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  1. Article ; Online: Using text and charts to provide social norm feedback to general practices with high overall and high broad-spectrum antibiotic prescribing

    Natalie Gold / Anna Sallis / Ayoub Saei / Rohan Arambepola / Robin Watson / Sarah Bowen / Matija Franklin / Tim Chadborn

    Trials, Vol 23, Iss 1, Pp 1-

    a series of national randomised controlled trials

    2022  Volume 15

    Abstract: Abstract Background Sending a social norms feedback letter to general practitioners who are high prescribers of antibiotics has been shown to reduce antibiotic prescribing. The 2017-9 Quality Premium for primary care in England sets a target for broad- ... ...

    Abstract Abstract Background Sending a social norms feedback letter to general practitioners who are high prescribers of antibiotics has been shown to reduce antibiotic prescribing. The 2017-9 Quality Premium for primary care in England sets a target for broad-spectrum prescribing, which should be at or below 10% of total antibiotic prescribing. We tested a social norm feedback letter that targeted broad-spectrum prescribing and the addition of a chart to a text-only letter that targeted overall prescribing. Methods We conducted three 2-armed randomised controlled trials, on different groups of practices: Trial A compared a broad-spectrum message and chart to the standard-practice overall prescribing letter (practices whose percentage of broad-spectrum prescribing was above 10% and who had relatively high overall prescribing). Trial C compared a broad-spectrum message and a chart to a no-letter control (practices whose percentage of broad-spectrum prescribing was above 10% and who had relatively moderate overall prescribing). Trial B compared an overall-prescribing message with a chart to the standard practice overall letter (practices whose percentage of broad-spectrum prescribing was below 10% but who had relatively high overall prescribing). Letters were posted to general practitioners, timed to be received on 1 November 2018. The primary outcomes were practices’ percentage of broad-spectrum prescribing (trials A and C) and overall antibiotic prescribing (trial B) each month from November 2018 to April 2019 (all weighted by the number and characteristics of patients registered in the practice). Results We randomly assigned 1909 practices; 58 closed or merged during the trial, leaving 1851 practices: 385 in trial A, 674 in trial C, and 792 in trial B. AR(1) models showed that there were no statistically significant differences in our primary outcome measures: trial A β = − .199, p = .13; trial C β = .006, p = .95; trial B β = − .0021, p = .81. In all three trials, there were statistically significant time trends, ...
    Keywords Antibiotics ; Antimicrobial resistance ; Behavioural intervention ; Broad-spectrum prescribing ; Data visualisation ; Feedback ; Medicine (General) ; R5-920
    Subject code 150
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Pre-notification and reminder SMS text messages with behaviourally informed invitation letters to improve uptake of NHS Health Checks

    Anna Sallis / Joseph Sherlock / Annabelle Bonus / Ayoub Saei / Natalie Gold / Ivo Vlaev / Tim Chadborn

    BMC Public Health, Vol 19, Iss 1, Pp 1-

    a factorial randomised controlled trial

    2019  Volume 12

    Abstract: Abstract Background The NHS Health Check (NHS HC) is a cardiovascular risk assessment to prevent cardiovascular disease. Public Health England (PHE) wants to increase uptake. Methods We explored the impact of behaviourally informed invitation letters and ...

    Abstract Abstract Background The NHS Health Check (NHS HC) is a cardiovascular risk assessment to prevent cardiovascular disease. Public Health England (PHE) wants to increase uptake. Methods We explored the impact of behaviourally informed invitation letters and pre-notification and reminder SMS on uptake of NHS HCs. Patients at 28 General Practices in the London Borough of Southwark who were eligible to receive an NHS HC between 1st November 2013 and 31st December 2014 were included. A double-blind randomised controlled trial with a mixed 2 (pre-notification SMS – yes or no) × 4 (letter – national template control, open-ended, time-limited, social norm) × 2 (reminder SMS – yes or no) factorial design was used. The open-ended letter used simplification, behavioural instruction and a personalised planning prompt for patients to record the date and time of their NHS HC. The time-limited letter was similar but stated the NHS HC was due in a named forthcoming month. The social norms letter was similar to the open-ended letter but included a descriptive social norms message and testimonials from local residents and no planning prompt. The outcome measure was attendance at an NHS HC. Results Data for 12, 244 invites were analysed. Uptake increased in almost all letter and SMS combinations compared to the control letter without SMS (Uptake 18%), with increases of up to 12 percentage points for the time-limited letter with pre-notification and reminder (Uptake 30%; Adjusted Odds Ratio AOR 1.86; 95% CI 1.45–2.83; p < 0.00); 10 percentage points for the open-ended letter with reminder (Uptake 27%; AOR 1.68; 95% CI 1.31–2.17; p < 0.00) and a 9 percentage point increase using the time-limited letter with reminder (Uptake 27%; AOR 1.61; 95% CI 1.25–2.10; p < 0.00). The reminder SMS increased uptake for all intervention letters. The pre-notification did not add to this effect. Conclusions This large randomised controlled trial adds support to the evidence that small, low cost behaviourally informed changes to letter-based invitations can increase uptake of NHS HCs. It also provides novel evidence on the effect of SMS reminders and pre-notification on NHS HC attendance. Trial registration Retrospectively Registered (24/01/2014) ISRCTN36027094.
    Keywords Behavioural insights ; Cardiovascular disease ; Invitation letters ; NHS Health Checks ; Pre-notifications ; SMS ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Reduction in Blood Lead Concentration in Children across the Republic of Georgia following Interventions to Address Widespread Exceedance of Reference Value in 2019

    Ekaterine Ruadze / Giovanni S. Leonardi / Ayoub Saei / Irma Khonelidze / Lela Sturua / Vladimer Getia / Helen Crabbe / Tim Marczylo / Paolo Lauriola / Amiran Gamkrelidze

    International Journal of Environmental Research and Public Health, Vol 18, Iss 11903, p

    2021  Volume 11903

    Abstract: In recent years, reports of lead contamination have dramatically increased in Georgia. Given concerns about the exposure of children to lead (Pb), the National Multiple Indicator Cluster Survey (MICS-2018) included a blood sampling component. The results ...

    Abstract In recent years, reports of lead contamination have dramatically increased in Georgia. Given concerns about the exposure of children to lead (Pb), the National Multiple Indicator Cluster Survey (MICS-2018) included a blood sampling component. The results showed that 41% of the children that participated had blood Pb levels (BLL) ≥ 5 µg/dL and that BLL in children living in Western Georgia were higher than those in Eastern regions. In response to these findings, NCDC implemented written and verbal advice to the families of children who participated in the MICS-2018 on how to reduce Pb exposure. From August 2019 onwards, the state program of clinical follow-up was implemented. The design of this study was a longitudinal study. The intervention of interest was the public health advice and medical follow-up, and the outcome was defined as the difference in BLL between the MICS-2018 survey and the state program follow-up. We observed a significant overall reduction in median BLL between MICS-2018 and state program follow-up in both August 2019 and the latest results (until December 2019). However, we did not observe any significant further reduction between August and the most recent BLL results. In the Georgian setting, written and verbal communication targeting individual households, alongside home visits to the most exposed, effectively reduced BLL in children.
    Keywords lead (Pb) ; Georgia ; public health interventions ; state program ; written and verbal communication ; multiple stakeholder response ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohortResearch in context

    Peter D. Kirwan / Victoria J. Hall / Sarah Foulkes / Ashley D. Otter / Katie Munro / Dominic Sparkes / Anna Howells / Naomi Platt / Jonathan Broad / David Crossman / Chris Norman / Diane Corrigan / Christopher H. Jackson / Michelle Cole / Colin S. Brown / Ana Atti / Jasmin Islam / Anne M. Presanis / Andre Charlett /
    Daniela De Angelis / Susan Hopkins / Tracy Lewis / Steve Bain / Rebeccah Thomas / John Geen / Carla Pothecary / Sean Cutler / John Northfield / Cathy Price / Johanne Tomlinson / Sarah Knight / Emily Macnaughton / Ekaterina Watson / Rajeka Lazarus / Aaran Sinclair / Joanne Galliford / Bridgett Masunda / Tabitha Mahungu / Alison Rodger / Esther Hanison / Simon Warren / Swati Jain / Mariyam Mirfenderesky / Natasha Mahabir / Rowan Pritchard-Jones / Diane Wycherley / Claire Gabriel / Elijah Matovu / Philippa Bakker / Simantee Guha / S. Gormley / James Pethick / Georgina Butt / Stacey Pepper / Luke Bedford / Paul Ridley / Jane Democratis / Manjula Meda / Anu Chawla / Fran Westwell / Nagesh Kalakonda / Sheena Khanduri / Allison Doel / Sumita Pai / Christian Hacon / Davis Nwaka / Veronica Mendez Moro / A. Moody / Cressida Auckland / Stephanie Prince / Thushan de Silva / Helen Shulver / A. Shah / C. Jones / Banerjee Subhro-Osuji / Angela Houston / Tim Planche / Martin Booth / Christopher Duff / Jonnie Aeron-Thomas / Ray Chaudhuri / David Hilton / Hannah Jory / Zehra'a Al-Khafaji / Philippa Kemsley / Ruth Longfellow / David Boss / Simon Brake / Louise Coke / Ngozi Elumogo / Scott Latham / Chinari Subudhi / Ina Hoad / Claire Thomas / Nihil Chitalia / Tracy Edmunds / Helen Ashby / John Elliott / Beverley Wilkinson / Abby Rand / Catherine Thompson / K. Agwuh / Anna Grice / Kelly Moran / Vijayendra Waykar / Yvonne Lester / Lauren Sach / Kathryn Court / Nikki White / Clair Favager / Kyra Holliday / Jayne Harwood / Brendan Payne / Karen Burns / Lynda Fothergill / Alejandro Arenas-Pinto / Abigail Severn / Kerryanne Brown / Katherine Gray / Jane Dare / Qi Zheng / Kathryn Hollinshead / Robert Shorten / Alun Roebuck / Christopher Holmes / Martin Wiselka / Barzo Faris / Liane Marsh / Clare McAdam / Lisa Ditchfield / Zaman Qazzafi / G. Boyd / N. Wong / Sarah Brand / Jack Squires / John Ashcroft / Ismaelette Del Rosario / Joanne Howard / Emma Ward / Gemma Harrison / Joely Morgan / Claire Corless / Ruth Penn / Nick Wong / Manny Bagary / Nadezda Starkova / Mandy Beekes / Mandy Carnahan / Shivani Khan / Shekoo Mackay / Keneisha Lewis / Graham Pickard / Joy Dawson / Lauren Finlayson / Euan Cameron / Anne Todd / Sebastien Fagegaltier / Sally Mavin / Alexandra Cochrane / Andrew Gibson / Sam Donaldson / Kate Templeton / Martin Malcolm / Beth Smith / Devesh Dhasmana / Susan Fowler / Antonia Ho / Michael Murphy / Claire Beith / Manish Patel / Elizabeth Boyd / Val Irvine / Alison Grant / Rebecca Temple-Purcell / Clodagh Loughrey / Elinor Hanna / Frances Johnston / Angel Boulos / Fiona Thompson / Yuri Protaschik / Susan Regan / Tracy Donaghy / Maurice O'Kane / Omolola Akinbami / Paola Barbero / Tim Brooks / Meera Chand / Ferdinando Insalata / Palak Joshi / Anne-Marie O'Connell / Mary Ramsay / Ayoub Saei / Maria Zambon / Ezra Linley / Simon Tonge / Enemona Adaji / Omoyeni Adebiyi / Nick Andrews / Joanna Conneely / Paul Conneely / Angela Dunne / Simone Dyer / Hannah Emmett / Nipunadi Hettiarachchi / Nishanthan Kapirial / Jameel Khawam / Edward Monk / Sophie Russell / Andrew Taylor-Kerr / Jean Timeyin / Silvia D'Arcangelo / Cathy Rowe / Amanda Semper / Eileen Gallagher / Robert Kyffin / Lisa Cromey / Desmond Areghan / Jennifer Bishop / Melanie Dembinsky / Laura Dobbie / Josie Evans / David Goldberg / Lynne Haahr / Annelysse Jorgenson / Ayodeji Matuluko / Laura Naismith / Desy Nuryunarsih / Alexander Olaoye / Caitlin Plank / Lesley Price / Nicole Sergenson / Sally Stewart / Andrew Telfer / Jennifer Weir / Ellen De Lacy / Yvette Ellis / Susannah Froude / Guy Stevens / Linda Tyson / Susanna Dunachie / Paul Klenerman / Chris Duncan / Rebecca Payne / Lance Turtle / Alex Richter / Thushan De Silva / Eleanor Barnes / Daniel Wootton / Oliver Galgut / Jonathan Heeney / Helen Baxendale / Javier Castillo-Olivares / Rupert Beale / Edward Carr / Wendy Barclay / Maya Moshe / Massimo Palmarini / Brian Willett / John Kenneth Baillie / Jennie Evans / Erika Aquino

    The Lancet Regional Health. Europe, Vol 36, Iss , Pp 100809- (2024)

    1481  

    Abstract: Summary: Background: The protection of fourth dose mRNA vaccination against SARS-CoV-2 is relevant to current global policy decisions regarding ongoing booster roll-out. We aimed to estimate the effect of fourth dose vaccination, prior infection, and ... ...

    Abstract Summary: Background: The protection of fourth dose mRNA vaccination against SARS-CoV-2 is relevant to current global policy decisions regarding ongoing booster roll-out. We aimed to estimate the effect of fourth dose vaccination, prior infection, and duration of PCR positivity in a highly-vaccinated and largely prior-COVID-19 infected cohort of UK healthcare workers. Methods: Participants underwent fortnightly PCR and regular antibody testing for SARS-CoV-2 and completed symptoms questionnaires. A multi-state model was used to estimate vaccine effectiveness (VE) against infection from a fourth dose compared to a waned third dose, with protection from prior infection and duration of PCR positivity jointly estimated. Findings: 1298 infections were detected among 9560 individuals under active follow-up between September 2022 and March 2023. Compared to a waned third dose, fourth dose VE was 13.1% (95% CI 0.9 to 23.8) overall; 24.0% (95% CI 8.5 to 36.8) in the first 2 months post-vaccination, reducing to 10.3% (95% CI −11.4 to 27.8) and 1.7% (95% CI −17.0 to 17.4) at 2–4 and 4–6 months, respectively. Relative to an infection >2 years ago and controlling for vaccination, 63.6% (95% CI 46.9 to 75.0) and 29.1% (95% CI 3.8 to 43.1) greater protection against infection was estimated for an infection within the past 0–6, and 6–12 months, respectively. A fourth dose was associated with greater protection against asymptomatic infection than symptomatic infection, whilst prior infection independently provided more protection against symptomatic infection, particularly if the infection had occurred within the previous 6 months. Duration of PCR positivity was significantly lower for asymptomatic compared to symptomatic infection. Interpretation: Despite rapid waning of protection, vaccine boosters remain an important tool in responding to the dynamic COVID-19 landscape; boosting population immunity in advance of periods of anticipated pressure, such as surging infection rates or emerging variants of concern. Funding: UK ...
    Keywords SARS-CoV-2 ; Vaccine effectiveness ; Asymptomatic ; Symptomatic ; Healthcare worker ; Cohort study ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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