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  1. Article ; Online: In Reply: Predictors of Academic Neurosurgical Career Trajectory Among International Medical Graduates Training Within the United States.

    Azzam, Ahmed Y / Ghozy, Sherief

    Neurosurgery

    2022  Volume 90, Issue 1, Page(s) e27

    MeSH term(s) Career Choice ; Education, Medical, Graduate ; Humans ; United States
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of COVID-19 pandemic on the management of glioma patients around the world. An evidence-based review.

    Azab, Mohammed A / Azzam, Ahmed Y

    Brain disorders (Amsterdam, Netherlands)

    2021  Volume 2, Page(s) 100012

    Abstract: Background: The coronavirus pandemic has affected many health care services worldwide since the emergence of the first case in Wuhan. Surgical neuro-oncology care is a fundamental part of hospital services, making it susceptible to strategic changes ... ...

    Abstract Background: The coronavirus pandemic has affected many health care services worldwide since the emergence of the first case in Wuhan. Surgical neuro-oncology care is a fundamental part of hospital services, making it susceptible to strategic changes amid the COVID-19 pandemic.
    Methods: An electronic search on several databases (PubMed/Medline, Scopus, and Google Scholar) from the beginning of the pandemic to the end of 2020, each paper was reviewed independently. The publication inclusion and exclusion criteria were done using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.
    Results: Eight studies were found to be eligible for our meta-analysis. Most of the studies were on a retrospective basis, except one which was retrospective and prospective. An overall of 951 glioma patients' were included for surgical admission from the beginning of the pandemic until 2020. Seventy-four patients' had mortality outcomes, and 250 patients had complications for both surgical admitted and non-surgical admitted purposes.
    Conclusions: To our knowledge, we made the first systematic review and meta-analysis regarding the management of glioma patients' during the pandemic of COVID-19. Our main findings are that the number of surgical admissions for glioma patients' did not significantly differ between COVID-19 negative and COVD-19 positive cases; however, surprisingly, we found that both overall complications and mortality outcomes were more significant COVID-19 negative patients' from the reported studies.
    Language English
    Publishing date 2021-05-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2666-4593
    ISSN (online) 2666-4593
    DOI 10.1016/j.dscb.2021.100012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: SARS-CoV-2 associated viral encephalitis with mortality outcome.

    Azab, Mohammed A / Azzam, Ahmed Y

    Interdisciplinary neurosurgery : Advanced techniques and case management

    2021  Volume 25, Page(s) 101132

    Abstract: Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) appeared in Wuhan, China, in December 2019; apart from common conditions such as cough, fever, and severe respiratory complications, difficulty in breathing, including tachypnea, ... ...

    Abstract Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) appeared in Wuhan, China, in December 2019; apart from common conditions such as cough, fever, and severe respiratory complications, difficulty in breathing, including tachypnea, new studies on neurological manifestations have gained public interest.
    Case report: An 89-year-old man was admitted to the neurocritical care department in a specialized hospital with headache, dizziness, hyperpyrexia, myalgia, rash, and tremors. MRI showed viral encephalitis near to basal ganglia and thalami.
    Discussion: Coronaviruses interfere with target cells by membrane-bound spike proteins. Angiotensin-converting enzyme 2 was identified as an input receptor for SARS-CoV-2. Due to its wide pattern of expression, COVID-19 was shown to affect several organs, including the central nervous system, where the receptor is mainly expressed as neurons.
    Conclusions: In the current pandemic, there is a rising number of global infections, the aim of our case to increase the awareness about SARS-CoV-2 possible complications, even if there are possible further mutations for the virus, especially in the central nervous system.
    Language English
    Publishing date 2021-02-25
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2785532-6
    ISSN 2214-7519
    ISSN 2214-7519
    DOI 10.1016/j.inat.2021.101132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Reply: A New Trend of Blended Learning in Neurosurgical Training: Fellowship of Neuroendoscopy.

    Azzam, Ahmed Y / Ghozy, Sherief

    Neurosurgery

    2021  Volume 90, Issue 2, Page(s) e55–e56

    MeSH term(s) Fellowships and Scholarships ; Humans ; Neuroendoscopy ; Neurosurgery/education ; Simulation Training
    Language English
    Publishing date 2021-12-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424: Show issues Location:
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  5. Article ; Online: Insights into how H19 works in glioma cells. A review article.

    Azab, Mohammed A / Azzam, Ahmed Y

    Cancer treatment and research communications

    2021  Volume 28, Page(s) 100411

    Abstract: Glioblastoma is a highly aggressive brain tumor and considered to be the most common primary one. Recurrence after treatment is a significant problem, with a survival rate after one year of about 39.7%. The recurrence of GBM is linked to different ... ...

    Abstract Glioblastoma is a highly aggressive brain tumor and considered to be the most common primary one. Recurrence after treatment is a significant problem, with a survival rate after one year of about 39.7%. The recurrence of GBM is linked to different cellular pathways and molecular signaling. Long non-coding RNA (LncRNA) comprises more than 200 nucleotides and is suggested to play a role in controlling genes that regulate the cell cycle, apoptosis and cellular growth in various tissues. Little is known about LncRNA compared to microRNAs, which are extensively studied in the literature. H19 is one of the most plentiful and conserved transcripts suggested to be involved in mammalian development and tumorigenesis. H19 is one of the LncRNA members transcribed by RNA polymerase II, spliced and polyadenylated, and the product is transferred to the cytoplasm without translation. HI9 maps to 1lp15, a region thought to be relevant to some childhood tumors as embryonal rhabdomyosarcoma and Wilm's Tumor. In these tumors, the analysis of the 11p15 locus showed loss of heterozygosity which is a feature associated with the tumor-suppressing activity. However, the role played by H19 in GBM is still enigmatic and needs further extensive evaluation. Uncovering the hidden role of such molecules in the pathogenesis in glioma will help tailor new targeted therapies that may affect the prognosis and survival of GBM.
    MeSH term(s) Cell Line, Tumor ; Glioma/genetics ; Humans ; Prognosis ; RNA, Long Noncoding/metabolism
    Chemical Substances H19 long non-coding RNA ; RNA, Long Noncoding
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2021.100411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Safety and efficacy of chimeric antigen receptor T-cell therapy for acute myeloid leukemia: A subgroup based meta-analysis.

    Morsy, Mahmoud M / Azzam, Ahmed Y / Elamin, Osman / Elswedy, Adam / Nashwan, Abdulqadir J

    Leukemia research

    2024  Volume 140, Page(s) 107498

    Abstract: Introduction: Acute myeloid leukemia (AML) is a significant hematological malignancy in the United States, with a high mortality rate and limited treatment options. CAR T-cell therapy, a new and promising treatment, is being investigated for its ... ...

    Abstract Introduction: Acute myeloid leukemia (AML) is a significant hematological malignancy in the United States, with a high mortality rate and limited treatment options. CAR T-cell therapy, a new and promising treatment, is being investigated for its efficacy and safety in AML. This meta-analysis aims to assess the safety and efficacy of CAR T-cell therapy in AML, considering various subgroups such as study location, study design, prior transplantation status, conditioning regimen, and CAR T-cell source.
    Methods: We conducted a comprehensive literature review across multiple databases, adhering to PRISMA guidelines and focusing on studies concerning CAR T-cell therapy in AML. We included original articles in English and excluded non-original reviews, abstracts, and non-English studies. The risk of bias was assessed using the Cochrane ROBINS-I tool. Statistical analysis involved meta-analysis with Cochrane's Q-test and I² statistic, using both fixed-effect and random-effects models, and assessed for publication bias.
    Results: Our search yielded studies encompassing 57 AML patients treated with CAR T-cell therapy. The meta-analysis revealed a 48% incidence of complete remission with CAR T-cell therapy, varying significantly across subgroups based on study design, location, prior transplantation, conditioning regimen, and CAR T-cell source. The highest complete remission rates were observed in patients from China, those who had undergone prior hematopoietic cell transplantation, and those treated with fludarabine and cyclophosphamide conditioning regimen. Adverse events included graft-versus-host disease (7%) and cytokine release syndrome (53%).
    Conclusions: This meta-analysis highlights the potential of CAR T-cell therapy in AML treatment, especially when integrated with certain prior treatments and conditioning regimens. The findings suggest a higher efficacy in patients with previous hematopoietic cell transplantation and specific conditioning regimens. Further large-scale, randomized trials are essential to confirm these findings and establish CAR T-cell therapy as a standard treatment for AML.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2024.107498
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  7. Article ; Online: Letter: The Modern Evolution of Simulations in Endovascular Neurosurgery-A Short Review.

    Azzam, Ahmed Y / Dmytriw, Adam A / Ghozy, Sherief

    Neurosurgery

    2022  Volume 90, Issue 6, Page(s) e182–e183

    MeSH term(s) Endovascular Procedures ; Humans ; Intracranial Aneurysm/surgery ; Neurosurgery ; Neurosurgical Procedures
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Letter ; Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000001946
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  8. Article ; Online: Letter: Robotic-Assisted Neuroendovascular Intervention: Great Potential and Halted Expansion.

    Ghozy, Sherief / Azzam, Ahmed Y / Dmytriw, Adam A

    Neurosurgery

    2022  Volume 90, Issue 6, Page(s) e190–e191

    MeSH term(s) Endovascular Procedures ; Humans ; Robotic Surgical Procedures ; Robotics ; Treatment Outcome
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Letter
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000001973
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  9. Article ; Online: In Reply: A New Trend of Blended Learning in Neurosurgical Training: Fellowship of Neuroendoscopy.

    Ghozy, Sherief / Azzam, Ahmed Y / Dmytriw, Adam A

    Neurosurgery

    2022  

    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Impact of COVID-19 on neurosurgical service: A one-year experience from a provincial countryside hospital in a rural area in north Egypt.

    Azab, Mohammed A / Azzam, Ahmed Y / Salem, Ahmed E

    Interdisciplinary neurosurgery : Advanced techniques and case management

    2021  Volume 27, Page(s) 101416

    Abstract: Background: Globally, there is a shooting pandemic that affected many healthcare systems. Healthcare facilities had to set up strategies to avoid exhaustion while facing a catastrophic health problem. Vaccines or perfect therapies were not available ... ...

    Abstract Background: Globally, there is a shooting pandemic that affected many healthcare systems. Healthcare facilities had to set up strategies to avoid exhaustion while facing a catastrophic health problem. Vaccines or perfect therapies were not available over a long pandemic time and also no certified immunity against that disease is guaranteed. Therefore, it is probable that healthcare systems will face it for an exceptionally long period. That already had a grave effect on the strategy of daily practice of different specialties' services at healthcare centers.
    Methods: We tried simply to share a countryside hospital's expertise in managing neurosurgical cases amid a dreadful health crisis. Healthcare workers' safety and patient safety were typical priorities for neurosurgical service at Damietta Specialized Hospital. We expose the lines of management, triaging cases, the methods of handling confirmed and suspected neurosurgical patients, and strategies for discharging and following up patients. We identified hospital admission and discharge records starting from February 2020 till February 2021 to track the neurosurgical case burden, the state of service offered and the rate of infection among healthcare workers who participated in surgeries.
    Results: At the peak time of the COVID‑19 pandemic in Egypt starting from February 2020 till February 2021, we have admitted about 500 neurosurgical patients. About 400 (80%) of them did surgeries according to the triaging protocol of the hospital. About 150 (30%) of those who did surgeries were urgent and the rest were borderline or semi‑urgent. About 20 (4%) were tested COVID-19 positive and six of them died due to acute respiratory distress syndrome. Only two mortality cases were reported due to post-operative complications and not related to SARS‑CoV‑2 infection. The rest of the cases (97.6%) were discharged for follow‑up without complications. No neurosurgeons but three anesthesia staff were infected with SARS‑CoV‑2. A successful undisturbed neurosurgical care was available for patients during COVID-19 time.
    Conclusions: Following the suggested strategies, a rural area-serving hospital managed to provide uninterrupted neurosurgical care amid COVID-19 pandemic in Egypt. Rural areas in developing countries are in need of strategies to deal with pandemics in the future without dismantling the normal health system, especially for life‑saving cases in a critical specialty as neurosurgery.
    Language English
    Publishing date 2021-10-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2785532-6
    ISSN 2214-7519
    ISSN 2214-7519
    DOI 10.1016/j.inat.2021.101416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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