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  1. Article: Aagab is required for zebrafish larval development by regulating neural activity.

    Ding, Shihui / Aziz, Tursunjan / Meng, Anming / Jia, Shunji

    Journal of genetics and genomics = Yi chuan xue bao

    2024  

    Abstract: Clathrin-mediated endocytosis has been implicated in various physiological processes, including nutrient uptake, signal transduction, synaptic vesicle recycling, maintenance of cell polarity, and antigen presentation. Despite prior knowledge of its ... ...

    Abstract Clathrin-mediated endocytosis has been implicated in various physiological processes, including nutrient uptake, signal transduction, synaptic vesicle recycling, maintenance of cell polarity, and antigen presentation. Despite prior knowledge of its importance as a key regulator in promoting clathrin-mediated endocytosis, the physiological function of α- and γ-adaptin binding protein (aagab) remains elusive. In this study, we investigate the biological function of aagab during zebrafish development. We establish a loss-of-function mutant of the aagab gene in zebrafish, revealing impaired swimming and early larval mortality. Given the high expression level of the aagab gene in the brain, we probe into its physiological role in the nervous system. aagab mutants display subdued calcium responses and local field potential in the optic tectal neurons, aligning with reduced neurotransmitter release (e.g., norepinephrine) in the tectal neuropil of aagab mutants. Overexpressing aagab message RNA (mRNA) or nervous stimulant treatment in mutants restores neurotransmitter release, calcium responses, swimming ability, and survival. Furthermore, our observations show delayed release of FM 1-43 in AAGAB knockdown differentiated neuroblastoma cells, pointing towards a probable link to defective clathrin-mediated synaptic vesicle recycling. In conclusion, our study underscores the significance of Aagab in neurobiology and suggests its potential impacts in neurological disorders.
    Language English
    Publishing date 2024-01-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 2374568-X
    ISSN 1873-5533 ; 1673-8527
    ISSN (online) 1873-5533
    ISSN 1673-8527
    DOI 10.1016/j.jgg.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CAT, AGTR2, L-SIGN and DC-SIGN are potential receptors for the entry of SARS-CoV-2 into human cells

    Guo, Dongjie / Guo, Ruifang / Li, Zhaoyang / Zhang, Yuyang / Zheng, Wei / Huang, Xiaoqiang / Aziz, Tursunjan / Zhang, Yang / Liu, Lijun

    bioRxiv

    Abstract: Since December 2019, the COVID-19 caused by SARS-CoV-2 has been widely spread all over the world. It is reported that SARS-CoV-2 infection affects a series of human tissues, including lung, gastrointestinal tract, kidney, etc. ACE2 has been identified as ...

    Abstract Since December 2019, the COVID-19 caused by SARS-CoV-2 has been widely spread all over the world. It is reported that SARS-CoV-2 infection affects a series of human tissues, including lung, gastrointestinal tract, kidney, etc. ACE2 has been identified as the primary receptor of the SARS-CoV-2 Spike (S) protein. The relatively low expression level of this known receptor in the lungs, which is the predominantly infected organ in COVID-19, indicates that there may be some other co-receptors or alternative receptors of SARS-CoV-2 to work in coordination with ACE2. Here, we identified twenty-one candidate receptors of SARS-CoV-2, including ACE2-interactor proteins and SARS-CoV receptors. Then we investigated the protein expression levels of these twenty-one candidate receptors in different human tissues and found that five of which CAT, MME, L-SIGN, DC-SIGN, and AGTR2 were specifically expressed in SARS-CoV-2 affected tissues. Next, we performed molecular simulations of the above five candidate receptors with SARS-CoV-2 S protein, and found that the binding affinities of CAT, AGTR2, L-SIGN and DC-SIGN to S protein were even higher than ACE2. Interestingly, we also observed that CAT and AGTR2 bound to S protein in different regions with ACE2 conformationally, suggesting that these two proteins are likely capable of the co-receptors of ACE2. Conclusively, we considered that CAT, AGTR2, L-SIGN and DC-SIGN were the potential receptors of SARS-CoV-2. Moreover, AGTR2 and DC-SIGN tend to be highly expressed in the lungs of smokers, which is consistent with clinical phenomena of COVID-19, and further confirmed our conclusion. Besides, we also predicted the binding hot spots for these putative protein-protein interactions, which would help develop drugs against SARS-CoV-2.
    Keywords covid19
    Language English
    Publishing date 2021-07-07
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2021.07.07.451411
    Database COVID19

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  3. Article ; Online: The m

    Weng, Hengyou / Huang, Feng / Yu, Zhaojin / Chen, Zhenhua / Prince, Emily / Kang, Yalin / Zhou, Keren / Li, Wei / Hu, Jiacheng / Fu, Chen / Aziz, Tursunjan / Li, Hongzhi / Li, Jingwen / Yang, Ying / Han, Li / Zhang, Subo / Ma, Yuelong / Sun, Mingli / Wu, Huizhe /
    Zhang, Zheng / Wunderlich, Mark / Robinson, Sean / Braas, Daniel / Hoeve, Johanna Ten / Zhang, Bin / Marcucci, Guido / Mulloy, James C / Zhou, Keda / Tao, Hong-Fang / Deng, Xiaolan / Horne, David / Wei, Minjie / Huang, Huilin / Chen, Jianjun

    Cancer cell

    2022  Volume 40, Issue 12, Page(s) 1566–1582.e10

    Abstract: ... ...

    Abstract N
    MeSH term(s) Humans ; Glutamine/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; RNA Stability ; Prognosis ; Minor Histocompatibility Antigens ; Amino Acid Transport System ASC/genetics ; Amino Acid Transport System ASC/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances Glutamine (0RH81L854J) ; SLC1A5 protein, human ; Minor Histocompatibility Antigens ; Amino Acid Transport System ASC ; IGF2BP2 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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