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  1. Article ; Online: Bacterial nano-factories as a tool for the biosynthesis of TiO

    Azizi, Zahra Latifi / Daneshjou, Sara

    Applied biochemistry and biotechnology

    2024  

    Abstract: The development of reliable and eco-conscious processes for nanoparticle synthesis constitutes a significant element in nanotechnology. ... ...

    Abstract The development of reliable and eco-conscious processes for nanoparticle synthesis constitutes a significant element in nanotechnology. TiO
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04839-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3053: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Mesenchymal stem cell-derived exosomes decrease Hyperplasia in Psoriasis by inducing transforming growth factor β2 (TGF-β2).

    Abed, Zahraa Ibrahim / Arianejad, Mona / Azizi, Zahra

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 635

    Abstract: Background: Psoriasis, a chronic inflammatory skin disease, is increasingly effectively managed with the targeted immunotherapy; however, long-term immunotherapy carries health risks, and loss of response. Therefore, we need to develop the alternative ... ...

    Abstract Background: Psoriasis, a chronic inflammatory skin disease, is increasingly effectively managed with the targeted immunotherapy; however, long-term immunotherapy carries health risks, and loss of response. Therefore, we need to develop the alternative treatment strategies. Mesenchymal stem/stromal cell (M.S.C.) exosomes stand out for their remarkable immunomodulatory properties, gaining widespread recognition. This study investigated whether M.S.C. exosomes can reduce psoriasis-induced hyperplasia by inducing Transforming Growth Factor beta 2 (TGF-beta2) signaling.
    Methodology: Exosomes were isolated from M.S.C.s by ultracentrifugation. Then, scanning electron microscopy was used for the morphology of exosomes. To ascertain the exosome concentration, the Bradford test was used. To ascertain the cellular toxicity of exosomes in Human Umbilical Vein Endothelial Cells ( H.U.V.E.C), an MTT experiment was then conducted. Real-time PCR was used to quantify TGF beta2 expression levels, whereas an ELISA immunosorbent assay was used to determine the protein concentration of TGF beta2.
    Results: In this study, the exosomes of 15-30 nm in size that were uniform, and cup-shaped were isolated. Moreover, the IC
    Conclusion: Upregulating the expression of TGF-β2 in psoriatic cells via TGF-β2 signaling is one way exosomes can help reduce hyperplasia.
    MeSH term(s) Exosomes/metabolism ; Mesenchymal Stem Cells/metabolism ; Psoriasis/metabolism ; Humans ; Transforming Growth Factor beta2/metabolism ; Hyperplasia/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Signal Transduction ; Animals
    Chemical Substances Transforming Growth Factor beta2 ; TGFB2 protein, human
    Language English
    Publishing date 2024-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09337-4
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    Zs.A 1140: Show issues Location:
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  3. Article ; Online: Explaining Integration of Evidence Separated by Temporal Gaps with Frontoparietal Circuit Models.

    Azizi, Zahra / Ebrahimpour, Reza

    Neuroscience

    2022  Volume 509, Page(s) 74–95

    Abstract: Perceptual decisions rely on accumulating sensory evidence over time. However, the accumulation process is complicated in real life when evidence resulted from separated cues over time. Previous studies demonstrate that participants are able to integrate ...

    Abstract Perceptual decisions rely on accumulating sensory evidence over time. However, the accumulation process is complicated in real life when evidence resulted from separated cues over time. Previous studies demonstrate that participants are able to integrate information from two separated cues to improve their performance invariant to an interval between the cues. However, there is no neural model that can account for accuracy and confidence in decisions when there is a time interval in evidence. We used behavioral and EEG datasets from a visual choice task -Random dot motion- with separated evidence to investigate three candid distributed neural networks. We showed that decisions based on evidence accumulation by separated cues over time are best explained by the interplay of recurrent cortical dynamics of centro-parietal and frontal brain areas while an uncertainty-monitoring module included in the model.
    MeSH term(s) Humans ; Reaction Time ; Decision Making ; Brain ; Neural Networks, Computer ; Cues
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2022.10.019
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    Zs.A 1215: Show issues Location:
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  4. Article: Clinical Trial Technologies for Improving Equity and Inclusion in Cardiovascular Clinical Research.

    Broadwin, Cassandra / Azizi, Zahra / Rodriguez, Fatima

    Cardiology and therapy

    2023  Volume 12, Issue 2, Page(s) 215–225

    Abstract: Approximately one-third of clinical trials fail to meet their recruitment goals, which can cause costly delays to sponsors and compromise the scientific integrity and generalizability of a trial. Inadequate recruitment and retention of patient groups who ...

    Abstract Approximately one-third of clinical trials fail to meet their recruitment goals, which can cause costly delays to sponsors and compromise the scientific integrity and generalizability of a trial. Inadequate recruitment and retention of patient groups who have the disease under investigation may produce insufficient medical knowledge about the therapeutic effects of drugs or products for the population at large. It is essential to address these issues to ensure that certain groups are not unduly subjected to disproportionate risks or denied the benefits of research. This commentary will present opportunities for clinical trialists to use emerging technologies and decentralized approaches to improve clinical trial recruitment, mitigate disparities, and improve individual and population-level outcomes within cardiovascular medicine.
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Letter
    ZDB-ID 2700626-8
    ISSN 2193-6544 ; 2193-8261
    ISSN (online) 2193-6544
    ISSN 2193-8261
    DOI 10.1007/s40119-023-00311-y
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  5. Article ; Online: Development of p-amino acetanilide functionalized multi-walled carbon nanotubes as an effective carrier for lansoprazole release.

    Abniki, Milad / Azizi, Zahra / Poorebrahim, Sepideh / Moniri, Elham

    Biomedical physics & engineering express

    2023  Volume 9, Issue 4

    Abstract: Nowadays the nano-drug delivery system is an appropriate procedure for solving the problem of controlling drug performance in a traditional method. For this purpose, a new nano-adsorbent of modification multi-walled carbon nanotubes with cyanuric ... ...

    Abstract Nowadays the nano-drug delivery system is an appropriate procedure for solving the problem of controlling drug performance in a traditional method. For this purpose, a new nano-adsorbent of modification multi-walled carbon nanotubes with cyanuric chloride and para-amino acetanilide was synthesized for the effective sorption and desorption of lansoprazole drugs. Physicochemical properties of the multi-walled carbon nanotubes with cyanuric chloride and para-amino acetanilide were then specified with energy dispersive spectroscopy, scanning electron microscope, infrared spectroscopy (IR), thermal gravimetric (TGA), and elemental analysis (CHN). The adsorption process followed by the drug release kinetics and isotherm models has indicated a good and acceptable kinetic adsorption and Langmuir isotherm model in conditions simulated. The maximum capacity value for the lansoprazole adsorption by nano-adsorbent was 48.781 mg g
    MeSH term(s) Nanotubes, Carbon/chemistry ; Acetanilides ; Spectroscopy, Fourier Transform Infrared
    Chemical Substances Nanotubes, Carbon ; 4-aminoacetanilide (IH5OX0I3Z9) ; acetanilide (SP86R356CC) ; Acetanilides
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ISSN 2057-1976
    ISSN (online) 2057-1976
    DOI 10.1088/2057-1976/acd459
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  6. Article ; Online: Missing Race and Ethnicity Data in Pediatric Studies.

    Vedelli, Jordan K H / Azizi, Zahra / Anand, Kanwaljeet J S

    JAMA pediatrics

    2023  Volume 178, Issue 1, Page(s) 6–8

    MeSH term(s) Child ; Humans ; Ethnicity ; Demography ; Racial Groups ; Research Design ; Data Collection
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.4745
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  7. Article ; Online: Informative Artifacts in AI-Assisted Care.

    Azizi, Zahra / Vedelli, Jordan K H / Anand, Kanwaljeet J S

    The New England journal of medicine

    2023  Volume 389, Issue 22, Page(s) 2113

    MeSH term(s) Humans ; Artifacts ; Artificial Intelligence
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2311525
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Identification of Hub Genes Associated with Resistance to Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene Co-expression Network Analysis.

    Nekoeian, Shahram / Ferdowsian, Shaghayegh / Asgari, Yazdan / Azizi, Zahra

    Molecular biotechnology

    2023  Volume 65, Issue 11, Page(s) 1913–1922

    Abstract: Resistance against glucocorticoids which are used to reduce inflammation and treatment of a number of diseases, including leukemia, is known as the first stage of treatment failure in acute lymphoblastic leukemia. Since these drugs are the essential ... ...

    Abstract Resistance against glucocorticoids which are used to reduce inflammation and treatment of a number of diseases, including leukemia, is known as the first stage of treatment failure in acute lymphoblastic leukemia. Since these drugs are the essential components of chemotherapy regimens for ALL and play an important role in stop of cell growth and induction of apoptosis, it is important to identify genes and the molecular mechanism that may affect glucocorticoid resistance. In this study, we used the GSE66705 dataset and weighted gene co-expression network analysis (WGCNA) to identify modules that correlated more strongly with prednisolone resistance in type B lymphoblastic leukemia patients. The PPI network was built using the DEGs key modules and the STRING database. Finally, we used the overlapping data to identify hub genes. out of a total of 12 identified modules by WGCNA, the blue module was find to have the most statistically significant correlation with prednisolone resistance and Nine genes including SOD1, CD82, FLT3, GART, HPRT1, ITSN1, TIAM1, MRPS6, MYC were recognized as hub genes Whose expression changes can be associated with prednisolone resistance. Enrichment analysis based on the MsigDB repository showed that the altered expressed genes of the blue module were mainly enriched in IL2_STAT5, KRAS, MTORC1, and IL6-JAK-STAT3 pathways, and their expression changes can be related to cell proliferation and survival. The analysis performed by the WGCNA method introduced new genes. The role of some of these genes was previously reported in the resistance to chemotherapy in other diseases. This can be used as clues to detect treatment-resistant (drug-resistant) cases in the early stages of diseases.
    MeSH term(s) Humans ; Gene Expression Profiling/methods ; Gene Regulatory Networks ; Inflammation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Prednisolone/pharmacology ; Prednisolone/therapeutic use
    Chemical Substances Prednisolone (9PHQ9Y1OLM) ; ELAVL2 protein, human
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1193057-3
    ISSN 1559-0305 ; 1073-6085
    ISSN (online) 1559-0305
    ISSN 1073-6085
    DOI 10.1007/s12033-023-00707-0
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    Zs.A 4031: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Targeting glucose metabolism for treatment of COVID-19.

    Ardestani, Amin / Azizi, Zahra

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 112

    MeSH term(s) Blood Glucose ; COVID-19 ; Glycolysis ; Humans ; Monocytes ; SARS-CoV-2
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2021-03-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00532-4
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  10. Article ; Online: The impact of flaxseed oil on lipid profiles, weight loss, and inflammatory markers in hemodialysis patients: A systematic review and meta-analysis of randomized controlled trials.

    Tabrizi, Reza / Azizi, Zahra / Bazmi, Sina / Keshavarzian, Omid / Akbari, Maryam / Karimimoghadam, Zeinab / Haghpanah, Abdolreza

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2024  

    Abstract: Studies investigating the effects of flaxseed oil on lipid profiles, weight loss, and inflammatory markers have produced inconsistent results. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to explore the impact of ... ...

    Abstract Studies investigating the effects of flaxseed oil on lipid profiles, weight loss, and inflammatory markers have produced inconsistent results. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to explore the impact of flaxseed oil on these parameters in hemodialysis patients. The study protocol was registered online (PROSPERO number: CRD42023484076). The meta-analyses showed a significant decrease in triglyceride (TG) levels (WMD = -85.78 mg/dL, 95% CI: -155.24 to -16.32, I
    Language English
    Publishing date 2024-05-10
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.14140
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    Zs.A 5208: Show issues Location:
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