and 28% of pre-vaccination participants showed IgG anti-N positivity, increasing to 59 and 39% respectively with anti-receptor binding domain (RBD) IgG-specific antibodies. Previous IgG anti-N positivity significantly increased post two-dose neutralizing antibody titres in both populations. Serological evidence of breakthrough infection was observed in 8/49 (16%). Neutralising antibodies were observed to wane in both populations, especially in anti-N negative participants with an observed waning rate of 20% highlighting the need for a combination of additional markers to characterise previous infection. We conclude that AZD1222 is immunogenic in two independent West African cohorts with high background seroprevalence and incidence of breakthrough infection in 2021. Waning titres post second dose indicates the need for booster dosing after AZD1222 in the African setting despite hybrid immunity from previous infection.
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; Antibody Formation ; COVID-19/epidemiology ; COVID-19/prevention & control ; ChAdOx1 nCoV-19 ; Ghana ; Humans ; Immunoglobulin G ; SARS-CoV-2 ; Seroepidemiologic Studies ; Vaccination ; Viral Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Viral Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2022-10-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-33792-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

Nepogodiev D. / Bhangu A. / Glasbey J.C. / Li E. / Omar O.M. / Simoes J.F. / Abbott T.E. / Alser O. / Arnaud A.P. / Bankhead-Kendall B.K. / Breen K.A. / Cunha M.F. / Davidson G.H. / Di Saverio S. / Gallo G. / Griffiths E.A. / Gujjuri R.R. / Hutchinson P.J. / Kaafarani H.M. /

Lederhuber H. / Loffler M.W. / Mashbari H.N. / Minaya-Bravo A. / Morton D.G. / Moszkowicz D. / Pata F. / Tsoulfas G. / Venn M.L. / Cox D. / Roslani A.C. / Alakaloko F. / de Vries J.-P.P. / Aaraj M.A. / Abbott S.J. / Abdalla M.O. / Abdelaal A.S. / Ademuyiwa A.O. / Aherne T.M. / Ali O.M. / Alkadeeki G.Z. / Almeida A.C. / Alrahawy M.M. / Ambler G.K. / Alameer E. / Andreani S.M. / De Andres-Asenjo B. / Antonanzas L.L. / Aoun S.G. / Ashoush F.M. / Augestad K.M. / Avellana R.B. / Ayeni F.A. / Ayorinde J.O. / Babu B.H. / Baig M.M. / Bajomo O.M. / Baker O.J. / Baker M.P. / Baldwin A.J. / Ban V.S. / Baron R.D. / Barranquero A.G. / Barry C.P. / DI Bartolomeo A. / Bass G.A. / Bath M.F. / Batjer H.H. / Beamish A.J. / Belgaumkar A.P. / Bence M.N. / Benson R.A. / Bernal-Sprekelsen J.C. / Bhama A.R. / Bhavaraju A.V. / Biffl W.L. / Blundell C.M. / Boddy A.P. / Borgstein A.B. / Bosanquet D.C. / Bosch K.D. / Bouhuwaish A.E. / Bozkurt M.A. / Brathwaite C.E. / Brown B.C. / Brown O.D. / Brown A.K. / Buarque I.L. / Bueno-Canones A.D. / Bulugma M.R. / Burke J.R. / Byrne M.H. / Cagigal-Ortega E.P. / Callcut R.A. / DI Candido F. / Canova M.E. / Carlos W.J. / Caruana E.J. / Cato L.D. / Catton A.B. / Ceretti A.P. / Chase T.J. / Chiara F.D. / Chowdhury A.H. / Chung E.A. / Cicerchia P.M. / Clough E.C. / Coleman N.L. / Collins C.G. / Collins M.L. / Colonna E.T. / Comini L.V. / Coughlin P.A. / Cruzado L.F.-G. / Davidson B.R. / Davies R.J. / Davies E.J. / Davis N.F. / Dawson B.E. / Dean B.J. / Delgado M.G.-C. / Diaz J.J. / Dickson K.E. / Diez-Alonso M.M. / Dixon J.R. / Doe M.J. / Drake T.D. / Drake F.T. / Duffy J.P. / Dunne D.F. / Dunne N.J. / Duran-Munoz-Cruzado V.M. / Durst A.Z. / Eardley N.J. / Edwards J.G. / Elfallal A.H. / Elfiky M.M. / Elliott J.A. / Emile S.H. / Emslie K.M. / Endorf F.W. / Engel J.L. / Enjuto D.T. / Etchill E.W. / Evans J.P. / Fahey B.A. / Faria C.S. / Feo C.V. / Ferguson H.J. / Fernandez B.D. / Fernandez A.G. / Fernandez A.J. / Fernandez-Pacheco B.C. / Fitzgerald 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G.S. / Mateo-Sierra O. / Martinez-Perez C. / Serrano Gonzalez J. / Hernandez Bartolome M.A. / Diaz Perez D. / Gutierrez Samaniego M. / Galindo Jara P. / Sharma N. / Smart N.J. / Keller D.S.

an international cohort study

2020

Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

Abstract	Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Keywords	Adult ; Aged ; Betacoronavirus ; Coronavirus Infections ; Elective Surgical Procedures ; Emergency Medical Services ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia ; Viral ; Postoperative Complications ; Respiratory Tract Diseases ; Retrospective Studies ; Surgical Procedures ; Operative ; Young Adult ; covid19
Subject code	610 ; 616
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

Nepogodiev, D / Bhangu, A / Glasbey, JC / Li, E / Omar, OM / Simoes, JFF / Abbott, TEF / Alser, O / Arnaud, AP / Bankhead-Kendall, BK / Breen, KA / Cunha, MF / Davidson, GH / Di Saverio, S / Gallo, G / Griffiths, EA / Gujjuri, RR / Hutchinson, PJ / Kaafarani, HMA /

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an international cohort study

2020

Abstract	Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Keywords	covid19
Language	English
Publisher	Elsevier
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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