LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 199

Search options

  1. Article ; Online: Immunopathogenesis of multiple sclerosis: molecular and cellular mechanisms and new immunotherapeutic approaches.

    Aliyu, Mansur / Zohora, Fatema Tuz / Ceylan, Ayca / Hossain, Fariha / Yazdani, Reza / Azizi, Gholamreza

    Immunopharmacology and immunotoxicology

    2024  , Page(s) 1–23

    Abstract: Background:: Methods:: Results:: Conclusion: ...

    Abstract Background:
    Methods:
    Results:
    Conclusion:
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 807033-7
    ISSN 1532-2513 ; 0892-3973
    ISSN (online) 1532-2513
    ISSN 0892-3973
    DOI 10.1080/08923973.2024.2330642
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A systematic review regarding the prevalence of malignancy in patients with the hyper-IgE syndrome.

    Mohammadi, Tayebeh / Azizi, Gholamreza / Rafiemanesh, Hosein / Farahani, Pouria / Nirouei, Matineh / Tavakol, Marzieh

    Clinical and experimental medicine

    2023  Volume 23, Issue 8, Page(s) 4835–4859

    Abstract: The hyper-immunoglobulin E syndrome (HIES) is a primary immunodeficiency disease originally described as Job syndrome. The fundamental causative variant of the HIES is an autosomal dominant mutation in the signal transducer and activator of transcription ...

    Abstract The hyper-immunoglobulin E syndrome (HIES) is a primary immunodeficiency disease originally described as Job syndrome. The fundamental causative variant of the HIES is an autosomal dominant mutation in the signal transducer and activator of transcription 3 (STAT3) gene. It is characterized by recurrent staphylococcal cold skin abscess, sinopulmonary infection, eczema, head and face anomalies, frequent bone fractures, eosinophilia and extremely high serum IgE levels (IgE ≥ 2000 IU/mL). However, multiple other genetic defects are also known as HIES-like disorders. Apart from infectious manifestations, STAT3, DOCK8 and TYK2 gene mutations are associated with various malignancies. The most common malignancies reported in these patients are lymphomas, including Hodgkin's and non-Hodgkin's lymphomas (NHL) of B and T cells. This systematic review aimed to investigate the prevalence of malignancies in HIES and the factors associated with malignancy in these patients. In this survey, all articles published until April 1st, 2023, in Scopus, PubMed and Web of Science databases based on three groups of keywords related to HIES syndrome and malignancy were reviewed by three different researchers. Finally, 26 articles were evaluated from which 24 papers were meta-analyzed. In the current study, the demographic information of 1133 patients with HIES, which was mentioned in 24 articles enrolled in the project, was collected, and the information related to patients who had malignancy was analyzed and meta-analyzed. A total of 96 patients out of 1133 studied patients had at least one type of malignancy, the overall prevalence of malignancies reported in the articles was 6.5% (95% confidence interval 4.1-9%), and the total prevalence of malignancy in patients with NHL type and patients with squamous cell carcinoma (SCC) was 2.9% (95% confidence interval 1.7-4.4%) and 2.2% (95% confidence interval 0.3-4.1%), respectively. The results of this study indicated that in 6.5% of cases, HIES was complicated with malignancy, and considering the higher rate of these malignancies in women as well as in DOCK8 mutation sufferers, it is necessary for physicians to be aware of this association and includes malignancy screening in follow-up and periodic examinations of these patients. Indeed, more studies in this field will help to clarify the precise figures and predisposing factors of the relationship between HIES and malignancy.
    MeSH term(s) Humans ; Female ; Job Syndrome/complications ; Job Syndrome/epidemiology ; Job Syndrome/genetics ; Prevalence ; Neoplasms ; Immunoglobulin E/genetics ; Lymphoma ; Mutation ; Guanine Nucleotide Exchange Factors/genetics
    Chemical Substances Immunoglobulin E (37341-29-0) ; DOCK8 protein, human ; Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2023-11-04
    Publishing country Italy
    Document type Systematic Review ; Journal Article
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01228-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Investigating the Effect of Plant Density and Nutrient Application on Yield and Physiological Characteristics of Guar (Cyamopsis tetragonoloba)

    Azizi, Gholamreza / Moosavi, Seyyed Gholamreza / Seghatoleslami, Mohammadjavad / Baradaran, Reza

    Gesunde Pflanzen. 2022 Dec., v. 74, no. 4 p.791-800

    2022  

    Abstract: Guar is a drought- and salt-tolerant annual summer legume which could be a potential alternative crop in semiarid regions. The increased use of guar gum in oil industries has increased the global demand for guar. An experiment was carried out during 2 ... ...

    Abstract Guar is a drought- and salt-tolerant annual summer legume which could be a potential alternative crop in semiarid regions. The increased use of guar gum in oil industries has increased the global demand for guar. An experiment was carried out during 2 consecutive years to investigate the effect of plant density and nutrient application on yield and physiological characteristics of guar. A factorial experiment based on randomized complete block design with three replications was conducted during the 2017 and 2018 growing seasons. Studied factors included phosphorous (P1: 0, P2: 75 kg/ha, P3: 150 kg/ha, P4: 225 kg/ha) and folic acid application (F1: 0, F2: 4 kg/ha, F3: 8 kg/ha, F4: 12 kg/ha) and plant density (D1: 10 plants/m² and D2: 20 plants/m²). Seed yield components, biological yield, protein value of seeds, leaf relative water content (RWC), guar percentage, and phosphorous-use efficiency (PUE) were measured. The highest biological yield (19058 kg/ha) and the highest seed yield (6129 kg/ha) were produced by the D1P4F4 and D2P4F4 treatments, respectively. Low plant density resulted in high biological yield, while high plant density resulted in high seed yield. The highest protein content (32.5%) was observed in D2P4F4. The highest RWC and gum percentage were produced in D2P4 and D2F4 treatments, respectively. An increase in P₂O₅ application rates up to 225 kg/ha significantly increased seed yield. The highest PUE (1.41 g/kg) was observed at a high plant density. Applying 225 kg/ha phosphorous fertilizer resulted in the highest PUE (1.5 g/kg). Therefore, increasing the application of phosphorous and folic acid could increase the yield and yield components of guar; a plant density of 20 plants/m² could also increase the biological yield. The results of this study may also help to extend guar cultivation in other regions.
    Keywords Cyamopsis tetragonoloba ; alternative crops ; fertilizers ; folic acid ; guar gum ; leaf relative water content ; legumes ; oils ; phosphorus ; plant density ; protein content ; protein value ; salt tolerance ; seed yield ; summer
    Language English
    Dates of publication 2022-12
    Size p. 791-800.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 820036-1
    ISSN 1439-0345 ; 0367-4223
    ISSN (online) 1439-0345
    ISSN 0367-4223
    DOI 10.1007/s10343-022-00745-9
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 1149: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Novel mutation of SLC37A4 in a glycogen storage disease type Ib patient with neutropenia, horseshoe kidney, and arteriovenous malformation: a case report.

    Meimand, Sepideh Ebrahimi / Azizi, Gholamreza / Yazdani, Reza / Sanadgol, Negin / Rezaei, Nima

    Immunologic research

    2022  Volume 71, Issue 1, Page(s) 107–111

    Abstract: Glycogen storage disease type Ib (GSDIb) is an autosomal recessive disorder caused by mutations of SLC37A4 gene, which encodes glucose 6-phosphate translocase (G6PT). Malfunction of G6PT leads to excessive fat and glycogen in liver, kidney, and ... ...

    Abstract Glycogen storage disease type Ib (GSDIb) is an autosomal recessive disorder caused by mutations of SLC37A4 gene, which encodes glucose 6-phosphate translocase (G6PT). Malfunction of G6PT leads to excessive fat and glycogen in liver, kidney, and intestinal mucosa. The clinical manifestations of GSD1b include hepatomegaly, renomegaly, neutropenia, hypoglycemia, and lactic acidosis. Furthermore, the disorder may result in severe complications in long-term including inflammatory bowel disease (IBD), hepatocellular adenomas (HCA), short stature, and autoimmune disorders, which stem from neutropenia and neutrophil dysfunction. Here, we represent a novel mutation of SLC37A4 in a 5-month girl who has a history of hospitalizations several times due to recurrent infection and her early presentations were failure to thrive and tachypnea. Further investigations revealed mild atrial septal defect, mild arteriovenous malformation from left lung, esophageal reflux, Horseshoe kidney, and urinary reflux in this patient. Moreover, the lab tests showed neutropenia, immunoglobulin (Ig) G and IgA deficiency, as well as thrombocytosis. Whole exome sequencing revealed c.1245G > A P.W415 homozygous mutation in SLC37A4 gene and c.580G > A p.V1941 heterozygous mutation in PIK3CD gene. This study shows that manifestations of GSD1b may not be limited to what was previously known and it should be considered in a wider range of patients.
    MeSH term(s) Female ; Humans ; Antiporters/genetics ; Arteriovenous Malformations/complications ; Fused Kidney/complications ; Glycogen Storage Disease Type I/genetics ; Glycogen Storage Disease Type I/complications ; Monosaccharide Transport Proteins/genetics ; Mutation/genetics ; Neutropenia/genetics ; Infant
    Chemical Substances Antiporters ; Monosaccharide Transport Proteins ; SLC37A4 protein, human
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-022-09320-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: The role of immune regulatory molecules in rheumatoid arthritis: Implication for etiopathogenesis and prospective for treatment.

    Hemmatzadeh, Maryam / Ahangar Parvin, Elham / Mohammadi, Hamed / Azizi, Gholamreza / Shomali, Navid / Jadidi-Niaragh, Farhad

    Journal of cellular physiology

    2022  Volume 237, Issue 9, Page(s) 3541–3553

    Abstract: Rheumatoid arthritis (RA) is considered an autoimmune chronic disorder and the most common inflammatory arthropathy. Disease progression in RA begins with asymptomatic autoimmune responses in cases with a genetic or environmental predisposition, that ... ...

    Abstract Rheumatoid arthritis (RA) is considered an autoimmune chronic disorder and the most common inflammatory arthropathy. Disease progression in RA begins with asymptomatic autoimmune responses in cases with a genetic or environmental predisposition, that alters to arthralgia phase as autoantibodies reach the joints and subjects begin demonstrating nonspecific musculoskeletal presentations lacking any clinical symptoms of synovial inflammation. After that, patients' symptoms develop to undifferentiated arthritis (UA)/idiopathic arthritis (IA) whenever the subjects progress to clinical synovitis systemic comorbidities affecting the vasculature, metabolism, and bone, and eventually with augmented immune cell infiltration, IA/UA patients progress to clinically classifiable RA. RA is mainly correlated with different immune cells and each of them contributes variously to the pathogenesis of the disease. The pathogenesis of RA is altered by the contribution of both T and B cells in an autoimmune irregularity. Modulation of the immune responses occurs through regulatory and inhibitory molecules that control activation of the adaptive system as well as immune hemostasis. To confine the exorbitant T cell-associated inflammatory reactions, the immune system provides a system of inhibitory feedbacks, collectively named immune checkpoints. In this review, we aimed to discuss about inhibitory members of immune checkpoint molecules, including programmed cell death 1 (PD-1)/PD-L1, cytotoxic-T-lymphocyte-antigen-4, lymphocyte activation gene-3, T cell immunoglobulin-3, V-domain Ig suppressor of T cell activation, B- and T-lymphocyte attenuator, and T cell immunoglobulin and ITIM domain and their role in RA.
    MeSH term(s) Arthritis, Rheumatoid ; Autoantibodies ; Humans ; Immune Checkpoint Proteins ; Prospective Studies ; Synovial Membrane/immunology ; Synovial Membrane/metabolism ; Synovitis/immunology ; Synovitis/pathology
    Chemical Substances Autoantibodies ; Immune Checkpoint Proteins
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30855
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Stem Cell-based and Advanced Therapeutic Modalities for Parkinson's Disease: A Risk-effectiveness Patient-centered Analysis.

    Salahi, Sarvenaz / Mousavi, Maryam Alsadat / Azizi, Gholamreza / Hossein-Khannazer, Nikoo / Vosough, Massoud

    Current neuropharmacology

    2022  Volume 20, Issue 12, Page(s) 2320–2345

    Abstract: Treatment of Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is currently considered a challenging issue since it causes substantial disability, poor quality of life, and mortality. Despite remarkable progress in advanced ... ...

    Abstract Treatment of Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is currently considered a challenging issue since it causes substantial disability, poor quality of life, and mortality. Despite remarkable progress in advanced conventional therapeutic interventions, the global burden of the disease has nearly doubled, prompting us to assess the riskeffectiveness of different treatment modalities. Each protocol could be considered as the best alternative treatment depending on the patient's situation. Prescription of levodopa, the most effective available medicine for this disorder, has been associated with many complications, i.e., multiple episodes of "off-time" and treatment resistance. Other medications, which are typically used in combination with levodopa, may have several adverse effects as well. As a result, the therapies that are more in line with human physiology and make the least interference with other pathways are worth investigating. On the other hand, remaining and persistent symptoms after therapy and the lack of effective response to the conventional approaches have raised expectations towards innovative alternative approaches, such as stem cell-based therapy. It is critical to not overlook the unexplored side effects of innovative approaches due to the limited number of research. In this review, we aimed to compare the efficacy and risk of advanced therapies with innovative cell-based and stemcell- based modalities in PD patients. This paper recapitulated the underlying factors/conditions, which could lead us to more practical and established therapeutic outcomes with more advantages and few complications. It could be an initial step to reconsider the therapeutic blueprint for patients with Parkinson's disease.
    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Levodopa/therapeutic use ; Antiparkinson Agents/therapeutic use ; Quality of Life ; Patient-Centered Care
    Chemical Substances Levodopa (46627O600J) ; Antiparkinson Agents
    Language English
    Publishing date 2022-02-01
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X20666220201100238
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Acute pericarditis: A peculiar manifestation of common variable immune deficiency.

    Ramzi, Nasim / Yazdani, Shahrooz / Talakoob, Hamed / Jamee, Mahnaz / Karim, Hossein / Azizi, Gholamreza

    Allergologia et immunopathologia

    2021  Volume 49, Issue 3, Page(s) 115–119

    Abstract: Common variable immune deficiency (CVID) is known as the most prevalent symptomatic inborn error of immunity associated with autoimmune and inflammatory complications in addition to recurrent infections. In this study, we investigated the prevalence of ... ...

    Abstract Common variable immune deficiency (CVID) is known as the most prevalent symptomatic inborn error of immunity associated with autoimmune and inflammatory complications in addition to recurrent infections. In this study, we investigated the prevalence of acute pericarditis as a complication in the past medical history of 337 CVID patients. We found five patients (1.5%) that had experienced acute pericarditis, and described the medical history of three patients.
    MeSH term(s) Acute Disease ; Adult ; Child ; Child, Preschool ; Common Variable Immunodeficiency/complications ; Fatal Outcome ; Female ; Humans ; Iran/epidemiology ; Pericardial Effusion/diagnostic imaging ; Pericarditis/epidemiology ; Pericarditis/etiology ; Pneumonia/etiology ; Prevalence ; Retrospective Studies
    Language English
    Publishing date 2021-05-01
    Publishing country Singapore
    Document type Case Reports ; Journal Article
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v49i3.99
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1165: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Salivary Cytokines as Potential Diagnostic Biomarkers for Systemic Lupus Erythematosus Disease.

    Zian, Zeineb / Bouhoudan, Assia / Mourabit, Nadira / Azizi, Gholamreza / Bennani Mechita, Mohcine

    Mediators of inflammation

    2021  Volume 2021, Page(s) 8847557

    Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune inflammatory disease characterized by an unknown etiology and a highly variable clinical presentation. This clinical heterogeneity might be explained by dysregulation of tolerance to self and ... ...

    Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune inflammatory disease characterized by an unknown etiology and a highly variable clinical presentation. This clinical heterogeneity might be explained by dysregulation of tolerance to self and apoptotic mechanisms, overproduction of autoantibodies, and abnormal cytokine levels. Cytokine imbalance levels have been associated with disease activity and severity in SLE patients. In the last years, salivary cytokines related to SLE have gained significant attention and researchers have begun to focus on the identification of cytokines in the saliva of SLE patients using it as a diagnostic fluid for the inflammatory process underlying SLE. This review highlights and summarizes recent studies revealing the cytokines that have been identified in the saliva of individuals with SLE. Data reported and discussed in this report may provide useful additional information to better understand the mechanisms associated with the disease.
    MeSH term(s) Biomarkers/analysis ; Cytokines/analysis ; Female ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/metabolism ; Male ; Saliva/chemistry
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2021/8847557
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3575: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment.

    Ihim, Stella Amarachi / Abubakar, Sharafudeen Dahiru / Zian, Zeineb / Sasaki, Takanori / Saffarioun, Mohammad / Maleknia, Shayan / Azizi, Gholamreza

    Frontiers in immunology

    2022  Volume 13, Page(s) 919973

    Abstract: Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, ... ...

    Abstract Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell. IL-18 could potentially induce inflammatory and cytotoxic immune cell activities leading to autoimmunity. Its elevated levels have been reported in the blood of patients with some immune-related diseases, including rheumatoid arthritis, systemic lupus erythematosus, type I diabetes mellitus, atopic dermatitis, psoriasis, and inflammatory bowel disease. In the present review, we aimed to summarize the biological properties of IL-18 and its pathological role in different autoimmune diseases. We also reported some monoclonal antibodies and drugs targeting IL-18. Most of these monoclonal antibodies and drugs have only produced partial effectiveness or complete ineffectiveness
    MeSH term(s) Antibodies, Monoclonal ; Autoimmune Diseases/immunology ; Cytokines ; Humans ; Immunity ; Inflammation/immunology ; Interleukin-18/immunology
    Chemical Substances Antibodies, Monoclonal ; Cytokines ; Interleukin-18
    Language English
    Publishing date 2022-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.919973
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The role of TNF-α and anti-TNF-α agents in the immunopathogenesis and management of immune dysregulation in primary immunodeficiency diseases.

    Abubakar, Sharafudeen Dahiru / Ihim, Stella Amarachi / Farshchi, Amir / Maleknia, Shayan / Abdullahi, Hamisu / Sasaki, Takanori / Azizi, Gholamreza

    Immunopharmacology and immunotoxicology

    2022  Volume 44, Issue 2, Page(s) 147–156

    Abstract: Primary immunodeficiency diseases (PIDs) consist of a heterogeneous group of genetically disorders that affect distinct components of the immune system. They manifest as increased susceptibility to life-threatening infections, as well as autoimmunity and ...

    Abstract Primary immunodeficiency diseases (PIDs) consist of a heterogeneous group of genetically disorders that affect distinct components of the immune system. They manifest as increased susceptibility to life-threatening infections, as well as autoimmunity and inflammatory disease. Among them, patients with diseases of immune dysregulation and autoinflammatory disorders are more complicated with autoimmunity. On the other hand, tumor necrosis factor alpha (TNF-α) is one of the major players in the pathogenesis of autoimmunity and inflammation in PID patients. Monoclonal antibodies (mAbs) targeting TNF-α would be a potential approach as a therapeutic tool for these diseases. In the current review, we aimed to highlight the characteristics of TNF-α and its important role in the pathogenesis of related complication in PID diseases. Critical evaluation of the mAbs targeting TNF-α (e.g. infliximab, etanercept, and adalimumab) in various immune-mediated complications in PID diseases will be provided, and finally, their clinical efficacy and safety will be reported.
    MeSH term(s) Adalimumab/therapeutic use ; Humans ; Infliximab/therapeutic use ; Primary Immunodeficiency Diseases ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Tumor Necrosis Factor-alpha
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 807033-7
    ISSN 1532-2513 ; 0892-3973
    ISSN (online) 1532-2513
    ISSN 0892-3973
    DOI 10.1080/08923973.2021.2023173
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top