LIVIVO - Search results -

Search results

Result 1 - 10 of total 109

Search options

Book ; Online: UAV Control Optimization via Decentralized Markov Decision Processes

Azam, Md Ali

2021

Abstract: Unmanned aerial vehicle (UAV) swarm control has applications including target tracking, surveillance, terrain mapping, and precision agriculture. Decentralized control methods are particularly useful when the swarm is large, as centralized methods (a ... ...

Abstract	Unmanned aerial vehicle (UAV) swarm control has applications including target tracking, surveillance, terrain mapping, and precision agriculture. Decentralized control methods are particularly useful when the swarm is large, as centralized methods (a single command center controlling the UAVs) suffer from exponential computational complexity, i.e., the computing time to obtain the optimal control for the UAVs grow exponentially with the number of UAVs in the swarm in centralized approaches. Although many centralized control methods exist, literature lacks decentralized control frameworks with broad applicability. To address this knowledge gap, we present a novel decentralized UAV swarm control strategy using a decision-theoretic framework called decentralized Markov decision process (Dec-MDP). We build these control strategies in the context of two case studies: a) swarm formation control problem; b) swarm control for multitarget tracking. As most decision theoretic formulations suffer from the curse of dimensionality, we adapt an approximate dynamic programming method called nominal belief-state optimization (NBO) to solve the decentralized control problems approximately in both the case studies. In the formation control case study, the objective is to drive the swarm from a geographical region to another geographical region where the swarm must form a certain geometrical shape (e.g., selected location on the surface of a sphere). The motivation for studying such problems comes from data fusion applications with UAV swarms where the fusion performance depends on the strategic relative separation of the UAVs from each other. In the target tracking case study, the objective is the control the motion of the UAVs in a decentralized manner while maximizing the overall target tracking performance. Motivation for this case study comes from the surveillance applications using UAV swarms. Comment: MS Thesis of Md Ali Azam, South Dakota School of Mines and Technology, 2020
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	629 ; 510
Publishing date	2021-07-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Computational Molecular Modeling Studies of Some Mycobacterium Tuberculosis Alanine Racemase Inhibitors.

Jayaram, Unni / Azam, Mohammed Afzal

Acta chimica Slovenica

2022 Volume 69, Issue 2, Page(s) 393–404

Abstract: Alanine racemase is a pyridoxal-5'-phosphate dependent bacterial enzyme that provides the essential peptidoglycan precursor D-alanine, utilized for cell wall synthesis. This enzyme is ubiquitous throughout bacteria, including Mycobacterium tuberculosis, ... ...

Abstract	Alanine racemase is a pyridoxal-5'-phosphate dependent bacterial enzyme that provides the essential peptidoglycan precursor D-alanine, utilized for cell wall synthesis. This enzyme is ubiquitous throughout bacteria, including Mycobacterium tuberculosis, making it an attractive target for antibacterial drug discovery. We investigated the binding mode of twenty five reported Mycobacterium tuberculosis alanine racemase inhibitors. The results obtained from molecular docking studies emphasized the importance of inhibitor interaction with Lys42, Tyr46, Arg140, His172 and Tyr175 residues at the catalytic binding pocket of alanine racemase enzyme. The predicted binding free energies showed that van der Waals and nonpolar solvation interactions are the driving force for binding of inhibitors. Molecular dynamics simulation studies of four such inhibitor-alanine racemase systems were further explored to study the inhibition mechanism. The quantum chemical parameters calculated at the B3LYP/6-31G**++ level of theory indicated that the inhibitors must have low values of the lowest unoccupied molecular orbital energy and high values of electrostatic potential for stronger interactions. We expect that this study can provide significant theoretical guidance for design of potent Mycobacterium tuberculosis alanine racemase inhibitors in future.
MeSH term(s)	Alanine/chemistry ; Alanine Racemase/chemistry ; Alanine Racemase/metabolism ; Anti-Bacterial Agents ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mycobacterium tuberculosis/metabolism
Chemical Substances	Anti-Bacterial Agents ; Alanine Racemase (EC 5.1.1.1) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-06-14
Publishing country	Slovenia
Document type	Journal Article
ZDB-ID	2029709-9
ISSN	1580-3155 ; 1318-0207
ISSN (online)	1580-3155
ISSN	1318-0207
DOI	10.17344/acsi.2021.7267
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: GlmU Inhibitors as Promising Antibacterial Agents: A Review.

Palathoti, Nagarjuna / Azam, Mohammed Afzal

Mini reviews in medicinal chemistry

2022 Volume 23, Issue 3, Page(s) 343–360

Abstract: Bacterial infections are a major cause of mortality and morbidity in humans throughout the world. Infections due to resistant bacterial strains such as methicillin-resistant Staphyloccocusaureus vancomycin, resistant Enterococci, Klebsiella pneumoniae, ... ...

Abstract	Bacterial infections are a major cause of mortality and morbidity in humans throughout the world. Infections due to resistant bacterial strains such as methicillin-resistant Staphyloccocusaureus vancomycin, resistant Enterococci, Klebsiella pneumoniae, Staphylococcus aureus, and Mycobacterium are alarming. Hence the development of new antibacterial agents, which act via a novel mechanism of action, became a priority in antibacterial research. One such approach to overcome bacterial resistance is to target novel protein and develop antibacterial agents that act via different mechanisms of action. Bacterial GlmU is one such bifunctional enzyme that catalyzes the two consecutive reactions during the biosynthesis of uridine 5'-diphospho-Nacetylglucosamine, an essential precursor for the biosynthesis of bacterial cell wall peptidoglycan. This enzyme comprises two distinct active sites; acetyltransferase and uridyltransferase and both these active sites act independently during catalytic reactions. GlmU is considered an attractive target for the design and development of newer antibacterial agents due to its important role in bacterial cell wall synthesis and the absence of comparable enzymes in humans. Availability of three dimensions X-crystallographic structures of GlmU and their known catalytic mechanism from different bacterial strains have instigated research efforts for the development of novel antibacterial agents. Several GlmU inhibitors belonging to different chemical classes like 2- phenylbenzofuran derivative, quinazolines, aminoquinazolines, sulfonamides, arylsulfonamide, D-glucopyranoside 6-phosphates, terreic acid, iodoacetamide, N-ethyl maleimide, and Nethylmaleimide etc., have been reported in the literature. In the present review, we present an update on GlmU inhibitors and their associated antibacterial activities. This review may be useful for the design and development of novel GlmU inhibitors with potent antibacterial activity.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Catalysis ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry
Chemical Substances	Anti-Bacterial Agents ; Enzyme Inhibitors
Language	English
Publishing date	2022-08-17
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/1389557522666220817114445
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5891: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effects of perioperative clinical hypnosis on heart rate variability in patients undergoing oncologic surgery: secondary outcomes of a randomized controlled trial.

Azam, Muhammad Abid / Weinrib, Aliza Z / Slepian, P Maxwell / Rosenbloom, Brittany N / Waisman, Anna / Clarke, Hance / Katz, Joel

Frontiers in pain research (Lausanne, Switzerland)

2024 Volume 5, Page(s) 1354015

Abstract: Introduction: Clinical hypnosis has been proposed for post-surgical pain management for its potential vagal-mediated anti-inflammatory properties. Evidence is needed to understand its effectiveness for post-surgical recovery. Iin this secondary outcome ... ...

Abstract	Introduction: Clinical hypnosis has been proposed for post-surgical pain management for its potential vagal-mediated anti-inflammatory properties. Evidence is needed to understand its effectiveness for post-surgical recovery. Iin this secondary outcome study, it was hypothesized that surgical oncology patients randomized to receive perioperative clinical hypnosis (CH) would demonstrate greater heart-rate variability (HRV) during rest and relaxation at a 1-month post-surgery assessment compared to a treatment-as-usual group (TAU). Methods: After REB approval, trial registration and informed consent, 92 participants were randomized to receive CH ( Results: One month after surgery, HRV was significantly higher in CH group ( Discussion: The results suggest that hypnosis prevents the deleterious effects of surgery on HRV by preserving pre-operative vagal activity. These findings underscore the potential of clinical hypnosis in mitigating the adverse effects of surgery on autonomic function and may have significant implications for enhancing post-surgical recovery and pain management strategies. Clinical trial registration: ClinicalTrials.gov, identifier (NCT03730350).
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-561X
ISSN (online)	2673-561X
DOI	10.3389/fpain.2024.1354015
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Synthesis, Molecular Docking and Biological Evaluation of 2-Aryloxy-N-Phenylacetamide and N'-(2-Aryloxyoxyacetyl) Benzohydrazide Derivatives as Potential Antibacterial Agents.

Yele, Vidyasrilekha / Azam, Mohammad Afzal / Wadhwani, Ashish D

Chemistry & biodiversity

2021 Volume 18, Issue 4, Page(s) e2000907

Abstract: A new class of 2-aryloxy-N-phenylacetamide and N'-(2-aryloxyoxyacetyl) benzohydrazide derivatives with different active moieties were synthesized and screened for their antibacterial activity. Structural characterization of synthesized compounds was ... ...

Abstract	A new class of 2-aryloxy-N-phenylacetamide and N'-(2-aryloxyoxyacetyl) benzohydrazide derivatives with different active moieties were synthesized and screened for their antibacterial activity. Structural characterization of synthesized compounds was performed using HR-MS,
MeSH term(s)	Acetamides/chemical synthesis ; Acetamides/chemistry ; Acetamides/pharmacology ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Hydrazines/chemical synthesis ; Hydrazines/chemistry ; Hydrazines/pharmacology ; Kinetics ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects
Chemical Substances	Acetamides ; Anti-Bacterial Agents ; Hydrazines ; acetamide (8XOE1JSO29)
Language	English
Publishing date	2021-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202000907
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Efficient quality assurance for isocentric stability in stereotactic body radiation therapy using machine learning.

Salahuddin, Sana / Buzdar, Saeed Ahmad / Iqbal, Khalid / Azam, Muhammad Adeel / Strigari, Lidia

Radiological physics and technology

2023 Volume 17, Issue 1, Page(s) 219–229

Abstract: This study aims to predict isocentric stability for stereotactic body radiation therapy (SBRT) treatments using machine learning (ML), covers the challenges of manual assessment and computational time for quality assurance (QA), and supports medical ... ...

Abstract	This study aims to predict isocentric stability for stereotactic body radiation therapy (SBRT) treatments using machine learning (ML), covers the challenges of manual assessment and computational time for quality assurance (QA), and supports medical physicists to enhance accuracy. The isocentric parameters for collimator (C), gantry (G), and table (T) tests were conducted with the RUBY phantom during QA using TrueBeam linac for SBRT. This analysis combined statistical features from the IsoCheck EPID software. Five ML models, including logistic regression (LR), decision tree (DT), random forest (RF), naive Bayes (NB), and support vector machines (SVM), were used to predict the outcome of the QA procedure. 247 Winston-Lutz (WL) tests were collected from 2020 to 2022. In our study, both DT and RF achieved the highest score on test accuracy (Acc. test) ranging from 93.5% to 99.4%, and area under curve (AUC) values from 90 to 100% on three modes (C, G, and T). The precision, recall, and F1 scores indicate the DT model consistently outperforms other ML models in predicting isocenter stability deviation in QA. The QA assessment using ML models can assist error prediction early to avoid potential harm during SBRT and ensure safe and effective patient treatments.
MeSH term(s)	Humans ; Radiosurgery/methods ; Bayes Theorem ; Particle Accelerators ; Software ; Machine Learning
Language	English
Publishing date	2023-12-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2433581-2
ISSN	1865-0341 ; 1865-0333
ISSN (online)	1865-0341
ISSN	1865-0333
DOI	10.1007/s12194-023-00768-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: A Randomized Controlled Trial of Clinical Hypnosis as an Opioid-Sparing Adjunct Treatment for Pain Relief in Adults Undergoing Major Oncologic Surgery

Rosenbloom BN / Slepian PM / Azam MA / Aternali A / Birnie KA / Curtis K / Thaker S / Ladak S / Waisman A / Clarke H / Katz J / Weinrib AZ

Journal of Pain Research, Vol Volume 17, Pp 45-

2024 Volume 59

Abstract: Brittany N Rosenbloom,1– 3 P Maxwell Slepian,1,2,4 Muhammed Abid Azam,1,2 Andrea Aternali,1 Kathryn A Birnie,5,6 Kathryn Curtis,2 Sonal Thaker,2 Salima Ladak,2 Anna Waisman,1 Hance Clarke,2,4 Joel Katz,1,2,4 Aliza Z Weinrib1,2 1Department of Psychology, ... ...

Abstract	Brittany N Rosenbloom,1– 3 P Maxwell Slepian,1,2,4 Muhammed Abid Azam,1,2 Andrea Aternali,1 Kathryn A Birnie,5,6 Kathryn Curtis,2 Sonal Thaker,2 Salima Ladak,2 Anna Waisman,1 Hance Clarke,2,4 Joel Katz,1,2,4 Aliza Z Weinrib1,2 1Department of Psychology, York University, Toronto, ON, Canada; 2Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, ON, Canada; 3Toronto Academic Pain Medicine Institute, Women’s College Hospital, Toronto, ON, Canada; 4Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada; 5Department of Anesthesiology, Perioperative and Pain Medicine, University of Calgary, Calgary, AB, Canada; 6Department of Community Health Sciences, University of Calgary, Calgary, AB, CanadaCorrespondence: Joel Katz; Aliza Z Weinrib, Department of Psychology, York University, BSB 232, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada, Email jkatz@yorku.ca; Aliza.Weinrib@gmail.comAbstract: Clinical hypnosis is an effective strategy for managing acute pain in the surgical setting. However, the opioid sparing effects of clinical hypnosis are not as well understood. This pre-registered (NCT03730350) randomized, controlled trial (RCT) examined the impact of clinical hypnosis, pre- and post-surgery, on opioid consumption during hospitalization as well as on measures of pain intensity, pain interference, depressed mood, anxiety, sleep, and pain catastrophizing. Participants (M = 57.6 years; SD = 10.9) awaiting oncologic surgery were randomized to treatment-as-usual (n = 47) or hypnosis (n = 45). Intent-to-treat analyses were conducted using linear mixed effects modeling. A significant Group × Time interaction, F(6, 323.34) = 3.32, p = 0.003, indicated an opioid sparing effect of clinical hypnosis during the acute postoperative period. Hypnosis also protected against increases in pain catastrophizing at one-week after surgery, F (1, 75.26) = 4.04, p = 0.048. A perioperative clinical hypnosis intervention had a sparing effect on opioid ...
Keywords	clinical hypnosis ; oncologic surgery ; postoperative opioid use ; postoperative pain ; pain catastrophizing ; Medicine (General) ; R5-920
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Recent Progress of Electrode Architecture for MXene/MoS

Kosnan, Muhammad Akmal / Azam, Mohd Asyadi / Safie, Nur Ezyanie / Munawar, Rose Farahiyan / Takasaki, Akito

Micromachines

2022 Volume 13, Issue 11

Abstract: Since their discovery, MXenes have conferred various intriguing features because of their distinctive structures. Focus has been placed on using MXenes in electrochemical energy storage including a supercapacitor showing significant and promising ... ...

Abstract	Since their discovery, MXenes have conferred various intriguing features because of their distinctive structures. Focus has been placed on using MXenes in electrochemical energy storage including a supercapacitor showing significant and promising development. However, like other 2D materials, MXene layers unavoidably experience stacking agglomeration because of its great van der Waals forces, which causes a significant loss of electrochemically active sites. With the help of MoS
Language	English
Publishing date	2022-10-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13111837
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Uncoupling cytosolic calcium from membrane voltage by transient receptor potential melastatin 4 channel (TRPM4) modulation: A novel strategy to treat ventricular arrhythmias.

Chakraborty, Praloy / Azam, Mohammed Ali / Massé, Stéphane / Lai, Patrick F H / Rose, Robert A / Ibarra Moreno, Carlos A / Riazi, Sheila / Nanthakumar, Kumaraswamy

Heart rhythm O2

2023 Volume 4, Issue 11, Page(s) 725–732

Abstract: The current antiarrhythmic paradigm is mainly centered around modulating membrane voltage. However, abnormal cytosolic calcium ( ... ...

Abstract	The current antiarrhythmic paradigm is mainly centered around modulating membrane voltage. However, abnormal cytosolic calcium (Ca
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2666-5018
ISSN (online)	2666-5018
DOI	10.1016/j.hroo.2023.10.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Pharmacophore generation, atom-based 3D-QSAR and molecular dynamics simulation analyses of pyridine-3-carboxamide-6-yl-urea analogues as potential gyrase B inhibitors.

Azam, M A / Thathan, J

SAR and QSAR in environmental research

2017 Volume 28, Issue 4, Page(s) 275–296

Abstract: DNA gyrase subunit B (GyrB) is an attractive drug target for the development of antibacterial agents with therapeutic potential. In the present study, computational studies based on pharmacophore modelling, atom-based QSAR, molecular docking, free ... ...

Abstract	DNA gyrase subunit B (GyrB) is an attractive drug target for the development of antibacterial agents with therapeutic potential. In the present study, computational studies based on pharmacophore modelling, atom-based QSAR, molecular docking, free binding energy calculation and dynamics simulation were performed on a series of pyridine-3-carboxamide-6-yl-urea derivatives. A pharmacophore model using 49 molecules revealed structural and chemical features necessary for these molecules to inhibit GyrB. The best fitted model AADDR.13 was generated with a coefficient of determination (r²) of 0.918. This model was validated using test set molecules and had a good r² of 0.78. 3D contour maps generated by the 3D atom-based QSAR revealed the key structural features responsible for the GyrB inhibitory activity. Extra precision molecular docking showed hydrogen bond interactions with key amino acid residues of ATP-binding pocket, important for inhibitor binding. Further, binding free energy was calculated by the MM-GBSA rescoring approach to validate the binding affinity. A 10 ns MD simulation of inhibitor #47 showed the stability of the predicted binding conformations. We identified 10 virtual hits by in silico high-throughput screening. A few new molecules were also designed as potent GyrB inhibitors. The information obtained from these methodologies may be helpful to design novel inhibitors of GyrB.
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2023559-8
ISSN	1029-046X ; 1062-936X
ISSN (online)	1029-046X
ISSN	1062-936X
DOI	10.1080/1062936X.2017.1310131
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Your last searches

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito