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  1. Article ; Online: Implementation of Medication Reconciliation conducted by hospital pharmacists: A case study guided by the Consolidated Framework for Implementation Research.

    Fernandes, Brígida Dias / Foppa, Aline Aparecida / Ayres, Lorena Rocha / Chemello, Clarice

    Research in social & administrative pharmacy : RSAP

    2022  Volume 18, Issue 9, Page(s) 3631–3637

    Abstract: Background: Medication reconciliation (MR) implementation in hospital care transitions has proved to be a challenge for health professionals and managers. It points to the need to conduct Implementation Research with a view to understanding the tasks of ...

    Abstract Background: Medication reconciliation (MR) implementation in hospital care transitions has proved to be a challenge for health professionals and managers. It points to the need to conduct Implementation Research with a view to understanding the tasks of the real world and knowing how they impact this process. Guided by the Consolidated Framework for Implementation Research (CFIR), this study aims to analyze the factors that influenced the MR implementation process conducted by pharmacists at a hospital setting.
    Methods: A qualitative case study was carried out in the cardiology and gastroenterology units of a teaching hospital in Brazil, involving participant observation and semi-structured interviews with physicians, pharmacists, nurses, nutritionists and a social worker. The CFIR was used to guide data collection and thematic analysis. The constructs were classified according to their influence and strength.
    Results: Sixteen health professionals involved directly or indirectly with MR implementation participated in the study. Based on the analysis of the participants' quotes and of the field diary, 18 constructs of the CFIR were identified as influencing MR implementation. The constructs that most strongly influenced MR implementation concerned "Inner Setting", "Characteristics of Individuals" and "Characteristics of Intervention". The participating professionals showed little knowledge of MR and had different points of view on its scope, weakly relating MR to patient safety. The tools used to conduct MR were adapted according to the hospital's needs, thus facilitating its implementation. However, MR proved to be complex and require clinical knowledge and aligned teamwork to identify and resolve undocumented medication discrepancies, being as well intertwined with culture and organizational communication.
    Conclusions: The results point to implementation failures and highlight that MR is a complex intervention, requiring specific knowledge from the multidisciplinary team and alignment with other existing workflows. The barriers and facilitators identified may serve to design and test implementation improvement strategies.
    MeSH term(s) Health Personnel ; Hospitals ; Humans ; Medication Reconciliation ; Pharmacists ; Qualitative Research
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2192059-X
    ISSN 1934-8150 ; 1551-7411
    ISSN (online) 1934-8150
    ISSN 1551-7411
    DOI 10.1016/j.sapharm.2022.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pharmacist prescribing: a review of perceptions and attitudes of patients, pharmacists and other interested professionals.

    Ramos, Diego Carneiro / Ferreira, Lorena / Santos Júnior, Genival Araujo Dos / Ayres, Lorena Rocha / Esposti, Carolina Dutra Degli

    Ciencia & saude coletiva

    2022  Volume 27, Issue 9, Page(s) 3531–3546

    Abstract: Pharmacist prescribing is a growing reality in some developed counties, with varied health systems. Understanding the contribution that this activity can offer in the healthcare process, and investigating its acceptance is of utmost importance for the ... ...

    Title translation Prescrição farmacêutica: uma revisão sobre percepções e atitudes de pacientes, farmacêuticos e outros interessados.
    Abstract Pharmacist prescribing is a growing reality in some developed counties, with varied health systems. Understanding the contribution that this activity can offer in the healthcare process, and investigating its acceptance is of utmost importance for the countries that implement and regulate this type of system. This literature review aimed to design a state-of-the-art academic investigation on the perception, opinions, and attitudes in the context of pharmacist prescribing practices in countries that have adopted this system. To achieve this, the present study conducted an investigation of the Medline, Scopus, Embase, SciELO, and Lilacs databases, resulting in the selection of 17 studies. From the analysis of the articles, three categories of discussion arose: "understanding of the practice and perceived benefits", "acceptance and adherence to the practice, and "hindrances to the practice". The results showed varied acceptance and perceptions among the different publics, depending, among other questions, on the level of knowledge and experience of the patients and health professionals, on the profile of the pharmacists, or on the prescribing modality. This study highlights some challenges involved in the practice of pharmacist prescribing, and its findings can be useful in suggesting a means through which to strengthen the practice.
    MeSH term(s) Attitude ; Attitude of Health Personnel ; Delivery of Health Care ; Drug Prescriptions ; Humans ; Pharmacists ; Professional Role
    Language English
    Publishing date 2022-05-28
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1678-4561
    ISSN (online) 1678-4561
    ISSN 1678-4561
    DOI 10.1590/1413-81232022279.19972021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Health-Related Quality of Life and Coping Strategies in a Cohort Study of Highly Active Antiretroviral Therapy Naïve Patients Adherence.

    de Oliveira França, Patricia / Ayres, Lorena Rocha / Pimassoni, Lúcia Helena / Cerutti Junior, Crispim

    International journal of clinical practice

    2022  Volume 2022, Page(s) 8341638

    Abstract: Objective: The main objective of this study was to describe the perceived quality of life (QoL) in patients living with AIDS (PLWA) and their chosen coping strategies in a cohort of individuals managed with HAART.: Methods: This is a prospective ... ...

    Abstract Objective: The main objective of this study was to describe the perceived quality of life (QoL) in patients living with AIDS (PLWA) and their chosen coping strategies in a cohort of individuals managed with HAART.
    Methods: This is a prospective cohort study conducted at the Medication Dispensing Unit of a university hospital (MDU-UH) located in southeastern Brazil. Study population comprised HIV/AIDS patients starting antiretroviral treatment at MDU. The final sample comprised 99 participants. Patients were followed up for 24 months from their recruitment. We used a face-to-face questionnaire to determine sociodemographic and behavioural variables. Quality of life (QoL) and coping strategies (CS) were measured through validated instruments.
    Results: Regarding the QoL dimensions, the general perception of QoL among these participants was considered good. Regarding CS, the adherent patients scored higher than the nonadherents.
    Conclusions: The present study revealed that the perceived QoL can be maintained in individuals treated for HIV/AIDS. There is an association between high score of coping strategies and adherence to HAART.
    MeSH term(s) Adaptation, Psychological ; Antiretroviral Therapy, Highly Active/methods ; Cohort Studies ; HIV Infections/drug therapy ; Humans ; Prospective Studies ; Quality of Life
    Language English
    Publishing date 2022-02-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1155/2022/8341638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pesticide exposure and poisoning in Brazil: Outcome severity, clinical manifestations and management of cases reported to a poison control center.

    Dos Santos, Josefa Cristina Pereira / Valli, Joanina Bicalho / Sesse, Nixon Souza / Mackenzie Ross, Sarah / Zandonade, Eliana / Ayres, Lorena Rocha / Sampaio, Karla Nívea

    Archives of environmental & occupational health

    2022  Volume 78, Issue 3, Page(s) 177–186

    Abstract: This work aimed to identify variables associated with increased risk of outcome severity as well as to describe clinical manifestations/symptoms and management of pesticide-related cases reported to a poison center in Brazil. An increased risk of more ... ...

    Abstract This work aimed to identify variables associated with increased risk of outcome severity as well as to describe clinical manifestations/symptoms and management of pesticide-related cases reported to a poison center in Brazil. An increased risk of more severe outcomes was observed when exposures occurred in rural areas, involved suicide attempts and moderately to extremely hazardous pesticides. Clinical manifestations with higher frequencies included vomiting, nausea, sialorrhea, headache, miosis and sweating. From the treatment initially applied to the patient, 51.91% encompassed gastric lavage, but this procedure was only recommended in 20.01% of cases by the CIATox. Identifying risk factors associated with poor outcome, describing clinical manifestations, and contrasting initial treatment measures adopted against those recommended by the Poison Center can help determine diagnosis, prognosis and ensure appropriate clinical interventions are used in cases of pesticide poisoning.
    MeSH term(s) Humans ; Pesticides ; Poison Control Centers ; Brazil/epidemiology ; Risk Factors ; Poisons ; Poisoning/diagnosis ; Poisoning/epidemiology ; Poisoning/therapy
    Chemical Substances Pesticides ; Poisons
    Language English
    Publishing date 2022-12-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2245323-4
    ISSN 2154-4700 ; 1933-8244 ; 0003-9896
    ISSN (online) 2154-4700
    ISSN 1933-8244 ; 0003-9896
    DOI 10.1080/19338244.2022.2161456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Obesity prevalence in Brazilian firefighters and the association of central obesity with personal, occupational and cardiovascular risk factors: a cross-sectional study.

    Damacena, Fernanda Camargo / Batista, Thatiany Jardim / Ayres, Lorena Rocha / Zandonade, Eliana / Sampaio, Karla Nívea

    BMJ open

    2020  Volume 10, Issue 3, Page(s) e032933

    Abstract: Objectives: This study aimed to investigate the obesity prevalence in a population of Brazilian firefighters and the association of central obesity (CO) with sociodemographic, occupational, life habits, fitness and health status variables.: Design: ... ...

    Abstract Objectives: This study aimed to investigate the obesity prevalence in a population of Brazilian firefighters and the association of central obesity (CO) with sociodemographic, occupational, life habits, fitness and health status variables.
    Design: Cross-sectional study.
    Settings: The data were collected during annual health inspections of firefighters from the Military Fire Service of the State of Espírito Santo, a state in Southeast Brazil.
    Participants: The study encompassed 1018 active military firefighters. After exclusion criteria, 892 male firefighters were analysed.
    Primary and secondary outcome measures: The collected data included: sociodemographic, occupational, lifestyle, fitness and health status variables. The associations between these factors and CO were calculated by adjusted OR through a hierarchical logistic regression model.
    Results: Obesity estimation by body mass index indicated that 48.65% of the firefighters were overweight and 10.99% were obese. Concerning the body fat percentage, 26.23% of the participants were considered obese, while 18.61% of the firefighters were considered centrally obese or at risk using the waist circumference measure. After adjusted OR analysis, CO was more likely associated with the age range of 50 to 59 years old (OR 2.93; 95% CI 1.05 to 8.14), low self-reported physical activity (OR 1.95; 95% CI 1.14 to 3.34), low cardiorespiratory fitness (OR 5.15; 95% CI 3.22 to 8.23), hyperglycaemia (OR 1.70; 95% CI 1.07 to 2.72) and hypertriglyceridaemia fasting status (OR 3.12; 95% CI 1.75 to 5.55).
    Conclusions: Our study identified an overall high prevalence of overweight and obese individuals in the examined firefighter population. Age and cardiovascular risk factors were directly associated with CO among the firefighters. Cardiovascular risk factors should be routinely inspected within the Brazilian firefighters' corporations in order to improve the health condition and wellness of these workers. These endeavours will improve the performance of the services provided to the population.
    MeSH term(s) Adult ; Body Mass Index ; Brazil/epidemiology ; Cross-Sectional Studies ; Firefighters ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Obesity, Abdominal/epidemiology ; Overweight/epidemiology ; Prevalence ; Risk Factors
    Language English
    Publishing date 2020-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2019-032933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Functional evaluation of immunoregulatory molecules HLA-G, galectin-1, and IL-10 in people living with HIV.

    Cortelette, Natalia Alves / Souza, Nayana De Oliveira / Cataldi-Rodrigues, Lilian / Arthur, Connie / Stowell, Sean R / Dias-Baruffi, Marcelo / Guimarães, Daniela Amorim Melgaço / Ayres, Lorena Rocha / Trés Pancoto, João Alexandre

    Medicine

    2022  Volume 101, Issue 2, Page(s) e28489

    Abstract: Objectives: Investigate polymorphisms and expressions of human leukocyte antigen-G (HLA-G), galectin-1 (Gal-1), and interleukin-10 (IL-10) in people living with HIV (PLHIV) with and without comorbidities to help understanding the mechanisms involved in ... ...

    Abstract Objectives: Investigate polymorphisms and expressions of human leukocyte antigen-G (HLA-G), galectin-1 (Gal-1), and interleukin-10 (IL-10) in people living with HIV (PLHIV) with and without comorbidities to help understanding the mechanisms involved in triggering these disorders in PLHIV and in their prognosis.
    Design: Here we evaluated the potential correlation between the genetic polymorphism and/or protein levels of HLA-G, Gal-1, and IL-10 with and without comorbidities of PLHIV.
    Methods: Two hundred HIV patients under antiretroviral treatment (83 with comorbidities and 117 without comorbidities) and 200 healthy individuals (controls) were genotyped, using PCR, for HLA-G 14-base pair polymorphism located at the 3' untranslated region in exon 8 insertion/insertion (Ins/Ins: low HLA-G expression) or deletion/deletion (Del/Del: high HLA-G expression). Soluble levels of HLA-G (sHLA-G), Gal-1, and IL-10 were quantified by enzyme-linked immunosorbet assay.
    Results: HIV patients without comorbidities exhibited higher frequency of 14-base pair Del/Del genotype than HIV patients with comorbidities. As expected, HIV patients Ins/Ins with and without comorbidities produced less sHLA-G than controls. However, HIV patients Del/Del with comorbidities expressed sHLA-G more than controls and HIV patients Del/Del without comorbidities. Interestingly, patients that showed low levels sHLA-G, and presence of comorbidities, exhibited high Gal-1 serum levels. However, an increase in soluble levels of IL-10 in PLHIV was observed when compared to controls, especially in the PLHIV group without comorbidities suggesting, a protective role of IL-10 in the development of comorbidities.
    Conclusions: These data suggested that the high expression of sHLA-G and IL-10 or Gal-1 could be associated and could be associated with the development or not of comorbidities in PLHIV.
    MeSH term(s) 3' Untranslated Regions ; Case-Control Studies ; Comorbidity ; Galectin 1/genetics ; Genotype ; HIV Infections/complications ; HIV Infections/drug therapy ; HLA-G Antigens/genetics ; Humans ; Interleukin-10/genetics ; Polymorphism, Genetic
    Chemical Substances 3' Untranslated Regions ; Galectin 1 ; HLA-G Antigens ; IL10 protein, human ; LGALS1 protein, human ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000028489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sociodemographic characteristics and exposure patterns of pesticide-related cases reported to a poison service center in Brazil between 2012 and 2016.

    Dos Santos, Josefa Cristina Pereira / Valli, Joanina Bicalho / Sesse, Nixon Souza / Mackenzie-Ross, Sarah / Zandonade, Eliana / Ayres, Lorena Rocha / Sampaio, Karla Nívea

    Archives of environmental & occupational health

    2020  Volume 76, Issue 8, Page(s) 494–503

    Abstract: Pesticide poisoning is a significant public health problem responsible for an estimated three million poisoning cases per year and more than 250,000 deaths, most of which occur in underdeveloped countries. We evaluated pesticide exposure cases reported ... ...

    Abstract Pesticide poisoning is a significant public health problem responsible for an estimated three million poisoning cases per year and more than 250,000 deaths, most of which occur in underdeveloped countries. We evaluated pesticide exposure cases reported to a toxicological service center in Brazil, between 2012 and 2016. There were 3211 cases of pesticide exposure, with a high prevalence in adults aged 20-39 years (41.2%). Attempted suicide was the leading cause of pesticide cases (48%). Occupational exposure to pesticides of agricultural use was more frequently observed among men. Accidental exposure and attempted suicide were more frequently observed in urban areas while occupational exposure was more prevalent in rural areas. A higher exposure rate was observed among men in counties with higher agricultural activities. Establishing prevalence and cause of pesticide exposure is important to provide subsidy for evidence-based interventions in the field.
    MeSH term(s) Accidents, Occupational/statistics & numerical data ; Agriculture/statistics & numerical data ; Brazil/epidemiology ; Female ; Geography/statistics & numerical data ; Humans ; Male ; Occupational Exposure/statistics & numerical data ; Pesticides/poisoning ; Poison Control Centers/statistics & numerical data ; Poisoning/epidemiology ; Poisoning/etiology ; Prevalence ; Sex Factors ; Suicide, Attempted/statistics & numerical data
    Chemical Substances Pesticides
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2245323-4
    ISSN 2154-4700 ; 1933-8244 ; 0003-9896
    ISSN (online) 2154-4700
    ISSN 1933-8244 ; 0003-9896
    DOI 10.1080/19338244.2020.1848773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hospital pharmacy workforce in Brazil.

    Santos, Thiago R / Penm, Jonathan / Baldoni, André O / Ayres, Lorena Rocha / Moles, Rebekah / Sanches, Cristina

    Human resources for health

    2018  Volume 16, Issue 1, Page(s) 1

    Abstract: Background: This study aims to describe the distribution of the hospital pharmacy workforce in Brazil.: Methods: Data were acquired, during 2016, through the Brazilian National Database of Healthcare Facilities (CNES). The following variables were ... ...

    Abstract Background: This study aims to describe the distribution of the hospital pharmacy workforce in Brazil.
    Methods: Data were acquired, during 2016, through the Brazilian National Database of Healthcare Facilities (CNES). The following variables were extracted: hospital name, registry number, telephone, e-mail, state, type of institution, subtype, management nature, ownership, presence of research/teaching activities, complexity level, number of hospital beds, presence of pharmacists, number of pharmacists, pharmacist specialization. All statistical analyses were performed by IBM SPSS v.19.
    Results: The number of hospitals with a complete registry in the national database was 4790. The majority were general hospitals (77.9%), managed by municipalities (66.1%), under public administration (44.0%), had no research/teaching activities (90.5%), classified as medium complexity (71.6%), and had no pharmacist in their team (50.6%). Furthermore, almost 60.0% of hospitals did not comply with the minimum recommendations of having a pharmacist per 50 hospital beds. The Southeast region had the highest prevalence of pharmacists, with 64.4% of hospitals having a pharmaceutical professional. This may have occurred as this region had the highest population to hospital ratio. Non-profit hospitals were more likely to have pharmacists compared to those under public administration and private hospitals.
    Conclusion: This study mapped the hospital pharmacy workforce in Brazil, showing a higher prevalence of hospital pharmacists in the Southeast region, and in non-profit specialized hospitals.
    MeSH term(s) Brazil ; Databases, Factual ; Health Workforce ; Hospitals/statistics & numerical data ; Humans ; Ownership ; Personnel, Hospital/supply & distribution ; Pharmacies/statistics & numerical data ; Pharmacists/supply & distribution ; Pharmacy Service, Hospital/statistics & numerical data ; Spatial Analysis
    Language English
    Publishing date 2018-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126923-3
    ISSN 1478-4491 ; 1478-4491
    ISSN (online) 1478-4491
    ISSN 1478-4491
    DOI 10.1186/s12960-017-0265-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pharmacist-led medication reconciliation at patient discharge: A scoping review.

    Fernandes, Brígida Dias / Almeida, Paulo Henrique Ribeiro Fernandes / Foppa, Aline Aparecida / Sousa, Camila Tavares / Ayres, Lorena Rocha / Chemello, Clarice

    Research in social & administrative pharmacy : RSAP

    2019  Volume 16, Issue 5, Page(s) 605–613

    Abstract: Background: One of the strategies to promote patient safety in care transitions is medication reconciliation (MR), which is conducted by the pharmacist at the patient's discharge from hospital. However, there are divergences about this process and about ...

    Abstract Background: One of the strategies to promote patient safety in care transitions is medication reconciliation (MR), which is conducted by the pharmacist at the patient's discharge from hospital. However, there are divergences about this process and about the pharmacist's role in conducting such intervention.
    Objective: To systematically review the literature that reports the MR process led by pharmacists at patient discharge and map the different methods, strategies and tools used in the process.
    Methods: Relevant studies were searched in the following databases: EMBASE, MEDLINE (PubMed), The Cochrane Library, and LILACS. No language restriction or publication date was applied. The studies considered eligible were those involving and describing pharmacist-led MR processes at acute patient discharge from hospital, with an experimental, quasi-experimental, or observational design. The characteristics of the studies and the MR processes were identified and then a qualitative synthesis was performed.
    Results: Fifty studies were included. The majority of them were observational ones (82%), and the main outcome was medication discrepancies (42%). The studies were mostly conducted in university hospitals (70%) and in internal medicine wards (54%). Pharmacists were responsible mainly for gathering medication histories (72%), and identifying (96%) and solving (98%) pharmacotherapeutic problems. The main sources of information on pre-admission medications were patient/caregiver interviews (66%) and records from other care providers (40%). Only 30% of the studies described a patient discharge plan, and 14% shared information of the patient's pharmacotherapy with community pharmacists.
    Conclusion: The concept of MR and the pharmacist-led activities in the process varied in the literature, as well as the pharmacotherapy assessment focus and the communication strategies towards patients and other care providers, showing that standardization of the process and concepts is necessary.
    MeSH term(s) Hospitals ; Humans ; Medication Reconciliation ; Patient Discharge ; Patient Transfer ; Pharmacists ; Pharmacy Service, Hospital
    Language English
    Publishing date 2019-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2192059-X
    ISSN 1934-8150 ; 1551-7411
    ISSN (online) 1934-8150
    ISSN 1551-7411
    DOI 10.1016/j.sapharm.2019.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparative efficacy of antiepileptic drugs for patients with generalized epileptic seizures: systematic review and network meta-analyses.

    Campos, Marília Silveira de Almeida / Ayres, Lorena Rocha / Morelo, Manuela Roque Siane / Carizio, Fabiana Angelo Marques / Pereira, Leonardo Régis Leira

    International journal of clinical pharmacy

    2018  Volume 40, Issue 3, Page(s) 589–598

    Abstract: Background Valproate is a widely prescribed antiepileptic drug for generalized epilepsies, due to the extensive knowledge on its efficacy since it is on the market for many decades. However, a large number of new antiepileptic medicines was introduced ... ...

    Abstract Background Valproate is a widely prescribed antiepileptic drug for generalized epilepsies, due to the extensive knowledge on its efficacy since it is on the market for many decades. However, a large number of new antiepileptic medicines was introduced into clinical practice and may be better options for treatment, considering that these medicines differ in terms of efficacy spectrum. Despite extensive research, questions regarding which medicine would constitute the first option for the monotherapy treatment of generalized epilepsy remain. Aim of the Review To compare the relative efficacy of all available antiepileptic drugs in the monotherapy treatment of generalized epileptic seizures; and also to compare all antiepoileptig drugs with valproate, which is the current first-line treatment for generalized epilepsy. Methods A systematic review for randomized controlled clinical trials was performed. Network meta-analyses used Bayesian random effects model. Sensitivity analyses determined the results´ robustness. The relative probability of two efficacy outcomes ("Seizure free" and "Therapeutic inefficacy") to happen for each medcicine was calculated using the Surface Under the Cumulative Ranking Curve. Results Seven papers (1809 patients) studied the efficacy of valproate, lamotrigine, phenytoin, carbamazepine, topiramate, levetiracetam, and phenobarbital in the treatment of generalized tonicclonic, tonic, and clonic seizures. Phenytoin demonstrated to be inferior to valproate in leaving the patient free of these seizures types [OR: 0.50 (95% CrI 0.27, 0.87)]. Lamotrigine (61%) showed the highest probability of presenting the outcome "Seizure free", followed by levetiracetam (47%), topiramate (44%), and valproate (38%) in the treatment of generalized tonic-clonic, tonic, and clonic seizures. Meanwhile, valproate exhibited greater chance of presenting the outcome "Therapeutic inefficacy" (62%). Regarding absence seizures itself, there was no difference in the efficacy of lamotrigine and ethosuximide when compared to valproate. However, the ranking indicates that ethosuximide (52%) and valproate (47%) are both more likely than lamotrigine to keep the patient free of seizures. Conclusions Lamotrigine, levetiracetam, and topiramate are as effective as valproate for treating generalized tonic-clonic, tonic, and clonic seizures. Meanwhile, valproate and ethosuximide are the best options for the treatment of absence seizures promoting better control of seizures, which is the primary goal of pharmacotherapy.
    MeSH term(s) Anticonvulsants/therapeutic use ; Bayes Theorem ; Epilepsy, Generalized/drug therapy ; Epilepsy, Generalized/physiopathology ; Humans ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Valproic Acid/therapeutic use
    Chemical Substances Anticonvulsants ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2018-05-09
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2601204-2
    ISSN 2210-7711 ; 2210-7703 ; 0928-1231
    ISSN (online) 2210-7711
    ISSN 2210-7703 ; 0928-1231
    DOI 10.1007/s11096-018-0641-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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