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  1. Article: Association of single nucleotide polymorphism at long non-coding RNA 8138.1 with duration of fertility in egg-laying hens.

    Adetula, Adeyinka Abiola / Azmal, Syed Ali / Sun, Chenghao / Elokil, Abdelmotaleb / Li, Shijun

    PeerJ

    2019  Volume 7, Page(s) e7282

    Abstract: A previous genome-wide transcriptional analysis identified long non-coding RNA 8138.1 ( ...

    Abstract A previous genome-wide transcriptional analysis identified long non-coding RNA 8138.1 (
    Language English
    Publishing date 2019-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.7282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Novel Polymorphisms in

    Azmal, Syed Ali / Bhuiyan, Ali Akbar / Omar, Abdullah Ibne / Ma, Shuai / Sun, Chenghao / Han, Zhongdong / Zhang, Meikuen / Zhao, Shuhong / Li, Shijun

    Genes

    2019  Volume 10, Issue 5

    Abstract: The improvement of egg production is of vital importance in the chicken industry to maintain optimum output throughout the laying period. Because of the elongation of the egg-laying cycle, a drop in egg-laying rates in the late laying period has provoked ...

    Abstract The improvement of egg production is of vital importance in the chicken industry to maintain optimum output throughout the laying period. Because of the elongation of the egg-laying cycle, a drop in egg-laying rates in the late laying period has provoked great concern in the poultry industry. In this study, we calculated the egg-laying rate at weeks 61-69 (60 days) of Jing Hong chickens parent generation as the phenotype, and the genotype were detected by the chicken 600K Affymetrix Axiom High Density (HD) Single Nucleotide Polymorphisms (SNP)-array. The Genome-Wide Association Study (GWAS) result showed that the egg production trait is significantly associated with five SNPs (AX-75745366, AX-75745380, AX-75745340, AX-75745388, and AX-75745341), which are in the rap guanine nucleotide exchange factor 6 (
    MeSH term(s) Alleles ; Animals ; Avian Proteins/genetics ; Chickens/genetics ; Eggs ; Female ; Genome-Wide Association Study ; Genotype ; Guanine Nucleotide Exchange Factors/genetics ; Haplotypes ; Oviposition/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics
    Chemical Substances Avian Proteins ; Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2019-05-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes10050384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A genome-wide single nucleotide polymorphism scan reveals genetic markers associated with fertility rate in Chinese Jing Hong chicken.

    Azmal, Syed Ali / Nan, Jiuhong / Bhuiyan, Ali Akbar / Elokil, Abdelmotaleb Ahmed / Ali, Mohammad Ishaque / Adetula, Adeyinka Abiola / Ma, Shuai / Sun, Chenghao / Han, Zhongdong / Yuan, Jingwei / Li, Shijun

    Poultry science

    2020  Volume 99, Issue 6, Page(s) 2873–2887

    Abstract: The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with ... ...

    Abstract The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing Hong chickens parent generation as the phenotype and the genotype were detected by the chicken 600K Affymetrix Axiom High Density single nucleotide polymorphisms (SNP)-array. The genome-wide association study using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2) were further genotyped by polymerase chain reaction-restriction fragments length polymorphisms method. The association analysis results revealed that 12 polymorphisms (AX-75769978, AX-76582632, AX-75730546, AX-75730496, AX-75730588, AX-76530282, AX-76530329, AX-76529310, AX-75769906, AX-75755394, AX-80813697 and AX-76582809) out of 20 showed highly significant effects (P < 0.0001) on fertility rate in P1, P2 and P1+P2. Six haplotypes (TTAA, TTGG, TTAG, CTAA, CTGG, and CTAG) were inferred based on significant loci (AX-75730546 and AX-76530282) also showed significant association with fertility rate, where haplotype CTAG was shown to be markedly associated with the significantly highest (P < 0.0001) fertility rate (in P1, 86.42 ± 0.59; P2, 85.98 ± 0.59 and P1+P2, 86.16 ± 0.42) followed by other haplotypes for the irrespective of population studied. Collectively, we report for the first time that 12 SNP in the chromosomes 3 and 13 were significantly associated with fertility rate during the later stage of egg production, which could be used as the potential genetic markers that would be able to facilitate in the selection and improvement of fertility rate through chicken breeding.
    MeSH term(s) Animals ; Breeding ; Chickens/genetics ; Chickens/growth & development ; Fertility/genetics ; Genetic Markers ; Genome-Wide Association Study/veterinary ; Polymerase Chain Reaction/veterinary ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2020-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2019.12.068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 853: Show issues Location:
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  4. Article: Association of single nucleotide polymorphism in NLRC3, NLRC5, HIP1, and LRP8 genes with fecal egg counts in goats naturally infected with Haemonchus contortus

    Omar, Abdullah Ibne / Alam, Mahmuda Bilkis Bintee / Notter, David Russell / Zhao, Shuhong / Faruque, Md.Omar / Thi, Thuy Nhien Tran / Yin, Lilin / Li, Jingjin / Azmal, Syed Ali / Du, Xiaoyong

    Tropical animal health and production. 2020 July, v. 52, no. 4

    2020  

    Abstract: Haemonchus contortus is a common, intractably pathogenic and economically important gastrointestinal nematode for goat producers worldwide, especially in tropical and subtropical regions. The objective of this study is to identify single nucleotide ... ...

    Abstract Haemonchus contortus is a common, intractably pathogenic and economically important gastrointestinal nematode for goat producers worldwide, especially in tropical and subtropical regions. The objective of this study is to identify single nucleotide polymorphisms (SNPs) of 12 candidate goat genes mainly related to the innate immune response associated with fecal egg counts (FECs) of Haemonchus contortus in goat as an indicator of the level of parasite infection. Phenotypic data including FEC and blood traits were recorded in 189 native goats from China and 191 ones from Bangladesh, respectively. Bangladeshi goats had significantly (P < 0.01) lower FEC compared to that of Chinese goats, suggesting higher susceptible and infection rates in Chinese goat populations. FEC was significantly positive correlated with body weight (r = 0.64, P < 0.01) and hemoglobin (r = 0.49, P < 0.01) value, but negative with pack cell volume (r = − 0.63, P < 0.05) in goats. Genotyping of SNPs was performed using a matrix-assisted laser desorption ionization time of flight mass spectrometry assay and a generalized linear model was used to evaluate the association between each SNP and goat FEC trait. Eleven novel SNPs in the NLRC3, NLRC5, HIP1, and LRP8, out of 46 variants from these 12 genes, were significantly associated with FEC of goats with a nominal significance level of P < 0.05. Of these 11 SNPs, linkage disequilibrium were revealed among SNPs in LRP8 (r² = 0.87 to 1), between SNPs in NLRC3, NLRC5, and HIP1 (r² = 0.96 to 0.99), respectively. Further, haplotypes within NLRC3, NLRC5, and HIP1 were significantly associated (P < 0.001) with FEC. In artificial challenge trail, quantitative real-time PCR exposed that the relative expression of mRNA was higher in the resistant group for NLRC3 (P < 0.01), LRP8 and HIP1 (P < 0.001) but lower in the resistant group for NLRC5 (P < 0.0001), compared to the susceptible group. The possible SNP markers and genes identified in this study could be potentially used in marker-assisted selection for breeding local goats breeds resistant to gastrointestinal nematode parasite particularly for Haemonchus contortus, and then for improving health and productivity of goat.
    Keywords Haemonchus contortus ; blood ; body weight ; desorption ; eggs ; gastrointestinal nematodes ; genotyping ; goats ; haplotypes ; hemoglobin ; innate immunity ; linear models ; linkage disequilibrium ; marker-assisted selection ; mass spectrometry ; phenotype ; quantitative polymerase chain reaction ; single nucleotide polymorphism ; Bangladesh ; China
    Language English
    Dates of publication 2020-07
    Size p. 1583-1598.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-019-02154-z
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2667: Show issues

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  5. Article: A genome-wide single nucleotide polymorphism scan reveals genetic markers associated with fertility rate in Chinese Jing Hong chicken

    Azmal, Syed Ali / Nan, Jiuhong / Bhuiyan, Ali Akbar / Elokil, Abdelmotaleb Ahmed / Ali, Mohammad Ishaque / Adetula, Adeyinka Abiola / Ma, Shuai / Sun, Chenghao / Han, Zhongdong / Yuan, Jingwei / Li, Shijun

    Poultry science. 2020 June, v. 99, no. 6

    2020  

    Abstract: The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with ... ...

    Abstract The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing Hong chickens parent generation as the phenotype and the genotype were detected by the chicken 600K Affymetrix Axiom High Density single nucleotide polymorphisms (SNP)-array. The genome-wide association study using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2) were further genotyped by polymerase chain reaction–restriction fragments length polymorphisms method. The association analysis results revealed that 12 polymorphisms (AX-75769978, AX-76582632, AX-75730546, AX-75730496, AX-75730588, AX-76530282, AX-76530329, AX-76529310, AX-75769906, AX-75755394, AX-80813697 and AX-76582809) out of 20 showed highly significant effects (P < 0.0001) on fertility rate in P1, P2 and P1+P2. Six haplotypes (TTAA, TTGG, TTAG, CTAA, CTGG, and CTAG) were inferred based on significant loci (AX-75730546 and AX-76530282) also showed significant association with fertility rate, where haplotype CTAG was shown to be markedly associated with the significantly highest (P < 0.0001) fertility rate (in P1, 86.42 ± 0.59; P2, 85.98 ± 0.59 and P1+P2, 86.16 ± 0.42) followed by other haplotypes for the irrespective of population studied. Collectively, we report for the first time that 12 SNP in the chromosomes 3 and 13 were significantly associated with fertility rate during the later stage of egg production, which could be used as the potential genetic markers that would be able to facilitate in the selection and improvement of fertility rate through chicken breeding.
    Keywords breeding ; egg production ; female fertility ; genetic markers ; genome-wide association study ; genotyping ; haplotypes ; laying hens ; loci ; phenotype ; polymerase chain reaction ; reproductive traits ; single nucleotide polymorphism ; spermatozoa
    Language English
    Dates of publication 2020-06
    Size p. 2873-2887.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2019.12.068
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 860: Show issues

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  6. Article ; Online: Association of single nucleotide polymorphism in NLRC3, NLRC5, HIP1, and LRP8 genes with fecal egg counts in goats naturally infected with Haemonchus contortus.

    Omar, Abdullah Ibne / Alam, Mahmuda Bilkis Bintee / Notter, David Russell / Zhao, Shuhong / Faruque, Md Omar / Thi, Thuy Nhien Tran / Yin, Lilin / Li, Jingjin / Azmal, Syed Ali / Du, Xiaoyong

    Tropical animal health and production

    2019  Volume 52, Issue 4, Page(s) 1583–1598

    Abstract: Haemonchus contortus is a common, intractably pathogenic and economically important gastrointestinal nematode for goat producers worldwide, especially in tropical and subtropical regions. The objective of this study is to identify single nucleotide ... ...

    Abstract Haemonchus contortus is a common, intractably pathogenic and economically important gastrointestinal nematode for goat producers worldwide, especially in tropical and subtropical regions. The objective of this study is to identify single nucleotide polymorphisms (SNPs) of 12 candidate goat genes mainly related to the innate immune response associated with fecal egg counts (FECs) of Haemonchus contortus in goat as an indicator of the level of parasite infection. Phenotypic data including FEC and blood traits were recorded in 189 native goats from China and 191 ones from Bangladesh, respectively. Bangladeshi goats had significantly (P < 0.01) lower FEC compared to that of Chinese goats, suggesting higher susceptible and infection rates in Chinese goat populations. FEC was significantly positive correlated with body weight (r = 0.64, P < 0.01) and hemoglobin (r = 0.49, P < 0.01) value, but negative with pack cell volume (r = - 0.63, P < 0.05) in goats. Genotyping of SNPs was performed using a matrix-assisted laser desorption ionization time of flight mass spectrometry assay and a generalized linear model was used to evaluate the association between each SNP and goat FEC trait. Eleven novel SNPs in the NLRC3, NLRC5, HIP1, and LRP8, out of 46 variants from these 12 genes, were significantly associated with FEC of goats with a nominal significance level of P < 0.05. Of these 11 SNPs, linkage disequilibrium were revealed among SNPs in LRP8 (r
    MeSH term(s) Animals ; Body Weight/genetics ; Breeding ; Feces/parasitology ; Female ; Genetic Predisposition to Disease ; Goat Diseases/genetics ; Goat Diseases/parasitology ; Goats/genetics ; Haemonchiasis/veterinary ; Haemonchus ; Immunity, Innate ; Intestinal Diseases, Parasitic/genetics ; Intestinal Diseases, Parasitic/parasitology ; Intestinal Diseases, Parasitic/veterinary ; Parasite Egg Count/veterinary ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2019-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-019-02154-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2159: Show issues Location:
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