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  1. AU="Azevedo, Helena S"
  2. AU=Molyneaux Phillip L.
  3. AU=Shimizu Kazuki
  4. AU=Pell Robert AU=Pell Robert
  5. AU="Aguiar, Liza"
  6. AU="Bahls, Christine"
  7. AU="Dongho Lee"
  8. AU=Houser Steven R.
  9. AU="Morgom M.M."
  10. AU="Jordana-Comajuncosa, Rosa"
  11. AU="Kaushansky, Alexis"
  12. AU="Bhatjiwale, Mohinish"
  13. AU="Velu, Chinavenmeni S"
  14. AU=Trayanova Natalia A
  15. AU=Jimeno-Gonzlez Silvia
  16. AU=Bussolino F
  17. AU="Almulla, Hanan"
  18. AU="Chen, Wenmei"
  19. AU=Zeng Weiqing

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  1. Artikel ; Online: Embracing complexity in biomaterials design.

    Azevedo, Helena S / Mata, Alvaro

    Biomaterials and biosystems

    2022  Band 6, Seite(n) 100039

    Abstract: Animate materials, man-made materials behaving like living systems, are attracting enormous interest across a range of sectors, from construction and transport industry to medicine. In this leading opinion article, we propose that embracing complexity in ...

    Abstract Animate materials, man-made materials behaving like living systems, are attracting enormous interest across a range of sectors, from construction and transport industry to medicine. In this leading opinion article, we propose that embracing complexity in biomaterials design offers untapped opportunities to create biomaterials with innovative life-like properties that extend their capabilities and unleash new paradigms in medical treatment.
    Sprache Englisch
    Erscheinungsdatum 2022-02-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2666-5344
    ISSN (online) 2666-5344
    DOI 10.1016/j.bbiosy.2022.100039
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Supramolecular Hydrogels for Protein Delivery in Tissue Engineering.

    Lyu, Yaqi / Azevedo, Helena S

    Molecules (Basel, Switzerland)

    2021  Band 26, Heft 4

    Abstract: Therapeutic proteins, such as growth factors (GFs), have been used in tissue engineering (TE) approaches for their ability to provide signals to cells and orchestrate the formation of functional tissue. However, to be effective and minimize off-target ... ...

    Abstract Therapeutic proteins, such as growth factors (GFs), have been used in tissue engineering (TE) approaches for their ability to provide signals to cells and orchestrate the formation of functional tissue. However, to be effective and minimize off-target effects, GFs should be delivered at the target site with temporal control. In addition, protein drugs are typically sensitive water soluble macromolecules with delicate structure. As such, hydrogels, containing large amounts of water, provide a compatible environment for the direct incorporation of proteins within the hydrogel network, while their release rate can be tuned by engineering the network chemistry and density. Being formed by transient crosslinks, afforded by non-covalent interactions, supramolecular hydrogels offer important advantages for protein delivery applications. This review describes various types of supramolecular hydrogels using a repertoire of diverse building blocks, their use for protein delivery and their further application in TE contexts. By reviewing the recent literature on this topic, the merits of supramolecular hydrogels are highlighted as well as their limitations, with high expectations for new advances they will provide for TE in the near future.
    Mesh-Begriff(e) Humans ; Hydrogels/chemistry ; Hydrogels/therapeutic use ; Intercellular Signaling Peptides and Proteins/chemistry ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Macromolecular Substances/chemistry ; Macromolecular Substances/therapeutic use ; Proteins/chemistry ; Proteins/therapeutic use ; Tissue Engineering ; Water/chemistry
    Chemische Substanzen Hydrogels ; Intercellular Signaling Peptides and Proteins ; Macromolecular Substances ; Proteins ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2021-02-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26040873
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  3. Artikel ; Online: Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and

    Redondo-Gómez, Carlos / Parreira, Paula / Martins, M Cristina L / Azevedo, Helena S

    Chemical Society reviews

    2024  Band 53, Heft 8, Seite(n) 3714–3773

    Abstract: Self-assembled monolayers (SAMs) represent highly ordered molecular materials with versatile biochemical features and multidisciplinary applications. Research on SAMs has made much progress since the early begginings of Au substrates and alkanethiols, ... ...

    Abstract Self-assembled monolayers (SAMs) represent highly ordered molecular materials with versatile biochemical features and multidisciplinary applications. Research on SAMs has made much progress since the early begginings of Au substrates and alkanethiols, and numerous examples of peptide-displaying SAMs can be found in the literature. Peptides, presenting increasing structural complexity, stimuli-responsiveness, and biological relevance, represent versatile functional components in SAMs-based platforms. This review examines the major findings and progress made on the use of peptide building blocks displayed as part of SAMs with specific functions, such as selective cell adhesion, migration and differentiation, biomolecular binding, advanced biosensing, molecular electronics, antimicrobial, osteointegrative and antifouling surfaces, among others. Peptide selection and design, functionalisation strategies, as well as structural and functional characteristics from selected examples are discussed. Additionally, advanced fabrication methods for dynamic peptide spatiotemporal presentation are presented, as well as a number of characterisation techniques. All together, these features and approaches enable the preparation and use of increasingly complex peptide-based SAMs to mimic and study biological processes, and provide convergent platforms for high throughput screening discovery and validation of promising therapeutics and technologies.
    Mesh-Begriff(e) Peptides/chemistry ; Humans ; Surface Properties ; Biosensing Techniques ; Cell Adhesion/drug effects
    Chemische Substanzen Peptides
    Sprache Englisch
    Erscheinungsdatum 2024-04-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d3cs00921a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Supramolecular Nanofibrous Peptide/Polymer Hydrogels for the Multiplexing of Bioactive Signals.

    Radvar, Elham / Azevedo, Helena S

    ACS biomaterials science & engineering

    2019  Band 5, Heft 9, Seite(n) 4646–4656

    Abstract: The ability to provide multiple functions within a single scaffold biomaterial is a major goal in tissue engineering. Self-assembling peptide-based hydrogels are gaining significant attention as three-dimensional biomaterials because they provide a ... ...

    Abstract The ability to provide multiple functions within a single scaffold biomaterial is a major goal in tissue engineering. Self-assembling peptide-based hydrogels are gaining significant attention as three-dimensional biomaterials because they provide a network of nanofibers similar to the native extracellular matrix while allowing the presentation of multiple biochemical cues for cell signaling. Herein, we combine a positively charged peptide amphiphile (PA) and the negatively charged synthetic polymer poly(sodium 4-styrenesulfonate) (PSS) to fabricate hybrid hydrogels through supramolecular self-assembly. PSS/PA hydrogels show rather high mechanical stiffness while being stable in buffered environment. The sulfonate functionality in PSS promotes hydrogel mineralization which can be controlled if undertaken in standard osteogenic medium. Loading proteins with different charges in the hydrogels reveals their ability to retain and sustain their release and indicates their potential for the controlled delivery of growth factors. Human mesenchymal stem cells encapsulated in PSS/PA hydrogels remain viable. The biomimetic nanofibrous structure of the hydrogels, together with multiplexing of bioactive signals, can provide a suitable environment for stem cell differentiation.
    Sprache Englisch
    Erscheinungsdatum 2019-07-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.9b00941
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Structuring supramolecular hyaluronan hydrogels via peptide self-assembly for modulating the cell microenvironment.

    Yuan, Yichen / Shi, Yejiao / Banerjee, Jayati / Sadeghpour, Amin / Azevedo, Helena S

    Materials today. Bio

    2023  Band 19, Seite(n) 100598

    Abstract: The use of synthetic extracellular matrices (ECMs) in ... ...

    Abstract The use of synthetic extracellular matrices (ECMs) in fundamental
    Sprache Englisch
    Erscheinungsdatum 2023-03-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2590-0064
    ISSN (online) 2590-0064
    DOI 10.1016/j.mtbio.2023.100598
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Correction to 'Crafting of functional biomaterials by directed molecular self-assembly of triple helical peptide building blocks'.

    Banerjee, Jayati / Azevedo, Helena S

    Interface focus

    2018  Band 8, Heft 4, Seite(n) 20180017

    Abstract: This corrects the article DOI: 10.1098/rsfs.2016.0138.]. ...

    Abstract [This corrects the article DOI: 10.1098/rsfs.2016.0138.].
    Sprache Englisch
    Erscheinungsdatum 2018-06-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Published Erratum
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2018.0017
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  7. Artikel ; Online: Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications.

    Radvar, Elham / Azevedo, Helena S

    Macromolecular bioscience

    2018  Band 19, Heft 1, Seite(n) e1800221

    Abstract: Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell ... ...

    Abstract Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses (adhesion, migration, differentiation). However, the use of polymers and peptides as structural components for fabricating supramolecular hydrogels is less well established. Here, the literature on the design of peptide/polymer systems for self-assembly into hybrid hydrogels, as either peptide-polymer conjugates or combining both components individually, is reviewed. The properties (stiffness, mesh structure, responsiveness, and biocompatibility) of the hydrogels are then discussed from the viewpoint of their potential biomedical applications.
    Mesh-Begriff(e) Animals ; Cell Adhesion/drug effects ; Cell Movement/drug effects ; Humans ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Peptides/chemistry ; Peptides/pharmacology
    Chemische Substanzen Hydrogels ; Peptides
    Sprache Englisch
    Erscheinungsdatum 2018-08-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2039130-4
    ISSN 1616-5195 ; 1616-5187
    ISSN (online) 1616-5195
    ISSN 1616-5187
    DOI 10.1002/mabi.201800221
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  8. Artikel: Modeling the Tumor Microenvironment of Ovarian Cancer: The Application of Self-Assembling Biomaterials.

    Mendoza-Martinez, Ana Karen / Loessner, Daniela / Mata, Alvaro / Azevedo, Helena S

    Cancers

    2021  Band 13, Heft 22

    Abstract: Ovarian cancer (OvCa) is one of the leading causes of gynecologic malignancies. Despite treatment with surgery and chemotherapy, OvCa disseminates and recurs frequently, reducing the survival rate for patients. There is an urgent need to develop more ... ...

    Abstract Ovarian cancer (OvCa) is one of the leading causes of gynecologic malignancies. Despite treatment with surgery and chemotherapy, OvCa disseminates and recurs frequently, reducing the survival rate for patients. There is an urgent need to develop more effective treatment options for women diagnosed with OvCa. The tumor microenvironment (TME) is a key driver of disease progression, metastasis and resistance to treatment. For this reason, 3D models have been designed to represent this specific niche and allow more realistic cell behaviors compared to conventional 2D approaches. In particular, self-assembling peptides represent a promising biomaterial platform to study tumor biology. They form nanofiber networks that resemble the architecture of the extracellular matrix and can be designed to display mechanical properties and biochemical motifs representative of the TME. In this review, we highlight the properties and benefits of emerging 3D platforms used to model the ovarian TME. We also outline the challenges associated with using these 3D systems and provide suggestions for future studies and developments. We conclude that our understanding of OvCa and advances in materials science will progress the engineering of novel 3D approaches, which will enable the development of more effective therapies.
    Sprache Englisch
    Erscheinungsdatum 2021-11-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13225745
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Crafting of functional biomaterials by directed molecular self-assembly of triple helical peptide building blocks.

    Banerjee, Jayati / Azevedo, Helena S

    Interface focus

    2017  Band 7, Heft 6, Seite(n) 20160138

    Abstract: Collagen is the most abundant extracellular matrix protein in the body and has widespread use in biomedical research, as well as in clinics. In addition to difficulties in the production of recombinant collagen due to its high non-natural imino acid ... ...

    Abstract Collagen is the most abundant extracellular matrix protein in the body and has widespread use in biomedical research, as well as in clinics. In addition to difficulties in the production of recombinant collagen due to its high non-natural imino acid content, animal-derived collagen imposes several major drawbacks-variability in composition, immunogenicity, pathogenicity and difficulty in sequence modification-that may limit its use in the practical scenario. However, in recent years, scientists have shifted their attention towards developing synthetic collagen-like materials from simple collagen model triple helical peptides to eliminate the potential drawbacks. For this purpose, it is highly desirable to develop programmable self-assembling strategies that will initiate the hierarchical self-assembly of short peptides into large-scale macromolecular assemblies with recommendable bioactivity. Herein, we tried to elaborate our understanding related to the strategies that have been adopted by few research groups to trigger self-assembly in the triple helical peptide system producing fascinating supramolecular structures. We have also touched upon the major epitopes within collagen that can be incorporated into collagen mimetic peptides for promoting bioactivity.
    Sprache Englisch
    Erscheinungsdatum 2017-10-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2016.0138
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion

    Pang, Xinqing / Li, Weiqi / Chang, Lan / Gautrot, Julien E / Wang, Wen / Azevedo, Helena S

    ACS applied materials & interfaces. 2021 May 26, v. 13, no. 22

    2021  

    Abstract: The extracellular matrix (ECM) modulates a multitude of cell functions, and this regulation is provided by key ECM components forming a complex network. Hyaluronic acid (HA) is an abundant component of the ECM that binds to proteins and influences ... ...

    Abstract The extracellular matrix (ECM) modulates a multitude of cell functions, and this regulation is provided by key ECM components forming a complex network. Hyaluronic acid (HA) is an abundant component of the ECM that binds to proteins and influences various activities of endothelial cells (ECs). Although the effect of soluble HA on cell spreading has been studied, the impact of peptide-bound HA has not yet been investigated in great detail. We aim to comprehensively study the roles of immobilized HA on the regulation of EC behavior compared to the more conventional use of soluble HA. A 2D model surface formed by self-assembled monolayers (SAMs) of a HA-binding peptide (Pep-1) is used as an anchor for HA immobilization. Mixed SAMs, consisting of thiolated Pep-1 and 1-octanethiol, are prepared and characterized by using ellipsometry and contact angle measurement. Full density Pep-1 SAMs are more hydrophilic and bind more HA than mixed SAMs. Cell spreading and migration are enhanced by immobilized low molecular weight (LMW) HA, which also facilitates cell alignment and elongation under laminar flow conditions and potentially drives directional migration. This effect is not mediated by the expression of CD44, and immobilized LMW HA is found to accelerate the assembly of focal adhesions. Such biomimetic surfaces provide new insights into the role of HA in regulating the spreading and phenotype of endothelial cells.
    Schlagwörter biomimetics ; contact angle ; endothelial cells ; extracellular matrix ; focal adhesions ; hyaluronic acid ; hydrophilicity ; laminar flow ; molecular weight ; peptides ; phenotype
    Sprache Englisch
    Erscheinungsverlauf 2021-0526
    Umfang p. 25792-25804.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ISSN 1944-8252
    DOI 10.1021/acsami.1c05574
    Datenquelle NAL Katalog (AGRICOLA)

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