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Article ; Online: Exposure to potentially harmful excipients in medications among neonates at a state hospital in Malaysia.

Wong, Shien Woan / Chew, Soo Piing / Abdul Aziz, Siti Azdiah / Mohamed Shah, Noraida

Drug development and industrial pharmacy

2024 , Page(s) 1–9

Abstract: Objectives: This study aimed to determine the incidence, types and predictors of Potentially Harmful Excipients (PHE) exposure among hospitalized neonates.: Methods: A prospective observational study was conducted from March to April 2022 in neonatal ...

Abstract	Objectives: This study aimed to determine the incidence, types and predictors of Potentially Harmful Excipients (PHE) exposure among hospitalized neonates. Methods: A prospective observational study was conducted from March to April 2022 in neonatal wards at a state hospital in Malaysia. The PHEs of interest were aspartame, benzalkonium chloride, benzyl alcohol, benzoic acid or benzoates, ethanol, parabens, polysorbate 80, propylene glycol, saccharin sodium, sorbitol and sulfites. Product information leaflets (PILs) and summaries of product characteristics (SPCs) were referred to obtain information on active pharmaceutical ingredient, strength, trade name as well as type and amount of the excipients. Results: A total of 108 neonates were recruited and 97.2% of them were exposed to at least one PHE. Parabens (47.2%) and sulfites (27.5%) were the two most commonly administered PHEs. Benzyl alcohol is contraindicated in neonates but was administered to 8% of neonates in this study. The median daily dose of ethanol (24.11 mg/kg/day, IQR 19.73, 28.49) exceeded the acceptable daily intake (ADI) by four times. However, the dose was not available for all PHEs as this information is not always available in the PIL or SPC. Administration of cardiovascular drugs was associated with a higher risk of exposure to any PHE (OR 6.38, CI 2.75, 14.79, p-value < 0.001). Conclusion: The exposure of PHE among neonates in this study is high with certain PHEs exceeding the ADI. It highlights the need for certain strategies to be implemented to reduce such exposure in neonates.
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2024.2327462
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Article ; Online: Vitamin D receptor gene polymorphism and serum vitamin D level as risk factors for acquiring Type II diabetes mellitus.

Mohammed, Maryam Salih / Ahmed Jaff, Basima Sadiq / Aziz, Sadat Abdulla

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 12, Page(s) 131–138

Abstract: The studies on the relationship between type 2 diabetes mellitus (T2DM) risk and vitamin D receptor (VDR) gene polymorphisms are still inconclusive. Therefore, the objective of the study was to assess possible risks of acquiring T2DM due to polymorphisms ...

Abstract	The studies on the relationship between type 2 diabetes mellitus (T2DM) risk and vitamin D receptor (VDR) gene polymorphisms are still inconclusive. Therefore, the objective of the study was to assess possible risks of acquiring T2DM due to polymorphisms in the VDR gene or abnormal serum levels of VD. 362 participants (181 T2DM patients and 181 healthy controls) from the Diabetic Center, Sulaimaniyah/Iraq, from December 2020 to May 2021 were volumtarily enrolled in the study. For each participant, HbA1c, fasting blood sugar (FBS), serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), markers of calcium homeostasis, alkaline phosphatase (ALP), phosphorus, VD and insulin were measured. In addition, FokI, TaqI, ApaI, and BsmI genotypes were also performed using Polymerase Chain Reaction (PCR). The results showed that VD level was significantly lower in T2DM compared to the control group. While, HbA1c was significantly higher in T2DM than in the control group. In contrast to AA (P=0.034) and CC (P=0.011) genotype of ApaI (rs7975232) gene polymorphism, which were dominant among the control group, AC-genotype was significantly (P=0.0001) dominat among T2DM group. Meanwhile, TT-genotype of TaqI (rs731236) was significantly (P=0.05) dominant among control group. While there were not any significant differences between other genotypes among T2DM and control groups. In conclusion, low VD-level is a possible risk factor for developing T2DM, and an association was found, especially between ApaI genotypes and T2DM.
MeSH term(s)	Humans ; Case-Control Studies ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Genetic Predisposition to Disease ; Genotype ; Glycated Hemoglobin ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide/genetics ; Receptors, Calcitriol/genetics ; Risk Factors ; Vitamin D/blood ; Vitamin D/chemistry
Chemical Substances	Glycated Hemoglobin ; methyl 4-azidophenylacetimidate (73710-32-4) ; Receptors, Calcitriol ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-11-30
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.12.21
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Article: A Literature Review of Work From Home Phenomenon During COVID-19 Toward Employees' Performance and Quality of Life in Malaysia and Indonesia.

Abiddin, Norhasni Zainal / Ibrahim, Irmohizam / Abdul Aziz, Shahrul Azuwar

Frontiers in psychology

2022 Volume 13, Page(s) 819860

Abstract: The purpose of this paper is to determine the performance of employees employed at home during the COVID-19 pandemic in Malaysia and Indonesia, also to examine the employee's quality of life affected by COVID-19. The current study is aimed to critically ... ...

Abstract	The purpose of this paper is to determine the performance of employees employed at home during the COVID-19 pandemic in Malaysia and Indonesia, also to examine the employee's quality of life affected by COVID-19. The current study is aimed to critically determine the performance of employees employed at home during the COVID-19 pandemic. The author has analyzed and reviewed various sources of articles, reports, and documents from previous research and literature. The findings explain that working from home has provided advantages and disadvantages for both the employees and the organization and is responsible for the decrease in employee productivity. In addition, the findings conclude that the fact that working from home is generally not feasible because many areas of work cannot be done from home, although for many employees, working from home has provided a work-life balance.
Language	English
Publishing date	2022-05-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.819860
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Article: Protective role of Avena fatua against drug-induced liver toxicity.

Ishtiaq, Sania / Qureshi, Shamim Akhtar / Aziz, Syed Abdul

Pakistan journal of pharmaceutical sciences

2022 Volume 35, Issue 4, Page(s) 1023–1030

Abstract: The study was conducted to examine the protective potential of ethanol seed extract (ESEt) of Avena fatua (wild oats) against antituberculosis drug (ATD)-induced hepatotoxicity in rats. Four groups of rats (n=6) were used. Of which, three groups were ... ...

Abstract	The study was conducted to examine the protective potential of ethanol seed extract (ESEt) of Avena fatua (wild oats) against antituberculosis drug (ATD)-induced hepatotoxicity in rats. Four groups of rats (n=6) were used. Of which, three groups were given ATD (Rimstar 900mg/15kg) and divided them into hepatotoxic control (distilled water 1mL/kg), positive control (silymarin 200mg/kg) and test group (ESEt 800mg/kg). The fourth was the normal control group treated only with distilled water (1mL/kg). All treatments were orally administered in their respective groups for 26 days. On the 27thday, rats were decapitated. Body and liver weights were measured whereas serum and liver samples were collected for biochemical and histopathological assessments. The rats treated with silymarin and ESEt showed a significant decrease (p<0.05, 0.01& 0.0001) in liver enzymes including alanine & aspartate transaminases, gamma glutamyltranspeptidase and alkaline phosphatase. ESEt also improved total bilirubin (particularly indirect bilirubin), total protein, albumin and low density lipoprotein cholesterol levels in test group. The hepatoprotective ability of extract was also evident by histological study of liver tissues of the test group that showed normal architecture as compared to liver of ATD treated hepatotoxic control group displayed heterogeneous hepatocytes, inflamed central vein, fatty deposits, enlarged sinusoid, Kupffer's cells infiltration, hypertrophy and fibrosis. In conclusion, ESEt of A.fatua is hepatoprotective in nature which may be due to the presence of total phenols and flavonoids already reported from the seeds of this plant.
MeSH term(s)	Alanine Transaminase ; Animals ; Antioxidants/pharmacology ; Antitubercular Agents/therapeutic use ; Antitubercular Agents/toxicity ; Avena ; Bilirubin ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/prevention & control ; Hepatitis/drug therapy ; Liver/metabolism ; Plant Extracts/therapeutic use ; Rats ; Silymarin/pharmacology ; Water/metabolism
Chemical Substances	Antioxidants ; Antitubercular Agents ; Plant Extracts ; Silymarin ; Water (059QF0KO0R) ; Alanine Transaminase (EC 2.6.1.2) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2022-08-25
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Fire Safety Index for High-Rise Buildings in the Emirate of Sharjah, UAE

Omar, Musab / Mahmoud, Abdelgadir / Aziz, Sa’ardin Bin Abdul

Fire. 2023 Feb. 01, v. 6, no. 2

2023

Abstract: The purpose of this paper was to develop a fire index system for measuring the compliance of high-rise residential buildings with fire requirements in the Emirate of Sharjah, and also to develop an index system for measuring the fire response efficiency, ...

Abstract	The purpose of this paper was to develop a fire index system for measuring the compliance of high-rise residential buildings with fire requirements in the Emirate of Sharjah, and also to develop an index system for measuring the fire response efficiency, which is linked the two indexes, and the higher the compliance rate, the greater chance of a successful response. The two systems depend on the automation of the firefighting system management processes using the techniques of the fourth industrial revolution, and they were developed based on consultation with subject matter experts in the field and used multiple methods, such as the analytic hierarchy process, failure mode effect, criticality analysis, and Delphi techniques. The main criteria of the indexes were identified as the fire risk assessment, fire suppression system, fire accident management, fire alarm system, fire extinguisher, employees, residents, service rooms, lifts, gas connections, waste, housekeeping, and evacuation facilities. Each main criterium was detailed in the sub-criteria and weighted to achieve the index for each sub-criteria based on the fire legislation in UAE, the fire response index (developed based on the high-rise building fire index), the category of the building in terms of floor numbers, and the distance between building and the fire station. The two index systems can contribute to improving emergency preparedness in high-rise residential buildings in the Emirate of Sharjah and are also considered as measurement indexes for compliance with fire requirements in the Emirate of Sharjah.
Keywords	accidents ; automation ; compliance ; disaster preparedness ; fire extinguishers ; fire fighting ; fire safety ; fire suppression ; laws and regulations ; risk assessment ; wastes ; United Arab Emirates
Language	English
Dates of publication	2023-0201
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ISSN	2571-6255
DOI	10.3390/fire6020051
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Critical Factors Affecting Fire Safety in High-Rise Buildings in the Emirate of Sharjah, UAE

Omar, Musab / Mahmoud, Abdelgadir / Abdul Aziz, Sa’ardin Bin

Fire. 2023 Feb. 15, v. 6, no. 2

2023

Abstract: The purpose of this paper is to identify the critical factors affecting fire accidents in high-rise residential buildings in the Emirate of Sharjah in order to find solutions that contribute to reducing injuries and deaths from fire accidents. A large ... ...

Abstract	The purpose of this paper is to identify the critical factors affecting fire accidents in high-rise residential buildings in the Emirate of Sharjah in order to find solutions that contribute to reducing injuries and deaths from fire accidents. A large urban expansion of the Emirate of Sharjah has taken place in the form of high-rise buildings, and the Emirate is now third in the UAE in terms of the number of high-rise buildings and is home to 19% of the population. As a consequence, an increase in the rate of fire accidents has also been observed. As such, there is a need to conduct research on enhancing fire safety in high-rise buildings by conducting a literature review, in which nineteen factors affecting fire globally were identified. Because the fire characteristic is unique in every country, to identify the nature of fire in the Emirate of Sharjah, we consulted sixteen subject matter experts in the field of fire in the Emirate of Sharjah to identify the factors applicable to the Emirate. We used the failure mode, effect, and criticality analysis methodology to accomplish this goal. The outcome of the consultations resulted in the three main factor categories, which are management factors, human factors, and technical factors, and the critical factors affecting the high-rise buildings in the Emirate of Sharjah were identified, which are: fire regulations, fire enforcement regulations, accident investigation, rescue speed, human behavior, lack of proper maintenance, fire training, building design, fire knowledge, combustible materials, fire culture of society, and urbanization. Using the Analytical Hierarchy Process (AHP) tools implemented to measure the effect level of the sub-critical fire factors, 45 effects were identified, and the most common effects were: the building is fully covered by cladding, the effect of stopping activities in HRBs that are non-compliant with fire regulations, the residents practice activities related to fire knowledge, fire regulations efficiency, the training of new employees by their employers, and the residents have fire-related knowledge.
Keywords	accidents ; cladding ; fire safety ; human behavior ; humans ; society ; urbanization ; United Arab Emirates
Language	English
Dates of publication	2023-0215
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ISSN	2571-6255
DOI	10.3390/fire6020068
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Recent Progress of Rice Husk Reinforced Polymer Composites: A Review.

Suhot, Mohamed Azlan / Hassan, Mohamad Zaki / Aziz, Sa'ardin Abdul / Md Daud, Mohd Yusof

Polymers

2021 Volume 13, Issue 15

Abstract: Recently, because of the rising population, carbon overloading, and environmental distress, human beings have needed to increase awareness and responsibility for the reduction of agricultural waste. The utilization of agricultural waste as a filler ... ...

Abstract	Recently, because of the rising population, carbon overloading, and environmental distress, human beings have needed to increase awareness and responsibility for the reduction of agricultural waste. The utilization of agricultural waste as a filler material in reinforced polymers is a fascinating discovery. This review paper attempts to study the physical, mechanical, and thermal behavior of rice husk (RH) as a fiber for reinforcing various synthetic polymers, based on recent studies, conducted between 2017 and 2021. It also highlights that advanced modification techniques could further improve the performance of composites by tailoring the physical and chemical substances of the fiber or matrix. The thermal properties, including flame-retardance and thermal behavior, are also discussed. The characteristics of the fiber-matrix interaction between RH and the polymer matrix provide essential insights into the future-ready applications of this agricultural waste fiber. The way forward in researching RH polymer composites is finally reviewed.
Language	English
Publishing date	2021-07-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym13152391
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Article ; Online: Bamboo-Fiber-Reinforced Thermoset and Thermoplastic Polymer Composites: A Review of Properties, Fabrication, and Potential Applications.

Radzi, A M / Zaki, Sheikh Ahmad / Hassan, Mohamad Zaki / Ilyas, R A / Jamaludin, Khairur Rijal / Daud, Mohd Yusof Md / Aziz, Sa'ardin Abd

Polymers

2022 Volume 14, Issue 7

Abstract: Natural-fiber-reinforced composites, especially bamboo, are an alternative material to compete with conventional materials. Their environmentally friendly, renewable, low-cost, low-density, non-toxic, and fully biodegradable properties are concerning for ...

Abstract	Natural-fiber-reinforced composites, especially bamboo, are an alternative material to compete with conventional materials. Their environmentally friendly, renewable, low-cost, low-density, non-toxic, and fully biodegradable properties are concerning for researchers because of their advantages over synthetic polymers. This comprehensive review presents the results of work on bamboo fiber composites with special reference to bamboo types, thermoplastic and thermoset polymers matrices, hybrid composites, and their applications. In addition, several studies prove that these properties are very good and efficient in various applications. However, in the development of composite technology, bamboo fiber has certain constraints, especially in moisture conditions. Moisture is one of the factors that reduces the potential of bamboo fiber and makes it a critical issue in the manufacturing industry. Therefore, various efforts have been made to ensure that these properties are not affected by moisture by treating the surface fibers using chemical treatments.
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14071387
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Article ; Online: Monoclonal antibody designed for SARS-nCoV-2 spike protein of receptor binding domain on antigenic targeted epitopes for inhibition to prevent viral entry.

Abduljaleel, Zainularifeen / Shahzad, Naiyer / Aziz, Syed A / Malik, Shaheer M

Molecular diversity

2022 Volume 27, Issue 2, Page(s) 695–708

Abstract: SARS, or severe acute respiratory syndrome, is caused by a novel coronavirus (COVID-19). This situation has compelled many pharmaceutical R&D companies and public health research sectors to focus their efforts on developing effective therapeutics. SARS- ... ...

Abstract	SARS, or severe acute respiratory syndrome, is caused by a novel coronavirus (COVID-19). This situation has compelled many pharmaceutical R&D companies and public health research sectors to focus their efforts on developing effective therapeutics. SARS-nCoV-2 was chosen as a protein spike to targeted monoclonal antibodies and therapeutics for prevention and treatment. Deep mutational scanning created a monoclonal antibody to characterize the effects of mutations in a variable antibody fragment based on its expression levels, specificity, stability, and affinity for specific antigenic conserved epitopes to the Spike-S-Receptor Binding Domain (RBD). Improved contacts between Fv light and heavy chains and the targeted antigens of RBD could result in a highly potent neutralizing antibody (NAbs) response as well as cross-protection against other SARS-nCoV-2 strains. It undergoes multipoint core mutations that combine enhancing mutations, resulting in increased binding affinity and significantly increased stability between RBD and antibody. In addition, we improved. Structures of variable fragment (Fv) complexed with the RBD of Spike protein were subjected to our established in-silico antibody-engineering platform to obtain enhanced binding affinity to SARS-nCoV-2 and develop ability profiling. We found that the size and three-dimensional shape of epitopes significantly impacted the activity of antibodies produced against the RBD of Spike protein. Overall, because of the conformational changes between RBD and hACE2, it prevents viral entry. As a result of this in-silico study, the designed antibody can be used as a promising therapeutic strategy to treat COVID-19.
MeSH term(s)	Humans ; COVID-19 ; Epitopes ; Severe acute respiratory syndrome-related coronavirus ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/metabolism ; Virus Internalization ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Antibodies, Viral/pharmacology ; Antibodies, Viral/metabolism ; SARS-CoV-2/metabolism ; Protein Binding
Chemical Substances	Epitopes ; Antibodies, Monoclonal ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral
Language	English
Publishing date	2022-05-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1376507-3
ISSN	1573-501X ; 1381-1991
ISSN (online)	1573-501X
ISSN	1381-1991
DOI	10.1007/s11030-022-10449-x
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Zs.A 4946: Show issues

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Article: Structural Characteristics and Microstructure Analysis of Soft Soil Stabilised with Fine Ground Tile Waste.

Md Isa, Mohd Hafizan / Koting, Suhana / Hashim, Huzaifa / Aziz, Salsabila Ab / Mohammed, Syakirah Afiza

Materials (Basel, Switzerland)

2023 Volume 16, Issue 15

Abstract: Using ceramic tile waste as a soil stabiliser in road construction is a potential solution to dispose of the waste material while providing a cost-effective alternative to traditional stabilising agents. The ceramic tile waste, when crushed and mixed ... ...

Abstract	Using ceramic tile waste as a soil stabiliser in road construction is a potential solution to dispose of the waste material while providing a cost-effective alternative to traditional stabilising agents. The ceramic tile waste, when crushed and mixed with soil, helps to improve the strength and durability of the road base. However, the effectiveness of the ceramic tile waste as a soil stabiliser depends on the type and size of ceramic tiles used and the soil properties being stabilised. This study investigated the effect of ground tile waste on the plasticity, compatibility, and mechanical properties such as the unconfined compressive strength (UCS), indirect tensile test (IDT), flexural test (FS), and microstructural analysis. A range of soil mixtures was prepared by adding the different percentages of fine tile waste (TW): 5% to 40%. Including tile waste in the soil led to a decrease in its water-holding capacity, reducing the optimum moisture content required for optimal compaction. Meanwhile, the maximum dry density increased. The UCS, IDT, and FS improved when the optimum 15% of TW was used in the mixes. However, the strength decreased after 20% of the TW addition. This effect was particularly pronounced in the presence of excessive TW contents in soil samples without a pozzolanic reaction. Reusing tile waste as a soil stabiliser can significantly reduce the costs of purchasing new materials and helps to conserve natural resources and reduce the environmental impact of waste disposal.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16155261
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