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  1. Article ; Online: Dermoscopy of dermatofibromas: A new perspective.

    Aytekin, Sema / Kaynak, Emre / Ayhan, Erhan

    International journal of clinical practice

    2021  Volume 75, Issue 10, Page(s) e14547

    Abstract: Aim: In dermoscopic studies on dermatofibromas, some publications divide the appearance of lesions into standardised patterns, and some publications classify the clinical appearance of the lesions by comparing them with existing dermatological lesions. ... ...

    Abstract Aim: In dermoscopic studies on dermatofibromas, some publications divide the appearance of lesions into standardised patterns, and some publications classify the clinical appearance of the lesions by comparing them with existing dermatological lesions. This study aims to re-evaluate the dermoscopic findings and patterns of dermatofibromas from a different perspective.
    Materials and methods: In this study, 142 lesions of 72 patients were evaluated dermoscopically and their patterns were schematised.
    Results: In our study, a total of 15 patterns consisting of main and sub-patterns were created. The most common patterns we detected were pattern 1 (1a: 13.4%, 1b: 8.5%), pattern 8 (8a: 10.6%, 8b: 4.2%) and pattern 2 (2a: 9.2%, 2b: 4.2%), respectively.
    Conclusion: Patterns of DFs were reclassified while preserving basic patterns. We think that the new sub-patterns and schematisation with this study can contribute to a better understanding of DFs.
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14547
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  2. Article ; Online: Telangiectatic Carcinoma - Like Lymphangioma Circumscriptum. A Rare Form of Cutaneous Metastasis of Breast Carcinoma: Case Report.

    Cebeci, Dua / Yaşar, Şirin / Güneş, Pembegül / Aytekin, Sema

    Medical archives (Sarajevo, Bosnia and Herzegovina)

    2020  Volume 74, Issue 5, Page(s) 391–392

    Abstract: Introduction: The Breast cancer is the most common malignancy in middle-aged women and that causes skin metastasis. Skin metastasis in internal cancer cases is a very rare condition and may be difficult to diagnose and have poor prognostic marker. ... ...

    Abstract Introduction: The Breast cancer is the most common malignancy in middle-aged women and that causes skin metastasis. Skin metastasis in internal cancer cases is a very rare condition and may be difficult to diagnose and have poor prognostic marker. Cutaneous metastasis of breast carcinoma is mostly seen as direct invasion and/or local infiltration. However, in addition to the well-known types, cutaneous metastases may mimic many benign skin lesions and therefore may be difficult to diagnose.
    Case report: In this article we present a 36-year-old woman with telangiectatic carcinoma-like lymphangioma circumscriptum, a rare form of cutaneous metastasis skin metastases. It can be the first sign of internal malignancies, so early diagnosis is very important at this stage.
    Conclusion: Therefore, solitary lesions or benign dermatoses seen in the skin and not associated with specific disease should be considered as tumor metastasis especially in female patients with a history of breast cancer and differential diagnosis must be made.
    MeSH term(s) Adult ; Breast Neoplasms/complications ; Breast Neoplasms/physiopathology ; Early Detection of Cancer/methods ; Female ; Humans ; Lymphangioma/diagnosis ; Lymphangioma/etiology ; Lymphangioma/physiopathology ; Neoplasm Metastasis/diagnosis ; Neoplasm Metastasis/physiopathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/etiology ; Skin Neoplasms/physiopathology ; Skin Neoplasms/therapy ; Telangiectasis/diagnosis ; Telangiectasis/etiology ; Telangiectasis/physiopathology
    Language English
    Publishing date 2020-09-04
    Publishing country Bosnia and Herzegovina
    Document type Case Reports
    ZDB-ID 128782-5
    ISSN 1986-5961 ; 0025-8083 ; 0350-199X
    ISSN (online) 1986-5961
    ISSN 0025-8083 ; 0350-199X
    DOI 10.5455/medarh.2020.74.391-392
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  3. Article ; Online: Cutaneous Myopericytoma on the Forehead: A Rare Localization.

    Cebeci, Dua / Yaşar, Şirin / Güneş, Pembegül / Aytekin, Sema

    Indian journal of dermatology

    2020  Volume 65, Issue 2, Page(s) 169–171

    Language English
    Publishing date 2020-02-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.IJD_310_18
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  4. Article ; Online: A Controlled Study to Examine the Effect of Topical Sucralfate on Radiofrequency-induced Burn Wounds in Rats

    Yaşar, Şirin / Yaşar, Bülent / Yörüsün, Aslı / Güneş, Pembegül / Kayadibi, Hüseyin / Erçin, Zuhal / Aytekin, Sema

    Wound management & prevention

    2020  Volume 66, Issue 2, Page(s) 34–42

    Abstract: Several preclinical studies have shown topical sucralfate facilitates wound repair.: Purpose: This study aimed to evaluate the effect of 10% topical sucralfate on healing radiofrequency-induced burn wounds in rats.: Methods: Twenty (20) male rats ... ...

    Abstract Several preclinical studies have shown topical sucralfate facilitates wound repair.
    Purpose: This study aimed to evaluate the effect of 10% topical sucralfate on healing radiofrequency-induced burn wounds in rats.
    Methods: Twenty (20) male rats were divided into 2 equal groups. Using radiofrequency, 4 full-thickness, 1 cm in diameter round burns were created on the backs of the rats that then were randomized to receive twice-daily treatment for 30 days with 10% sucralfate or neutral cream. Biopsies were taken on days 4, 7, 14, and 21 to analyze fibrin-leukocyte crut, edema density, epidermal-dermal cell infiltration, amount of fibroblast and collagen fibers, amount of elastic fibers, neovascularization-angiogenesis, and reepithelialization-granulation tissue. Data were collected to a spreadsheet and entered into statistical software for analysis. Histopathological features were classified as categorical variables and compared using the χ2 test and Fisher's exact test. When χ2 was used, Yates' correction for continuity was performed. All reported P values were 2-tailed; P less than .05 was considered statistically significant.
    Results: On day 4, improvement in edema density (P = .034), epidermal detachment (P = .020), epidermal-dermal cell infiltration (P = .007), and polymorphonuclear leukocyte infiltration (P = .021) were statistically more significant in the sucralfate than control group. On day 7, epidermal-dermal cell infiltration (P = .007) and elastic fibers P = .050) were statistically more significant in the sucralfate group. On day 14, angiogenesis (P = .029), reepithelialization (P = .035), and granulation tissue (P = .003) were statistically more significant in the sucralfate group. By the end of the study (day 30), angiogenesis (P = .010), reepithelialization (P <.001), fibroblast density (P = .016), granulation tissue (P = .035), and collagen density (P = .002) were significantly improved in the sucralfate group versus the control group.
    Conclusion: In a rat wound model, 10% topical sucralfate was found to histopathologically facilitate the healing process compared to the control group. Controlled clinical studies are needed to elucidate the effect of this treatment in human wounds.
    MeSH term(s) Administration, Topical ; Animals ; Burns/drug therapy ; Burns/physiopathology ; Disease Models, Animal ; Male ; Radiation Injuries/drug therapy ; Radiation Injuries/physiopathology ; Rats ; Rats, Sprague-Dawley ; Sucralfate/pharmacology ; Sucralfate/standards ; Wound Healing/drug effects
    Chemical Substances Sucralfate (54182-58-0)
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2964376-4
    ISSN 2640-5245 ; 2640-5237
    ISSN (online) 2640-5245
    ISSN 2640-5237
    DOI 10.25270/wmp.2020.2.3442
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  5. Article ; Online: Clinical course of psoriasis patients that discontinued biologics during the COVID-19 pandemic.

    Topaloğlu Demir, Filiz / Polat Ekinci, Algün / Aytekin, Sema / Topkarcı, Zeynep / Aslan Kayıran, Melek / Özkök Akbulut, Tuğba / Oğuz Topal, İlteriş / Sarıkaya Solak, Sezgi / Kara Polat, Asude / Karadağ, Ayşe Serap

    Journal of cosmetic dermatology

    2023  Volume 22, Issue 3, Page(s) 722–731

    Abstract: Background: Since psoriasis is a chronic disease, it is not recommended to discontinue the treatment agents used. However, in real life, the treatment of psoriasis patients may be interrupted for various reasons. During the pandemic period, the ... ...

    Abstract Background: Since psoriasis is a chronic disease, it is not recommended to discontinue the treatment agents used. However, in real life, the treatment of psoriasis patients may be interrupted for various reasons. During the pandemic period, the treatment of many patients was also interrupted.
    Objectives: To evaluate relapse and clinical worsening in psoriasis patients whose biological therapy was interrupted during the pandemic and reveal associated factors.
    Methods: The study included patients aged ≥18 years, who were followed up with moderate and severe chronic psoriasis controlled by the last biological agent [Psoriasis Area Severity Index (PASI) 75 response achieved] but had to discontinue their treatment during the pandemic. The patients' demographic and clinical characteristics, clinical course after the discontinuation of these agents, presence of clinical worsening, and relapse were evaluated. Risk factors were analyzed with the logistic regression analysis.
    Results: The study included 169 patients, with a mean age of 47.3 ± 14.5 (18-87) years. The mean biologics-free time was 18.2 ± 12.3 (2-56) weeks. Clinical worsening was detected in 41.4% and relapse in 48.5% of the patients. The significant risk factors for clinical worsening and relapse in both univariate and multivariate analyses were alcohol use during the biologics-free period, total time off biologics, and the presence of an additional triggering factor. The use of secukinumab and ustekinumab was found to be a protective factor against clinical worsening in multivariate analyses.
    Conclusion: As the biologics-free period is prolonged, the likelihood of clinical worsening and relapse increases, therefore, we do not recommend discontinuing biological agents.
    MeSH term(s) Humans ; Adolescent ; Adult ; Middle Aged ; Biological Products ; Pandemics ; Treatment Outcome ; Severity of Illness Index ; COVID-19 ; Biological Factors ; Psoriasis/drug therapy ; Chronic Disease ; Disease Progression
    Chemical Substances Biological Products ; Biological Factors
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15638
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  6. Article ; Online: Morphology, growth rate, and thickness of the nail plate during the pregnancy.

    Altan Ferhatoğlu, Zeynep / Göktay, Fatih / Yaşar, Şirin / Aytekin, Sema

    International journal of dermatology

    2018  Volume 57, Issue 10, Page(s) 1253–1258

    Abstract: Pregnancy causes some physiological skin changes, such as hyperpigmentation and striae gravidarum. Thickening of scalp hair and a prolonged anagen phase are also known to occur during pregnancy. However, a limited number of studies have been conducted on ...

    Abstract Pregnancy causes some physiological skin changes, such as hyperpigmentation and striae gravidarum. Thickening of scalp hair and a prolonged anagen phase are also known to occur during pregnancy. However, a limited number of studies have been conducted on the effect of pregnancy on the nails. We aimed to investigate the effect of pregnancy on the morphology of the nail plate, specifically its growth rate and thickness. Pregnant women and a control group consisting of healthy female volunteers were included in the study. The distance from the apical point of the lunula to the midpoint of the free edge of the nail plate of the the thumb was measured with digital calipers. The measurement was repeated during the control visits and recorded in millimeters per day. The thickness of the nail plate of the thumb was measured at the midpoint of the free edge of the nail plate. A dermatological examination of the fingernails was performed for both groups. A survey was also conducted to identify any changes that occurred in the nails during pregnancy. The mean growth rate of the nail plate in pregnant women was 0.1 ± 0.05 mm/day, and in the control group it was 0.09 ± 0.05 mm/day. There was no statistically significant difference between the pregnant and control groups regarding the growth rate of the nail plate (P = 0.438). The mean thickness of the nail plate in pregnant women was 0.87 ± 0.19 mm, and in the control group it was 0.75 ± 0.17 mm. There was a statistically significant difference between the groups with respect to nail plate thickness (P < 0.001). A dermatological examination of the fingernails in the two groups did not reveal any statistically significant differences with respect to the nail findings. We determined in our study that pregnancy did not affect the growth rate and the morphology of the nails but increased the thickness of the nail plates.
    MeSH term(s) Adult ; Case-Control Studies ; Female ; Humans ; Nails/anatomy & histology ; Nails/growth & development ; Pregnancy ; Thumb ; Young Adult
    Language English
    Publishing date 2018-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.14152
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  7. Article ; Online: Two new cases with Costello syndrome.

    Aytekin, Sema / Alyamac, Gokcen

    Dermatology online journal

    2013  Volume 19, Issue 8, Page(s) 19267

    Abstract: Costello syndrome (CS) was described in 1977 by Costello who reported two unrelated children with a new syndrome comprising short stature, redundant skin of the neck, palms, soles, and fingers, curly hair, papillomata around the mouth and nares, and ... ...

    Abstract Costello syndrome (CS) was described in 1977 by Costello who reported two unrelated children with a new syndrome comprising short stature, redundant skin of the neck, palms, soles, and fingers, curly hair, papillomata around the mouth and nares, and mental retardation. Several additional cases have been reported since then. Herein we report two patients with Costello syndrome; one of these patients had associated mesenteric cyst.
    MeSH term(s) Abdominal Neoplasms/complications ; Abdominal Neoplasms/surgery ; Adolescent ; Child ; Costello Syndrome/complications ; Costello Syndrome/diagnosis ; Female ; Humans ; Lymphangioma/complications ; Lymphangioma/surgery
    Language English
    Publishing date 2013-08-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
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  8. Article ; Online: Acemetacin-induced fixed drug eruption.

    Cebeci, Filiz / Yaşar, Şirin / Aytekin, Sema / Güneş, Pembegül

    Indian journal of pharmacology

    2016  Volume 48, Issue 2, Page(s) 219–220

    Abstract: Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and various antibiotics. Acemetacin, a prodrug of indomethacin, is an NSAID licensed for use in rheumatic disease and other ... ...

    Abstract Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and various antibiotics. Acemetacin, a prodrug of indomethacin, is an NSAID licensed for use in rheumatic disease and other musculoskeletal disorders. We present a case of acemetacin-induced FDE in a 49-year-old woman. To the best of our knowledge, this is the second case report detailing clinical and histopathological findings of a patient with FDE caused by acemetacin.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Drug Eruptions/etiology ; Female ; Humans ; Indomethacin/adverse effects ; Indomethacin/analogs & derivatives ; Middle Aged
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; acemetacin (5V141XK28X) ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2016-03
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/0253-7613.178824
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  9. Article: Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp.

    Yaşar, Şirin / Kaynak, Emre / Güneş, Pembegül / Göktay, Fatih / Aytekin, Sema

    Skin appendage disorders

    2017  Volume 3, Issue 2, Page(s) 92–94

    Language English
    Publishing date 2017-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000462980
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  10. Article: A Rare Syndrome Resembling Scleroderma: Huriez Syndrome.

    Çelik, Nil Su / Yaşar, Şirin / Aytekin, Sema / Güneş, Pembegül

    Skin appendage disorders

    2017  Volume 4, Issue 2, Page(s) 82–85

    Abstract: Huriez syndrome, also referred to as "sclerotylosis," is a rare autosomal dominant genodermatosis characterized by the triad of congenital scleroatrophy of the distal extremities, palmoplantar keratoderma, and hypoplastic nails. The development of ... ...

    Abstract Huriez syndrome, also referred to as "sclerotylosis," is a rare autosomal dominant genodermatosis characterized by the triad of congenital scleroatrophy of the distal extremities, palmoplantar keratoderma, and hypoplastic nails. The development of aggressive squamous cell carcinoma (SCC) arising in the scleroatrophic area is also a distinctive feature of the syndrome. Early diagnosis is important due to the early onset, mostly in the third to fourth decades of life, and aggressive progress of SCC, which occurs in around 15% of affected individuals. Our patient had palmoplantar keratoderma, scleroatrophy of the hands, and hypoplastic nails. Her mother and father had a second-degree blood relation. Two of her siblings had similar complaints and findings. She showed no sign of actinic keratosis or SCC, and was called for regular follow-ups. With this case, we want to emphasize that Huriez syndrome is a rare genodermatosis, mimicking scleroderma-like acrosclerosis, and early diagnosis is critical for recognizing and preventing the development of SCC.
    Language English
    Publishing date 2017-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000479036
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