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  1. Article ; Online: Editorialist response: Clinical outcomes of asleep vs awake deep brain stimulation for Parkinson disease.

    Aziz, Tipu Z

    Neurology

    2018  Volume 91, Issue 5, Page(s) 240

    MeSH term(s) Deep Brain Stimulation ; Humans ; Neurosurgical Procedures ; Parkinson Disease ; Wakefulness
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000005919
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  2. Article: Neuromodulation for Intractable Pain.

    Green, Alexander L / Aziz, Tipu Z

    Brain sciences

    2020  Volume 10, Issue 5

    Abstract: Over 7% of the Western population suffer from intractable pain and despite pharmacotherapy, [ ... ]. ...

    Abstract Over 7% of the Western population suffer from intractable pain and despite pharmacotherapy, [...].
    Language English
    Publishing date 2020-04-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci10050267
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  3. Article ; Online: Security of implantable medical devices with wireless connections: The dangers of cyber-attacks.

    Pycroft, Laurie / Aziz, Tipu Z

    Expert review of medical devices

    2018  Volume 15, Issue 6, Page(s) 403–406

    MeSH term(s) Computer Security ; Equipment and Supplies ; Humans ; Prostheses and Implants ; Wireless Technology
    Language English
    Publishing date 2018-06-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2018.1483235
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  4. Article: Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson's disease.

    Cury, Rubens Gisbert / Pavese, Nicola / Aziz, Tipu Z / Krauss, Joachim K / Moro, Elena

    NPJ Parkinson's disease

    2022  Volume 8, Issue 1, Page(s) 8

    Abstract: Gait issues in Parkinson's disease (PD) are common and can be highly disabling. Although levodopa and deep brain stimulation (DBS) of the subthalamic nucleus and the globus pallidus internus have been established therapies for addressing the motor ... ...

    Abstract Gait issues in Parkinson's disease (PD) are common and can be highly disabling. Although levodopa and deep brain stimulation (DBS) of the subthalamic nucleus and the globus pallidus internus have been established therapies for addressing the motor symptoms of PD, their effects on gait are less predictable and not well sustained with disease progression. Given the high prevalence of gait impairment in PD and the limitations in currently approved therapies, there has been considerable interest in alternative neuromodulation targets and techniques. These have included DBS of pedunculopontine nucleus and substantia nigra pars reticulata, spinal cord stimulation, non-invasive modulation of cortical regions and, more recently, vagus nerve stimulation. However, successes and failures have also emerged with these approaches. Current gaps and controversies are related to patient selection, optimal electrode placement within the target, placebo effects and the optimal programming parameters. Additionally, recent advances in pathophysiology of oscillation dynamics have driven new models of closed-loop DBS systems that may or may not be applicable to gait issues. Our aim is to describe approaches, especially neuromodulation procedures, and emerging challenges to address PD gait issues beyond subthalamic nucleus and the globus pallidus internus stimulation.
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-021-00276-6
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  5. Article: Deep Brain Stimulation of the Nucleus Accumbens in Severe Enduring Anorexia Nervosa: A Pilot Study.

    Scaife, Jessica C / Eraifej, John / Green, Alexander L / Petric, Beth / Aziz, Tipu Z / Park, Rebecca J

    Frontiers in behavioral neuroscience

    2022  Volume 16, Page(s) 842184

    Abstract: Introduction: Anorexia nervosa (AN) is one of the most debilitating psychiatric disorders, becoming severe and enduring in a third of cases; with few effective treatments. Deep brain stimulation is a reversible, adjustable neurosurgical procedure that ... ...

    Abstract Introduction: Anorexia nervosa (AN) is one of the most debilitating psychiatric disorders, becoming severe and enduring in a third of cases; with few effective treatments. Deep brain stimulation is a reversible, adjustable neurosurgical procedure that has been gaining ground in psychiatry as a treatment for depression and obsessive-compulsive disorder, yet few studies have investigated AN. Abnormal eating behavior and the compulsive pursuit of thinness in AN is, in part, a consequence of dysfunction in reward circuitry and the nucleus accumbens (NAcc) is central to reward processing.
    Methods: Phase 1 prospective open-label pilot study of seven individuals with severe enduring AN. Electrodes were implanted bilaterally into the NAcc with stimulation at the anterior limb of the internal capsule using rechargeable implantable pulse generators. The protocol of 15 months included 12 months of deep brain stimulation incorporating two consecutive, randomized blind on-off fortnights 9 months after stimulation onset. The primary objectives were to investigate safety and feasibility, together with changes in eating disorder psychopathology.
    Results: Feasibility and safety was demonstrated with no serious adverse events due to deep brain stimulation. Three patients responded to treatment [defined as > 35% reduction in Eating Disorders Examination (EDE) score at 12 months] and four patients were non-responders. Responders had a statistically significant mean reduction in EDE scores (50.3% reduction; 95% CI 2.6-98.2%), Clinical Impairment Assessment (45.6% reduction; 95% CI 7.4-83.7%). Responders also had a statistically significant mean reduction in Hamilton Depression Scale, Hamilton Anxiety Scale and Snaith-Hamilton pleasure scale. There were no statistically significant changes in Body Mass Index, Yale-Brown-Cornell Eating Disorder Scale, Yale-Brown Obsessive-Compulsive Scale and World Health Organization Quality of Life Psychological subscale.
    Conclusion: This study provides some preliminary indication that deep brain stimulation to the NAcc. Might potentially improve some key features of enduring AN. In this small study, the three responders had comorbid obsessive-compulsive disorder which predated AN diagnosis. Future studies should aim to further elucidate predictors of outcome.
    Clinical trial registration: [www.ClinicalTrials.gov], identifier [Project ID 128658].
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2022.842184
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  6. Article ; Online: Neural oscillatory characteristics of feedback-associated activity in globus pallidus interna.

    Choubdar, Hadi / Mahdavi, Mahdi / Rostami, Zahra / Zabeh, Erfan / Gillies, Martin J / Green, Alexander L / Aziz, Tipu Z / Lashgari, Reza

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 4141

    Abstract: Neural oscillatory activities in basal ganglia have prominent roles in cognitive processes. However, the characteristics of oscillatory activities during cognitive tasks have not been extensively explored in human Globus Pallidus internus (GPi). This ... ...

    Abstract Neural oscillatory activities in basal ganglia have prominent roles in cognitive processes. However, the characteristics of oscillatory activities during cognitive tasks have not been extensively explored in human Globus Pallidus internus (GPi). This study aimed to compare oscillatory characteristics of GPi between dystonia and Parkinson's Disease (PD). A dystonia and a PD patient performed the Intra-Extra-Dimension shift (IED) task during both on and off-medication states. During the IED task, patients had to correctly choose between two visual stimuli containing shapes or lines based on a hidden rule via trial and error. Immediate auditory and visual feedback was provided upon the choice to inform participants if they chose correctly. Bilateral GPi Local Field Potentials (LFP) activity was recorded via externalized DBS leads. Transient high gamma activity (~ 100-150 Hz) was observed immediately after feedback in the dystonia patient. Moreover, these bursts were phase synchronous between left and right GPi with an antiphase clustering of phase differences. In contrast, no synchronous high gamma activity was detected in the PD patient with or without dopamine administration. The off-med PD patient also displayed enhanced low frequency clusters, which were ameliorated by medication. The current study provides a rare report of antiphase homotopic synchrony in human GPi, potentially related to incorporating and processing feedback information. The absence of these activities in off and on-med PD patient indicates the potential presence of impaired medication independent feedback processing circuits. Together, these findings suggest a potential role for GPi's synchronized activity in shaping feedback processing mechanisms required in cognitive tasks.
    MeSH term(s) Humans ; Globus Pallidus ; Dystonia/therapy ; Feedback ; Deep Brain Stimulation/methods ; Parkinson Disease/drug therapy ; Dystonic Disorders/therapy
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-30832-4
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  7. Article ; Online: To sleep or not to sleep during deep brain stimulation surgery for Parkinson disease?

    Aziz, Tipu Z / Hariz, Marwan

    Neurology

    2017  Volume 89, Issue 19, Page(s) 1938–1939

    MeSH term(s) Deep Brain Stimulation ; Humans ; Parkinson Disease ; Sleep ; Subthalamic Nucleus ; Wakefulness
    Language English
    Publishing date 2017-10-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000004635
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  8. Article ; Online: Tinnitus and the neurosurgeon.

    Aziz, Tipu Z

    World neurosurgery

    2012  Volume 77, Issue 5-6, Page(s) 650

    MeSH term(s) Electrodes, Implanted ; Humans ; Male ; Prefrontal Cortex/physiology ; Tinnitus/therapy ; Transcranial Magnetic Stimulation/methods
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2011.10.020
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  9. Article ; Online: Sensory thalamus and periaqueductal grey area local field potential signals during bladder filling.

    Roy, Holly A / Aziz, Tipu Z / Green, Alexander L

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2019  Volume 68, Page(s) 342–343

    Abstract: The periaqueductal grey area and sensory thalamus are thought to be important nuclei involved in the supraspinal bladder control network. Deep brain stimulation of the periqueductal grey area has been shown to increase bladder capacity in the human. In a ...

    Abstract The periaqueductal grey area and sensory thalamus are thought to be important nuclei involved in the supraspinal bladder control network. Deep brain stimulation of the periqueductal grey area has been shown to increase bladder capacity in the human. In a single patient, we have recorded local field potential signals from implanted deep brain stimulation electrodes within the sensory thalamus during filling cystometry with periaqueductal grey area deep brain stimulation in the ON and OFF states. In the OFF stimulation state, we demonstrate correlations between bladder volume and oscillations in the high gamma frequency band in the sensory thalamus. Stimulation of the periaqueductal grey area abolishes this correlated activity in the gamma frequency band and also suppresses oscillations within the sensory thalamus in the alpha frequency band. These findings support the involvement of the sensory thalamus in the afferent limb of bladder-related brain networks. They also suggest that periaqueductal grey area deep brain stimulation may disrupt the normal processing of afferent signals within the sensory thalamus which may be related to the effect of stimulation on bladder capacity.
    MeSH term(s) Deep Brain Stimulation ; Humans ; Male ; Middle Aged ; Periaqueductal Gray/physiology ; Phantom Limb/therapy ; Thalamus/physiology ; Urinary Bladder/innervation ; Urinary Bladder/physiology
    Language English
    Publishing date 2019-07-19
    Publishing country Scotland
    Document type Case Reports ; Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2019.07.037
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  10. Article ; Online: Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients.

    Luo, Huichun / Huang, Yongzhi / Green, Alexander L / Aziz, Tipu Z / Xiao, Xiao / Wang, Shouyan

    NeuroImage. Clinical

    2021  Volume 32, Page(s) 102876

    Abstract: The periventricular/periaqueductal gray (PAG/PVG) is critical for pain perception and is associated with the emotional feelings caused by pain. However, the electrophysiological characteristics of the PAG/PVG have been little investigated in humans with ... ...

    Abstract The periventricular/periaqueductal gray (PAG/PVG) is critical for pain perception and is associated with the emotional feelings caused by pain. However, the electrophysiological characteristics of the PAG/PVG have been little investigated in humans with chronic pain. The present study analyzed the oscillatory characteristics of local field potentials (LFPs) in the PAG/PVG of eighteen neuropathic pain patients. Power spectrum analysis and neural state analysis were applied to the PAG/PVG LFPs. Neural state analysis is based on a dynamic neural state identification approach and discriminates the LFPs into different neural states, including a single neural state based on one oscillation and a combinational neural state based on two paired oscillations. The durations and occurrence rates were used to quantify the dynamic features of the neural state. The results show that the combined neural state forms three local networks based on neural oscillations that are responsible for the perceptive, sensory, and affective components of pain. The first network is formed by the interaction of the delta oscillation with other oscillations and is responsible for the coding of pain perception. The second network is responsible for the coding of sensory pain information, uses high gamma as the main node, and is widely connected with other neural oscillations. The third network is responsible for the coding of affective pain information, and beta oscillations play an important role in it. This study suggested that the combination of two neural oscillations in the PAG/PVG is essential for encoding perceptive, sensory, and affective measures of pain.
    MeSH term(s) Humans ; Neuralgia ; Pain Perception ; Periaqueductal Gray
    Language English
    Publishing date 2021-11-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2021.102876
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