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  1. Article ; Online: Trends in Neisseria meningitidis serogroups amongst patients with suspected cerebrospinal meningitis in the meningitis belt of Ghana: a 5-year retrospective study.

    Azure, Stebleson / Abdul-Karim, Abass / Abubakari, Braimah Baba / Eleeza, John B / Agboyie, Daron Davies A / Weyori, Enoch Weikem / Choi, Jun Yong

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 202

    Abstract: Background: Serogroup A Neisseria meningitidis was the major cause of meningococcal meningitis epidemics in the African meningitis belt before 2010 when the monovalent meningococcal A conjugate vaccine (MenAfriVac) was introduced in the region. ... ...

    Abstract Background: Serogroup A Neisseria meningitidis was the major cause of meningococcal meningitis epidemics in the African meningitis belt before 2010 when the monovalent meningococcal A conjugate vaccine (MenAfriVac) was introduced in the region. Therefore, this study aimed to establish the trends in N. meningitidis serogroups from 2016 to 2020 in Ghana's meningitis belt.
    Methods: Polymerase chain reaction (PCR) confirmed laboratory results of suspected cases of cerebrospinal meningitis from January, 2016 to March, 2020 were obtained from the Tamale Public Health Laboratory. The data were subjected to trend analysis using Statistical Package for the Social Sciences version 25. Differences between discrete variables were analyzed using the Cochran-Armitage trend test.
    Results: Of the 2,426 suspected cases, 395 (16.3%) were confirmed positive for N. meningitidis using PCR. Serogroup X showed a significant upward trend (P < 0.01), and serogroup W showed a downward trend (P < 0.01). However, no significant trend was observed for any other serogroup.
    Conclusion: This study showed the emergence of serogroup X, a non-vaccine type, as the predominant N. meningitidis serogroup in the wake of a declining serogroup W in Ghana's meningitis belt.
    MeSH term(s) Humans ; Neisseria meningitidis ; Serogroup ; Retrospective Studies ; Ghana/epidemiology ; Meningitis, Meningococcal/epidemiology ; Meningitis, Meningococcal/prevention & control ; Meningococcal Vaccines
    Chemical Substances Meningococcal Vaccines
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08196-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictive signs and symptoms of bacterial meningitis isolates in Northern Ghana.

    Weyori, Enoch Weikem / Abubakari, Braimah Baba / Nkrumah, Bernard / Abdul-Karim, Abass / Abiwu, Hilarius Asiwome Kosi / Kuugbee, Eugene Dogkotenge / Yidana, Adadow / Ziblim, Shamsu-Deen / Nuertey, Benjamin / Weyori, Benjamin Asubam / Yakubu, Etowi Boye / Azure, Stebleson / Koyiri, Valentine Cheba / Adatsi, Richard Kujo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13400

    Abstract: Cerebrospinal meningitis (CSM) is a public health burden in Ghana that causes up to 10% mortality in confirmed cases annually. About 20% of those who survive the infection suffer permanent sequelae. The study sought to understand the predictive signs and ...

    Abstract Cerebrospinal meningitis (CSM) is a public health burden in Ghana that causes up to 10% mortality in confirmed cases annually. About 20% of those who survive the infection suffer permanent sequelae. The study sought to understand the predictive signs and symptoms of bacterial meningitis implicated in its outcomes. Retrospective data from the Public Health Division, Ghana Health Service on bacterial meningitis from 2015 to 2019 was used for this study. A pre-tested data extraction form was used to collect patients' information from case-based forms kept at the Disease Control Unit from 2015 to 2019. Data were transcribed from the case-based forms into a pre-designed Microsoft Excel template. The data was cleaned and imported into SPSS version 26 for analysis. Between 2015 and 2019, a total of 2446 suspected bacterial meningitis cases were included in the study. Out of these, 842 (34.4%) were confirmed. Among the confirmed cases, males constituted majority with 55.3% of the cases. Children below 14 years of age were most affected (51.4%). The pathogens commonly responsible for bacterial meningitis were Neisseria meningitidis (43.7%) and Streptococcus pneumoniae (53.0%) with their respective strains Nm W135 (36.7%), Nm X (5.1%), Spn St. 1 (26.2%), and Spn St. 12F/12A/12B/44/4 (5.3%) accounting for more than 70.0% of the confirmed cases. The presence of neck stiffness (AOR = 1.244; C.I 1.026-1.508), convulsion (AOR = 1.338; C.I 1.083-1.652), altered consciousness (AOR = 1.516; C.I 1.225-1.876), and abdominal pains (AOR = 1.404; C.I 1.011-1.949) or any of these signs and symptoms poses a higher risk for testing positive for bacterial meningitis adjusting for age. Patients presenting one and/or more of these signs and symptoms (neck stiffness, convulsion, altered consciousness, and abdominal pain) have a higher risk of testing positive for bacterial meningitis after statistically adjusting for age.
    MeSH term(s) Child ; Male ; Humans ; Ghana/epidemiology ; Retrospective Studies ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/epidemiology ; Meningitis, Meningococcal/diagnosis ; Meningitis, Meningococcal/epidemiology ; Abdominal Pain ; Seizures
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38253-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Common bacteria in sputum or gastric lavage of patients presenting with signs and symptoms of lower respiratory tract infections

    Oliver Deberu / Bernard Nkrumah / Augustina Angelina Sylverken / David Sambian / Godfred Acheampong / John Amuasi / Azure Stebleson / Daron Agboyie / Monica Yenbaree / Sylvester Mensah / Abaifa Dombadoh / Dorcas Ohui Owusu / Abass Abdul-Karim / Michael Owusu

    The Pan African Medical Journal, Vol 38, Iss

    2021  Volume 383

    Abstract: INTRODUCTION: Lower respiratory tract infections (LRTIs) are infections involving the trachea, primary bronchi and lungs. People with LRTIs typically experience coughs as the primary symptoms; however, shortness of breath, weakness, fever and fatigue may ...

    Abstract INTRODUCTION: Lower respiratory tract infections (LRTIs) are infections involving the trachea, primary bronchi and lungs. People with LRTIs typically experience coughs as the primary symptoms; however, shortness of breath, weakness, fever and fatigue may be coupled with the cough. It is common among the aged, children under five and the immune-suppressed. Persons with symptoms suggestive of pulmonary tuberculosis (TB) may have tuberculosis, other respiratory tract infection or co-infection of tuberculosis and other respiratory pathogens. This study aimed to identify the presence of pathogens in sputum of suspected tuberculosis cases and their antimicrobial resistance patterns. METHODS: this was a retrospective study conducted from September 2018 to November 2019 at Tamale Public Health Laboratory. Sputum or gastric lavage samples were collected from persons with suspected clinical presentations of TB and/or LRTI. These samples were cultured using standard microbiological protocols and antimicrobial susceptibility test performed on the positive cultures by Kirby-Bauer disc diffusion method. Molecular identification of M. tuberculosis was performed on all the suspected TB cases using GeneXpert mycobacterium tuberculosis/rifampin (MTB/RIF) assay.
    Keywords sputum ; pathogens ; tuberculosis ; culture ; lower respiratory tract ; tamale public health laboratory ; infection ; Medicine ; R
    Subject code 572
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher The Pan African Medical Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Diagnosis of bacterial meningitis in Ghana

    Nafiu Amidu / Benedict Boateng Antuamwine / Otchere Addai-Mensah / Abass Abdul-Karim / Azure Stebleson / Braimah Baba Abubakari / John Abenyeri / Afia Serwaa Opoku / John Eyulaku Nkukah / Ali Sidi Najibullah

    PLoS ONE, Vol 14, Iss 1, p e

    Polymerase chain reaction versus latex agglutination methods.

    2019  Volume 0210812

    Abstract: Bacterial meningitis is a public health crisis in the northern part of Ghana, where it contributes to very high mortality and morbidity rates. Early detection of the causative organism will lead to better management and effective treatment. Our aim was ... ...

    Abstract Bacterial meningitis is a public health crisis in the northern part of Ghana, where it contributes to very high mortality and morbidity rates. Early detection of the causative organism will lead to better management and effective treatment. Our aim was to evaluate the diagnostic accuracy of Pastorex and Wellcogen latex agglutination tests for the detection of bacterial meningitis in a resource-limited setting. CSF samples from 330 suspected meningitis patients within the northern zone of Ghana were analysed for bacterial agents at the zonal Public Health Reference Laboratory in Tamale using polymerase chain reaction (PCR) and two latex agglutination test kits; Pastorex and Wellcogen. The overall positivity rate of samples tested for bacterial meningitis was 46.4%. Streptococcus pneumoniae was the most common cause of bacterial meningitis within the sub-region, with positivity rate of 25.2%, 28.2% and 28.8% when diagnosed using Wellcogen, Pastorex and PCR respectively. The Pastorex method was 97.4% sensitive while the Wellcogen technique was 87.6% sensitive. Both techniques however produced the same specificity of 99.4%. Our study revealed that the Pastorex method has a better diagnostic value for bacterial meningitis than the Wellcogen method and should be the method of choice in the absence of PCR.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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