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  1. Article ; Online: The Use of Serological Tests in the Care of Patients with Lupus Nephritis.

    Ayoub, Isabelle / Rovin, Brad H

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 17, Issue 2, Page(s) 305–307

    MeSH term(s) Adult ; Female ; Humans ; Lupus Nephritis/blood ; Lupus Nephritis/diagnosis ; Serologic Tests
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.13431021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6584: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Advances in ANCA-associated vasculitis and lupus nephritis.

    Ayoub, Isabelle / Nachman, Patrick H

    Nature reviews. Nephrology

    2020  Volume 17, Issue 2, Page(s) 89–90

    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/etiology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/therapy ; Humans ; Lupus Nephritis/diagnosis ; Lupus Nephritis/etiology ; Lupus Nephritis/therapy
    Language English
    Publishing date 2020-12-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-00388-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  3. Article: The Use of Glucocorticoids in Lupus Nephritis: New Pathways for an Old Drug.

    Mejía-Vilet, Juan M / Ayoub, Isabelle

    Frontiers in medicine

    2021  Volume 8, Page(s) 622225

    Abstract: Glucocorticoids therapy has greatly improved the outcome of lupus nephritis patients. Since their discovery, their adverse effects have counterbalanced their beneficial anti-inflammatory effects. Glucocorticoids exert their effects through both genomic ... ...

    Abstract Glucocorticoids therapy has greatly improved the outcome of lupus nephritis patients. Since their discovery, their adverse effects have counterbalanced their beneficial anti-inflammatory effects. Glucocorticoids exert their effects through both genomic and non-genomic pathways. Differential activation of these pathways is clinically relevant in terms of benefit and adverse effects. Ongoing aims in lupus nephritis treatment development focus on a better use of glucocorticoids combined with immunosuppressant drugs and biologics. Newer regimens aim to decrease the peak glucocorticoid dose, allow a rapid glucocorticoid tapering, and intend to control disease activity with a lower cumulative glucocorticoid exposure. In this review we discuss the mechanisms, adverse effects and recent strategies to limit glucocorticoid exposure without compromising treatment efficacy.
    Language English
    Publishing date 2021-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.622225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Vasculitic neuropathy associated with IgG4-related kidney disease: A case report and literature review.

    Jiang, Benjamin / Sahenk, Zarife / Satoskar, Anjali / Freimer, Miriam / Ayoub, Isabelle

    Clinical nephrology

    2021  Volume 96, Issue 3, Page(s) 175–179

    Abstract: IgG4-related disease is an immune-mediated systemic inflammatory condition characterized by tissue infiltration of IgG4-positive plasma cells and elevated serum IgG4 concentrations. Peripheral neuropathy is an atypical manifestation of this disease. We ... ...

    Abstract IgG4-related disease is an immune-mediated systemic inflammatory condition characterized by tissue infiltration of IgG4-positive plasma cells and elevated serum IgG4 concentrations. Peripheral neuropathy is an atypical manifestation of this disease. We describe an unusual case of vasculitic neuropathy in a patient with IgG4-related kidney disease. A 55-year-old woman presented with right leg weakness progressing to bilateral leg weakness, pain and numbness of the legs, and impaired gait. She was previously evaluated for weight loss and anemia with a CT scan of the abdomen due to concern for malignancy. Abnormal enhancement of the kidneys was seen, and laboratory work-up and kidney biopsy were consistent with IgG4-related disease. Myeloperoxidase-antineutrophil cytoplasmic antibodies were also positive. In combination with the patient's asymmetric leg weakness and painful neuropathy, this raised concern for vasculitis. Sural nerve biopsy confirmed vasculitic neuropathy. Recent studies have demonstrated an overlap in the clinical characteristics of IgG4-related disease and the anti-neutrophil cytoplasmic antibody-associated vasculitides, which are known to cause vasculitic neuropathy. Clinicians should recognize this association, and IgG4-related disease should be considered in the differential diagnosis in patients with peripheral neuropathy in the right clinical context.
    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Female ; Humans ; Immunoglobulin G4-Related Disease ; Kidney ; Middle Aged ; Peripheral Nervous System Diseases/diagnosis ; Peripheral Nervous System Diseases/etiology ; Peroxidase
    Chemical Substances Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2021-08-07
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN110547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Membranoproliferative Glomerulonephritis With Changing Immunofluorescence Pattern.

    Satoskar, Anjali A / Ibrahim, Dalia Y / Brodsky, Sergey V / Ayoub, Isabelle / Nadasdy, Tibor / Rovin, Brad H

    Kidney international reports

    2022  Volume 7, Issue 5, Page(s) 1123–1127

    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Which Is a Better Predictor of GFR Decline: 24-h Urine Protein or 24-h Protein-Creatinine Ratio? An Exploration of the MDRD Study Data.

    Ayoub, Isabelle / Nagaraja, Haikady N / Kang, Rima / Rovin, Brad / Bhatt, Udayan

    Frontiers in nephrology

    2022  Volume 1, Page(s) 797431

    Abstract: Background: Proteinuria is a known risk factor for progression of chronic kidney disease. Proteinuria magnitude can be estimated by measuring spot urine protein-to-creatinine ratio (least accurate), 24-h urine collection for protein (24 P), or 24-h ... ...

    Abstract Background: Proteinuria is a known risk factor for progression of chronic kidney disease. Proteinuria magnitude can be estimated by measuring spot urine protein-to-creatinine ratio (least accurate), 24-h urine collection for protein (24 P), or 24-h protein-creatinine ratio (24 PCR). The MDRD study found that 24 P measured at baseline was the strongest single predictor of the rate of GFR decline during study follow-up. However, predictive powers of 24 P and 24 PCR have not been compared in the literature. The current study addresses this question using the MDRD cohort data.
    Methods: The study is a retrospective analysis of prospectively collected data from the MDRD cohort using simple and multiple regression models. Slope of measured GFR (mGFR) over time was used as the response and models that included baseline 24 PCR or 24 P were compared for the entire sample and for subgroups formed by restricting the values of 24-h creatinine and 24 P.
    Results: Log 24 P and Log 24 PCR correlated almost equally with mGFR slope. However, in simple linear regression models and multivariable linear regression models adjusting for age and sex, the model with 24 PCR had a higher
    Conclusion: We observe that 24 PCR may be a better marker of proteinuria magnitude in predicting decline in kidney function compared to 24 P in particular for patients with 24 P ≥ 1. This finding needs validation in prospective clinical trials.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2813-0626
    ISSN (online) 2813-0626
    DOI 10.3389/fneph.2021.797431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Calcineurin Inhibitors in the Treatment of Lupus Nephritis: A Hare Versus Turtle Story?

    Ayoub, Isabelle / Rovin, Brad H

    Journal of the American Society of Nephrology : JASN

    2017  Volume 28, Issue 12, Page(s) 3435–3437

    MeSH term(s) Calcineurin Inhibitors/therapeutic use ; Lupus Nephritis/drug therapy ; Proteinuria
    Chemical Substances Calcineurin Inhibitors
    Language English
    Publishing date 2017-10-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2017080830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Commentary on the Current Guidelines for the Diagnosis of Lupus Nephritis Flare.

    Ayoub, Isabelle / Birmingham, Dan / Rovin, Brad / Hebert, Lee

    Current rheumatology reports

    2019  Volume 21, Issue 4, Page(s) 12

    Abstract: Purpose of review: Lupus nephritis flare is a frequent complication in patients with systemic lupus erythematosus. Recognizing disease activity is crucial in lupus nephritis management. Proteinuria magnitude and urine sediment change are major clinical ... ...

    Abstract Purpose of review: Lupus nephritis flare is a frequent complication in patients with systemic lupus erythematosus. Recognizing disease activity is crucial in lupus nephritis management. Proteinuria magnitude and urine sediment change are major clinical indicators of lupus nephritis activity. This work updates these insights in light of recent findings regarding proteinuria quantification and urine sediment analyses.
    Recent findings: Currently, BILAG and SLEDAI estimate proteinuria magnitude based on the protein/creatinine ratio of "spot" (single void collections) or "intended" 24-h urine collections without specifying the extent to which the collection approaches a 24-h collection. As discussed here, and based on our recently published work, these approaches often incur serious errors that can adversely affect SLE patient management. Also incorporated into this work is a new analysis of the clinical significance of urine sediment hematuria and pyuria changes with regard to recent-onset SLE glomerulonephritis (GN) flare. This analysis is based on a prospective study of urine sediment changes in the Ohio SLE Study, which was an NIH-sponsored prospective observational study of SLE GN patients with SLE flare of recent onset. We propose that BILAG and SLEDAI renal flare criteria can be made more rigorous by incorporating recently published insights into proteinuria quantification using the protein/creatinine ratio of an intended 24-h urine collection that is at least 50% complete based on its creatinine content. Also proposed are new insights into the interpretation of urine sediment hematuria and pyuria based on findings from the Ohio SLE Study.
    MeSH term(s) Creatinine/urine ; Hematuria/urine ; Humans ; Lupus Erythematosus, Systemic ; Lupus Nephritis/diagnosis ; Lupus Nephritis/urine ; Practice Guidelines as Topic ; Proteinuria/urine ; Pyuria/urine ; Symptom Flare Up
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2019-02-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-019-0809-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5531: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Spot Urine Protein/Creatinine Ratio Testing at a Large University Medical Center: Evidence for Overuse of This Low-Value Diagnostic Test.

    Ayoub, Isabelle / Williams, JoAnna / Birmingham, Dan / Hebert, Lee

    Kidney international reports

    2020  Volume 5, Issue 5, Page(s) 566–568

    Language English
    Publishing date 2020-04-11
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hemophagocytic Lymphohistiocytosis, a Rare Presentation in Lupus Nephritis.

    Li, Nicholas L / Kang, Rima / Ardoin, Stacy P / Ayoub, Isabelle

    Kidney international reports

    2020  Volume 6, Issue 3, Page(s) 842–845

    Language English
    Publishing date 2020-12-13
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.11.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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