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Article ; Online: Multicentricity in different molecular subtypes of breast cancer

Azar Baradaran / Maryam Derakhshan / Saba Raeisi / Sina Neshat / Sina Raeisi

Advanced Biomedical Research, Vol 12, Iss 1, Pp 9-

A cross-sectional study in Isfahan

2023 Volume 9

Abstract: Background: Breast cancer is the most common cancer leading to death in women. Women with multicentric breast cancer were reported more likely to have poor prognosis. Here, we decided to study and compare the frequency distribution of multicentricity in ... ...

Abstract	Background: Breast cancer is the most common cancer leading to death in women. Women with multicentric breast cancer were reported more likely to have poor prognosis. Here, we decided to study and compare the frequency distribution of multicentricity in different subtypes of breast cancer. Materials and Methods: This is a cross-sectional study that was performed in 2019–20 on medical records and breast pathology reports of 250 patients who undergone mastectomy due to breast cancer. Demographic data of all patients including age, along with other medical data such as menstruation condition, breast cancer grade, multicentricity status, stage, and expression of estrogen receptor (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) receptors were collected from medical records. Samples were divided into four subtypes of Luminal B, Luminal A, HER2 expressing, and basal-like. Results: The mean age of patients was 50.21 ± 11.15 years. Ninety-five patients (38%) had multicentricity and HER2 expressing (48.5%) and Luminal A (41.4%) were most common in patients with multicentricity. In addition, basal-like group presented with least multicentricity (13.5%) among the subtypes (P = 0.008). We also showed significant increased chances of multicentricity in Luminal B (odds ratio [OR] = 3.782) (P = 0.033), Luminal A (OR = 5.164) (P = 0.002), and HER2-expressing group (OR = 5.393) (P = 0.011). Conclusions: Taken together, we showed significantly increased chances of multicentricity in patients with HER2-expression, Luminal A, and Luminal B groups compared to basal-like group or triple negative. These results were in line with most previous studies; however, we showed higher rates of multicentricity among our population compared to some previous reports.
Keywords	breast neoplasms ; immunohistochemistry ; mastectomy ; multicentricity ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	616 ; 610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlation between fine needle aspiration and intraoperative frozen section findings for thyroid patients; a single center study

Azar Baradaran / Maryam Derakhshan / Negin Ghanbari

Journal of Preventive Epidemiology, Vol 7, Iss 1, Pp e04-e

2022 Volume 04

Abstract: Introduction: Thyroid nodules are one of the most common diseases. Objectives: The aim of this study was to evaluate the correlation between fine needle aspiration (FNA) and intraoperative frozen section findings for thyroid disease patients. Patients ... ...

Abstract	Introduction: Thyroid nodules are one of the most common diseases. Objectives: The aim of this study was to evaluate the correlation between fine needle aspiration (FNA) and intraoperative frozen section findings for thyroid disease patients. Patients and Methods: In this study, the FNA and intraoperative frozen section findings of 143 patients who were admitted to an educational hospital, Isfahan, Iran were collected and classified using these diagnostic methods during 2015. To find the correlation between FNA and intraoperative frozen section findings, statistical analysis was conducted using SPSS software version 16.0 (Chicago, IL). Results: Sensitivity and specificity of the positive FNA findings were 71% and 86.8%, respectively (P<0.001). The maximum concordance between FNA and intraoperative frozen section for papillary thyroid cancer was seen (P<0.001). Conclusion: In this study, a significant association between FNA and intraoperative frozen section of thyroid cancers, among our patients, however this finding requires further investigation by larger studies.
Keywords	fine needle aspiration ; intraoperative frozen section ; thyroid ; Specialties of internal medicine ; RC581-951 ; Infectious and parasitic diseases ; RC109-216
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Society of Diabetic Nephropathy Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Subacute toxic effects of polyvinyl chloride microplastics (PVC-MPs) in juvenile common carp, Cyprinus carpio (Pisces

Hosna Darabi / Azar Baradaran / Karim Ebrahimpour

Caspian Journal of Environmental Sciences, Vol 20, Iss 2, Pp 233-

Cyprinidae)

2022 Volume 242

Abstract: Pollution of the aquatic environment by microplastics (MPs) is one of the most serious environmental issues worldwide and has raised many concerns about their availability and hazards for aquatic biota. In addition, fish is an important source of protein ...

Abstract	Pollution of the aquatic environment by microplastics (MPs) is one of the most serious environmental issues worldwide and has raised many concerns about their availability and hazards for aquatic biota. In addition, fish is an important source of protein for humans, hence, the accumulation, and toxic effects of the MPs in fish deserve special attention. This study aims to examine the ingestion, tissue accumulation and toxic effects of polyvinyl chloride microplastics (PVC-MPs) in juvenile common carp. Fluorescent-tagged PVC-MPs were found in various tissues of fish only after 4-5 days of exposure. The size of MPs showed a significant role in acute toxicity and mortality due to PVC-MPs. 100% mortality were observed after 7 and 10 days exposures to 1000 and 100 µg L-1 class A-PVC-MPs (100>µm) respectively, while 1000 µg L-1 of class A-PVC-MPs (300-1000 µm) killed only 16.6% of fish after ten days. Different grades of tissue damage were found in the gills, gut, and liver of fish in proportion to size, time, and concentration of PVC-MPs. Epithelial detachment, thinning of the bowel wall, and lesions of villi in the gastric wall were the dominant damages in the gastrointestinal tract. Gills also were affected in the form of necrosis, adhesion, and partial fusion of secondary lamellae. Hepatic damages (cellular necrosis and infiltration) were found only due to exposure of fish to class A-PVC-MPs. Altogether, these findings suggest that common carp intake significant levels of environmental microplastics (intentionally or accidentally), which seriously affect fish health and raise significant concerns about marine ecosystem health and seafood safety due to microplastic pollution.
Keywords	polyvinyl chloride (pvc) ; microplastics ; environmental toxicity ; common carp ; pathological damages ; Environmental sciences ; GE1-350 ; Science ; Q
Subject code	333
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	University of Guilan
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Commentary on

Azar Baradaran

DARU : Journal of Pharmaceutical Sciences, Vol 21, Iss March, p

Effect of Vitamin D on Insulin Resistance and Anthropometric Parameters in Type 2 Diabetes; a Randomized Double-Blind Clinical Trial

2013 Volume 19

Keywords	Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Pharmacy and materia medica ; RS1-441 ; DOAJ:Pharmacy and materia medica
Language	English
Publishing date	2013-03-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comment on

Azar Baradaran

International Journal of Preventive Medicine, Vol 4, Iss 6, Pp 734-

The protective role of silymarin and deferoxamine against iron dextran-induced renal iron deposition in male rats

2013 Volume 735

Keywords	Medicine ; R
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the relationship between neutrophil-to-lymphocyte ratio and 25-hydroxy vitamin D levels in hemodialysis patients, Isfahan, Iran

Azar Baradaran / Zahra Hoseini / Parin Hedayati / Reyhaneh Shirvani

Journal of Preventive Epidemiology, Vol 6, Iss 2, Pp e26-e

2021 Volume 26

Abstract: Introduction: Chronic low-grade inflammation is a comorbid factor in Chronic kidney disease (CKD), and especially in chronic dialysis patients. Recently, neutrophil-to-lymphocyte ratio (NLR), which is very available and affordable, has emerged as an ... ...

Abstract	Introduction: Chronic low-grade inflammation is a comorbid factor in Chronic kidney disease (CKD), and especially in chronic dialysis patients. Recently, neutrophil-to-lymphocyte ratio (NLR), which is very available and affordable, has emerged as an inflammatory index in many disorders such as CKD. Several studies also have shown the anti-inflammatory effects of vitamin D, and scientists believe that we must prevent vitamin D deficiency in CKD patients. Vitamin D supplementation may decrease mortality and morbidity in end-stage renal disease (ESRD) patients. Objectives: There are few studies on the association between serum 25-hydroxy vitamin D levels and NLR in ESRD patients. Therefore, we tried to evaluate this correlation, hoping to be a key for more researches. Patients and Methods: We enrolled 140 ESRD hemodialysis patients in a cross-sectional study and evaluated the correlation of NLR with serum 25-hydroxy vitamin D levels and some demographic factors in these patients. Results: Our results showed a statistically significant negative correlation between NLR and serum 25-hydroxy vitamin D levels (P=0.010, r= -0.216). However, other variables such as disease duration and age had no correlation with NLR (P=0.649, r= - 0.039 and P=0.781, r= - 0.024, respectively). We also used a linear regression test to check any confounder associated with NLR, and the regression was only significant for serum 25-hydroxy vitamin D levels (P=0.011, B=-0.009). Conclusion: Based on the results, serum 25-hydroxy vitamin D levels can be considered a predictor for NLR in hemodialysis patients.
Keywords	neutrophil-to-lymphocyte ratio ; vitamin d ; end-stage renal disease ; hemodialysis ; inflammation ; inflammatory marker ; Specialties of internal medicine ; RC581-951 ; Infectious and parasitic diseases ; RC109-216
Subject code	610 ; 616
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Society of Diabetic Nephropathy Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acute toxic effects of polyurethane microplastics on adult Zebra fish (Danio rerio)

Fatemeh Sadat Hosseini Dinani / Azar Baradaran / Karim Ebrahimpour

International Journal of Environmental Health Engineering, Vol 10, Iss 1, Pp 9-

2021 Volume 9

Abstract: Aim: Microplastics (MPs) have become an emerging environmental contaminant and there are increasing concerns about potentially toxic effects on living organisms. This study is aimed to determine uptake, tissue accumulation, and toxic effects of ... ...

Abstract	Aim: Microplastics (MPs) have become an emerging environmental contaminant and there are increasing concerns about potentially toxic effects on living organisms. This study is aimed to determine uptake, tissue accumulation, and toxic effects of polyurethane microplastics (PUR-MPs) on zebra fish. Materials and Methods: The zebra fish were exposed to different concentrations of PURs-MPs of different sizes for 10 days. Mortality and behavioral changes were monitored. Ingestion and tissue accumulation of PUR-MPs were studied by fluorescent tagging of PUR-MPs. Pathological damages of tissues were investigated with hematoxylin-eosin staining. Results: Microsize PUR-MPs can be ingested by zebra fish and fluorescent-tagged PUR-MPs were found in gills and gastrointestinal (GI) tract of fish after 10 days of exposure. A significant negative correlation was found between fluorescence intensity in fish tissues and size of PUR-MPs. Gills, GI tract, and liver were the most affected tissues by PUR-MP toxicity. GI damages included epithelial detachment, thinning of the bowel wall, congestive inflammation, epithelial damage, and lesions of villi in the gastric wall. Necrosis, adhesion, and partial fusion of secondary lamellae were the dominant pathological damages in the gills. Liver also was affected by cellular necrosis, infiltration, and lipid droplets. Conclusion: Exposure of zebra fish to PUR-MPs leads to ingestion of these particles by fish and significant increase in fish mortality and tissue damages. Particle size and MP concentration were the key determinant factors in PUR-MP toxicity. The results of the present study provide novel insights into environmental toxicity of PUR-MPs and toxic effect of PUR-MPs in aquatic organisms.
Keywords	environmental toxicity ; microplastics ; pathological damages ; polyurethane ; zebra fish ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental engineering ; TA170-171 ; Environmental sciences ; GE1-350
Subject code	590
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lipoprotein(a), type 2 diabetes and nephropathy; the mystery continues

Azar Baradaran

Journal of Nephropathology, Vol 1, Iss 3, Pp 126-

2012 Volume 129

Keywords	lipoprotein(a) ; renal failure ; diabetic nephropathy ; Pathology ; RB1-214 ; Internal medicine ; RC31-1245 ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2012-10-01T00:00:00Z
Publisher	Society of Diabetic Nephropathy Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of diagnostic value of neutrophil to lymphocyte ratio in younger and older pediatrics suspect to acute appendicitis in Imam Hossein hospital

Azar Baradaran / Azar Naimi / Elahe Pirpiran / Masoud Akhlaghi

Journal of Preventive Epidemiology, Vol 5, Iss 2, Pp e26-e

2020 Volume 26

Abstract: Introduction: Acute appendicitis in children is the most common acute surgical condition in children. Each year, 80000 children in the United States suffer from appendicitis. Objectives: The aim of this study was to evaluate diagnostic value of ... ...

Abstract	Introduction: Acute appendicitis in children is the most common acute surgical condition in children. Each year, 80000 children in the United States suffer from appendicitis. Objectives: The aim of this study was to evaluate diagnostic value of neutrophil to lymphocyte ratio (NLR) in younger and older pediatrics suspect of acute appendicitis in Imam Hossein hospital. Patients and Methods: This was a retrospective study conducted at Imam Hossein hospital from 2015-2017. The study population was all children with suspected appendicitis who refer to Imam Hossein medical center in Isfahan. The sample size was 423 people. The collected data were imported into SPSS software version 22 and analyzed with appropriate statistical tests. The significance level in the present study was less than 0.05. Results: The average age of participants was 7.2 ± 3.8 years. In both study groups, it was observed that the mean NLR in the normal and reactive follicular groups was significantly lower than the appendicitis and complication groups (P<0.05). The results of the present study showed that NLR diagnostic test can be a good predictor for the evaluation of appendicitis in both groups under 4 years and over 4 years. For more than 4 years’ group; AUC=0.74, P<0.001 and for less than 4 years’ group; AUC=0.69, P<0.001. For less than 4 years’ group, the cut-off score for appendicitis diagnosis was 2.3. In this cut-off, the sensitivity and specificity were equal to 0.65% and 0.72%. Additionally, for more than 4 years’ group, the cut-off for the diagnosis of appendix was 3.5. In this cut-off, the sensitivity and specificity were equal to 0.73% and 67%. Conclusion: This analysis demonstrates that NLR, in the context of appropriate clinical assessment of patients with a high a priori probability of appendicitis, has a greater diagnostic accuracy in supporting the diagnosis of appendicitis.
Keywords	diagnostic ; imam hossein hospital ; neutrophil to lymphocyte ; appendicitis ; Specialties of internal medicine ; RC581-951 ; Infectious and parasitic diseases ; RC109-216
Subject code	796
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Society of Diabetic Nephropathy Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antifungal effects of iranian propolis extract and royal jelly against candida albicans in-vitro

Hassan Moghim / Simin Taghipour / Soleiman Kheiri / Hamideh Khabbazi / Azar Baradaran

International Journal of Preventive Medicine, Vol 12, Iss 1, Pp 163-

2021 Volume 163

Abstract: Background: Candida albicans is the most important opportunistic fungal that can establish infection in susceptible individuals. Iranian Propolis and Royal jelly are bee products that are traditionally used against fungal infections. This study was aimed ...

Abstract	Background: Candida albicans is the most important opportunistic fungal that can establish infection in susceptible individuals. Iranian Propolis and Royal jelly are bee products that are traditionally used against fungal infections. This study was aimed to evaluate the antifungal effects of Iranian Propolis extract and Royal jelly against C. albicans in vitro. Methods: Antifungal activities of the extracts were performed according to microbroth dilution method in 96-well microdilution plates. The amount of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) based on counting the number of fungal colonies (CFU) were evaluated for each of Royal jelly and Iranian Propolis extracts against C. albicans compared with the control group. Results: In this study, the MIC, MIC50, and MFC of Royal jelly on C. albicans were, respectively, 80, 103 ± 25, and 160 ± 34 mg/mL and for the Iranian Propolis alcoholic extract were, respectively, 0.030 ± 0.015, 0.0618 ± 0.027, and 0.0833 ± 0.0599 mg/mL. Conclusions: The results indicate that both Royal jelly and Iranian Propolis alcoholic extract are effective against C. albicans, but the former species has higher antifungal activity. If the clinical trials confirm the results of this study, Iranian propolis, as a new antifungal agent by replacing chemical drugs, can be used to develop antifungal medicinal herbs.
Keywords	candida albicans ; iranian propolis ; royal jelly ; Medicine ; R
Subject code	001
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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